UA94264C2 - Стабильная жидкая фармацевтическая композиция, которая содержит антагонистическое моноклональное антитело к cd40 - Google Patents
Стабильная жидкая фармацевтическая композиция, которая содержит антагонистическое моноклональное антитело к cd40Info
- Publication number
- UA94264C2 UA94264C2 UAA200813220A UAA200813220A UA94264C2 UA 94264 C2 UA94264 C2 UA 94264C2 UA A200813220 A UAA200813220 A UA A200813220A UA A200813220 A UAA200813220 A UA A200813220A UA 94264 C2 UA94264 C2 UA 94264C2
- Authority
- UA
- Ukraine
- Prior art keywords
- antibody
- antagonist anti
- stable liquid
- pharmaceutical composition
- containing pharmaceutical
- Prior art date
Links
- 239000005557 antagonist Substances 0.000 title abstract 4
- 239000007788 liquid Substances 0.000 title abstract 4
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 abstract 3
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 abstract 1
- 229960003589 arginine hydrochloride Drugs 0.000 abstract 1
- 230000001363 autoimmune Effects 0.000 abstract 1
- 239000006172 buffering agent Substances 0.000 abstract 1
- 230000002757 inflammatory effect Effects 0.000 abstract 1
- 230000002062 proliferating effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
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- A—HUMAN NECESSITIES
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pulmonology (AREA)
- Neurology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Endocrinology (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Hospice & Palliative Care (AREA)
- Microbiology (AREA)
- Obesity (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US79401106P | 2006-04-21 | 2006-04-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA94264C2 true UA94264C2 (ru) | 2011-04-26 |
Family
ID=38556677
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UAA200813220A UA94264C2 (ru) | 2006-04-21 | 2007-04-17 | Стабильная жидкая фармацевтическая композиция, которая содержит антагонистическое моноклональное антитело к cd40 |
Country Status (30)
| Country | Link |
|---|---|
| US (2) | US8945564B2 (enExample) |
| EP (1) | EP2019841A2 (enExample) |
| JP (2) | JP5290152B2 (enExample) |
| KR (1) | KR101317235B1 (enExample) |
| CN (1) | CN101426817B (enExample) |
| AR (1) | AR060487A1 (enExample) |
| AU (1) | AU2007240507B2 (enExample) |
| BR (1) | BRPI0710826A2 (enExample) |
| CA (1) | CA2649907A1 (enExample) |
| CR (1) | CR10379A (enExample) |
| CU (1) | CU23856A3 (enExample) |
| EA (1) | EA018301B1 (enExample) |
| EC (1) | ECSP088903A (enExample) |
| GE (1) | GEP20125628B (enExample) |
| GT (1) | GT200700034A (enExample) |
| HN (1) | HN2008001572A (enExample) |
| IL (1) | IL194642A0 (enExample) |
| MA (1) | MA30470B1 (enExample) |
| ME (1) | MEP39508A (enExample) |
| MX (1) | MX2008013508A (enExample) |
| NI (1) | NI200800284A (enExample) |
| NO (1) | NO20084796L (enExample) |
| NZ (1) | NZ571757A (enExample) |
| SA (1) | SA07280191B1 (enExample) |
| SM (1) | SMP200800064B (enExample) |
| SV (1) | SV2008003071A (enExample) |
| TN (1) | TNSN08412A1 (enExample) |
| TW (1) | TW200808349A (enExample) |
| UA (1) | UA94264C2 (enExample) |
| WO (1) | WO2007124299A2 (enExample) |
Families Citing this family (111)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8277810B2 (en) | 2003-11-04 | 2012-10-02 | Novartis Vaccines & Diagnostics, Inc. | Antagonist anti-CD40 antibodies |
| EP3351269B1 (en) | 2005-06-14 | 2020-01-29 | Amgen Inc. | Self-buffering protein formulations |
| AU2007240507B2 (en) * | 2006-04-21 | 2013-07-18 | Novartis Ag | Antagonist anti-CD40 antibody pharmaceutical compositions |
| BRPI0712987A2 (pt) | 2006-06-21 | 2012-04-10 | Musc Found For Res Dev | tratamento de doenças direcionado ao fator h do complemento |
| PE20091174A1 (es) * | 2007-12-27 | 2009-08-03 | Chugai Pharmaceutical Co Ltd | Formulacion liquida con contenido de alta concentracion de anticuerpo |
| SG190572A1 (en) | 2008-04-29 | 2013-06-28 | Abbott Lab | Dual variable domain immunoglobulins and uses thereof |
| HUE029003T2 (en) * | 2008-05-30 | 2017-01-30 | Xbiotech Inc | IL-1 alpha antibodies |
| SG191639A1 (en) | 2008-06-03 | 2013-07-31 | Abbott Lab | Dual variable domain immunoglobulins and uses thereof |
| PE20100054A1 (es) | 2008-06-03 | 2010-03-03 | Abbott Lab | Inmunoglobulina con dominio variable dual |
| MX2010014574A (es) | 2008-07-08 | 2011-04-27 | Abbott Lab | Inmunoglobulinas de dominio variable dual para prostaglandina e2 y usos de las mismas. |
| RU2015132478A (ru) | 2009-03-05 | 2015-12-10 | Эббви Инк. | Связывающие il-17 белки |
| WO2011003098A1 (en) | 2009-07-02 | 2011-01-06 | Musc Foundation For Research Development | Methods of stimulating liver regeneration |
| NZ598929A (en) | 2009-09-01 | 2014-05-30 | Abbvie Inc | Dual variable domain immunoglobulins and uses thereof |
| AR078651A1 (es) | 2009-10-15 | 2011-11-23 | Abbott Lab | Inmunoglobulinas con dominio variable dual y usos de las mismas |
| UY32979A (es) | 2009-10-28 | 2011-02-28 | Abbott Lab | Inmunoglobulinas con dominio variable dual y usos de las mismas |
| NZ600393A (en) | 2009-11-05 | 2014-08-29 | Alexion Cambridge Corp | Treatment of paroxysmal nocturnal hemoglobinuria, hemolytic anemias and disease states involving intravascular and extravascular hemolysis |
| GB0920944D0 (en) | 2009-11-30 | 2010-01-13 | Biotest Ag | Agents for treating disease |
| AU2013202276B2 (en) * | 2009-12-21 | 2016-03-24 | Genentech, Inc. | Antibody formulation |
| SG181834A1 (en) * | 2009-12-21 | 2012-07-30 | Genentech Inc | Antibody formulation |
| SI3178851T1 (sl) * | 2010-03-31 | 2020-09-30 | Boehringer Inhelheim International Gmbh | Anti-CD40 protitelesa |
| SG185502A1 (en) | 2010-05-14 | 2012-12-28 | Abbvie Inc | Il-1 binding proteins |
| BR112012029067A2 (pt) | 2010-05-14 | 2019-09-24 | Univ Colorado Regents | grupos-alvo de receptor do complemento 2 (cr2) melhorados. |
| CA2803588A1 (en) | 2010-06-22 | 2011-12-29 | The Regents Of The University Of Colorado, A Body Corporate | Antibodies to the c3d fragment of complement component 3 |
| UY33492A (es) | 2010-07-09 | 2012-01-31 | Abbott Lab | Inmunoglobulinas con dominio variable dual y usos de las mismas |
| CA2807014A1 (en) | 2010-08-03 | 2012-02-09 | Abbvie Inc. | Dual variable domain immunoglobulins and uses thereof |
| CA2809433A1 (en) | 2010-08-26 | 2012-03-01 | Abbvie Inc. | Dual variable domain immunoglobulins and uses thereof |
| CN103517990A (zh) | 2010-10-07 | 2014-01-15 | 通用医疗公司 | 癌症生物标志物 |
| AR083847A1 (es) | 2010-11-15 | 2013-03-27 | Novartis Ag | Variantes de fc (fragmento constante) silenciosas de los anticuerpos anti-cd40 |
| WO2012075111A1 (en) | 2010-11-30 | 2012-06-07 | Novartis Ag | Uses of anti-cd40 antibodies in combination therapy for b cell-related cancers |
| CA2821976A1 (en) | 2010-12-21 | 2012-09-13 | Abbvie Inc. | Il-1 -alpha and -beta bispecific dual variable domain immunoglobulins and their use |
| US9125893B2 (en) | 2011-02-17 | 2015-09-08 | Kyowa Hakko Kirin Co., Ltd. | Highly concentrated anti-CD40 antibody pharmaceutical preparation |
| ES2733646T3 (es) * | 2011-03-11 | 2019-12-02 | Beth Israel Deaconess Medical Ct Inc | Anticuerpos anti-CD40 y usos de los mismos |
| DK2699601T3 (en) | 2011-04-21 | 2018-04-23 | Bristol Myers Squibb Co | ANTIBODY POLYPEPTIDES ANTAGONIZING CD40 |
| WO2012151247A2 (en) | 2011-05-02 | 2012-11-08 | Millennium Pharmaceuticals, Inc. | FORMULATION FOR ANTI-α4β7 ANTIBODY |
| UA116189C2 (uk) | 2011-05-02 | 2018-02-26 | Мілленніум Фармасьютікалз, Інк. | КОМПОЗИЦІЯ АНТИ-α4β7 АНТИТІЛА |
| DK2714738T3 (en) | 2011-05-24 | 2019-01-28 | Zyngenia Inc | MULTIVALENT AND MONOVALENT MULTISPECIFIC COMPLEXES AND THEIR APPLICATIONS |
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| DE102004028815A1 (de) | 2004-06-15 | 2006-01-12 | Siemens Ag | Verfahren zur Ressourcen-Reservierung für ein Inter-Domain-Routing mit Dienstgütemerkmalen |
| TW200621282A (en) * | 2004-08-13 | 2006-07-01 | Wyeth Corp | Stabilizing formulations |
| US20080057070A1 (en) | 2004-11-04 | 2008-03-06 | Chiron Corporation | Antagonist Anti-Cd40 Monoclonal Antibodies and Methods for Their Use |
| PT1889065E (pt) | 2005-05-18 | 2013-09-27 | Novartis Ag | Métodos para o diagnóstico e tratamento de doenças tendo uma componente autoimune e/ou inflamatória |
| WO2006125143A2 (en) | 2005-05-18 | 2006-11-23 | Novartis Ag | Methods for diagnosis and treatment of proliferative disorders mediated by cd40 signaling |
| AU2006247039B2 (en) * | 2005-05-19 | 2011-03-03 | Amgen Inc. | Compositions and methods for increasing the stability of antibodies |
| US20080071063A1 (en) * | 2006-02-03 | 2008-03-20 | Medimmune, Inc. | Protein Formulations |
| AU2007240507B2 (en) * | 2006-04-21 | 2013-07-18 | Novartis Ag | Antagonist anti-CD40 antibody pharmaceutical compositions |
-
2007
- 2007-04-17 AU AU2007240507A patent/AU2007240507B2/en not_active Ceased
- 2007-04-17 CA CA002649907A patent/CA2649907A1/en not_active Abandoned
- 2007-04-17 SM SM200800064T patent/SMP200800064B/it unknown
- 2007-04-17 GE GEAP2007010985 patent/GEP20125628B/en unknown
- 2007-04-17 UA UAA200813220A patent/UA94264C2/ru unknown
- 2007-04-17 JP JP2009506711A patent/JP5290152B2/ja not_active Expired - Fee Related
- 2007-04-17 AR ARP070101626 patent/AR060487A1/es not_active Application Discontinuation
- 2007-04-17 US US12/297,382 patent/US8945564B2/en not_active Expired - Fee Related
- 2007-04-17 BR BRPI0710826-5A patent/BRPI0710826A2/pt not_active IP Right Cessation
- 2007-04-17 EA EA200802135A patent/EA018301B1/ru not_active IP Right Cessation
- 2007-04-17 WO PCT/US2007/066757 patent/WO2007124299A2/en not_active Ceased
- 2007-04-17 NZ NZ571757A patent/NZ571757A/en not_active IP Right Cessation
- 2007-04-17 KR KR1020087025721A patent/KR101317235B1/ko not_active Expired - Fee Related
- 2007-04-17 ME MEP-395/08A patent/MEP39508A/xx unknown
- 2007-04-17 EP EP07760754A patent/EP2019841A2/en not_active Withdrawn
- 2007-04-17 MX MX2008013508A patent/MX2008013508A/es active IP Right Grant
- 2007-04-17 CN CN2007800139737A patent/CN101426817B/zh not_active Expired - Fee Related
- 2007-04-18 SA SA7280191A patent/SA07280191B1/ar unknown
- 2007-04-18 GT GT200700034A patent/GT200700034A/es unknown
- 2007-04-18 TW TW96113569A patent/TW200808349A/zh unknown
-
2008
- 2008-10-07 IL IL194642A patent/IL194642A0/en unknown
- 2008-10-17 TN TNP2008000412A patent/TNSN08412A1/en unknown
- 2008-10-20 CR CR10379A patent/CR10379A/es not_active Application Discontinuation
- 2008-10-21 SV SV2008003071A patent/SV2008003071A/es unknown
- 2008-10-21 NI NI200800284A patent/NI200800284A/es unknown
- 2008-10-21 CU CU2008000196A patent/CU23856A3/es not_active IP Right Cessation
- 2008-10-21 HN HN2008001572A patent/HN2008001572A/es unknown
- 2008-11-10 MA MA31374A patent/MA30470B1/fr unknown
- 2008-11-13 NO NO20084796A patent/NO20084796L/no not_active Application Discontinuation
- 2008-11-21 EC ECSP088903 patent/ECSP088903A/es unknown
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2013
- 2013-03-22 JP JP2013059446A patent/JP2013129673A/ja active Pending
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2014
- 2014-12-18 US US14/575,182 patent/US20150110783A1/en not_active Abandoned
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