US20050075337A1 - Pharmaceutical compositions including carotenoid analogs or derivatives for the inhabition and amelioration of disease - Google Patents

Pharmaceutical compositions including carotenoid analogs or derivatives for the inhabition and amelioration of disease Download PDF

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Publication number
US20050075337A1
US20050075337A1 US10/793,702 US79370204A US2005075337A1 US 20050075337 A1 US20050075337 A1 US 20050075337A1 US 79370204 A US79370204 A US 79370204A US 2005075337 A1 US2005075337 A1 US 2005075337A1
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Prior art keywords
pharmaceutical composition
derivative
carotenoid
carotene
carotenoid analog
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US10/793,702
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English (en)
Inventor
Samuel Lockwood
Sean O'Malley
David Watumull
Laura Hix
Henry Jackson
Geoff Nadolski
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Cardax Pharmaceuticals Inc
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Hawaii Biotech Inc
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Application filed by Hawaii Biotech Inc filed Critical Hawaii Biotech Inc
Priority to US10/793,702 priority Critical patent/US20050075337A1/en
Assigned to HAWAII BIOTECH, INC. reassignment HAWAII BIOTECH, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: HIX, LAURA M., JACKSON, HENRY, LOCKWOOD, SAMUEL FOURNIER, NADOLSKI, GEOFF, O'MALLEY, SEAN, WATUMULL, DAVID G.
Publication of US20050075337A1 publication Critical patent/US20050075337A1/en
Assigned to CARDAX PHARMACEUTICALS, INC. reassignment CARDAX PHARMACEUTICALS, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: HAWAII BIOTECH, INC.
Abandoned legal-status Critical Current

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    • C07C403/24—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by six-membered non-aromatic rings, e.g. beta-carotene
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US20050004235A1 (en) * 2002-07-29 2005-01-06 Lockwood Samuel Fournier Carotenoid analogs or derivatives for the inhibition and amelioration of liver disease
US20050009930A1 (en) * 2002-07-29 2005-01-13 Lockwood Samuel Fournier Carotenoid analogs or derivatives for controlling connexin 43 expression
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WO2008042338A2 (en) 2006-09-28 2008-04-10 Microbia, Inc. Production of carotenoids in oleaginous yeast and fungi
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US20120171303A1 (en) * 2009-09-11 2012-07-05 Nestec S.A. Compositions and methods for ehnancing cognitive and related functions in animals
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Citations (95)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3755422A (en) * 1970-01-15 1973-08-28 Rhone Poulenc Sa Preparation of carotenoid compounds
US3965261A (en) * 1975-04-29 1976-06-22 University Of Virginia Method for treating papillomas
US3975519A (en) * 1975-06-09 1976-08-17 University Of Virginia Method for increasing the oxygen partial pressure in the bloodstream of mammals
US4009270A (en) * 1975-11-21 1977-02-22 The University Of Virginia Method for treating spinal cord injury
US4038144A (en) * 1976-04-19 1977-07-26 The University Of Virginia Method of increasing fermentation yields
US4046880A (en) * 1976-04-20 1977-09-06 The University Of Virginia Method of treating hypertension
US4070460A (en) * 1975-11-10 1978-01-24 University Of Virginia Patents Foundation Method for treating cerebral edema
US4176179A (en) * 1978-04-17 1979-11-27 The University Of Virginia Alumni Patents Foundation Method for treating arthritis
US4245109A (en) * 1978-06-02 1981-01-13 Hoffmann-La Roche Inc. Process for producing astaxanthin
US4283559A (en) * 1978-06-02 1981-08-11 Hoffmann-La Roche Inc. Process for the manufacture of cyclohexene derivatives
US4304784A (en) * 1978-03-31 1981-12-08 Takeda Chemical Industries, Ltd. Composition and method for inhibiting platelet aggregation
US4435427A (en) * 1980-12-19 1984-03-06 Basf Aktiengesellschaft Stable injectable β-carotene micellar solutions and their preparation
US4491574A (en) * 1983-03-02 1985-01-01 Albert Einstein College Of Medicine Of Yeshiva University, A Division Of Yeshiva University Reduction of high dose aspirin toxicity by dietary vitamin A
US4585885A (en) * 1982-08-20 1986-04-29 Hoffmann-La Roche Inc. Cyclohexenone derivatives and process for making same
US4952716A (en) * 1987-03-27 1990-08-28 Hoffmann-La Roche Inc. Ethynylcyclohexene compounds
US5057494A (en) * 1988-08-03 1991-10-15 Ethicon, Inc. Method for preventing tissue damage after an ischemic episode
US5153001A (en) * 1984-01-28 1992-10-06 Roshdy Ismail Agent for treating heart disease
US5221668A (en) * 1992-02-26 1993-06-22 Abbott Laboratories Nutritional product for trauma and surgery patients
US5278189A (en) * 1990-06-04 1994-01-11 Rath Matthias W Prevention and treatment of occlusive cardiovascular disease with ascorbate and substances that inhibit the binding of lipoprotein (A)
US5310554A (en) * 1992-10-27 1994-05-10 Natural Carotene Corporation High purity beta-carotene
US5326757A (en) * 1992-01-06 1994-07-05 Health Maintenance Programs, Inc. Pharmaceutically active antioxidant containing composition and the method of its use to prevent and treat restenosis following angioplasty
US5328845A (en) * 1992-03-27 1994-07-12 Universal Foods Corporation Fungal negative microorganism capable of producing high levels of beta-carotene
US5346488A (en) * 1985-04-08 1994-09-13 The General Hospital Corporation Laser-induced ablation of atherosclerotic plaque
US5364563A (en) * 1989-07-25 1994-11-15 Hoffmann-La Roche Inc. Powdered aqueous carotenoid dispersions
US5422247A (en) * 1992-03-27 1995-06-06 Universal Foods Corporation Blakeslea trispora mated culture capable of increased beta-carotene production
US5455362A (en) * 1993-07-05 1995-10-03 Basf Aktiengesellschaft Preparation of astaxanthin novel intermediates therefor and the preparation thereof
US5457135A (en) * 1992-05-08 1995-10-10 Baranowitz; Steven Treatment of age related macular degeneration with beta-carotene
US5492701A (en) * 1993-07-08 1996-02-20 Rhone-Poulenc Nutrition Animale Process for the preparation of spherules
US5536504A (en) * 1993-11-19 1996-07-16 Marigen S.A. Ultramicroemulsions from spontaneously dispersible concentrates containing xanthophyll esters and having antitumor activity
US5589468A (en) * 1995-01-13 1996-12-31 Clintec Nutrition Co. Method for providing nutrition to elderly patients
US5607707A (en) * 1992-09-15 1997-03-04 Smithkline Beecham P.L.C. Compositions
US5607839A (en) * 1993-07-22 1997-03-04 Nippon Oil Company, Ltd. Bacteria belonging to new genus process for production of carotenoids using same
US5612485A (en) * 1992-06-04 1997-03-18 Betatene Ltd Of Cheltenham High cis beta-carotene composition
US5643943A (en) * 1994-12-23 1997-07-01 Alcon Laboratories, Inc. Systemic administration of esters and amides of antioxidants which may be used as antioxidant prodrug therapy for oxidative and inflammatory pathogenesis
US5668183A (en) * 1992-04-14 1997-09-16 Roche Vitamins Inc. Water dispersible compositions
US5705180A (en) * 1993-03-22 1998-01-06 Betatene Limited Therapeutic agent for the treatment of melanomas
US5744502A (en) * 1994-09-19 1998-04-28 Astacarotene Ab Method for increasing the production of/in breeding and production animals in the poultry industry
US5773026A (en) * 1993-03-22 1998-06-30 Betatene Limited Aqueous formulations of water-insoluble therapeutic agent comprising carotenoids and/or tocopherols
US5801159A (en) * 1996-02-23 1998-09-01 Galileo Laboratories, Inc. Method and composition for inhibiting cellular irreversible changes due to stress
US5811446A (en) * 1997-04-18 1998-09-22 Cytos Pharmaceuticals Llc Prophylactic and therapeutic methods for ocular degenerative diseases and inflammations and histidine compositions therefor
US5837224A (en) * 1996-01-19 1998-11-17 The Regents Of The University Of Michigan Method of inhibiting photoaging of skin
US5849345A (en) * 1994-12-21 1998-12-15 Roche Vitamins Inc. Carotenoid ketones and esters
US5854015A (en) * 1995-10-31 1998-12-29 Applied Food Biotechnology, Inc. Method of making pure 3R-3'R stereoisomer of zeaxanthin for human ingestion
US5858700A (en) * 1997-04-03 1999-01-12 Kemin Foods, Lc Process for the isolation and purification of lycopene crystals
US5863953A (en) * 1996-11-27 1999-01-26 Basf Aktiengesellschaft Liquid, oil-miscible carotenoid preparations
US5871766A (en) * 1990-10-01 1999-02-16 Brigham And Women's Hospital Beta-carotene vitamin E therapy for inhibition of major vascular events
US5876782A (en) * 1997-05-14 1999-03-02 Kemin Industries, Inc. Method for the conversion of xanthophylls in plant material
US5886053A (en) * 1995-02-03 1999-03-23 Basf Aktiengesellschaft Use of carotenoids for producing drugs for the treatment of dermatoses
US5891907A (en) * 1996-03-11 1999-04-06 Basf Aktiengesellschaft Stable aqueous solubilizates of carotenoids and vitamins
US5895659A (en) * 1993-03-11 1999-04-20 Basf Akteingesellschaft Finely dispersed carotenoid and retinoid suspension and their preparation
US5925684A (en) * 1996-03-11 1999-07-20 Basf Aktiengesellschaft Stable carotenoid emulsions suitable for parenteral administration
US5959138A (en) * 1997-11-25 1999-09-28 Industrial Organica S.A. De C.V. Short chain diesters and process for making the same
US5968251A (en) * 1996-09-09 1999-10-19 Basf Aktiengesellschaft Production of carotenoid preparations in the form of coldwater-dispersible powders, and the use of the novel carotenoid preparations
US5976575A (en) * 1995-12-28 1999-11-02 Amway Corporation Dry carotenoid-oil powder and process for making same
US6020003A (en) * 1998-02-23 2000-02-01 Basf Corporation Method of making spray-dried powders with high edible-oil loadings based on non-hydrolyzed gelatin
US6040147A (en) * 1997-04-02 2000-03-21 The Brigham And Women's Hospital, Inc. Systemic inflammatory markers as diagnostic tools in the prevention of atherosclerotic diseases and as tools to aid in the selection of agents to be used for the prevention and treatment of atherosclerotic disease
US6043259A (en) * 1998-07-09 2000-03-28 Medicure Inc. Treatment of cardiovascular and related pathologies
US6046181A (en) * 1995-10-17 2000-04-04 Showa Denko K.K. Highly purified tocopheryl phosphate, process for producing the same, analytical method therefor and cosmetic
US6051587A (en) * 1998-04-16 2000-04-18 Medicure, Inc. Treatment of iatrogenic and age-related hypertension and pharmaceutical compositions useful therein
US6054491A (en) * 1996-03-27 2000-04-25 Astacarotene Ab Agent for increasing the production of/in breeding and production mammals
US6060511A (en) * 1995-10-05 2000-05-09 Gainer; John L. Trans-sodium crocetinate, methods of making and methods of use thereof
US6075058A (en) * 1998-12-12 2000-06-13 Tufts University Compositions for increased bioavailability of carotenoids
US6083520A (en) * 1994-05-19 2000-07-04 Ewos Aktiebolag Bioactive feed
US6093348A (en) * 1996-05-14 2000-07-25 Roche Vitamins Inc. Process for manufacture of carotenoid compositions
US6132790A (en) * 1991-09-06 2000-10-17 Betatene Limited Carotenoid composition
US6218436B1 (en) * 1993-06-28 2001-04-17 The Howard Foundation Pharmaceutically active carotenoids
US6232060B1 (en) * 1996-01-19 2001-05-15 Galileo Laboratories, Inc. Assay system for anti-stress agents
US6245818B1 (en) * 1997-09-04 2001-06-12 Astacarotene Ab Medicament for improvement of duration of muscle function or treatment of muscle disorders or diseases
US6258855B1 (en) * 2000-02-08 2001-07-10 Cyanotech Corporation Method of retarding and ameliorating carpal tunnel syndrome
US6265450B1 (en) * 1995-10-26 2001-07-24 Suntory Limited Anti-stress composition
US6313169B1 (en) * 1997-04-04 2001-11-06 Phyllis E. Bowen Lutein esters having high bioavailability
US6331537B1 (en) * 1998-06-03 2001-12-18 Gpi Nil Holdings, Inc. Carboxylic acids and carboxylic acid isosteres of N-heterocyclic compounds
US6335015B1 (en) * 1997-12-16 2002-01-01 Astacarotene Ab Method of the prophylactic treatment of mastitis
US6344214B1 (en) * 1999-12-13 2002-02-05 Cyanotech Corporation Method for retarding and ameliorating fever blisters and canker sores
US6399105B1 (en) * 1999-01-20 2002-06-04 Peter Donald Collin Sea cucumber carotenoid lipid fraction products and methods of use
US6428816B1 (en) * 1994-04-08 2002-08-06 Cognis Australia Pty., Ltd. Carotenoid agent for inhibiting the conversion of epithelial cells to tumors
US6540654B2 (en) * 2001-02-23 2003-04-01 Luis W. Levy Carotenoid esters
US6541519B2 (en) * 2000-04-06 2003-04-01 Coastside Bio Resources Methods and compositions for treating lipoxygenase-mediated disease states
US20040162329A1 (en) * 2002-07-29 2004-08-19 Lockwood Samuel Fournier Structural carotenoid analogs for the inhibition and amelioration of disease
US20050004235A1 (en) * 2002-07-29 2005-01-06 Lockwood Samuel Fournier Carotenoid analogs or derivatives for the inhibition and amelioration of liver disease
US20050009758A1 (en) * 2002-07-29 2005-01-13 Lockwood Samuel Fournier Carotenoid ether analogs or derivatives for the inhibition and amelioration of disease
US20050009788A1 (en) * 2002-07-29 2005-01-13 Lockwood Samuel Fournier Carotenoid ester analogs or derivatives for controlling connexin 43 expression
US20050009930A1 (en) * 2002-07-29 2005-01-13 Lockwood Samuel Fournier Carotenoid analogs or derivatives for controlling connexin 43 expression
US20050026874A1 (en) * 2002-07-29 2005-02-03 Lockwood Samuel Fournier Carotenoid ether analogs or derivatives for the inhibition and amelioration of liver disease
US20050049248A1 (en) * 2002-07-29 2005-03-03 Lockwood Samuel Fournier Carotenoid ether analogs or derivatives for controlling C-reactive protein levels
US20050059659A1 (en) * 2002-07-29 2005-03-17 Lockwood Samuel Fournier Carotenoid analogs or derivatives for controlling C-reactive protein levels
US20050059635A1 (en) * 2002-07-29 2005-03-17 Lockwood Samuel Fournier Carotenoid ester analogs or derivatives for controlling C-reactive protein levels
US20050065096A1 (en) * 2002-07-29 2005-03-24 Lockwood Samuel Fournier Pharmaceutical compositions including carotenoid ether analogs or derivatives for the inhibition and amelioration of disease
US20050075316A1 (en) * 2002-07-29 2005-04-07 Lockwood Samuel Fournier Pharmaceutical compositions including carotenoid ester analogs or derivatives for the inhibition and amelioration of disease
US20050090469A1 (en) * 2002-07-29 2005-04-28 Lockwood Samuel F. Carotenoid ester analogs or derivatives for the inhibition and amelioration of liver disease
US20050113372A1 (en) * 2002-07-29 2005-05-26 Lockwood Samuel F. Carotenoid analogs or derivatives for the inhibition and amelioration of disease
US20050143475A1 (en) * 2002-07-29 2005-06-30 Lockwood Samuel F. Carotenoid analogs or derivatives for the inhibition and amelioration of ischemic reperfusion injury
US20050148517A1 (en) * 2002-07-29 2005-07-07 Lockwood Samuel F. Carotenoid ether analogs or derivatives for controlling connexin 43 expression
US20050261254A1 (en) * 2004-04-14 2005-11-24 Lockwood Samuel F Carotenoid analogs or derivatives for the inhibition and amelioration of inflammation
US20060058269A1 (en) * 2004-04-14 2006-03-16 Lockwood Samuel F Carotenoid analogs or derivatives for the inhibition and amelioration of inflammation

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH314001A (de) * 1952-12-18 1956-05-31 Hoffmann La Roche Verfahren zur Herstellung von Vitamin-A-Estern
CH420822A (de) * 1960-10-17 1966-09-15 Hoffmann La Roche Wasserdispergierbare Carotinoidzubereitung
US3354218A (en) 1963-05-10 1967-11-21 Hoffmann La Roche Process for preparing 4-(2, 6, 6-trimethyl-4-methoxy-1-cyclohexen-1-yl)-3-buten-2-one
US3788468A (en) * 1973-05-01 1974-01-29 Univ Virginia Process for increasing oxygen diffusivity
US3853993A (en) * 1973-05-01 1974-12-10 Univ Virginia Process for increasing oxygen diffusivity and method for treating atherosclerosis
US3989757A (en) 1973-08-29 1976-11-02 Hoffmann-La Roche Inc. Isomerizing cis-carotenoids to all-trans-carotenoids
CH609320A5 (US20050075337A1-20050407-C00089.png) * 1974-06-20 1979-02-28 Hoffmann La Roche
CH623304A5 (US20050075337A1-20050407-C00089.png) * 1975-11-30 1981-05-29 Hoffmann La Roche
DE3273463D1 (en) * 1981-10-16 1986-10-30 Hoffmann La Roche Process for the preparation of cyclohexene derivatives, and a starting product and intermediary products in this process
DE3264086D1 (en) * 1982-02-09 1985-07-11 Hoffmann La Roche Process for the preparation of cyclohexen derivatives
US4851339A (en) * 1986-04-01 1989-07-25 Hills Christopher B Extraction of anti-mutagenic pigments from algae and vegetables
DK0630578T3 (da) * 1993-06-24 2000-09-11 Hoffmann La Roche Pigmentering med carotenoider
JP3249867B2 (ja) * 1993-10-21 2002-01-21 株式会社クラレ アスタキサンチンの製造方法
JPH0873312A (ja) * 1994-09-02 1996-03-19 Noevir Co Ltd 皮膚外用剤
US5527533A (en) 1994-10-27 1996-06-18 Board Of Trustees Of The University Of Illinois Method of retarding and ameliorating central nervous system and eye damage
US5532009A (en) * 1995-06-07 1996-07-02 The Procter & Gamble Company Fat substitutes containing water soluble beta-carotene
JPH08337592A (ja) * 1995-06-13 1996-12-24 Kaiyo Bio Technol Kenkyusho:Kk 新規カロテノイド
JPH0984591A (ja) * 1995-09-26 1997-03-31 Kaiyo Bio Technol Kenkyusho:Kk カロテノイド硫酸エステルおよびその製造方法
JPH09202730A (ja) * 1996-01-24 1997-08-05 Nippon Mektron Ltd 発ガン抑制作用剤
AU7888498A (en) * 1996-12-25 1998-07-31 Designer Foods Association Ltd. Carcinogenesis inhibitors
JPH10327865A (ja) * 1997-05-29 1998-12-15 Kirin Brewery Co Ltd カロテノイド配糖体およびその製造法
US6008417A (en) 1997-10-20 1999-12-28 Roche Vitamins Inc. Process for making metabolites of lycopene
DE19802134A1 (de) * 1998-01-21 1999-07-22 Basf Ag Verwendung von Carotinoid-Aggregaten als Färbemittel
NL1010351C2 (nl) * 1998-10-19 2001-01-08 Werklust & Beheer B V Esters van caroteno´den voor gebruik in de preventie en behandeling van oogaandoeningen.
JP4491090B2 (ja) * 1999-10-08 2010-06-30 ヒガシマル醤油株式会社 アポトーシス誘導剤
US6426362B1 (en) 1999-10-08 2002-07-30 Galileo Laboratories, Inc. Formulations of tocopherols and methods of making and using them
AU2257401A (en) 1999-12-08 2001-06-18 California Institute Of Technology Directed evolution of biosynthetic and biodegration pathways
US20030104090A1 (en) 2000-05-05 2003-06-05 Levy Pedro E. Supplements containing annatto extracts and carotenoids and methods for using the same
US6579544B1 (en) 2000-05-31 2003-06-17 Nutriex, L.L.C. Method for supplementing the diet
US20020110604A1 (en) 2000-08-11 2002-08-15 Ashni Naturaceuticals, Inc. Composition exhibiting synergistic antioxidant activity
JP2004515508A (ja) 2000-12-16 2004-05-27 アベンティス・ファーマ・ドイチユラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 化合物の健康促進組成物
US6984523B2 (en) 2001-08-02 2006-01-10 E.I. Du Pont De Nemours And Company Carotenoid ketolase gene
GB0119052D0 (en) 2001-08-03 2001-09-26 Mars Uk Ltd Foodstuff
US7253297B2 (en) * 2002-02-06 2007-08-07 Dsm Ip Assetts B.V. Astaxanthin esters
US7514107B2 (en) 2002-03-21 2009-04-07 Mars, Incorporated Treatment of diseases involving defective gap junctional communication
EP1500645B1 (en) * 2002-04-30 2009-07-15 Suntory Holdings Limited Astaxanthin medium-chain fatty acid ester, process for producing the same and composition containing the ester
US20060167319A1 (en) * 2004-10-01 2006-07-27 Lockwood Samuel F Methods for the synthesis of unsaturated ketone intermediates useful for the synthesis of carotenoids

Patent Citations (98)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3755422A (en) * 1970-01-15 1973-08-28 Rhone Poulenc Sa Preparation of carotenoid compounds
US3965261A (en) * 1975-04-29 1976-06-22 University Of Virginia Method for treating papillomas
US3975519A (en) * 1975-06-09 1976-08-17 University Of Virginia Method for increasing the oxygen partial pressure in the bloodstream of mammals
US4070460A (en) * 1975-11-10 1978-01-24 University Of Virginia Patents Foundation Method for treating cerebral edema
US4009270A (en) * 1975-11-21 1977-02-22 The University Of Virginia Method for treating spinal cord injury
US4038144A (en) * 1976-04-19 1977-07-26 The University Of Virginia Method of increasing fermentation yields
US4046880A (en) * 1976-04-20 1977-09-06 The University Of Virginia Method of treating hypertension
US4304784A (en) * 1978-03-31 1981-12-08 Takeda Chemical Industries, Ltd. Composition and method for inhibiting platelet aggregation
US4176179A (en) * 1978-04-17 1979-11-27 The University Of Virginia Alumni Patents Foundation Method for treating arthritis
US4245109A (en) * 1978-06-02 1981-01-13 Hoffmann-La Roche Inc. Process for producing astaxanthin
US4283559A (en) * 1978-06-02 1981-08-11 Hoffmann-La Roche Inc. Process for the manufacture of cyclohexene derivatives
US4435427A (en) * 1980-12-19 1984-03-06 Basf Aktiengesellschaft Stable injectable β-carotene micellar solutions and their preparation
US4585885A (en) * 1982-08-20 1986-04-29 Hoffmann-La Roche Inc. Cyclohexenone derivatives and process for making same
US4491574A (en) * 1983-03-02 1985-01-01 Albert Einstein College Of Medicine Of Yeshiva University, A Division Of Yeshiva University Reduction of high dose aspirin toxicity by dietary vitamin A
US5153001A (en) * 1984-01-28 1992-10-06 Roshdy Ismail Agent for treating heart disease
US5346488A (en) * 1985-04-08 1994-09-13 The General Hospital Corporation Laser-induced ablation of atherosclerotic plaque
US4952716A (en) * 1987-03-27 1990-08-28 Hoffmann-La Roche Inc. Ethynylcyclohexene compounds
US5057494A (en) * 1988-08-03 1991-10-15 Ethicon, Inc. Method for preventing tissue damage after an ischemic episode
US5364563A (en) * 1989-07-25 1994-11-15 Hoffmann-La Roche Inc. Powdered aqueous carotenoid dispersions
US5278189A (en) * 1990-06-04 1994-01-11 Rath Matthias W Prevention and treatment of occlusive cardiovascular disease with ascorbate and substances that inhibit the binding of lipoprotein (A)
US5871766A (en) * 1990-10-01 1999-02-16 Brigham And Women's Hospital Beta-carotene vitamin E therapy for inhibition of major vascular events
US6132790A (en) * 1991-09-06 2000-10-17 Betatene Limited Carotenoid composition
US5326757A (en) * 1992-01-06 1994-07-05 Health Maintenance Programs, Inc. Pharmaceutically active antioxidant containing composition and the method of its use to prevent and treat restenosis following angioplasty
US5221668A (en) * 1992-02-26 1993-06-22 Abbott Laboratories Nutritional product for trauma and surgery patients
US5328845A (en) * 1992-03-27 1994-07-12 Universal Foods Corporation Fungal negative microorganism capable of producing high levels of beta-carotene
US5422247A (en) * 1992-03-27 1995-06-06 Universal Foods Corporation Blakeslea trispora mated culture capable of increased beta-carotene production
US5668183A (en) * 1992-04-14 1997-09-16 Roche Vitamins Inc. Water dispersible compositions
US5457135A (en) * 1992-05-08 1995-10-10 Baranowitz; Steven Treatment of age related macular degeneration with beta-carotene
US5612485A (en) * 1992-06-04 1997-03-18 Betatene Ltd Of Cheltenham High cis beta-carotene composition
US5607707A (en) * 1992-09-15 1997-03-04 Smithkline Beecham P.L.C. Compositions
US5310554A (en) * 1992-10-27 1994-05-10 Natural Carotene Corporation High purity beta-carotene
US5895659A (en) * 1993-03-11 1999-04-20 Basf Akteingesellschaft Finely dispersed carotenoid and retinoid suspension and their preparation
US5705180A (en) * 1993-03-22 1998-01-06 Betatene Limited Therapeutic agent for the treatment of melanomas
US5773026A (en) * 1993-03-22 1998-06-30 Betatene Limited Aqueous formulations of water-insoluble therapeutic agent comprising carotenoids and/or tocopherols
US5897871A (en) * 1993-03-22 1999-04-27 Betatine Limited Therapeutic agent for the treatment of melanomas
US6218436B1 (en) * 1993-06-28 2001-04-17 The Howard Foundation Pharmaceutically active carotenoids
US5455362A (en) * 1993-07-05 1995-10-03 Basf Aktiengesellschaft Preparation of astaxanthin novel intermediates therefor and the preparation thereof
US5492701A (en) * 1993-07-08 1996-02-20 Rhone-Poulenc Nutrition Animale Process for the preparation of spherules
US5607839A (en) * 1993-07-22 1997-03-04 Nippon Oil Company, Ltd. Bacteria belonging to new genus process for production of carotenoids using same
US5536504A (en) * 1993-11-19 1996-07-16 Marigen S.A. Ultramicroemulsions from spontaneously dispersible concentrates containing xanthophyll esters and having antitumor activity
US6428816B1 (en) * 1994-04-08 2002-08-06 Cognis Australia Pty., Ltd. Carotenoid agent for inhibiting the conversion of epithelial cells to tumors
US6083520A (en) * 1994-05-19 2000-07-04 Ewos Aktiebolag Bioactive feed
US5744502A (en) * 1994-09-19 1998-04-28 Astacarotene Ab Method for increasing the production of/in breeding and production animals in the poultry industry
US5849345A (en) * 1994-12-21 1998-12-15 Roche Vitamins Inc. Carotenoid ketones and esters
US5643943A (en) * 1994-12-23 1997-07-01 Alcon Laboratories, Inc. Systemic administration of esters and amides of antioxidants which may be used as antioxidant prodrug therapy for oxidative and inflammatory pathogenesis
US5589468A (en) * 1995-01-13 1996-12-31 Clintec Nutrition Co. Method for providing nutrition to elderly patients
US5886053A (en) * 1995-02-03 1999-03-23 Basf Aktiengesellschaft Use of carotenoids for producing drugs for the treatment of dermatoses
US6060511A (en) * 1995-10-05 2000-05-09 Gainer; John L. Trans-sodium crocetinate, methods of making and methods of use thereof
US6046181A (en) * 1995-10-17 2000-04-04 Showa Denko K.K. Highly purified tocopheryl phosphate, process for producing the same, analytical method therefor and cosmetic
US6265450B1 (en) * 1995-10-26 2001-07-24 Suntory Limited Anti-stress composition
US5854015A (en) * 1995-10-31 1998-12-29 Applied Food Biotechnology, Inc. Method of making pure 3R-3'R stereoisomer of zeaxanthin for human ingestion
US5976575A (en) * 1995-12-28 1999-11-02 Amway Corporation Dry carotenoid-oil powder and process for making same
US5837224A (en) * 1996-01-19 1998-11-17 The Regents Of The University Of Michigan Method of inhibiting photoaging of skin
US6232060B1 (en) * 1996-01-19 2001-05-15 Galileo Laboratories, Inc. Assay system for anti-stress agents
US5801159A (en) * 1996-02-23 1998-09-01 Galileo Laboratories, Inc. Method and composition for inhibiting cellular irreversible changes due to stress
US5925684A (en) * 1996-03-11 1999-07-20 Basf Aktiengesellschaft Stable carotenoid emulsions suitable for parenteral administration
US5891907A (en) * 1996-03-11 1999-04-06 Basf Aktiengesellschaft Stable aqueous solubilizates of carotenoids and vitamins
US6054491A (en) * 1996-03-27 2000-04-25 Astacarotene Ab Agent for increasing the production of/in breeding and production mammals
US6093348A (en) * 1996-05-14 2000-07-25 Roche Vitamins Inc. Process for manufacture of carotenoid compositions
US5968251A (en) * 1996-09-09 1999-10-19 Basf Aktiengesellschaft Production of carotenoid preparations in the form of coldwater-dispersible powders, and the use of the novel carotenoid preparations
US5863953A (en) * 1996-11-27 1999-01-26 Basf Aktiengesellschaft Liquid, oil-miscible carotenoid preparations
US6040147A (en) * 1997-04-02 2000-03-21 The Brigham And Women's Hospital, Inc. Systemic inflammatory markers as diagnostic tools in the prevention of atherosclerotic diseases and as tools to aid in the selection of agents to be used for the prevention and treatment of atherosclerotic disease
US5858700A (en) * 1997-04-03 1999-01-12 Kemin Foods, Lc Process for the isolation and purification of lycopene crystals
US6313169B1 (en) * 1997-04-04 2001-11-06 Phyllis E. Bowen Lutein esters having high bioavailability
US5811446A (en) * 1997-04-18 1998-09-22 Cytos Pharmaceuticals Llc Prophylactic and therapeutic methods for ocular degenerative diseases and inflammations and histidine compositions therefor
US5876782A (en) * 1997-05-14 1999-03-02 Kemin Industries, Inc. Method for the conversion of xanthophylls in plant material
US6245818B1 (en) * 1997-09-04 2001-06-12 Astacarotene Ab Medicament for improvement of duration of muscle function or treatment of muscle disorders or diseases
US5959138A (en) * 1997-11-25 1999-09-28 Industrial Organica S.A. De C.V. Short chain diesters and process for making the same
US6335015B1 (en) * 1997-12-16 2002-01-01 Astacarotene Ab Method of the prophylactic treatment of mastitis
US6020003A (en) * 1998-02-23 2000-02-01 Basf Corporation Method of making spray-dried powders with high edible-oil loadings based on non-hydrolyzed gelatin
US6051587A (en) * 1998-04-16 2000-04-18 Medicure, Inc. Treatment of iatrogenic and age-related hypertension and pharmaceutical compositions useful therein
US6331537B1 (en) * 1998-06-03 2001-12-18 Gpi Nil Holdings, Inc. Carboxylic acids and carboxylic acid isosteres of N-heterocyclic compounds
US6043259A (en) * 1998-07-09 2000-03-28 Medicure Inc. Treatment of cardiovascular and related pathologies
US6075058A (en) * 1998-12-12 2000-06-13 Tufts University Compositions for increased bioavailability of carotenoids
US6399105B1 (en) * 1999-01-20 2002-06-04 Peter Donald Collin Sea cucumber carotenoid lipid fraction products and methods of use
US6344214B1 (en) * 1999-12-13 2002-02-05 Cyanotech Corporation Method for retarding and ameliorating fever blisters and canker sores
US6258855B1 (en) * 2000-02-08 2001-07-10 Cyanotech Corporation Method of retarding and ameliorating carpal tunnel syndrome
US6541519B2 (en) * 2000-04-06 2003-04-01 Coastside Bio Resources Methods and compositions for treating lipoxygenase-mediated disease states
US6540654B2 (en) * 2001-02-23 2003-04-01 Luis W. Levy Carotenoid esters
US20050004235A1 (en) * 2002-07-29 2005-01-06 Lockwood Samuel Fournier Carotenoid analogs or derivatives for the inhibition and amelioration of liver disease
US20050059635A1 (en) * 2002-07-29 2005-03-17 Lockwood Samuel Fournier Carotenoid ester analogs or derivatives for controlling C-reactive protein levels
US20050009758A1 (en) * 2002-07-29 2005-01-13 Lockwood Samuel Fournier Carotenoid ether analogs or derivatives for the inhibition and amelioration of disease
US20050009788A1 (en) * 2002-07-29 2005-01-13 Lockwood Samuel Fournier Carotenoid ester analogs or derivatives for controlling connexin 43 expression
US20050009930A1 (en) * 2002-07-29 2005-01-13 Lockwood Samuel Fournier Carotenoid analogs or derivatives for controlling connexin 43 expression
US20050026874A1 (en) * 2002-07-29 2005-02-03 Lockwood Samuel Fournier Carotenoid ether analogs or derivatives for the inhibition and amelioration of liver disease
US20050037995A1 (en) * 2002-07-29 2005-02-17 Lockwood Samuel Fournier Carotenoid ester analogs or derivatives for the inhibition and amelioration of ischemic reperfusion injury
US20050049248A1 (en) * 2002-07-29 2005-03-03 Lockwood Samuel Fournier Carotenoid ether analogs or derivatives for controlling C-reactive protein levels
US20050059659A1 (en) * 2002-07-29 2005-03-17 Lockwood Samuel Fournier Carotenoid analogs or derivatives for controlling C-reactive protein levels
US20040162329A1 (en) * 2002-07-29 2004-08-19 Lockwood Samuel Fournier Structural carotenoid analogs for the inhibition and amelioration of disease
US20050065097A1 (en) * 2002-07-29 2005-03-24 Lockwood Samuel Fournier Carotenoid ether analogs or derivatives for the inhibition and amelioration of ischemic reperfusion injury
US20050065096A1 (en) * 2002-07-29 2005-03-24 Lockwood Samuel Fournier Pharmaceutical compositions including carotenoid ether analogs or derivatives for the inhibition and amelioration of disease
US20050075316A1 (en) * 2002-07-29 2005-04-07 Lockwood Samuel Fournier Pharmaceutical compositions including carotenoid ester analogs or derivatives for the inhibition and amelioration of disease
US20050090469A1 (en) * 2002-07-29 2005-04-28 Lockwood Samuel F. Carotenoid ester analogs or derivatives for the inhibition and amelioration of liver disease
US20050113372A1 (en) * 2002-07-29 2005-05-26 Lockwood Samuel F. Carotenoid analogs or derivatives for the inhibition and amelioration of disease
US20050143475A1 (en) * 2002-07-29 2005-06-30 Lockwood Samuel F. Carotenoid analogs or derivatives for the inhibition and amelioration of ischemic reperfusion injury
US20050148517A1 (en) * 2002-07-29 2005-07-07 Lockwood Samuel F. Carotenoid ether analogs or derivatives for controlling connexin 43 expression
US20050261254A1 (en) * 2004-04-14 2005-11-24 Lockwood Samuel F Carotenoid analogs or derivatives for the inhibition and amelioration of inflammation
US20060058269A1 (en) * 2004-04-14 2006-03-16 Lockwood Samuel F Carotenoid analogs or derivatives for the inhibition and amelioration of inflammation

Cited By (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7145025B2 (en) 2002-07-29 2006-12-05 Hawaii Biotech, Inc. Structural carotenoid analogs for the inhibition and amelioration of disease
US20050009788A1 (en) * 2002-07-29 2005-01-13 Lockwood Samuel Fournier Carotenoid ester analogs or derivatives for controlling connexin 43 expression
US7763649B2 (en) 2002-07-29 2010-07-27 Cardax Pharmaceuticals, Inc. Carotenoid analogs or derivatives for controlling connexin 43 expression
US20050009758A1 (en) * 2002-07-29 2005-01-13 Lockwood Samuel Fournier Carotenoid ether analogs or derivatives for the inhibition and amelioration of disease
US20050026874A1 (en) * 2002-07-29 2005-02-03 Lockwood Samuel Fournier Carotenoid ether analogs or derivatives for the inhibition and amelioration of liver disease
US20050037995A1 (en) * 2002-07-29 2005-02-17 Lockwood Samuel Fournier Carotenoid ester analogs or derivatives for the inhibition and amelioration of ischemic reperfusion injury
US20050049248A1 (en) * 2002-07-29 2005-03-03 Lockwood Samuel Fournier Carotenoid ether analogs or derivatives for controlling C-reactive protein levels
US20050059635A1 (en) * 2002-07-29 2005-03-17 Lockwood Samuel Fournier Carotenoid ester analogs or derivatives for controlling C-reactive protein levels
US20050059659A1 (en) * 2002-07-29 2005-03-17 Lockwood Samuel Fournier Carotenoid analogs or derivatives for controlling C-reactive protein levels
US20050065096A1 (en) * 2002-07-29 2005-03-24 Lockwood Samuel Fournier Pharmaceutical compositions including carotenoid ether analogs or derivatives for the inhibition and amelioration of disease
US20050065097A1 (en) * 2002-07-29 2005-03-24 Lockwood Samuel Fournier Carotenoid ether analogs or derivatives for the inhibition and amelioration of ischemic reperfusion injury
US20050075316A1 (en) * 2002-07-29 2005-04-07 Lockwood Samuel Fournier Pharmaceutical compositions including carotenoid ester analogs or derivatives for the inhibition and amelioration of disease
US20050090469A1 (en) * 2002-07-29 2005-04-28 Lockwood Samuel F. Carotenoid ester analogs or derivatives for the inhibition and amelioration of liver disease
US7723327B2 (en) 2002-07-29 2010-05-25 Cardax Pharmaceuticals, Inc. Carotenoid ester analogs or derivatives for the inhibition and amelioration of liver disease
US7592449B2 (en) 2002-07-29 2009-09-22 Cardax Pharmaceuticals, Inc. Structural carotenoid analogs for the inhibition and amelioration of disease
US20050009930A1 (en) * 2002-07-29 2005-01-13 Lockwood Samuel Fournier Carotenoid analogs or derivatives for controlling connexin 43 expression
US20050004235A1 (en) * 2002-07-29 2005-01-06 Lockwood Samuel Fournier Carotenoid analogs or derivatives for the inhibition and amelioration of liver disease
US7247752B2 (en) 2004-10-01 2007-07-24 Cardax Pharmaceuticals, Inc. Methods for the synthesis of astaxanthin
US20060178538A1 (en) * 2004-10-01 2006-08-10 Lockwood Samuel F Methods for the synthesis of chiral dihydroxy intermediates useful for the chiral synthesis of carotenoids
US20060183947A1 (en) * 2004-10-01 2006-08-17 Lockwood Samuel F Methods for the synthesis of astaxanthin
US20060183185A1 (en) * 2004-10-01 2006-08-17 Lockwood Samuel F Method for the synthesis of astaxanthin
US20060155150A1 (en) * 2004-10-01 2006-07-13 Lockwood Samuel F Methods for the synthesis of lutein
US20060167319A1 (en) * 2004-10-01 2006-07-27 Lockwood Samuel F Methods for the synthesis of unsaturated ketone intermediates useful for the synthesis of carotenoids
US20060111580A1 (en) * 2004-10-01 2006-05-25 Lockwood Samuel F Methods for the synthesis of chiral dihydroxy ketone intermediates useful for the chiral synthesis of carotenoids
US20060088904A1 (en) * 2004-10-01 2006-04-27 Lockwood Samuel F Methods for the synthesis of astaxanthin
US20060088905A1 (en) * 2004-10-01 2006-04-27 Lockwood Samuel F Methods for the synthesis of zeazanthin
US10071141B2 (en) 2015-05-08 2018-09-11 Spectral Platforms, Inc. Albumin-based non-covalent complexes and methods of use thereof
US10342855B2 (en) 2015-05-08 2019-07-09 Spectral Platforms, Inc. Albumin-based non-covalent complexes and methods of use thereof
US10940183B2 (en) 2015-05-08 2021-03-09 Spectral Platforms, Inc. Albumin-based non-covalent complexes and methods of use thereof
US11105747B2 (en) 2017-03-20 2021-08-31 Spectral Platforms, Inc. Spectroscopic methods to detect and characterize microorganisms

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