UA97506C2 - Inhibitors of poly(adp-ribose)polymerase - Google Patents

Inhibitors of poly(adp-ribose)polymerase

Info

Publication number
UA97506C2
UA97506C2 UAA200907943A UAA200907943A UA97506C2 UA 97506 C2 UA97506 C2 UA 97506C2 UA A200907943 A UAA200907943 A UA A200907943A UA A200907943 A UAA200907943 A UA A200907943A UA 97506 C2 UA97506 C2 UA 97506C2
Authority
UA
Ukraine
Prior art keywords
adp
ribose
polymerase
inhibitors
poly
Prior art date
Application number
UAA200907943A
Other languages
English (en)
Ukrainian (uk)
Inventor
Вирадж Б. ГАНДХИ
Винсент Л. ЖИРАНДА
Цзяньчунь ГУН
Томас Д. ПЕННИНГ
Гуй-дун ЧЖУ
Original Assignee
Эбботт Лаборетриз
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39584870&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA97506(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Эбботт Лаборетриз filed Critical Эбботт Лаборетриз
Publication of UA97506C2 publication Critical patent/UA97506C2/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/14—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/58—1,2-Diazines; Hydrogenated 1,2-diazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/30—Phthalazines
    • C07D237/32—Phthalazines with oxygen atoms directly attached to carbon atoms of the nitrogen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Abstract

Заявлены ингибиторы поли(АОР-рибозо)полимеразы, способи их получения и способы лечения пациентов с их использованием.
UAA200907943A 2006-12-28 2007-12-20 Inhibitors of poly(adp-ribose)polymerase UA97506C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US88231706P 2006-12-28 2006-12-28
PCT/US2007/088319 WO2008083027A1 (en) 2006-12-28 2007-12-20 Inhibitors of poly(adp-ribose)polymerase

Publications (1)

Publication Number Publication Date
UA97506C2 true UA97506C2 (en) 2012-02-27

Family

ID=39584870

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200907943A UA97506C2 (en) 2006-12-28 2007-12-20 Inhibitors of poly(adp-ribose)polymerase

Country Status (31)

Country Link
US (1) US20080161280A1 (ru)
EP (2) EP2120579B1 (ru)
JP (2) JP5523837B2 (ru)
KR (2) KR101449436B1 (ru)
CN (2) CN103690542B (ru)
AU (1) AU2007340020B2 (ru)
BR (1) BRPI0722070A2 (ru)
CA (1) CA2672868C (ru)
CO (1) CO6220961A2 (ru)
CR (1) CR10901A (ru)
DK (2) DK2698062T3 (ru)
DO (1) DOP2009000159A (ru)
EC (1) ECSP099530A (ru)
ES (2) ES2548353T3 (ru)
GT (1) GT200900182A (ru)
HK (1) HK1194922A1 (ru)
HR (1) HRP20140115T1 (ru)
HU (1) HUE027641T2 (ru)
MX (2) MX2009007051A (ru)
MY (2) MY165570A (ru)
NO (1) NO20092698L (ru)
NZ (2) NZ598352A (ru)
PL (2) PL2120579T3 (ru)
PT (2) PT2698062E (ru)
RS (1) RS53196B (ru)
RU (1) RU2455286C2 (ru)
SG (2) SG193664A1 (ru)
SI (2) SI2120579T1 (ru)
TW (1) TWI429438B (ru)
UA (1) UA97506C2 (ru)
WO (1) WO2008083027A1 (ru)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7151102B2 (en) 2000-10-30 2006-12-19 Kudos Pharmaceuticals Limited Phthalazinone derivatives
GB0419072D0 (en) 2004-08-26 2004-09-29 Kudos Pharm Ltd Phthalazinone derivatives
GB0521373D0 (en) 2005-10-20 2005-11-30 Kudos Pharm Ltd Pthalazinone derivatives
GB0610680D0 (en) * 2006-05-31 2006-07-12 Istituto Di Ricerche D Biolog Therapeutic compounds
UY30639A1 (es) 2006-10-17 2008-05-31 Kudos Pharm Ltd Derivados sustituidos de 2h-ftalazin-1-ona, sus formas cristalinas, proceso de preparacion y aplicaciones
US8466150B2 (en) * 2006-12-28 2013-06-18 Abbott Laboratories Inhibitors of poly(ADP-ribose)polymerase
US20080280910A1 (en) * 2007-03-22 2008-11-13 Keith Allan Menear Phthalazinone derivatives
CA2687931C (en) 2007-05-31 2016-05-24 Boehringer Ingelheim International Gmbh Ccr2 receptor antagonists and uses thereof
US20090023727A1 (en) 2007-07-05 2009-01-22 Muhammad Hashim Javaid Phthalazinone derivatives
AU2008299721A1 (en) * 2007-09-14 2009-03-19 Astrazeneca Ab Phthalazinone derivatives
MX2010005070A (es) * 2007-11-15 2010-05-24 Angeletti P Ist Richerche Bio Derivados de piridazinona como inhibidores de parp.
UY31603A1 (es) 2008-01-23 2009-08-31 Derivados de ftalazinona
HUE030800T2 (en) 2008-10-07 2017-05-29 Astrazeneca Uk Ltd Pharmaceutical Form No. 514
PE20120061A1 (es) 2008-12-19 2012-02-19 Boehringer Ingelheim Int Derivados de pirimidina como antagonistas del receptor ccr2
KR101779137B1 (ko) * 2009-01-23 2017-09-18 다케다 야쿠힌 고교 가부시키가이샤 폴리(ａｄｐ-리보스)폴리머라제(ｐａｒｐ) 억제제
US20100222381A1 (en) 2009-02-27 2010-09-02 Hariprasad Vankayalapati Cyclopentathiophene/cyclohexathiophene DNA methyltransferase inhibitors
US8541417B2 (en) 2009-07-30 2013-09-24 Takeda Pharmaceutical Company Limited Poly (ADP-ribose) polymerase (PARP) inhibitors
PT3091012T (pt) 2009-12-17 2018-06-27 Centrexion Therapeutics Corp Antagonistas do receptor ccr2 e suas utilizações
US8946218B2 (en) 2010-05-12 2015-02-03 Boehringer Ingelheim International Gmbh CCR2 receptor antagonists, method for producing the same, and use thereof as medicaments
JP2013526507A (ja) 2010-05-12 2013-06-24 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規ｃｃｒ２受容体アンタゴニスト、その製造方法及び薬物としてのその使用
US8841313B2 (en) 2010-05-17 2014-09-23 Boehringer Ingelheim International Gmbh CCR2 antagonists and uses thereof
JP5636094B2 (ja) 2010-05-25 2014-12-03 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｃｃｒ２受容体アンタゴニスト
EP2576538B1 (en) 2010-06-01 2015-10-28 Boehringer Ingelheim International GmbH New CCR2 antagonists
EP2600867A1 (en) * 2010-08-03 2013-06-12 Nerviano Medical Sciences S.r.l. Therapeutic combination comprising a parp-1 inhibitor and an anti-neoplastic agent
CN102372716A (zh) 2010-08-09 2012-03-14 江苏恒瑞医药股份有限公司 酞嗪酮类衍生物、其制备方法及其在医药上的应用
TW201244714A (en) 2011-04-11 2012-11-16 Abbott Lab PARP inhibitors for the treatment of CIPN
EP3925962A1 (en) 2011-05-31 2021-12-22 Rakovina Therapeutics Inc. Tricyclic inhibitors of poly(adp-ribose) polymerase
JP5786258B2 (ja) 2011-07-15 2015-09-30 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規かつ選択的なｃｃｒ２拮抗薬
TWI548637B (zh) * 2011-07-26 2016-09-11 江蘇豪森藥業集團有限公司 酞嗪酮類衍生物、其製備方法及其在醫藥上的應用
EP2748166B1 (en) 2011-08-23 2018-07-11 Asana BioSciences, LLC Pyrimido-pyridazinone compounds and use thereof
AU2012318874A1 (en) 2011-10-06 2014-05-15 Merck Sharp & Dohme Corp. 1,3-substituted azetidine PDE10 inhibitors
CN103242273B (zh) * 2012-02-09 2015-06-03 中国科学院上海药物研究所 2-芳基苯并呋喃-7-甲酰胺类化合物、其制备方法及用途
CN102627620B (zh) * 2012-04-10 2015-12-16 江苏先声药物研究有限公司 一类苯并呋喃衍生物及其医药应用
CN103570725B (zh) 2012-08-01 2017-03-22 中国科学院上海药物研究所 哌嗪并三唑类化合物及其制备方法和用途
RU2527457C2 (ru) * 2012-09-27 2014-08-27 Федеральное Государственное Бюджетное Учреждение Науки Институт Молекулярной Биологии Им. В.А. Энгельгардта Российской Академии Наук (Имб Ран) Ингибиторы поли(адф-рибозо)полимеразы-1 человека на основе производных урацила
GEP201706691B (en) * 2012-12-31 2017-06-26 Cadila Healthcare Ltd Substituted phthalazin-1 (2h)-one derivatives as selecti- ve inhibitors of poly (adp-ribose) polymerase-1
BR112015023328A2 (pt) 2013-03-13 2017-07-18 Flatley Discovery Lab compostos de piridazinona e métodos para o tratamento de fibrose cística
KR101670126B1 (ko) 2013-09-13 2016-10-27 일동제약(주) 신규 프탈라지논 유도체 및 그 제조방법
CN103772395B (zh) * 2014-01-23 2016-05-11 中国药科大学 一类具有parp抑制活性的化合物、其制备方法及用途
CN106146492A (zh) * 2015-04-17 2016-11-23 上海汇伦生命科技有限公司 杂环并咪唑类化合物、其药物组合物及其制备方法和用途
MX2017017177A (es) 2015-07-02 2018-11-09 Centrexion Therapeutics Corp Citrato de (4-((3r,4r)-3-metoxitetrahidro-piran-4-ilamino)piperidi n-1-il)(5-metil-6-(((2r,6s)-6-(p-tolil)tetrahidro-2h-piran-2-il)m etilamino)pirimidin-4il) metanona.
ES2814325T3 (es) * 2016-07-07 2021-03-26 Bristol Myers Squibb Co Derivados de lactama, urea cíclica y carbamato y de triazolona como inhibidores potentes y selectivos de ROCK
CN109311897B (zh) 2017-03-20 2021-07-20 福马治疗股份有限公司 作为丙酮酸激酶(pkr)活化剂的吡咯并吡咯组合物
TWI796596B (zh) 2018-02-13 2023-03-21 美商基利科學股份有限公司 Pd‐1/pd‐l1抑制劑
CA3093130C (en) 2018-04-19 2023-10-17 Gilead Sciences, Inc. Pd-1/pd-l1 inhibitors
KR20230159715A (ko) 2018-07-13 2023-11-21 길리애드 사이언시즈, 인코포레이티드 Pd-1/pd-l1 억제제
US20230055923A1 (en) 2018-09-19 2023-02-23 Forma Therapeutics, Inc. Activating pyruvate kinase r
US20200129485A1 (en) 2018-09-19 2020-04-30 Forma Therapeutics, Inc. Treating sickle cell disease with a pyruvate kinase r activating compound
KR102635333B1 (ko) 2018-10-24 2024-02-15 길리애드 사이언시즈, 인코포레이티드 Pd-1/pd-l1 억제제
US20220315545A1 (en) * 2019-07-10 2022-10-06 Bayer Aktiengesellschaft Process of preparing 2-(phenylimino)-1,3-thiazolidin-4-ones
AU2020444056A1 (en) 2020-04-21 2022-11-17 Idience Co., Ltd. Crystalline forms of phthalazinone compound
BR112022024729A2 (pt) 2020-06-05 2023-02-28 Kinnate Biopharma Inc Inibidores de quinases do receptor do fator de crescimento de fibroblastos
US20220117961A1 (en) * 2020-10-16 2022-04-21 Idience Co., Ltd. Pharmaceutical composition comprising phthalazinone derivatives
WO2022159745A1 (en) * 2021-01-22 2022-07-28 Hibercell, Inc. Gcn2 modulating compounds and uses thereof
CN115477640A (zh) * 2021-05-31 2022-12-16 由理生物医药（上海）有限公司 作为parp7抑制剂的哒嗪酮类化合物
WO2023278222A1 (en) * 2021-06-28 2023-01-05 Merck Sharp & Dohme Llc Il4i1 inhibitors and methods of use

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2128175C1 (ru) * 1994-08-09 1999-03-27 Эйсай Ко., Лтд. Конденсированный пиридазин или его фармакологически приемлемая соль, средство, проявляющее ингибирующую активность в отношении циклической гмф- фосфодиэстеразы
DE19921567A1 (de) * 1999-05-11 2000-11-16 Basf Ag Verwendung von Phthalazine-Derivaten
GB0026505D0 (en) * 2000-10-30 2000-12-13 Kudos Pharm Ltd Phthalazinone derivatives
US7151102B2 (en) * 2000-10-30 2006-12-19 Kudos Pharmaceuticals Limited Phthalazinone derivatives
WO2003015785A1 (en) * 2001-08-15 2003-02-27 Icos Corporation 2h-phthalazin-1-ones and methods for use thereof
AUPS019702A0 (en) * 2002-01-29 2002-02-21 Fujisawa Pharmaceutical Co., Ltd. Condensed heterocyclic compounds
BR0307780A (pt) * 2002-02-19 2004-12-28 Ono Pharmaceutical Co Compostos derivados de piridazina fundida e medicamentos contendo os compostos como o ingrediente ativo
US7196085B2 (en) * 2002-04-30 2007-03-27 Kudos Pharmaceuticals Limited Phthalazinone derivatives
MXPA05000983A (es) * 2002-07-24 2005-08-18 Kyorin Seiyaku Kk Derivados de 4-(aril substituido)-5-hidroxiisoquinolinona.
CA2517629C (en) * 2003-03-12 2011-07-12 Kudos Pharmaceuticals Limited Phthalazinone derivatives
US7449464B2 (en) * 2003-03-12 2008-11-11 Kudos Pharmaceuticals Limited Phthalazinone derivatives
WO2005049593A2 (en) * 2003-11-13 2005-06-02 Abbott Laboratories N-acylsulfonamide apoptosis promoters
EA014955B1 (ru) * 2004-06-30 2011-04-29 Янссен Фармацевтика Н. В. Производные фталазина в качестве ингибиторов parp
GB0419072D0 (en) * 2004-08-26 2004-09-29 Kudos Pharm Ltd Phthalazinone derivatives
GB0521373D0 (en) * 2005-10-20 2005-11-30 Kudos Pharm Ltd Pthalazinone derivatives
UY30639A1 (es) * 2006-10-17 2008-05-31 Kudos Pharm Ltd Derivados sustituidos de 2h-ftalazin-1-ona, sus formas cristalinas, proceso de preparacion y aplicaciones
EP2091538B1 (en) * 2006-12-20 2010-03-03 Glaxo Group Limited 4-benzyl-1(2h)-phthalazinones as h1 receptor antagonists
EA200901389A1 (ru) * 2007-04-23 2010-04-30 Новартис Аг Производные фталазина и изохинолина с модулирующим действием на s1p рецепторы
AU2008299721A1 (en) * 2007-09-14 2009-03-19 Astrazeneca Ab Phthalazinone derivatives
ATE525370T1 (de) * 2007-10-11 2011-10-15 Glaxo Group Ltd Phthalazin- und pyridoä3,4- düpyridazinverbindungen als h1-rezeptor- antagonisten

Also Published As

Publication number Publication date
HK1194922A1 (en) 2014-10-31
KR101491998B1 (ko) 2015-02-10
ES2548353T3 (es) 2015-10-15
MY165570A (en) 2018-04-05
HRP20140115T1 (hr) 2014-03-14
KR101449436B1 (ko) 2014-10-14
US20080161280A1 (en) 2008-07-03
NZ598352A (en) 2013-08-30
NO20092698L (no) 2009-09-28
SI2698062T1 (sl) 2015-12-31
RS53196B (en) 2014-06-30
BRPI0722070A2 (pt) 2014-04-08
TWI429438B (zh) 2014-03-11
RU2455286C2 (ru) 2012-07-10
CN103690542A (zh) 2014-04-02
KR20140056395A (ko) 2014-05-09
RU2009128984A (ru) 2011-02-10
AU2007340020B2 (en) 2013-06-20
KR20090094116A (ko) 2009-09-03
MX347085B (es) 2017-04-06
JP2010514785A (ja) 2010-05-06
MX2009007051A (es) 2009-07-10
EP2698062A1 (en) 2014-02-19
ECSP099530A (es) 2009-08-28
DK2698062T3 (en) 2015-09-14
CN101641014B (zh) 2013-12-18
HUE027641T2 (en) 2016-11-28
PL2120579T3 (pl) 2014-04-30
EP2120579A4 (en) 2011-04-27
SG2014013411A (en) 2014-07-30
GT200900182A (es) 2010-02-19
EP2120579B1 (en) 2013-11-13
CN101641014A (zh) 2010-02-03
CA2672868C (en) 2015-11-24
CO6220961A2 (es) 2010-11-19
NZ577348A (en) 2012-04-27
TW200840579A (en) 2008-10-16
CR10901A (es) 2009-07-23
PT2698062E (pt) 2015-10-19
WO2008083027A1 (en) 2008-07-10
DOP2009000159A (es) 2015-11-30
CA2672868A1 (en) 2008-07-10
CN103690542B (zh) 2015-11-18
AU2007340020A1 (en) 2008-07-10
MY190838A (en) 2022-05-12
ES2442496T3 (es) 2014-02-11
EP2698062B1 (en) 2015-06-24
SG193664A1 (en) 2013-10-30
SI2120579T1 (sl) 2014-03-31
PT2120579E (pt) 2014-02-17
EP2120579A1 (en) 2009-11-25
PL2698062T3 (pl) 2015-12-31
JP5523837B2 (ja) 2014-06-18
DK2120579T3 (da) 2014-02-03
JP2014001209A (ja) 2014-01-09

Similar Documents

Publication Publication Date Title
MY190838A (en) Inhibitors of poly(adp-ribose)polymerase
MX2009007053A (es) Inhibidores de poli (adp-ribosa) polimerasa.
EP2079500A4 (en) DEVICES AND METHODS FOR INFUSION
WO2009012280A3 (en) Benzimidazole poly(adp-ribose)polymerase inhibitors
ZA201103036B (en) Haloaryl substituted aminopurines, compositions thereof, and methods of treatment therewith
BRPI0814941A2 (pt) Composição de tratamentode semente, e, método de tratamento de semente.
WO2009044173A3 (en) Methods of treating cancer using notch pathway inhibitors
MX346924B (es) Compuestos de diarilhidantoina.
MX2009009761A (es) Composiciones y estuches para tratamiento de la influenza.
MY160041A (en) Compositions and methods for treating parasitic infections
TW200738262A (en) Methods for preventing and treating cancer metastasis and bone loss associated with cancer metastasis
EA200900091A1 (ru) Новые показания к применению прямых ингибиторов тромбина в лечении сердечно-сосудистых заболеваний
MX2008014004A (es) 1h-benzimidazol-4-carboxamidas sustituidas son inhibidores de parp potentes.
MX2010005395A (es) Metodo para tratar artritis.
TN2012000170A1 (en) Compositions for treating centrally mediated nausea and vomiting
DE602007010764D1 (en) Benzamidglucokinaseaktivatoren
EP2165715A4 (en) THERAPEUTIC AGENT FOR CANCER AND METHOD FOR TREATING CANCER
MX2009005725A (es) Metodos y composiciones para tratamiento y monitoreo de tratamiento de trastornos asociados con il-13.
MX2008015775A (es) Compuestos y composiciones para tratamiento de cancer.
MX2009006812A (es) Moduladores del receptor c3a y metodos de uso de los mismos.
MX2010002667A (es) Cianoaminoquinolonas y tetrazoloaminoquinolonas como inhibidores de gsk-3.
WO2008039642A3 (en) Methods and compounds for treatment of clostridium based infection
AP2011005849A0 (en) Methods of using and compositions comprising PDE4 modulations for treatment, prevention and management of tuberculosis.
MX2009003022A (es) Composiciones y metodos para tratar picaduras de medusa.
WO2008115478A3 (en) Method of cancer detection and treatment