US20050182443A1 - Adhesive-containing wound closure device and method - Google Patents

Adhesive-containing wound closure device and method Download PDF

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Publication number
US20050182443A1
US20050182443A1 US10/779,721 US77972104A US2005182443A1 US 20050182443 A1 US20050182443 A1 US 20050182443A1 US 77972104 A US77972104 A US 77972104A US 2005182443 A1 US2005182443 A1 US 2005182443A1
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US
United States
Prior art keywords
article
flexible material
wound
flexible substrate
adhesive composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
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US10/779,721
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English (en)
Inventor
Jerry Jonn
Glenn Hoskin
Julian Quintero
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ethicon Inc
Original Assignee
Closure Medical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Closure Medical Corp filed Critical Closure Medical Corp
Priority to US10/779,721 priority Critical patent/US20050182443A1/en
Assigned to CLOSURE MEDICAL CORPORATION reassignment CLOSURE MEDICAL CORPORATION ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: HOSKIN, GLENN, JONN, JERRY, QUINTERO, JULIAN
Priority to BRPI0507782A priority patent/BRPI0507782B8/pt
Priority to JP2006554188A priority patent/JP5101110B2/ja
Priority to AU2005215776A priority patent/AU2005215776B2/en
Priority to MXPA06009358A priority patent/MXPA06009358A/es
Priority to CA2555739A priority patent/CA2555739C/en
Priority to EP05723162.3A priority patent/EP1715793B1/en
Priority to EP14166813.7A priority patent/EP2762086A1/en
Priority to ES05723162.3T priority patent/ES2474722T3/es
Priority to PCT/US2005/004948 priority patent/WO2005079674A1/en
Publication of US20050182443A1 publication Critical patent/US20050182443A1/en
Priority to US12/207,984 priority patent/US9655622B2/en
Assigned to ETHICON, INC. reassignment ETHICON, INC. MERGER (SEE DOCUMENT FOR DETAILS). Assignors: CLOSURE MEDICAL CORPORATION
Priority to HK15101038.5A priority patent/HK1200302A1/en
Priority to US15/490,176 priority patent/US10434211B2/en
Priority to US15/964,538 priority patent/US10398802B2/en
Priority to US16/556,443 priority patent/US11413370B2/en
Abandoned legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/06—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/00491—Surgical glue applicators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/08—Wound clamps or clips, i.e. not or only partly penetrating the tissue ; Devices for bringing together the edges of a wound
    • A61B17/085—Wound clamps or clips, i.e. not or only partly penetrating the tissue ; Devices for bringing together the edges of a wound with adhesive layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/02—Adhesive bandages or dressings
    • A61F13/0203—Adhesive bandages or dressings with fluid retention members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/02—Adhesive bandages or dressings
    • A61F13/023—Adhesive bandages or dressings wound covering film layers without a fluid retention layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0036—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0042—Materials resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/16—Materials with shape-memory or superelastic properties

Definitions

  • the present invention relates to medical and surgical wound closure and management, and methods for making and using such devices.
  • the present invention relates to medical and surgical wound closure and management, and related methods, where the device incorporates a polymerizable adhesive material.
  • the materials and methods of the present invention provide an improvement over, and a substitute for, conventional bandages, sutures and staples, and provide improved methods for both approximating and covering wounds, thus providing improved wound management.
  • Sutures are generally recognized as providing adequate wound support for the duration of wound healing.
  • suturing involves additional trauma to the wound, as the needle and suture material must be passed through the tissue at the margins of the wound.
  • suturing can cause cosmetically unattractive wound closure marks, can be time consuming, and, depending on techniques and types of sutures used, may require removal. Such removal entails further medical attention and can involve additional pain and trauma to the patient particularly if the sutures become embedded in the wound.
  • Surgical staples have disadvantages similar to sutures in terms of cosmetic result. Further, removal of the staples can be painful and, depending on location and patient pain threshold, may require topical anesthetics.
  • Skin closure strips such as conventional adhesive bandages, are utilized for closure of relatively superficial skin wounds.
  • the contact adhesives that are used with such strips typically retain holding power for no more than a day or two and can lose holding power quickly in the presence of moisture, for example, perspiration.
  • monomer and polymer adhesives are used in both industrial (including household) and medical applications. Included among these adhesives are the 1,1-disubstituted ethylene monomers and polymers, such as the ⁇ -cyanoacrylates. Since the discovery of the adhesive properties of such monomers and polymers, they have found wide use due to the speed with which they cure, the strength of the resulting bond formed, and their relative ease of use. These characteristics have made ⁇ -cyanoacrylate adhesives the primary choice for numerous applications such as bonding plastics, rubbers, glass, metals, wood, and, more recently, biological tissues.
  • ⁇ -cyanoacrylates are extremely reactive, polymerizing rapidly in the presence of even minute amounts of an initiator, including moisture present in the air or on moist surfaces such as animal tissue.
  • Monomers of ⁇ -cyanoacrylates are anionically polymerizable or free radical polymerizable, or polymerizable by zwitterions or ion pairs to form polymers. Once polymerization has been initiated, the cure rate can be very rapid.
  • Medical applications of 1,1-disubstituted ethylene adhesive compositions include use as an alternate or an adjunct to surgical sutures and staples in wound closure as well as for covering and protecting surface wounds such as lacerations, abrasions, burns, stomatitis, sores, and other surface wounds.
  • an adhesive When an adhesive is applied, it is usually applied in its monomeric form, and the resultant polymerization gives rise to the desired adhesive bond.
  • polymerizable 1,1-disubstituted ethylene monomers and adhesive compositions comprising such monomers, are disclosed in U.S. Pat. No. 5,328,687 to Leung et al. Suitable methods for applying such compositions to Substrates, and particularly in medical applications, are described in, for example, U.S. Pat. Nos. 5,582,834, 5,575,997, and 5,624,669, all to Leung et al.
  • a need continues to exist for improved materials and methods for wound approximation.
  • a need also continues to exist for improved materials and methods that have a wider range of applications, from external to internal use, and from essentially non-biodegradable (where the materials are removed from the application site) to biodegradable (where the materials are not directly removed from the application site, but instead degrade over time).
  • the present invention addresses the above needs in the art, and others, by providing improved materials and methods for wound approximation.
  • the materials and methods of the present invention provide significant advantages over the current materials and methods for wound closure.
  • the materials and methods of the present invention can fully replace the use of bandages, sutures, and/or staples on a variety of wounds and tissue surfaces, thereby providing not only improved wound approximation, but also improved wound closure.
  • These advantages include, among others, improved wound closure, provision of an improved durable microbial barrier, reduced procedure time, improved cosmesis, less pain (during staple/suture removal) resulting in increased patient satisfaction, and improved financial/economic outcomes by eliminating follow-up visits for staple/suture removal.
  • the present invention provides a tissue bonding article, comprising:
  • the tissue bonding article can further include a polymerization initiator or rate modifier, a bioactive material, or combinations thereof.
  • a polymerization initiator or rate modifier e.g., titanium dioxide, titanium dioxide, titanium dioxide, magnesium calcium, magnesium, magnesium magnesium, magnesium magnesium, magnesium magnesium, magnesium magnesium, magnesium magnesium, magnesium magnesium, magnesium magnesium, magnesium magnesium, magnesium magnesium, magnesium magnesium, magnesium magnesium, magnesium magnesium, magnesium magnesium, magnesium magnesium, magnesium magnesium, magnesium magnesium, magnesium magnesium, magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium
  • the present invention provides a method of bonding tissue, comprising:
  • the method of bonding tissue according to the present invention can also incorporate a polymerization initiator or rate modifier, a bioactive material, or combinations thereof.
  • a polymerization initiator or rate modifier e.g., titanium dioxide, titanium dioxide, titanium dioxide, magnesium calcium, magnesium, magnesium, magnesium, magnesium, magnesium, magnesium, magnesium, magnesium, magnesium, magnesium, magnesium, magnesium, magnesium, magnesium, magnesium, magnesium, magnesium, magnesium, magnesium, magnesium, magnesium, magnesium, magnesium, magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium magnesium
  • the flexible substrate can include one or more adhesive strips, which carry the adhesive substance and thereby adhere the flexible substrate to the desired application site.
  • FIG. 1 is a schematic view of a first embodiment of the present invention.
  • FIGS. 2 a and 2 b are cross-sectional views of the embodiment of FIG. 1 .
  • FIG. 3 is a schematic view of another embodiment of the present invention.
  • FIG. 4 is a schematic view of another embodiment of the present invention.
  • FIG. 5 is a schematic view of another embodiment of the present invention.
  • FIGS. 6 a - 6 e illustrate a method of using a composite structure according to an embodiment of the present invention.
  • FIG. 7 a is a perspective view of another embodiment of the present invention.
  • FIG. 7 b is a perspective view of a different embodiment of the present invention shown in FIG. 7 a.
  • FIG. 7 c is a perspective view of a further embodiment of the present invention shown in FIG. 7 b.
  • FIG. 1 An embodiment of the present invention is shown schematically in FIG. 1 .
  • a flexible substrate 1 is shown as including a flexible material 10 coated on several portions with an adhesive substance 2 .
  • FIGS. 2 a and 2 b are cross-sectional views of the flexible substrate 1 of FIG. 1 , taken along lines 2 a - 2 a and 2 b - 2 b , respectively.
  • FIGS. 1 and 2 a - 2 b show that, in embodiments, the adhesive substance does not cover an entire portion of the flexible substrate, but only portions thereof.
  • the flexible or compliant material 10 can be formed of any suitable flexible or compliant material, providing that the aims of the present invention are obtained.
  • the flexible or compliant material 10 is a material that is flexible, porous, and non-toxic.
  • the term “flexible” is used to refer to the flexible or compliant material 10 .
  • the term “flexible” is meant to cover a range of materials, which exhibit one or more properties such as being flexible, compliant, elastic, or memory retentive.
  • “flexible” is also meant to refer to materials that exhibits elastic or memory properties, i.e., the ability for the material to return to its original shape when stresses applied thereto are reduced or eliminated.
  • the flexible material is preferably flexible or compliant, to allow the flexible substrate to be placed on the desired surface (such as skin, organ, tissue, or the like) in a manner that allows the flexible substrate to conform to the topology of the desired surface.
  • the flexible material is preferably porous, to allow the subsequently applied polymerizable adhesive material to pass through or permeate through the flexible material and to polymerize as a layer beneath the flexible material, while adhering the flexible material to the desired substrate.
  • porosity will also preferably allow air and water to pass through the flexible material.
  • the flexible material is also preferably non-toxic, as it is intended to be used as a wound covering, such as on biological tissues.
  • the flexible material should be biologically compatible with the desired substrate (such as tissue, skin, organ, or the like), and is preferably a material that is governmentally approved or generally regarded as safe for the desired purpose.
  • the flexible material may be selected to be elastic or have some memory effect.
  • the elastic properties of the flexible material may desirably provide a degree of pressure or stress at the application site, for example, to maintain wound edge approximation.
  • the flexible material may be selected to have less or no elasticity.
  • the flexible material can be either biodegradable, or not biodegradable.
  • biodegradable in this invention is meant that the flexible substrate biodegrades over time in vivo, such that it does not require physical removal of the composite structure after a set period of time.
  • a biodegradable flexible material is one that, in the in vivo environment, will biodegrade over a period of from about one week to about five years.
  • a non biodegradable material is one that does not biodegrade in an in vivo environment within about five years. Such a non biodegradable material thus would require physical removal of the composite structure at a desired time, rather than slowly deteriorating over time.
  • the combination of materials forming the composite structure i.e., the flexible material and the polymerizable adhesive composition
  • the combination of materials forming the composite structure i.e., the flexible material and the polymerizable adhesive composition
  • the combination of materials forming the composite structure i.e., the flexible material and the polymerizable adhesive composition
  • be not biodegradable Biodegradable and non-biodegradable polymerizable adhesive compositions are known in the art and are described below.
  • combination of two or more biodegradable and/or non-biodegradable materials can be used, to provide tailored results in terms of properties such as biodegradation and the like.
  • a range of materials can be selected as the flexible material, preferably to provide a desired target biodegradation time.
  • suitable materials can be selected to provide either a short biodegradation period (such as between about one week and about two months) or a longer biodegradation period (such as between about two months and about five years).
  • Suitable selection of the flexible material will thus allow tailoring of the flexible substrate to the particular application. For example, in embodiments where the flexible substrate is used to form a composite structure on the surface of a patient's skin (such as in the conventional context of a bandage), it is desirable that the flexible substrate is not biodegradable.
  • the composite structure is physically removed, either to permit completion of healing or to reapply a new composite structure.
  • the flexible material is a mesh material.
  • Suitable mesh materials can be formed of either synthetic or natural materials. Such mesh material can be formed of either woven or non-woven fabrics or materials.
  • the flexible material may be, for example, any suitable polymeric film, plastic foam (including open celled foam), a woven fabric, knitted fabric, a non-woven fabric, mixture thereof, or the like.
  • suitable flexible materials may thus be prepared, for example, from nylon, a polyolefin film, such as polyethylene, polypropylene, ethylene propylene copolymers, and ethylene butylene copolymers, polyurethanes, polyurethane foams, polystyrenes, plasticized polyvinylchlorides, polyesters, polyamides, and cotton.
  • Suitable specific examples include, for example, nylon, polyethylene, polypropylene, ethylene propylene copolymers, ethylene butylene copolymers, polyurethane, polystyrene, plasticized polyvinylchloride, polyester, polyamide, cotton, polytetrafluoroethylene (PTFE), biovascular material, collagen, Gore-Tex®, DacronTM, etc.
  • the mesh material not be formed of elastin, or elastin-based materials.
  • elastin may be suitable for some uses, synthetic materials are preferred in embodiments in view of their availability, ease of manufacture, physical properties such as strength and durability, and biological compatibility.
  • the mesh material is substantially or completely free of elastin or elastin-based materials.
  • the entire flexible substrate i.e., the combination of the flexible material and the adhesive substance
  • the flexible material be formed of a synthetic, semi-synthetic, or natural organic material.
  • the flexible material be formed of a synthetic or natural polymer material, but not from a material such as metal (such as silver, steel or the like) or glass or ceramic.
  • the flexible material is preferably flexible, as described above, yet resistant to tearing.
  • the thickness of the flexible material of the present invention is from about 0.1 mil to about 50 mils. In another embodiment, the thickness of the flexible material is from about 0.5 mil to about 20, preferably from about 0.7 mil to about 10 mils, or from about 1 mil to about 5 mils.
  • the flexible material may be opaque or translucent.
  • the flexible material is provided to have a skin color, such that the flexible material masks the appearance of the underlying surface (such as a wound).
  • the flexible material can be provided with “designer” colors and/or patterns, or even cartoon character designs.
  • the flexible material may be clear, thus not masking the underlying surface.
  • the flexible substrate 1 includes an adhesive substance 20 applied to portions of the flexible material 10 .
  • the adhesive substance 20 is applied to the flexible material 10 on opposite ends of the flexible material 10 .
  • the flexible substrate 1 can be applied over a wound or other desired substrate such that the portion of the flexible material not coated with the adhesive substance straddles the wound. (This use of the composite structure will be described in more detail below.)
  • the adhesive substance is applied to the same side of the flexible material, and the exposed adhesive substance can be covered by a suitable release layer or liner (not shown) to preserve the adhesiveness of the flexible substrate until time of use.
  • the adhesive substance can be applied either on a short or a long edge of the flexible material 10 .
  • FIG. 1 shows the adhesive substance 20 applied on opposite short (substantially parallel) ends of a rectangular flexible material 10 .
  • This embodiment roughly corresponds to a conventional bandage, where the adhesive portions are applied on opposite sides of a wound and the central (uncoated) portion of the flexible material covers the wound.
  • FIG. 3 shows an embodiment where the adhesive substance 20 is applied on opposite long (substantially parallel) ends of a rectangular flexible material 10 .
  • This embodiment roughly corresponds to a tape design, where the edges of the tape are applied on opposite sides of a lengthwise wound and the central (uncoated) portion of the flexible material covers the lengthwise wound.
  • FIG. 4 shows an embodiment where the adhesive substance 20 is applied on all four ends or edges of a square flexible material 10
  • FIG. 5 shows an embodiment where the flexible substrate is in a form of a roll of material 5 , and the adhesive substance 20 is applied on the long lengthwise edges of the flexible material 10 .
  • the adhesive substance is thus applied to the flexible material so as to form distinct first, second and third regions across a width or length dimension of the flexible material.
  • the flexible substrate is not covered with the adhesive substance.
  • This region is intended to be placed over an underlying wound or tissue trauma, such that the wound is not contacted (or is substantially not contacted) by the adhesive substance.
  • the second and third regions which adjoin the first region on opposing edges thereof, are the regions where the adhesive substance is applied. These second and third regions are intended to be placed on opposite sides of an underlying wound or tissue trauma, to temporarily secure the flexible substrate to the desired application site, such that the wound per se is not contacted (or is substantially not contacted) by the adhesive substance.
  • a suitable backing or release material may also be used to cover the adhesive substances applied to the bottom side of the flexible material.
  • Such backing materials are well known in the art for covering pressure sensitive adhesives and can include, for example, paper, plastic, or the like.
  • any suitable dimensions of the material can be provided.
  • the flexible material can range in width from about 1/4 inch to about 2 or 3 inches or more, although preferred widths in embodiments may be from about 1 ⁇ 2 to about 1 or 1 1/2 inches, and can range in length from about 1 ⁇ 2 inch to about 4 or 5 inches or more, although preferred lengths in embodiments may be from about 1 to about 2 or 3 inches.
  • the flexible material can range in width from about 1/2 inch to about 4 or 5 inches or more, although preferred widths in embodiments may be from about 1 to about 2 or 3 inches, and can range in length from about 1 inch to about 6 or 8 inches or more, although preferred lengths in embodiments may be from about 2 to about 4 or 5 inches.
  • a particular advantage of this embodiment is that the flexible substrate may be used to form a composite structure over a longer wound, such as a long laceration on incision.
  • embodiments of the present invention can provide a flexible substrate having length exceeding 8 or even 12 inches, such as ranging in lengths up to 18 inches, 24 inches, 30 inches, or more.
  • the flexible substrate can have virtually any practical length, such as 5, 6, 8, 10, or 12 feet or more, which can be cut to desired length at the time of use.
  • the materials of the present invention are not limited to ant particular dimensions, and that the dimensions (length, width, thickness, etc.) of the flexible substrate can be varied and tailored, as desired.
  • various sized flexible materials can be prepared and packaged for use. For example, shorter length materials (for example, 15-inch) can be prepared and packaged for use in “short laceration” applications, while longer length materials (for example, 30-inch) can be prepared and packaged for use in “long laceration” applications.
  • a variety of length materials can be provided, with the intention that the materials are single use materials, where any leftover length of the flexible material is discarded.
  • Such single-use embodiments are particularly desirable where the flexible material is sterilized, and sterility is desired to be maintained until the time of use.
  • a longer length of flexible material can be provided where any unused portion can be saved for later use.
  • the flexible substrate 1 can take any number of other shapes, which can be designed for particular applications.
  • circular or round flexible materials can be used, such as to cover blister bases, sores, or the like;
  • arc-shaped (curved rectangular shaped) flexible materials can be used, such as to cover curved lacerations or incisions; and the like.
  • Other shapes such as oval, triangular, polygonal, semi-circular, and the like, can also be used, in embodiments.
  • the adhesive substance may be applied to the desired portions of the flexible material in either a continuous or discontinuous manner.
  • the adhesive substance can be applied as a solid layer over the desired area, or in a set or random pattern.
  • the adhesive substance is applied to form a pattern on the flexible material.
  • the adhesive may be applied in any number of patterns, including, for example, in a sine wave using either a smooth pattern (rounded waves) or a sharp pattern (triangle shaped waves) closely packed together.
  • the adhesive forms a continuous network so that the adhesive-free areas are not interconnected.
  • the adhesive substance is typically present in coat weight from about 10 to about 200, or from about 20 to 150 grams per square meter (gsm). Of course, other coat weights of the adhesive substance can be used, as desired.
  • the adhesive substance used in the flexible substrate of the present invention may, for example, be any suitable adhesive substance.
  • the adhesive substance is a medical grade adhesive, such as acrylic based pressure sensitive adhesives (PSAs), rubber based pressure sensitive adhesives, silicone pressure sensitive adhesives, mixtures thereof, or the like.
  • PSAs acrylic based pressure sensitive adhesives
  • the adhesive substance it is preferred that the adhesive substance be different from the polymerizable adhesive composition.
  • the polymerizable adhesive composition can be, for example, a polymerizable monomeric adhesive composition
  • the adhesive substances is an adhesive material that is not a polymerizable adhesive composition, such as a pressure sensitive adhesive.
  • Suitable rubber based PSAs include, but are not limited to, those taught in U.S. Pat. No. 5,705,551 and in U.S. Pat. No. 4,080,348, the disclosures of which are hereby incorporated by reference.
  • polymeric rubber bases include one or more of styrene-isoprene-styrene polymers, styrene-olefin-styrene polymers including styrene-ethylene/propylene-styrene polymers, polyisobutylene, styrene-butadiene-styrene polymers, polyisoprene, polybutadiene, natural rubber, silicone rubber, acrylonitrile rubber, nitrile rubber, polyurethane rubber, polyisobutylene rubber, butyl rubber, halobutyl rubber including bromobutyl rubber, butadiene-acrylonitrile rubber, polychloroprene, and styrene
  • a particularly useful rubber based adhesive is that which has a thermoplastic elastomeric component and a resin component.
  • the thermoplastic elastomeric component contains about 55-85 parts of a simple A-B block copolymer wherein the A-blocks are derived from styrene homologs and the B-blocks are derived from isoprene, and about 15-45 parts of a linear or radical A-B-A block copolymer wherein the A-blocks are derived from styrene or styrene homologs and the B-blocks are derived from conjugated dienes or lower alkenes, the A-blocks in the A-B block copolymer constituting about 10-18 percent by weight of the A-B copolymer and the total A-B and A-B-A copolymers containing about 20 percent or less styrene.
  • the resin component consists of essentially of tackifier resins for the elastomeric component.
  • any compatible conventional tackifier resin or mixture of such resins may be used. These include hydrocarbon resins, rosin and rosin derivatives, polyterpenes and other tackifiers.
  • the adhesive composition contains about 20-300 parts of the resin component per one hundred parts by weight of the thermoplastic elastomeric component.
  • One such rubber based adhesive is commercially available from Ato Findley under the trade name HM3210.
  • Useful acrylic based PSAs include, but are not limited to, those taught in U.S. Pat. No. 5,947,917 and U.S. Pat. No. 5,164,444 (acrylic emulsion), U.S. Pat. No. 5,623,011 (tackified acrylic emulsion). It can also be radiation curable mixture of monomers with initiators and other ingredients such as those taught in U.S. Pat. No. 5,232,958 (UV cured acrylic) and U.S. Pat. No. 5,232,958 (EB cured). The disclosures of these patents are hereby incorporated by reference.
  • any acrylic based polymer capable of forming an adhesive layer with sufficient tack to adhere to the flexible material, the release liner or to a substrate, and with acceptable adhesion to skin may function in the present invention.
  • the acrylic polymers for the pressure-sensitive adhesive layers include those formed from polymerization of at least one alkyl acrylate monomer or methacrylate, an unsaturated carboxylic acid and optionally a vinyl lactam.
  • alkyl acrylate or methacrylate esters include, but are not limited to, butyl acrylate, ethyl acrylate, 2-ethylhexyl acrylate, isooctyl acrylate, isononyl acrylate, isodecyl acrylate, methyl acrylate, methylbutyl acrylate, 4-methyl-2-pentyl acrylate, sec-butyl acrylate, ethyl methacrylate, isodecyl methacrylate, methyl methacrylate, and the like, and mixtures thereof.
  • Suitable ethylenically unsaturated carboxylic acids include, but are not limited to, acrylic acid, methacrylic acid, fumaric acid, itaconic acid, and the like, and mixtures thereof.
  • a preferred ethylenically unsaturated carboxylic acid monomer is acrylic acid.
  • suitable vinyl lactams include, but are not limited to, N-vinyl caprolactam, 1-vinyl-2-piperidone, 1-vinyl-5-methyl-2-pyrrolidone, vinyl pyrrolidone, and the like, and mixtures thereof.
  • the adhesive substance may also include a tackifier.
  • Tackifiers are generally hydrocarbon resins, wood resins, rosins, rosin derivatives, and the like. It is contemplated that any tackifier known by those of skill in the art to be compatible with elastomeric polymer compositions may be used with the present embodiment of the invention.
  • One such tackifier, found to be useful is Wingtak 10, a synthetic polyterpene resin that is liquid at room temperature, and sold by the Goodyear Tire and Rubber Company of Akron, Ohio.
  • Wingtak 95 is a synthetic tackifier resin also available from Goodyear that comprises predominantly a polymer derived from piperylene and isoprene.
  • tackifying additives may include Escorez 1310, an aliphatic hydrocarbon resin, and Escorez 2596, a C 5 -C 9 (aromatic modified aliphatic) resin, both manufactured by Exxon of Irving, Tex.
  • Escorez 1310 an aliphatic hydrocarbon resin
  • Escorez 2596 a C 5 -C 9 (aromatic modified aliphatic) resin
  • plasticizers may be included and they are known to decrease the glass transition temperature of an adhesive composition containing elastomeric polymers.
  • Shellflex 371 plasticizer is an example of a useful naphthenic processing oil available from Shell Oil Company of Houston, Tex.
  • Antioxidants also may be included on the adhesive substance.
  • Irgafos 168 antioxidant and Irganox 565 antioxidant available from Ciba-Geigy, Hawthorne, N.Y.
  • Cutting agents such as waxes and surfactants also may be included in the adhesive substance.
  • pH controllers include pH controllers, medicaments, bactericides, growth factors, wound healing components such as collagen, antioxidants, deodorants, perfumes, antimicrobials and fungicides.
  • silicone pressure sensitive adhesives include those commercially available from Dow Corning Corp., Medical Products and those available from General Electric. Examples of silicone adhesives available from Dow Corning include those sold under the trademarks BIO-PSA X7-3027, BIO-PSA X7-4919, BIO-PSA X7-2685, BIO-PSA X7-3122 and BIO-PSA X7-4502. Additional examples of silicone pressure sensitive adhesives useful in the present invention are described in U.S. Pat. Nos. 4,591,622, 4,584,355, 4,585,836 and 4,655,767, the entire disclosures of which are incorporated herein by reference.
  • the flexible substrate can be coated on one side with an adhesive substance.
  • the adhesive substance can be located on substantially an entire surface of the flexible substrate, rather than only on opposing edges of the flexible substrate as described above.
  • the adhesive substance can be coated to cover the entire surface in a continuous coating or layer.
  • the coating is discontinuous to provide areas that are not covered by the adhesive substance, such as by the adhesive substance being provided in a form of regular or random spots, lines, or the like.
  • the adhesive does not cover the entire surface of the flexible substrate to form a continuous layer, it is preferred that the adhesive is coated on at least 25% but no more than 75% of the surface area, and more preferably between about 40 and about 60% of the surface area.
  • the flexible substrate can be applied to the desired surface much in the same manner as a piece of tape, where substantially the entire surface of the flexible substrate adheres to the desired surface.
  • the polymerizable adhesive composition can then be applied to the exposed surface of the flexible substrate, in the manner as described above.
  • a benefit of this embodiment is that the entire applied flexible substrate can be retained on the desired surface, without trimming off the adhered portions in the manner described above.
  • the adhesive substance applied to the surface of the flexible substrate be a pressure sensitive adhesive, which preferably exhibits a low degree of adhesiveness.
  • the adhesive substance to be applied can be, if desired, the same as the adhesive substance described above, which is applied to only portions of the flexible substrate.
  • the adhesive substance used in this embodiment can be a weaker or different adhesive substance. That is, the purpose of the adhesive substance is only to maintain the flexible substrate in position on the desired surface, and optionally provide a minimal adhesion force to approximate or appose the wound surfaces, until the polymerizable adhesive composition is applied and allowed to set to fully adhere the flexible substrate to the desired surface.
  • the adhesive substance is thus weak enough to allow the applied polymerizable adhesive material to penetrate through the flexible substrate and the applied adhesive substance, to form a polymerized bond between the flexible substrate (and applied adhesive substance) and the underlying desired substrate.
  • any suitable adhesive substance can be used, as desired.
  • the adhesive substance should be non-toxic, and capable and/or approved for use on biological surfaces. Suitable adhesive substances thus include, for example, those adhesive substances commonly used in production of conventional adhesive bandages.
  • the polymerizable adhesive composition (described in more detail below) be able to interact with and/or solubilize the adhesive substances. That is, it is preferred that the polymerizable adhesive composition be able to in essence replace the adhesive substance as the primary means of attaching the composite structure to the underlying substrate (application site, such as tissue or wound).
  • the adhesive substances is the only attachment means present on the flexible substrate for attaching the flexible material to the desired application or treatment site.
  • the flexible substrate does not further include other physical attachment means such as hooks, barbs, pins, projections, or the like, which operate to physically latch or otherwise attach the flexible substrate to the desired application or treatment site.
  • attachment means are not desired, for example, because they introduce additional trauma to the underlying surface.
  • the flexible substrate not include features that penetrate even surface layers of the underlying substrate, such as dermal layers of the skin.
  • the flexible substrate can, if desired, include one or more chemical materials located within the flexible material.
  • one or more chemical substances can be dispersed in the flexible material, such as being chemically bound, physically bound, absorbed, or adsorbed to the flexible material.
  • the flexible substrate can include a polymerization initiator or rate modifier, or can include one or more bioactive materials.
  • the one or more chemical substances can be either immobilized on the flexible material, for example so that it has a desired effect but is not detached from the flexible material during use, or it can be attached to the flexible material in a manner such that it becomes detached during use.
  • a polymerization initiator or rate modifier may be desirable to immobilize a polymerization initiator or rate modifier on the flexible material, so that the initiator or rate modifier provides the desired initiation or rate modification effect to a subsequently applied polymerizable adhesive composition, but without the initiator or rate modifier becoming detached from the flexible material and its residues dispersed in the resultant polymeric material.
  • a bioactive material may be initially attached to the flexible material, but only in such a manner that it becomes mobilized or solubilized by a subsequently applied polymerizable adhesive composition and dispersed in the resultant polymeric material.
  • a combination of chemical substances can also be provided on the flexible material, to provide multiple effects.
  • a first chemical species such as a polymerization initiator or rate modifier
  • a second, different chemical species such as a bioactive material
  • Other combinations of chemical species and resultant effects are also envisioned by the present invention.
  • the chemical substances i.e., polymerization initiator, rate modifier, and/or bioactive materials, or other additives
  • the chemical substance can be added to the flexible material by contacting the flexible material with a solution, mixture, or the like including the chemical substances.
  • the chemical substance can be incorporated into or onto the flexible material during manufacture of the flexible material, such as during molding or the like of the flexible material.
  • the materials of the present invention are advantageously used as wound dressings.
  • the materials of the present invention are advantageously used as replacements for conventional bandages, or as replacements for conventional use of sutures and staples for closing wounds.
  • the flexible substrate of the present invention generally provides the same wound approximation and pressure benefits.
  • the flexible substrate is used to provide a composite structure by the addition of a polymerizable adhesive composition, the resultant composite structure provides significant benefits over the conventional bandage in terms of improved wound management, stronger adhesion to the underlying application site, microbial barrier properties, improved patient satisfaction, and the like.
  • the materials of the present invention by means of the applied adhesive substance on the bottom side of the flexible material, provide wound approximation prior to application of a polymerizable adhesive material to the upper surface of the flexible material, which subsequently permeates through the flexible material as the adhesive polymerizes, to form a flexible, adherent wound dressing.
  • the portions of the flexible material previously coated with the adhesive substance can then, if desired, be trimmed away to provide a unitary composite structure over the wound.
  • the composite structure of the present invention also generally provides the same wound approximation and pressure benefits.
  • the composite structure uses a polymerizable adhesive composition rather than punctures for adhesion to the underlying application site
  • the resultant composite structure provides significant benefits over the conventional sutures and staples in terms of improved wound management, stronger adhesion to the underlying application site, microbial barrier properties, improved patient satisfaction, less tissue trauma (since additional punctures are not made), lessened scarring, and the like.
  • FIGS. 6 a - 6 e One method according to the present invention is shown successively in FIGS. 6 a - 6 e .
  • the method is shown using a flexible substrate such as that shown in FIG. 3 or FIG. 5 , the invention is not limited to this embodiment.
  • FIGS. 6 a - 6 e a surface is shown having a lengthwise wound.
  • the figures show a skin surface (arm or leg 30 ) having a jagged, lengthwise wound or laceration 40 .
  • the wound is closed using the composite structure according to the present invention.
  • the arm or leg 30 is shown having an open wound 40 .
  • the wound is first cleaned by removing excess exudates (blood or the like) to provide as dry a wound as possible to assist in wound closure.
  • a length of flexible substrate is provided.
  • the length of flexible substrate is longer than the wound to be closed, and extends beyond opposite ends of the wound a sufficient distance to permit sufficient bonding.
  • the length of flexible material is preferably sufficient to extend at least 1/4 inch, more preferably at least 1 ⁇ 2 inch or at least 3/4 inch, and even more preferably at least one inch beyond each end of the wound.
  • the flexible substrate is preferably wide enough to extend beyond each lateral edge of the wound throughout the length of the wound. The width of the flexible substrate is preferably wide enough that the entire wound is covered, with excess coverage, by the portion of the flexible substrate that is not previously coated with an adhesive substance for temporary bonding to the desired surface.
  • the uncoated portions of the flexible substrate preferably cover the full width of the wound, and extend beyond opposite lateral edges of the wound a sufficient distance to permit sufficient bonding.
  • the width of flexible substrate is preferably sufficient to extend at least 1 ⁇ 4 inch, more preferably at least 1 ⁇ 2 inch or at least 3/4 inch, and even more preferably at least one inch beyond each lateral edge of the wound.
  • the previously applied adhesive substance on one edge of the flexible substrate is exposed.
  • the adhesive substance can be exposed either by applying the adhesive substance to the edge of the flexible substrate (or to the area of application adjacent the wound), or by removing a release layer covering the adhesive substance on the flexible substrate.
  • the flexible substrate 1 is then applied to the arm or leg 30 at an area adjacent the wound 40 , by applying the exposed adhesive substance to the arm or leg surface. If necessary, pressure can be applied to the flexible substrate 1 to help adhere the flexible substrate to the arm or leg 30 .
  • the opposite end of the flexible substrate is applied to the wound.
  • slight to moderate pressure is applied to opposite edges of the wound (such as by forceps, fingers, clamps, or the like) to approximate or appose the wound edges.
  • such approximation is conducted in a medically accepted manner, such as to as precisely as possible position the wound edges to help reduce subsequent scarring.
  • the previously applied adhesive substance on the second edge of the flexible substrate is exposed.
  • the remaining edge of the flexible substrate 1 is then applied to the arm or leg 30 at an area adjacent the wound 40 , but opposite the wound 40 from the previously applied first edge of the flexible substrate 1 , by applying the exposed adhesive substance to the arm or leg surface. If necessary, pressure can be applied to the flexible substrate 1 to help adhere the flexible substrate to the arm or leg 30 .
  • a polymerizable adhesive composition such as a polymerizable monomeric adhesive composition 50
  • a polymerizable adhesive composition 50 is applied over at least a portion of the surface of the flexible substrate 1 .
  • the polymerizable adhesive composition 50 is applied to fully cover the surface of the flexible substrate 1 .
  • a lesser amount of the polymerizable adhesive composition can be used to conserve materials and assist in subsequent steps.
  • the polymerizable adhesive composition is preferably applied to the flexible substrate 1 at least in an area sufficient to cover the portion of the flexible substrate that will remain on the surface following completion of the application process.
  • the polymerizable adhesive composition is applied to the flexible substrate to fully cover the non-removed portions.
  • the polymerizable adhesive composition can be applied to only portions of the flexible substrate, such as only to portions overlying an underlying wound, or to portions overlying part, but not all, of the underlying wound.
  • a sufficient amount of polymerizable adhesive composition should be applied to form the desired composite structure once the polymerizable adhesive composition has polymerized (or cured).
  • the amount of polymerizable adhesive composition should be sufficient to preferably allow the composition to penetrate through the flexible material to form a continuous coating between the arm or leg 30 and wound 40 , and the flexible material of the flexible substrate 1 , which continuous coating subsequently polymerizes or cures to form a continuous polymeric coating between the flexible substrate and the underlying surface.
  • the quantity of polymerizable adhesive composition should preferably further allow for a quantity of the composition to remain in, and preferably over, the flexible substrate. This further amount of polymerizable adhesive composition polymerizes or cures with the remaining polymerizable adhesive composition to provide a unitary composite structure that is bonded to the underlying surface, such as the underlying surface of the arm or leg 30 and wound 40 .
  • the step of applying polymerizable adhesive composition to the flexible substrate can be repeated one or more times.
  • a second or subsequent coating of the polymerizable adhesive composition can be applied, either prior or subsequent to complete curing of the underlying layer of polymerizable adhesive composition.
  • subsequent layers be applied after curing of the underlying layer has begin, but before curing is complete.
  • the polymerizable adhesive composition When applying the polymerizable adhesive composition to the flexible substrate, the polymerizable adhesive composition is preferably applied over an entire surface of the flexible substrate. That is, while the flexible substrate may provide some wicking, flowing, or capillary movement of the polymerizable adhesive composition within the bulk material of the flexible substrate, such wicking or capillary movement is minimal, and is not intended to provide complete coverage of the polymerizable adhesive composition over the flexible substrate. Thus, for example, it will generally not be possible to apply one or two drops of the polymerizable adhesive composition to the flexible substrate, and expect the polymerizable adhesive composition to completely cover the flexible substrate (unless, of course, the flexible substrate is such a small size that the drops substantially cover the surface).
  • the polymerizable adhesive composition is applied by dabbing, brushing, rolling, painting, swabbing or the like, the polymerizable adhesive composition onto the flexible substrate. If necessary, the applied polymerizable adhesive composition can be spread around on the surface of the flexible substrate to provide improved coverage.
  • portions of the thus-formed composite structure are trimmed off, to provide a final composite structure covering the underlying wound.
  • the portions of the composite structure 1 corresponding to the portions of the flexible substrate 10 coated with the adhesive substance 20 are trimmed off.
  • Such trimming may be preferred and/or required, for example, because the adhesive properties of the adhesive substance differ from the adhesive properties provided by the polymerizable adhesive composition.
  • the adhesive substance 20 provides less adhesion than the polymerizable adhesive composition 50 , it is likely that the portions adhered only by the adhesive substance 20 will prematurely separate from the underlying tissue. To prevent such premature separation, and resulting problems of lessened appearance and the like, these portions can be trimmed off after the polymerizable adhesive composition has cured.
  • the portions are to be trimmed off, such trimming can be conducted by any desired and suitable means.
  • the portions can be peeled back from the underlying surface, and trimmed using scissors, a knife, a scalpel, or the like.
  • the flexible material used in forming the flexible substrate can be provided with one or more perforations or tear lines, to assist in the subsequent trimming operation.
  • the adhesive substance applied to the underside of the flexible material be provided in such a manner that the polymerizable adhesive composition applied to the topside of the flexible substrate does not penetrate into or under the adhesive substance. That is, it is preferred that the relatively weaker adhesiveness provided by the adhesive substance, is not strengthened by interaction with the relatively stronger polymerizable adhesive composition. Preventing such interaction will assist in being able to peel back the flexible substrate in the areas of the adhesive substance to permit trimming of those portions.
  • This interaction between the adhesive materials can be prevented, for example, by using adhesive materials that are not soluble in each other, by providing a substantially continuous coating of the adhesive substance on the desired portions of the flexible material, or the like.
  • the adhesive bond provided by the resultant combined adhesive may still be weak enough to permit trimming of the desired portions of the flexible substrate.
  • the portions of the flexible substrate having the adhesive substance can be retained on the application site, as the bond will tend not to prematurely separate and thus trimming of the portions may not be necessary.
  • a modification of the above-described process involves “rolling” or “taping” the flexible substrate onto the desired application site.
  • the flexible material is applied to the application site starting at one lengthwise end of the site, and straddling the width direction of the site, and progresses along the application site to the opposite lengthwise end of the site.
  • This application is particularly useful, for example, when the application site is long and the flexible material is, for example, a length or roll of flexible material.
  • the application site e.g., arm or leg 30 having an open wound 40
  • the application site is preferably first cleaned by removing excess exudates (blood or the like) to provide as dry a wound as possible to assist in wound closure.
  • a length of flexible substrate is provided.
  • the length of flexible substrate is longer than the wound to be closed, and extends beyond opposite ends of the wound a sufficient distance to permit sufficient bonding.
  • the length of flexible material is preferably sufficient to extend at least 1 ⁇ 4 inch, more preferably at least 1 ⁇ 2 inch or at least 3 ⁇ 4 inch, and even more preferably at least one inch beyond each end of the wound.
  • the flexible substrate is preferably wide enough to extend beyond each lateral edge of the wound throughout the length of the wound. The width of the flexible substrate is preferably wide enough that the entire wound is covered, with excess coverage, by the portion of the flexible substrate that is not previously coated with an adhesive substance for temporary bonding to the desired surface.
  • the uncoated portions of the flexible substrate preferably cover the full width of the wound, and extend beyond opposite lateral edges of the wound a sufficient distance to permit sufficient bonding.
  • the width of flexible substrate is preferably sufficient to extend at least 1 ⁇ 4 inch, more preferably at least 1 ⁇ 2 inch or at least 3/4 inch, and even more preferably at least one inch beyond each lateral edge of the wound.
  • the adhesive substances on the edges of one lengthwise end of the flexible substrate are exposed.
  • the adhesive substances can be exposed either by applying the adhesive substance to the edges of the flexible substrate (or to the areas of application adjacent the wound), or by removing release layers coving the adhesive substance on the flexible substrate.
  • the flexible substrate is then applied to the application site at areas adjacent the wound, by applying one of the exposed adhesive substances to the arm or leg surface on one side of the wound and the other of the exposed adhesive substances to the arm or leg surface on opposite lateral side of the wound. If necessary, pressure can be applied to the flexible substrate to help adhere the flexible substrate to the application site.
  • the wound edges are preferably approximated.
  • one hand can be used to approximate the wound edges, as the other hand is used to apply the flexible material.
  • slight to moderate pressure can be applied to opposite edges of the wound (such as by forceps, fingers, clamps, or the like) to approximate or appose the wound edges.
  • approximation is preferably conducted in a medically accepted manner, such as to as precisely as possible position the wound edges to help reduce subsequent scarring.
  • application of the flexible substrate continues along the length of the application site.
  • application can continue by “rolling” or “taping” the flexible material onto the application site, progressing from one lengthwise end of the site to the other lengthwise end.
  • lateral edges of the wound at the application site can be approximated in the manner described above as the flexible material is applied in the lengthwise direction.
  • a polymerizable adhesive composition such as a polymerizable monomeric adhesive composition
  • the polymerizable adhesive composition can be applied in the same manner as described above, and thus the details are not repeated here.
  • portions of the thus-formed composite structure can be trimmed off, if desired, to provide a final composite structure covering the underlying wound.
  • the trimming likewise can be conducted in the same manner as described above, and thus the details are not repeated here.
  • a particular advantage of this application method is that the method is particularly well suited for longer wounds or longer application sites. Once a first end of the flexible substrate is applied to the wound, the remaining length of the flexible substrate is applied by rolling or taping the flexible substrate in place, with gradual approximation of wound edges as necessary. Where wounds or application sites are long, this method is well suited for use by a single individual, as assistance in applying the flexible substrate may not be required.
  • FIGS. 7 a and 7 b A still further embodiment of the present invention is shown in FIGS. 7 a and 7 b .
  • the flexible substrate 1 includes a flexible material 10 , as described above.
  • the adhesive substance 20 is applied to bottom sides of one or more adhesive strips, such as pressure sensitive adhesive strips 25 .
  • the adhesive strips 25 can then be suitably located either on the bottom (application site contacting) side of the flexible material 10 (as shown in FIG. 7 a ), or on the top (exposed) side of the flexible material 10 (as shown in FIG. 7 b ).
  • the adhesive substance 20 applied to the adhesive strips 25 can extend across the entire length of the adhesive strip, such as shown in FIG. 7 b , or only across one or more portions of the adhesive strip, such as shown in FIG. 7 a . Applying the adhesive substance 20 across the entire length of the adhesive strip 25 is useful, for example, when the adhesive strip is being applied to the top (exposed) side of the flexible material 10 .
  • the adhesive substance serves two purposes—adhering the adhesive strip to the flexible material, and adhering the flexible substrate (composite flexible material and adhesive substance) to the application site prior to application of the polymerizable adhesive composition.
  • the adhesive substance can be provided on only one or more portions of the adhesive strip, for example, where it is desired to provide as much surface area as possible for application and setting of the polymerizable adhesive composition. It will be understood that where the adhesive strips 25 are provided on the bottom side of the flexible material 10 , the adhesive substance can be provided on both sides of the adhesive strip, so that one side can be adhered to the flexible material while the other side provides adhesion to the application site.
  • FIG. 7 c represents a modification of the embodiment of FIG. 7 b , but where the adhesive strips 25 do not extend completely across the flexible material 10 .
  • the adhesive strips are attached to sides of the flexible material 10 , but do not traverse the flexible material 10 .
  • the adhesive strips could be located either on the top or bottom sides of the flexible material 10 , as desired.
  • the flexible substrate can be applied substantially by the methods described above. That is, the flexible substrate can be applied by exposing the adhesive substance and applying the flexible substrate to the application site. Once the polymerizable adhesive composition is applied and set, the adhesive strips can be trimmed off or retained, as desired. Other modification of these embodiments will also be apparent to those skilled in the art.
  • one or more chemical substances may be applied to the flexible substrate, which can subsequently chemically or physically interact with an applied polymerizable adhesive composition.
  • Such chemical substances can include, for example, one or more polymerization initiators or rate modifiers, one or more bioactive materials, and combinations thereof.
  • Suitable polymerization and/or cross-linking initiators and rate modifiers, and methods for applying them to substrates are described in, for example, U.S. Pat. Nos. 5,928,611, 6,352,704, 6,455,064, 6,579,469 and 6,595,940 and U.S. patent applications Ser. No. 09/430,177, filed Oct. 29, 1999, Ser. Nos. 09/430,289 09/430,180 filed Oct. 29, 1999; Ser. No. 09/385,030 filed Aug. 30, 1999; and Ser. No. 09/176,889 filed Oct. 22, 1998, the entire disclosures of which are incorporated herein by reference.
  • Preferred initiators for some medical uses include benzalkonium chloride, and for some industrial uses include dimethyl toluidine.
  • Particular initiators and rate modifiers for particular monomers may be readily selected by one of skill in the art without undue experimentation. Control of the molecular weight distribution of the applied adhesive can be enhanced by selection of the concentration and functionality of the initiator or rate modifier vis-a-vis the selected monomer.
  • Suitable polymerization initiators and rate modifiers for cyanoacrylate compositions include, but are not limited to, detergent compositions; surfactants, including nonionic surfactants such as polysorbate 20 product (e.g., Tween 20TM product; ICI Americas), polysorbate 80 product (e.g., Tween 80TM product; ICI Americas), and poloxamers; cationic surfactants such as tetrabutylammonium bromide; anionic surfactants, including quaternary ammonium halides such as benzalkonium chloride or its pure components, and benzethonium chloride; stannous octoate (tin (II) 2-ethylhexanoate), and sodium tetradecyl sulfate; and amphoteric or zwitterionic surfactants such as dodecyldimethyl(3-sulfopropyl)ammonium hydroxide, inner salt; amines, imines, and
  • the initiator may be a bioactive material, including quaternary ammonium halides such as alkylbenzyldimethylammonium chloride (benzalkonium chloride; BAC) its pure components, or mixtures thereof, especially those with an alkyl containing 6-18 carbon atoms; benzethonium chloride; and salts of sulfadiazine.
  • quaternary ammonium halides such as alkylbenzyldimethylammonium chloride (benzalkonium chloride; BAC) its pure components, or mixtures thereof, especially those with an alkyl containing 6-18 carbon atoms; benzethonium chloride; and salts of sulfadiazine.
  • Cobalt napthenate can be used as an accelerator for peroxide.
  • the initiator may be a bioactive material that possesses antiviral, antimicrobial, antifungal and/or wound healing properties.
  • a bioactive material that possesses antiviral, antimicrobial, antifungal and/or wound healing properties.
  • An example of such a material that possesses polymerization initiation and antiviral, antimicrobial, and/or antifungal properties is Gentian Violet, also known as crystal violet or methylrosaniline chloride.
  • Examples of materials that possess polymerization initiation and wound healing properties also include various zinc complexes and zinc salts, antioxidants such as vitamin E and other vitamins and the like, and copper compounds such as copper chloride, copper sulfate and copper peptides.
  • Such materials are particularly preferred because they can serve not only as the polymerization initiator or rate modifier for the cyanoacrylate monomer, they can also provide additional benefits to the wound site, such as antiviral effects, antimicrobial effects and/or antifungal effects or help to promote wound healing.
  • the zinc compound can be present in various forms, such as zinc salts.
  • suitable zinc compounds include, but are not limited to, zinc salts of cyanoacrylic acid, zinc salts of cyanoacetic acid, zinc salts of dicyanoglutaric acid, zinc salts of rosin, zinc oxide, zinc salts of polycyanoacrylic acid, zinc salts of polyacrylic acid, zinc bacitracin, zinc salicylate, zinc stearate, zinc citrate, zinc lactate, mixtures thereof, and the like.
  • the zinc compounds are of Zn 2+ . Incorporation of such zinc compounds into the applied cyanoacrylate composition, either prior to or concurrent with application and/or initiation, is particularly effective in promoting wound healing of leg ulcers, thermal burns, and the like.
  • the polymerizable and/or cross-linkable material may also contain an initiator and/or a rate modifier which is inactive until activated by a catalyst or accelerator (included within the scope of the term “initiator” as used herein).
  • Initiators activated by stimulation such as heat and/or light (e.g., ultraviolet or visible light) are also suitable if the flexible substrate is appropriately subjected to such stimulation.
  • the flexible substrate can also include various other materials that may or may not act as a polymerization initiator and/or rate modifier.
  • the flexible substrate can include a bioactive material, which may or may not also be a polymerization and/or cross-linking initiator and/or rate modifier.
  • suitable bioactive materials include, but are not limited to, medicaments such as antibiotics, antimicrobials, antiseptics, bacteriocins, bacteriostats, disinfectants, steroids, anesthetics, antifungal agents, anti-inflammatory agents, antibacterial agents, antiviral agents, antitumor agents, growth promoting substances, antioxidants, or mixtures thereof.
  • the initiator and/or the rate modifier can be, but does not have to be, bioactive.
  • the method of the invention can be used to close, cover, or protect tissue and wounds while simultaneously providing a bioactive material to the tissue or wound.
  • Suitable bioactive materials include, but are not limited to, medicaments such as antibiotics, antimicrobials, antiseptics, bacteriocins, bacteriostats, disinfectants, steroids, anesthetics, antifungal agents, anti-inflammatory agents, antibacterial agents, antiviral agents, antitumor agents, growth promoting substances, antioxidants, or mixtures thereof.
  • medicaments such as antibiotics, antimicrobials, antiseptics, bacteriocins, bacteriostats, disinfectants, steroids, anesthetics, antifungal agents, anti-inflammatory agents, antibacterial agents, antiviral agents, antitumor agents, growth promoting substances, antioxidants, or mixtures thereof.
  • Such compounds include, but are not limited to, acetic acid, aluminum acetate, bacitracin, bacitracin zinc, benzalkonium chloride, benzethonium chloride, betadine, calcium chloroplatinate, certrimide, cloramine T, chlorhexidine phosphanilate, chlorhexidine, chlorhexidine sulfate, chloropenidine, chloroplatinatic acid, ciprofloxacin, clindamycin, clioquinol, cysostaphin, gentamicin sulfate, hydrogen peroxide, iodinated polyvinylidone, iodine, iodophor, minocycline, mupirocin, neomycin, neomycin sulfate, nitrofurazone, non-onynol 9, potassium permanganate, penicillin, polymycin, polymycin B, polymyxin, polymyxin B sulfate, polyviny
  • the polymerization and/or cross-linking initiator and/or rate modifier, and/or the bioactive material may be applied to the flexible substrate by any suitable means, including, but not limited to, spraying, dipping, injecting, or brushing the flexible substrate with a liquid medium containing the material to be applied.
  • the composite structure is formed by applying a polymerizable adhesive composition to the flexible substrate, and allowing the polymerizable adhesive composition to polymerize.
  • the polymerizable (i.e., monomer and/or prepolymeric) adhesive composition may include one or more polymerizable monomers, which preferably are synthetic or semi-synthetic monomers.
  • Preferred monomers that may be used in this invention are readily polymerizable, e.g. anionically polymerizable or free radical polymerizable, or polymerizable by zwitterions or ion pairs to form polymers.
  • Such monomers include those that form polymers, that may, but do not need to, biodegrade.
  • Such monomers are disclosed in, for example, U.S. Pat. Nos. 5,328,687, 5,928,611 and 6,183,593, U.S. patent application Ser. No. 09/430,177, filed on Oct. 29, 1999, and U.S. Pat. No. 6,183,593, which are hereby incorporated in their entirety by reference herein.
  • Preferred monomers include 1,1-disubstituted ethylene monomers, such as ⁇ -cyanoacrylates including, but not limited to, alkyl ⁇ -cyanoacrylates having an alkyl chain length of from about 1 to about 20 carbon atoms or more, preferably from about 3 to about 8 carbon atoms.
  • ⁇ -cyanoacrylates of the present invention can be prepared according to several methods known in the art.
  • Preferred ⁇ -cyanoacrylate monomers used in this invention include methyl cyanoacrylate, ethyl cyanoacrylate, n-butyl cyanoacrylate, 2-octyl cyanoacrylate, methoxyethyl cyanoacrylate, ethoxyethyl cyanoacrylate, dodecyl cyanoacrylate, 2-ethylhexyl cyanoacrylate, butyl cyanoacrylate, 3-methoxybutyl cyanoacrylate, 2-butoxyethyl cyanoacrylate, 2-isopropoxyethyl cyanoacrylate, 1-methoxy-2-propyl cyanoacrylate, hexyl cyanoacrylate, or dodecylcyanoacrylate.
  • Suitable cyanoacrylates for use in the present invention also include, but are not limited to, alkyl ester cyanoacrylate monomers such as those having the formula wherein R 1 and R 2 are, independently H, a straight, branched or cyclic alkyl, or are combined together in a cyclic alkyl group, and R 3 is a straight, branched or cyclic alkyl group.
  • R 1 is H or a C 1 , C 2 or C 3 alkyl group, such as methyl or ethyl
  • R 2 is H or a C 1 , C 2 or C 3 alkyl group, such as methyl or ethyl
  • R 3 is a C 1 -C 16 alkyl group, more preferably a C 1 -C 10 alkyl group, such as methyl, ethyl, propyl, butyl, pentyl, hexyl, heptyl, octyl, nonyl or decyl, and even more preferably a C 2 , C 3 or C 4 alkyl group.
  • alkyl ester cyanoacrylates and other suitable monomers are disclosed in, for example, U.S. patent application Ser. No. 09/919,877, filed Aug. 2, 2001, and U.S. Pat. No. 6,620,846, the entire disclosures of which are incorporated herein by reference.
  • alkyl ester cyanoacrylates include, but are not limited to, butyl lactoyl cyanoacrylate (BLCA), butyl glycoloyl cyanoacrylate (BGCA), ethyl lactoyl cyanoacrylate (ELCA), and ethyl glycoloyl cyanoacrylate (EGCA).
  • BLCA may be represented by the above formula, wherein R 1 is H, R 2 is methyl and R 3 is butyl.
  • BGCA may be represented by the above formula, wherein R 1 is H, R 2 is H and R 3 is butyl.
  • ELCA may be represented by the above formula, wherein R 1 is H, R 2 is methyl and R 3 is ethyl.
  • EGCA may be represented by the above formula, wherein R 1 is H, R 2 is H and R 3 is ethyl.
  • the composition may optionally also include at least one other plasticizing agent that assists in imparting flexibility to the polymer formed from the monomer.
  • the plasticizing agent preferably contains little or no moisture and should not significantly affect the stability or polymerization of the monomer.
  • suitable plasticizers include but are not limited to tributyl citrate, acetyl tri-n-butyl citrate (ATBC), polymethylmethacrylate, polydimethylsiloxane, hexadimethylsilazane and others as listed in U.S. Pat. No. 6,183,593, the disclosure of which is incorporated in its entirety by reference herein.
  • the composition may also include one or more polymerization initiators or rate modifiers.
  • the polymerization initiator or rate modifier is described above as being incorporated into or onto the flexible material, it is also possible for the polymerization initiator or rate modifier to be incorporated directly into the polymerizable adhesive composition.
  • the polymerization initiator or rate modifier is mixed with the polymerizable adhesive composition preferably immediately prior to or concurrent with application of the polymerizable adhesive composition to the flexible substrate.
  • the polymerization initiator or rate modifier and polymerizable adhesive composition can be mixed prior to application by suitable mixing devices in an applicator itself or in a separate container, or they can be mixed concurrent with application by mixing as the polymerizable adhesive material is expressed form an applicator. Any suitable polymerization initiators or rate modifiers, including those described above, can be used in these embodiments.
  • the composition may also optionally include at least one thixotropic agent.
  • Suitable thixotropic agents are known to the skilled artisan and include, but are not limited to, silica gels such as those treated with a silyl isocyanate, and optionally surface treated titanium dioxide. Examples of suitable thixotropic agents and thickeners are disclosed in, for example, U.S. Pat. No. 4,720,513, and U.S. Pat. No. 6,310,166, the disclosures of which are hereby incorporated in their entireties by reference herein.
  • composition may optionally also include thickeners.
  • thickeners may include poly(2-ethylhexy methacrylate), poly(2-ethylhexyl acrylate) and others as listed in U.S. Pat. No. 6,183,593, the disclosure of which is incorporated by reference herein in its entirety.
  • the composition may also optionally include at least one natural or synthetic rubber to impart impact resistance.
  • Suitable rubbers are known to the skilled artisan. Such rubbers include, but are not limited to, dienes, styrenes, acrylonitriles, and mixtures thereof. Examples of suitable rubbers are disclosed in, for example, U.S. Pat. Nos. 4,313,865 and 4,560,723, the disclosures of which are hereby incorporated in their entireties by reference herein.
  • the composition may optionally also include one or more stabilizers, preferably both at least one anionic vapor phase stabilizer and at least one anionic liquid phase stabilizer. These stabilizing agents may inhibit premature polymerization. Suitable stabilizers may include those listed in U.S. Pat. No. 6,183,593, the disclosure of which is incorporated by reference herein in its entirety. Furthermore, certain stabilizers may also function as anti-microbial agents, such as, for example, various acidic anti-microbials, as identified above.
  • compositions may also include pH modifiers to control the rate of degradation of the resulting polymer, as disclosed in U.S. Pat. No. 6,143,352, the entire disclosure of which is hereby incorporated by reference herein in its entirety.
  • difunctional monomeric cross-linking agents may be added to the monomer compositions of this invention.
  • Such crosslinking agents are known.
  • U.S. Pat. No. 3,940,362 to Overhults which is hereby incorporated herein in its entirety by reference, discloses exemplary cross-linking agents.
  • compositions of this invention may further contain fibrous reinforcement and colorants such as dyes, pigments, and pigment dyes.
  • fibrous reinforcement include PGA microfibrils, collagen microfibrils, and others as described in U.S. Pat. No. 6,183,593, the disclosure of which is incorporated by reference herein in its entirety.
  • the polymerizable compositions useful in the present invention may also further contain one or more preservatives, for prolonging the storage life of the composition.
  • preservatives for prolonging the storage life of the composition.
  • Suitable preservatives, and methods for selecting them and incorporating them into adhesive compositions, are disclosed in U.S. patent application Ser. No. 09/430,180, the entire disclosure of which is incorporated herein by reference.
  • Such preservatives can be in addition to any anti-microbial agent that may or may not be added to the composition.
  • Such preservatives can be included irrespective of whether the composition and containers are sterilized.
  • the materials and processes of the present invention provide significant advantages over the current materials and methods for wound closure. These advantages include, among others, improved wound closure, provision of an improved durable microbial barrier, reduced procedure time, improved cosmesis, less pain (during staple/suture removal) resulting in increased patient satisfaction, and improved financial/economic outcomes by eliminating follow-up visits for staple/suture removal.
  • the materials and processes of the present invention provide improved wound closure. Because the composite structure provides a flexible polymeric covering over the wound site, it provides a degree of tension to assist in closing the wound and maintain the wound closed. By a combination of the flexible material within the composite structure, and the rigidity and adhesion provided by polymerization of the polymerizable adhesive composition, the composite structure provides improved strength, decreases wound dehiscence, and assists healing.
  • the materials and processes of the present invention also provide an improved microbial barrier. Because the composite structure fully covers the wound, microbial transport into and out of the wound are decreased. This in turn helps battle or prevent infection, in turn resulting in faster wound healing.
  • the materials and processes of the present invention also provide improved cosmesis.
  • Such cosmesis benefits includes improved cosmetic appearances both during and after the wound healing process.
  • the composite structures of the present invention provide decreased dressing bulk and thickness and improved appearance.
  • the composite structures permit more precise and sustained wound approximation, the composite structures can provide decreased scar appearance, such as in terms of scar width, scar tissue height, scar coloration, and the like.
  • the materials and processes of the present invention provide increased patient satisfaction. Increased satisfaction is provided, for example, due to the improved “feel” of the wound dressing, the improved cosmetic results, and improved assurance of wound closure and dressing strength, and the like.
  • the composite structure of the present invention is expected to remain in place over an external wound for about 10 to 14 days, although shorter or longer times may be provided. During that time, the patient can bathe without worrying about water and contaminants entering the wound through the dressing. Furthermore, because staple or suture removal is not required, the patient experiences less pain and anticipation, improving the healing experience.
  • the present invention is thus applicable to a wide range of treatments, including wound treatment and other medical procedures.
  • the present invention can be used as a replacement for, or in addition to, sutures or staples to join together two surfaces.
  • the invention can also be used to coat, protect, or otherwise cover surface, superficial, internal, or topical wounds including, but not limited to, minor cuts, scrapes, irritations, compromised skin, superficial lacerations, abrasions, burns, sores, and stomatitis.
  • the methods of the invention can also be used on tissues that do not show any signs of tissue damage.
  • the methods can be used to deliver medicaments to a patient through healthy tissue. They can also be used, for example, to locally deliver medicaments to tissues such as tumors or organs.
  • a length of polypropylene mesh material is obtained having a length of about four feet and a width of about 1 3/4 inches.
  • the polypropylene mesh is dipped into a solution of benzalkonium chloride and acetone, to adsorb the benzalkonium chloride on the polypropylene mesh.
  • the mesh is subsequently dried to volatilize and remove the acetone solvent.
  • a conventional pressure sensitive adhesive is applied as a continuous layer along the 4-foot length of the mesh, and extending about 3/8 inch from each edge, thus leaving a 1 inch strip along the center of the length of the mesh that is not covered by the adhesive substance.
  • the applied pressure sensitive adhesive is subsequently covered by respective 4-foot by 3/8 inch strips of release paper.
  • a patient is presented having a one inch cut on the arm. The cut does not extend fully through the dermal layers of the skin.
  • a 2-inch length of the prepared flexible substrate is applied to the wound site.
  • the flexible substrate is applied by first removing one of the two release strip papers and affixing the pressure sensitive adhesive edge to one side of the cut, about 7/8 inch from the edge of the cut.
  • the second release strip paper is then removed from the flexible substrate.
  • the remaining pressure sensitive adhesive edge of the flexible substrate is applied to the other side of the cut, about 7/8 inch from the edge of the cut.
  • the flexible substrate extends about 1 ⁇ 2 inch beyond each end of the wound.
  • a quantity of a stabilized 2-octyl cyanoacrylate adhesive is applied to the exposed surface of the flexible substrate, and is spread to permeate into and fully cover the flexible substrate. Polymerization of the composition proceeds in about 1 minute. After complete polymerization, the edges of the flexible substrate adhered to the tissue using pressure sensitive adhesive are peeled back, and those portions of the flexible substrate are removed by trimming with surgical scissors. The result is a firmly bonded composite structure, bonded to the skin over the full area of the cut.
  • the composite structure remains in place for about 10 to 14 days, during which time the wound heals.
  • a patient is presented having a four inch cut on the leg. The cut extends fully through the dermal layers of the skin.
  • a 5-inch length of the prepared flexible substrate is applied to the wound site.
  • the flexible substrate is applied by first removing one of the two release strip papers and affixing the pressure sensitive adhesive edge to one side of the cut, about 7/8 inch from the edge of the cut.
  • the second release strip paper is then removed from the flexible substrate.
  • the remaining pressure sensitive adhesive edge of the flexible substrate is applied to the other side of the cut, about 7/8 inch from the edge of the cut.
  • the flexible substrate extends about 1 ⁇ 2 inch beyond each end of the wound.
  • a quantity of a stabilized 2-octyl cyanoacrylate adhesive is applied to the exposed surface of the flexible substrate, and is spread to permeate into and fully cover the flexible substrate. Polymerization of the composition proceeds in about 1 minute. After complete polymerization, the edges of the flexible substrate adhered to the tissue using pressure sensitive adhesive are peeled back, and those portions of the flexible substrate are removed by trimming with surgical scissors. The result is a firmly bonded composite structure, bonded to the skin over the full area of the laceration.
  • the composite structure remains in place for about 10 to 14 days, during which time the cut heals.
  • a patient is presented having a four inch cut on the leg, substantially similar to the laceration of the patient in Example 2.
  • the cut extends fully through the dermal layers of the skin.
  • subcutaneous dissolvable sutures are used to approximate and close the subcutaneous layers in the wound, in a similar manner to Example 2.
  • conventional sutures and staples are used to close the surface layers of the wound.
  • the wound is subsequently covered by gauze pads and an ace bandage to control residual bleeding.
  • the wound dressing is maintained in place for about 10 to 14 days, being changed several times over that period to provide clean gauze. After the dressing is removed, the sutures and staples on the surface of the skin are removed.
  • Example 2 A comparison of the results of Example 2 and Comparative Example 1 indicate that healing of the wounds is substantially identical. However, the results of Example 2 indicate an improvement in wound appearance, with less evident skin trauma. The patient in Example 2 also reports increased comfort in initial dressing application, in appearance and feeling over the intervening 10-14 days, and in removal of the dressing.

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US10/779,721 2004-02-18 2004-02-18 Adhesive-containing wound closure device and method Abandoned US20050182443A1 (en)

Priority Applications (15)

Application Number Priority Date Filing Date Title
US10/779,721 US20050182443A1 (en) 2004-02-18 2004-02-18 Adhesive-containing wound closure device and method
PCT/US2005/004948 WO2005079674A1 (en) 2004-02-18 2005-02-17 Adhesive-containing wound closure device and method
ES05723162.3T ES2474722T3 (es) 2004-02-18 2005-02-17 Dispositivo de cierre de heridas que contiene adhesivo
JP2006554188A JP5101110B2 (ja) 2004-02-18 2005-02-17 接着剤を有する創部閉鎖器具および方法
AU2005215776A AU2005215776B2 (en) 2004-02-18 2005-02-17 Adhesive-containing wound closure device and method
MXPA06009358A MXPA06009358A (es) 2004-02-18 2005-02-17 Dispositivo y metodo para el cierre de una herida que contiene adhesivo.
CA2555739A CA2555739C (en) 2004-02-18 2005-02-17 Adhesive-containing wound closure device and method
EP05723162.3A EP1715793B1 (en) 2004-02-18 2005-02-17 Adhesive-containing wound closure device
EP14166813.7A EP2762086A1 (en) 2004-02-18 2005-02-17 Adhesive-containing wound closure device
BRPI0507782A BRPI0507782B8 (pt) 2004-02-18 2005-02-17 método de ligar tecidos e dispositivo para fechamento de ferimentos
US12/207,984 US9655622B2 (en) 2004-02-18 2008-09-10 Adhesive-containing wound closure device and method
HK15101038.5A HK1200302A1 (en) 2004-02-18 2015-01-30 Adhesive-containing wound closure device
US15/490,176 US10434211B2 (en) 2004-02-18 2017-04-18 Adhesive-containing wound closure device and method
US15/964,538 US10398802B2 (en) 2004-02-18 2018-04-27 Adhesive-containing wound closure device and method
US16/556,443 US11413370B2 (en) 2004-02-18 2019-08-30 Adhesive-containing wound closure device and method

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US12/207,984 Active 2028-06-24 US9655622B2 (en) 2004-02-18 2008-09-10 Adhesive-containing wound closure device and method
US15/490,176 Expired - Lifetime US10434211B2 (en) 2004-02-18 2017-04-18 Adhesive-containing wound closure device and method
US15/964,538 Expired - Lifetime US10398802B2 (en) 2004-02-18 2018-04-27 Adhesive-containing wound closure device and method
US16/556,443 Expired - Lifetime US11413370B2 (en) 2004-02-18 2019-08-30 Adhesive-containing wound closure device and method

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US15/490,176 Expired - Lifetime US10434211B2 (en) 2004-02-18 2017-04-18 Adhesive-containing wound closure device and method
US15/964,538 Expired - Lifetime US10398802B2 (en) 2004-02-18 2018-04-27 Adhesive-containing wound closure device and method
US16/556,443 Expired - Lifetime US11413370B2 (en) 2004-02-18 2019-08-30 Adhesive-containing wound closure device and method

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US (5) US20050182443A1 (es)
EP (2) EP2762086A1 (es)
JP (1) JP5101110B2 (es)
AU (1) AU2005215776B2 (es)
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CA (1) CA2555739C (es)
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HK (1) HK1200302A1 (es)
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BRPI0507782A (pt) 2007-07-17
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AU2005215776A1 (en) 2005-09-01
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CA2555739A1 (en) 2005-09-01
US9655622B2 (en) 2017-05-23
BRPI0507782B1 (pt) 2018-06-19
WO2005079674A1 (en) 2005-09-01
US20090076542A1 (en) 2009-03-19
HK1200302A1 (en) 2015-08-07
EP1715793A4 (en) 2009-12-16
US20170216482A1 (en) 2017-08-03
JP2007522882A (ja) 2007-08-16
US20180243467A1 (en) 2018-08-30
US20190381207A1 (en) 2019-12-19
BRPI0507782B8 (pt) 2021-06-22
AU2005215776B2 (en) 2011-06-09
EP2762086A1 (en) 2014-08-06
US11413370B2 (en) 2022-08-16
US10398802B2 (en) 2019-09-03
US10434211B2 (en) 2019-10-08
ES2474722T3 (es) 2014-07-09
CA2555739C (en) 2015-04-14
EP1715793B1 (en) 2014-05-07

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