US20070190115A1 - Feed additive for laying hen and feed containing the same - Google Patents
Feed additive for laying hen and feed containing the same Download PDFInfo
- Publication number
- US20070190115A1 US20070190115A1 US10/587,945 US58794505A US2007190115A1 US 20070190115 A1 US20070190115 A1 US 20070190115A1 US 58794505 A US58794505 A US 58794505A US 2007190115 A1 US2007190115 A1 US 2007190115A1
- Authority
- US
- United States
- Prior art keywords
- lactobionic acid
- laying
- feed
- egg
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000003674 animal food additive Substances 0.000 title claims abstract description 35
- 210000003278 egg shell Anatomy 0.000 claims abstract description 41
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- 102000002322 Egg Proteins Human genes 0.000 claims abstract description 26
- 108010000912 Egg Proteins Proteins 0.000 claims abstract description 26
- 230000017448 oviposition Effects 0.000 claims abstract description 25
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- 230000003014 reinforcing effect Effects 0.000 claims abstract description 10
- 235000013601 eggs Nutrition 0.000 claims description 52
- 239000002970 Calcium lactobionate Substances 0.000 claims description 16
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- 239000010452 phosphate Substances 0.000 description 2
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- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
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Images
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/116—Heterocyclic compounds
- A23K20/121—Heterocyclic compounds containing oxygen or sulfur as hetero atom
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/70—Feeding-stuffs specially adapted for particular animals for birds
- A23K50/75—Feeding-stuffs specially adapted for particular animals for birds for poultry
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7032—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a polyol, i.e. compounds having two or more free or esterified hydroxy groups, including the hydroxy group involved in the glycosidic linkage, e.g. monoglucosyldiacylglycerides, lactobionic acid, gangliosides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Definitions
- This invention relates to a feed additive for laying hens and a feed containing the same. More specifically, it relates to a feed additive having an effect of reinforcing eggshells and a feed containing the same.
- Bird eggs such as chicken eggs are highly nutritious foods containing various nutritional components. Moreover, eggs are highly suitable for cooking. Owing to these characteristics, eggs are very important food resources. In the process of delivering newly laid eggs to consumers, however, eggshells are sometimes broken (egg breakage) or finely cracked (egg cracking). These broken eggs and cracked eggs have little or no commercial value, which causes an increase in the cost. Owing to the introduction of automatic detectors, the rate of eliminating cracked eggs, which used to range from 7 to 8%, attains 12 to 15% in these days and puts serious pressure on egg farmers' profits.
- Examples of the eggshell reinforcing agent as described above in 3) include beef meat-and-bone meal serving as a calcium source, calcium carbonate, CPP (casein phosphopeptide) capable of increasing the absorptivity of calcium (see Patent Document 1), an eggshell reinforcing agent comprising crab shell for reinforcing an eggshell per se together with chitosan, etc. for strengthening the eggshell membrane supporting the eggshell (see Patent Document 2).
- a feed containing poly- ⁇ -glutamic acid see Patent Document 3
- an eggshell reinforcing agent comprising trehalose see Patent Document 4).
- lactobionic acid represented by O- ⁇ -D-galactopyranosyl-(1-4)-D-gluconic acid has been already approved by FDA and added to pudding premixes as a solidifying agent or employed in cosmetics as a humidifier in the United States. Concerning functions, it has been reported that lactobionic acid shows activities of selectively stimulate the proliferation of bifid bacteria (see Patent Document 5) and stimulating mineral absorption (see Patent Document 6). It has been also reported that the administration of a chelate composed of lactobionic acid, iron and copper resulted in an increase in the hemoglobin level and improvement in anemia (see Non-patent Document 1). However, it has never been known that lactobionic acid has an effect of reinforcing eggshells.
- Patent Document 1 JP-A-1-285158
- Patent Document 2 JP-A-9-47232
- Patent Document 3 JP-A-9-28309
- Patent Document 4 JP-A-2001-95499
- Patent Document 5 JP-A-7-277990
- Patent Document 6 JP-A-7-277991
- Non-patent Document 1 The American Journal of Clinical Nutrition, 1982, Vol. 36, p. 1162 to 1169
- the forced molting 2 suffers from a problem from the viewpoint of animal protection. Moreover, it is reported that forced molting induces salmonella infection, which brings about another problem of worsening safety of chicken eggs. Furthermore, there arises an additional problem that the egg-laying rate is lowered due to stress caused by forced molting, cage transfer, etc.
- the existing eggshell reinforcing agents 3) suffer from a problem that their effects would lower in the second half of the laying period.
- An object of the present invention is to provide a feed additive for laying hens, which is excellent in effect of reinforcing eggshells and expected as showing a particularly remarkable effect of improving eggshell qualities in the second half of the laying period, relieves stress caused by forced molting, cage transfer and so on and can inhibit lowering in the egg-laying rate.
- lactobionic acid which is represented by a general formula O- ⁇ -D-galactopyranosyl-(1-4)-D-gluconic acid, or its salt can remarkably reinforce eggshells, thereby completing the present invention.
- the gist of the invention resides in a feed additive for laying hens which comprises lactobionic acid or its salt.
- the gist of the invention resides in a feed characterized by containing a feed additive for laying hens comprising lactobionic acid or its salt.
- eggshells of chicken eggs and so on can be reinforced and thus the egg breakage rate and the egg cracking rate can be lowered. It is also possible to lessen fecal odor of chickens etc. Moreover, it is possible to relieve stress due to cage transfer, forced molting, etc. and improve the egg-laying rate, the egg qualities and the eggshell qualities.
- FIG. 1 shows changes in egg-laying rate with the passage of time.
- Lactobionic acid to be used in the present invention which is represented by a general formula O- ⁇ -D-galactopyranosyl-(1-4)-D-gluconic acid, can be obtained by oxidizing lactose. More specifically, it can be obtained by treating lactose as the substrate with a microorganism having a lactose dehydrogenase activity such as Pseudomonas graveolens or oxidizing lactose with bromine or the like.
- the lactobionic acid acids usable in the invention include calcium salt, sodium salt, potassium salt, magnesium salt, iron salt, zinc salt, copper salt and so on. These salts can be prepared by conventional reaction methods for converting into salt such as neutralization. Among them, calcium salt can be also prepared by a method which comprises preliminarily adding calcium carbonate to a reaction system for producing lactobionic acid from lactose by a biological conversion method with the use of an enzyme or a microorganism. This method is more convenient.
- calcium lactobionate is excellent in the calcium-supplying effect and usable as a calcium source for eggshells even in the absence of any other calcium sources.
- the feed additive for laying hens according to the invention which comprises lactobionic acid or its salt as described above, can be obtained by processing them into a powder, an aqueous solution or compressed tablets to give a feed additive for laying hens.
- the feed additive for laying hens according to the invention may be administered to any birds without restriction.
- it is usable for quails, ducks and so on in addition to domestic fowl. That is to say, the term “laying hens” as used in the present invention involves quails, ducks and so on.
- the feed according to the invention can be obtained by adding the feed additive for laying hens as described above to a basic feed.
- the basic feed for chickens may be an arbitrary one commonly employed for a feed for chickens.
- organic nutritional sources such as corn, milo, soybean meal, fish meal and wheat flour
- inorganic nutritional sources such as sodium chloride, calcium phosphate and calcium carbonate
- feed additives comprising trace elements such as vitamins, metals and antibiotics.
- the feed additive for laying hens is added to the basic feed preferably in an amount of from 0.01 to 10% by weight, more preferably from 0.05 to 1% by weight and most desirably from 0.1 to 0.5% by weight.
- the addition level is too low, it frequently takes a long time to achieve the desired effects.
- the addition level is too high, there sometimes arise problems in nutritional balance or cost.
- lactobionic acid as the feed additive for laying hens
- a calcium lactobionate as the feed additive for laying hens, it is not always necessary to add another calcium source.
- the feed additive for laying hens may be added to a feed by any method without particular restriction.
- a method of adding as a powder as such, a method of adding as an aqueous solution, a method of adding as compressed tablets and so on.
- no restriction is imposed on feed form (powder, solid), feeding method or feeding time (day age of laying hens).
- the feed according to the invention is administered to laying hens in an amount of from 10 mg to 10 g per day in terms of the feed additive for laying hens contained therein, more preferably from 50 mg to 1.0 g and most desirably from 0.1 g to 0.5 g.
- the obtained supernatant was supplied into an active carbon column (5 cm (diameter) ⁇ 40 cm) having been equilibrated with deionized water and eluted with 1500 ml of deionized water.
- the eluate was collected, concentrated to 300 mL under reduced pressure and then precipitated by adding ethanol 2.3 times as much.
- the precipitate was dried under reduced pressure to thereby give 1020 g of calcium lactobionate.
- each of the test lots of Examples 2 to 5 showed no difference in the egg-laying rate from the control lot but an obvious decrease in the egg breakage and egg cracking rate and an improvement in the eggshell strength.
- Each of the test lots of Examples 2 to 5 showed no difference in the egg weight from the control lot.
- fecal odor was lessened and this tendency was particularly remarkable in the test lots of Examples 4 and 5.
- lactobionic acid manufactured by Wako Pure Chemical Industries
- concentrations of 0.05, 0.1, 1.0 and 2.0% by weight were added at concentrations of 0.05, 0.1, 1.0 and 2.0% by weight to give feeds which were referred to respectively as Examples 6 to 9.
- each of the test lots of Examples 6 to 9 showed no difference in the egg-laying rate from the control lot but an obvious decrease in the egg breakage and egg cracking rate and an improvement in the eggshell strength.
- Each of the test lots of Examples 6 to 9 showed no difference in the egg weight from the control lot.
- fecal odor was lessened and this tendency was particularly remarkable in the test lots of Examples 8 and 9.
- each of the test lots of Examples 10 and 11 showed no difference in the egg-laying rate from the control lot but an obvious decrease in the egg breakage and egg cracking rate and an improvement in the eggshell strength. Accordingly, it was clarified that calcium lactobionate alone showed an effect of reinforcing eggshells even in the case of adding no calcium source except calcium lactobionate to feeds.
- Each of the test lots of Examples 10 and 11 showed no difference in the egg weight from the control lot. In Examples 9 and 10, fecal odor was remarkably lessened.
- each of the test lots of Examples 12 to 14 showed an obvious improvement in the eggshell strength. Thus, it was clarified that an eggshell reinforcing effect could be obtained by adding calcium lactobionate to a feed. Each of the test lots of Examples 12 to 14 showed no difference in the egg weight from the control lot.
- FIG. 1 summarizes the results.
- a feed additive for laying hens which is excellent in effect of reinforcing eggshells, shows a particularly remarkable effect of improving eggshell qualities in the second half of the laying period, relieves stress caused by forced molting, cage transfer and so on and can inhibit lowering in the egg-laying rate.
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Polymers & Plastics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Food Science & Technology (AREA)
- Animal Husbandry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12/574,779 US8808728B2 (en) | 2004-02-06 | 2009-10-07 | Feed additive for laying hen and feed containing the same |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2004030898 | 2004-02-06 | ||
| JP2004-030898 | 2004-02-06 | ||
| PCT/JP2005/001592 WO2005074708A1 (ja) | 2004-02-06 | 2005-02-03 | 産卵鶏用飼料添加剤及び該剤を含有する飼料 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/JP2005/001592 A-371-Of-International WO2005074708A1 (ja) | 2004-02-06 | 2005-02-03 | 産卵鶏用飼料添加剤及び該剤を含有する飼料 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| US12/574,779 Division US8808728B2 (en) | 2004-02-06 | 2009-10-07 | Feed additive for laying hen and feed containing the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| US20070190115A1 true US20070190115A1 (en) | 2007-08-16 |
Family
ID=34836018
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| US10/587,945 Abandoned US20070190115A1 (en) | 2004-02-06 | 2005-02-03 | Feed additive for laying hen and feed containing the same |
| US12/574,779 Expired - Fee Related US8808728B2 (en) | 2004-02-06 | 2009-10-07 | Feed additive for laying hen and feed containing the same |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| US12/574,779 Expired - Fee Related US8808728B2 (en) | 2004-02-06 | 2009-10-07 | Feed additive for laying hen and feed containing the same |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US20070190115A1 (enExample) |
| EP (1) | EP1731042B1 (enExample) |
| JP (3) | JPWO2005074708A1 (enExample) |
| KR (1) | KR101147630B1 (enExample) |
| CN (1) | CN1917775B (enExample) |
| WO (1) | WO2005074708A1 (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090233880A1 (en) * | 2006-06-20 | 2009-09-17 | Oe Kenichi | Equol production accelerating composition |
| CN110178983A (zh) * | 2019-06-24 | 2019-08-30 | 广东省农业科学院动物科学研究所 | 一种提高抗氧化功能的黄羽肉鸡饲料 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007116972A (ja) * | 2005-10-27 | 2007-05-17 | Unitika Ltd | 骨折予防剤及び脚弱予防剤 |
| JP5839815B2 (ja) * | 2011-03-29 | 2016-01-06 | 日清丸紅飼料株式会社 | 栄養強化鶏卵及びその製造方法 |
| AU2012334962B2 (en) * | 2011-11-11 | 2017-02-16 | Chr. Hansen A/S | Lactic acid bacteria and their use as dietary supplementals for poultry |
| CN103005165B (zh) * | 2013-01-08 | 2014-03-19 | 长沙兴嘉动物营养科技有限公司 | 乳糖酸微量元素配合物的制备方法及其作为动物饲料添加剂的应用 |
| CN105188402A (zh) * | 2013-12-27 | 2015-12-23 | 起源生物技术株式会社 | 含有麦角硫因的鸡蛋与产该鸡蛋的蛋鸡的饲料以及喂食饲养方法 |
| KR20160026042A (ko) * | 2014-08-29 | 2016-03-09 | (주)아모레퍼시픽 | 락토비온산을 함유하는 항스트레스용 또는 항상성 유지용 조성물 |
| US10435204B2 (en) * | 2017-08-04 | 2019-10-08 | Anchor Packaging, Llc | Tamper evident food container with accordiated pull tab |
| CN109123181A (zh) * | 2018-08-14 | 2019-01-04 | 播恩生物技术股份有限公司 | 提高蛋鸡骨密度和蛋壳质量的预混合饲料及其制备方法 |
| CN111612359B (zh) * | 2020-05-25 | 2022-02-18 | 武汉轻工大学 | 生长育肥猪日粮营养品质的评价方法、装置及存储介质 |
| CN114885890A (zh) * | 2022-04-21 | 2022-08-12 | 扬州大学 | 一种改善产蛋后期蛋鸡的鸡蛋品质的方法 |
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| US2746916A (en) * | 1952-02-20 | 1956-05-22 | Nat Dairy Res Lab Inc | Production of lactobionic acid and its delta-lactone |
| US3754084A (en) * | 1970-10-26 | 1973-08-21 | Takeda Chemical Industries Ltd | Stabilized composition for poultry and livestock containing a vitaminb2compound and a macrolide antibiotic |
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| US2749616A (en) * | 1954-10-15 | 1956-06-12 | John J Curry | Dental matrix unit |
| DE2547181C3 (de) * | 1975-10-22 | 1978-04-20 | Josef 8752 Moembris Hofmann | Taubenfuttermittel |
| JPS6418628A (en) | 1987-07-15 | 1989-01-23 | Dainippon Ink & Chemicals | Extrusion molding of flexible continuous rack gear made of synthetic resin |
| JPH01285158A (ja) | 1988-05-12 | 1989-11-16 | Itochu Shiryo Kk | 家禽用飼料 |
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| JPH07147910A (ja) * | 1993-11-30 | 1995-06-13 | Nippon Oil & Fats Co Ltd | 鶏用飼料 |
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-
2005
- 2005-02-03 KR KR1020067015788A patent/KR101147630B1/ko not_active Expired - Fee Related
- 2005-02-03 WO PCT/JP2005/001592 patent/WO2005074708A1/ja not_active Ceased
- 2005-02-03 CN CN2005800042766A patent/CN1917775B/zh not_active Expired - Fee Related
- 2005-02-03 EP EP05709685A patent/EP1731042B1/en not_active Expired - Lifetime
- 2005-02-03 US US10/587,945 patent/US20070190115A1/en not_active Abandoned
- 2005-02-03 JP JP2005517722A patent/JPWO2005074708A1/ja active Pending
-
2009
- 2009-10-07 US US12/574,779 patent/US8808728B2/en not_active Expired - Fee Related
-
2011
- 2011-12-06 JP JP2011267077A patent/JP2012055319A/ja active Pending
-
2014
- 2014-09-24 JP JP2014194083A patent/JP2015002748A/ja active Pending
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| US2746916A (en) * | 1952-02-20 | 1956-05-22 | Nat Dairy Res Lab Inc | Production of lactobionic acid and its delta-lactone |
| US3754084A (en) * | 1970-10-26 | 1973-08-21 | Takeda Chemical Industries Ltd | Stabilized composition for poultry and livestock containing a vitaminb2compound and a macrolide antibiotic |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090233880A1 (en) * | 2006-06-20 | 2009-09-17 | Oe Kenichi | Equol production accelerating composition |
| US8822432B2 (en) | 2006-06-20 | 2014-09-02 | Unitika Ltd. | Equol production accelerating composition |
| CN110178983A (zh) * | 2019-06-24 | 2019-08-30 | 广东省农业科学院动物科学研究所 | 一种提高抗氧化功能的黄羽肉鸡饲料 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP1731042A1 (en) | 2006-12-13 |
| US8808728B2 (en) | 2014-08-19 |
| EP1731042B1 (en) | 2011-10-05 |
| JP2015002748A (ja) | 2015-01-08 |
| KR20060123514A (ko) | 2006-12-01 |
| WO2005074708A1 (ja) | 2005-08-18 |
| US20100022463A1 (en) | 2010-01-28 |
| CN1917775A (zh) | 2007-02-21 |
| JPWO2005074708A1 (ja) | 2007-09-13 |
| JP2012055319A (ja) | 2012-03-22 |
| CN1917775B (zh) | 2010-11-24 |
| EP1731042A4 (en) | 2009-07-22 |
| KR101147630B1 (ko) | 2012-05-23 |
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