MX2009004714A - Derivados de pirazol fusionado 3-aminocarbonilo sustituidos como moduladores de proteina cinasa. - Google Patents

Derivados de pirazol fusionado 3-aminocarbonilo sustituidos como moduladores de proteina cinasa.

Info

Publication number
MX2009004714A
MX2009004714A MX2009004714A MX2009004714A MX2009004714A MX 2009004714 A MX2009004714 A MX 2009004714A MX 2009004714 A MX2009004714 A MX 2009004714A MX 2009004714 A MX2009004714 A MX 2009004714A MX 2009004714 A MX2009004714 A MX 2009004714A
Authority
MX
Mexico
Prior art keywords
protein kinase
aminocarbonyi
derivatives
substituted fused
kinase modulators
Prior art date
Application number
MX2009004714A
Other languages
English (en)
Inventor
Patricia Imbach
Pascal Furet
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MX2009004714A publication Critical patent/MX2009004714A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Los compuestos de fórmula (I), en donde los residuos tienen varios significados, su utilización farmacéutica, las composiciones farmacéuticas que comprenden dichos compuestos y métodos para la preparación y utilización para el tratamiento de desordenes que responden a modulación de proteína cinasa.
MX2009004714A 2006-10-30 2007-10-29 Derivados de pirazol fusionado 3-aminocarbonilo sustituidos como moduladores de proteina cinasa. MX2009004714A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06123186A EP1918291A1 (en) 2006-10-30 2006-10-30 3-Aminocarbonyl-substituted fused pyrazolo-derivatives as protein kinase modulators
PCT/EP2007/061618 WO2008052964A1 (en) 2006-10-30 2007-10-29 3-aminocarbonyi-substituted fused pyrazolo-derivatives as protein kinase modulators

Publications (1)

Publication Number Publication Date
MX2009004714A true MX2009004714A (es) 2009-05-20

Family

ID=37745980

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009004714A MX2009004714A (es) 2006-10-30 2007-10-29 Derivados de pirazol fusionado 3-aminocarbonilo sustituidos como moduladores de proteina cinasa.

Country Status (10)

Country Link
US (1) US20100069395A1 (es)
EP (2) EP1918291A1 (es)
JP (1) JP2010508324A (es)
KR (1) KR20090084837A (es)
CN (1) CN101535313A (es)
AU (1) AU2007316180A1 (es)
BR (1) BRPI0718269A2 (es)
CA (1) CA2667963A1 (es)
MX (1) MX2009004714A (es)
WO (1) WO2008052964A1 (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010031816A1 (en) * 2008-09-19 2010-03-25 Nerviano Medical Sciences S.R.L. 3,4 DIHYDRO-2H-PYRROLO[1,2-a]PYRAZIN-1-ONE DERIVATIVES
CA2790070C (en) * 2010-02-18 2018-03-06 Incyte Corporation Cyclobutane and methylcyclobutane derivatives as janus kinase inhibitors
EP3521291A1 (en) 2010-05-20 2019-08-07 Array Biopharma, Inc. Macrocyclic compounds as trk kinase inhibitors
CN103298500A (zh) * 2010-11-26 2013-09-11 雷扎·古特比 用于治疗或预防血管瘤的植入物
GB201322333D0 (en) 2013-12-17 2014-01-29 Agency Science Tech & Res WNT pathway modulators
CN103819478B (zh) * 2014-03-21 2016-05-04 成都诺维尔生物医药有限公司 阿拉格列汀中间体2-甲基-吡唑并[1,5-a]嘧啶-6-羧酸的制备方法
WO2015152319A1 (ja) * 2014-04-02 2015-10-08 株式会社 三和化学研究所 ５，７－無置換－ピラゾロ［１，５－ａ］ピリミジン－６－カルボン酸の製造方法
RS61485B1 (sr) 2015-07-16 2021-03-31 Array Biopharma Inc Supstituisana pirazolo [1,5-a] piridinska jedinjenja kao inhibitori ret kinaze
CA3020793C (en) * 2016-04-15 2024-05-21 Bayer Animal Health Gmbh Pyrazolopyrimidine derivatives
TWI704148B (zh) 2016-10-10 2020-09-11 美商亞雷生物製藥股份有限公司 作為ｒｅｔ激酶抑制劑之經取代吡唑并[1,5-a]吡啶化合物
JOP20190077A1 (ar) 2016-10-10 2019-04-09 Array Biopharma Inc مركبات بيرازولو [1، 5-a]بيريدين بها استبدال كمثبطات كيناز ret
CA3049136C (en) 2017-01-18 2022-06-14 Array Biopharma Inc. Substituted pyrazolo[1,5-a]pyrazine compounds as ret kinase inhibitors
WO2018136663A1 (en) 2017-01-18 2018-07-26 Array Biopharma, Inc. Ret inhibitors
JOP20190213A1 (ar) 2017-03-16 2019-09-16 Array Biopharma Inc مركبات حلقية ضخمة كمثبطات لكيناز ros1
CN106866680B (zh) * 2017-03-31 2019-02-01 陕西理工大学 一种3-芳基-6-甲酰胺吡唑并[1,5-a]嘧啶类化合物及其应用
SG11201909243TA (en) 2017-04-27 2019-11-28 Bayer Animal Health Gmbh New bicyclic pyrazole derivatives
TWI791053B (zh) 2017-10-10 2023-02-01 美商亞雷生物製藥股份有限公司 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之結晶形式及其醫藥組合物
TWI812649B (zh) 2017-10-10 2023-08-21 美商絡速藥業公司 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之調配物
US11472802B2 (en) 2018-01-18 2022-10-18 Array Biopharma Inc. Substituted pyrazolyl[4,3-c]pyridine compounds as RET kinase inhibitors
JP7061195B2 (ja) 2018-01-18 2022-04-27 アレイ バイオファーマ インコーポレイテッド ＲＥＴキナーゼ阻害剤としての置換ピラゾロ［３，４－ｄ］ピリミジン化合物
CA3087354C (en) 2018-01-18 2023-01-03 Array Biopharma Inc. Substituted pyrrolo[2,3-d]pyrimidines compounds as ret kinase inhibitors
EP3849986B1 (en) 2018-09-10 2022-06-08 Array Biopharma, Inc. Fused heterocyclic compounds as ret kinase inhibitors
CN112876482B (zh) * 2020-12-31 2023-07-28 中国药科大学 一类多取代杂环衍生物、其制备方法及其在医药上的应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA05008955A (es) * 2003-02-28 2006-02-22 Teijin Pharma Ltd Derivados de pirazolo [1,5-a] pirimidina.
AR049769A1 (es) * 2004-01-22 2006-09-06 Novartis Ag Derivados de pirazolo(1,5-a)pirimidin 7-il-amina para utilizarse en el tratamiento de enfermedades dependientes de la quinasa de proteina

Also Published As

Publication number Publication date
BRPI0718269A2 (pt) 2013-11-12
EP2079745A1 (en) 2009-07-22
AU2007316180A1 (en) 2008-05-08
KR20090084837A (ko) 2009-08-05
WO2008052964A1 (en) 2008-05-08
EP1918291A1 (en) 2008-05-07
US20100069395A1 (en) 2010-03-18
JP2010508324A (ja) 2010-03-18
CA2667963A1 (en) 2008-05-08
CN101535313A (zh) 2009-09-16

Similar Documents

Publication Publication Date Title
MX2009004714A (es) Derivados de pirazol fusionado 3-aminocarbonilo sustituidos como moduladores de proteina cinasa.
GEP20146101B (en) Pyridine and pyrazine derivatives as protein kinase modulators
WO2010006086A3 (en) Kinase inhibitors and methods of use
TW200738659A (en) Novel compounds
IL196543A (en) Pyridazinone derivatives, pharmaceutical preparations containing them for use in the treatment of disorders
TW200612892A (en) Novel compounds
MXPA06011327A (es) Azaindoles utiles como inhibidores de jak y otras proteinas cinasas.
EA024842B9 (ru) Соединения в качестве модуляторов протеинкиназы pi3k
WO2009114870A3 (en) Kinase inhibitors and methods of use
GEP20135785B (en) Pyrrolopyrimidine compounds as cdk inhibitors
MX2009004716A (es) Compuestos y composiciones en la forma de inhibidores de quinasa de proteina.
EA201290209A1 (ru) Новые модуляторы бензопиран киназы
MX341591B (es) Inhibidores de cinasa de benzoxazol y metodos de uso de los mismos.
WO2005116025A3 (en) 2-substituted-4-heteroaryl-pyrimidines useful for the treatment of proliferative disorders
WO2007076085A3 (en) Fused pyrimidones and thiopyrimidones, and uses thereof
BRPI0920261A8 (pt) Composto, composição farmacêutica, uso do composto, e, método para inibir ou modular atividade de proteína quinase em uma amostra biológica
MX2009010984A (es) Moduladores de heterociclo cinasa de anillo fusionado.
MX2008001538A (es) Aril piridinas y metodos para su uso.
EA200701930A1 (ru) Производные пиримидина для лечения гиперпролиферативных нарушений
TW200621721A (en) Methods of preparing indazole compounds
TNSN08370A1 (en) Tetrahydropyridothienopyrimidine compounds and methods of use thereof
WO2010042925A3 (en) Compositions and methods for treating alcohol use disorders, pain and other diseases
MY167575A (en) Heterocyclic compounds and use thereof as modulators of type iii receptor tyrosine kinases
MX2009003981A (es) Agentes moduladores del receptor de calcio.
WO2009071689A3 (de) 5-halogen-substituierte oxindol-derivate und ihre verwendung zur behandlung von vasopressin-abhängigen erkrankungen

Legal Events

Date Code Title Description
FA Abandonment or withdrawal