EA200802135A1 - Фармацевтические композиции антагонистического антитела к cd40 - Google Patents

Фармацевтические композиции антагонистического антитела к cd40

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Publication number
EA200802135A1
EA200802135A1 EA200802135A EA200802135A EA200802135A1 EA 200802135 A1 EA200802135 A1 EA 200802135A1 EA 200802135 A EA200802135 A EA 200802135A EA 200802135 A EA200802135 A EA 200802135A EA 200802135 A1 EA200802135 A1 EA 200802135A1
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Prior art keywords
pharmaceutical compositions
antibody
antagonistic
antagonistic antibody
methods
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EA200802135A
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English (en)
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EA018301B1 (ru
Inventor
Сяофэн Лю
Баолю Чэнь
Кидисти Арая
Огастус Окхамафе
Original Assignee
Новартис Аг
Ксома Текнолоджи Лтд.
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Application filed by Новартис Аг, Ксома Текнолоджи Лтд. filed Critical Новартис Аг
Publication of EA200802135A1 publication Critical patent/EA200802135A1/ru
Publication of EA018301B1 publication Critical patent/EA018301B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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Abstract

В заявке описаны стабильные жидкие фармацевтические композиции, содержащие антагонистическое антитело к CD40 в качестве обладающего терапевтической или профилактической активностью компонента, и способы, которые можно применять для их получения. Эти композиции содержат антагонистическое антитело к CD40, забуферивающий агент для поддержания значения рН композиции на уровне от примерно рН 5,0 до примерно рН 7,0, аргинин-HCl в количестве, достаточном для того, чтобы сделать жидкую композицию практически изотонической. Предлагаемые в изобретении стабильные жидкие фармацевтические композиции, содержащие антагонистическое антитело к CD40, можно применять в способах лечения пролиферативных заболеваний и заболеваний, которые имеют аутоиммунный и/или воспалительный компонент.
EA200802135A 2006-04-21 2007-04-17 Фармацевтические композиции, содержащие антагонистическое моноклональное антитело к cd40, и их применение EA018301B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US79401106P 2006-04-21 2006-04-21
PCT/US2007/066757 WO2007124299A2 (en) 2006-04-21 2007-04-17 Antagonist anti-cd40 antibody pharmaceutical compositions

Publications (2)

Publication Number Publication Date
EA200802135A1 true EA200802135A1 (ru) 2009-04-28
EA018301B1 EA018301B1 (ru) 2013-07-30

Family

ID=38556677

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200802135A EA018301B1 (ru) 2006-04-21 2007-04-17 Фармацевтические композиции, содержащие антагонистическое моноклональное антитело к cd40, и их применение

Country Status (30)

Country Link
US (2) US8945564B2 (ru)
EP (1) EP2019841A2 (ru)
JP (2) JP5290152B2 (ru)
KR (1) KR101317235B1 (ru)
CN (1) CN101426817B (ru)
AR (1) AR060487A1 (ru)
AU (1) AU2007240507B2 (ru)
BR (1) BRPI0710826A2 (ru)
CA (1) CA2649907A1 (ru)
CR (1) CR10379A (ru)
CU (1) CU23856A3 (ru)
EA (1) EA018301B1 (ru)
EC (1) ECSP088903A (ru)
GE (1) GEP20125628B (ru)
GT (1) GT200700034A (ru)
HN (1) HN2008001572A (ru)
IL (1) IL194642A0 (ru)
MA (1) MA30470B1 (ru)
ME (1) MEP39508A (ru)
MX (1) MX2008013508A (ru)
NI (1) NI200800284A (ru)
NO (1) NO20084796L (ru)
NZ (1) NZ571757A (ru)
SA (1) SA07280191B1 (ru)
SM (1) SMP200800064B (ru)
SV (1) SV2008003071A (ru)
TN (1) TNSN08412A1 (ru)
TW (1) TW200808349A (ru)
UA (1) UA94264C2 (ru)
WO (1) WO2007124299A2 (ru)

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RU2715597C2 (ru) * 2015-05-29 2020-03-02 Эббви Инк. Антитела к cd40 и способы их применения

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