UA94129C2 - Соединения для ингибирования митоза - Google Patents

Соединения для ингибирования митоза

Info

Publication number
UA94129C2
UA94129C2 UAA200906211A UAA200906211A UA94129C2 UA 94129 C2 UA94129 C2 UA 94129C2 UA A200906211 A UAA200906211 A UA A200906211A UA A200906211 A UAA200906211 A UA A200906211A UA 94129 C2 UA94129 C2 UA 94129C2
Authority
UA
Ukraine
Prior art keywords
mythosis
inhibits
compounds
cancer
treatment
Prior art date
Application number
UAA200906211A
Other languages
English (en)
Russian (ru)
Ukrainian (uk)
Inventor
Кристофер Ф. Клейборн
Тодд Б. Селлс
Стефен Г. Страуд
Original Assignee
Милленниум Фармасьютикалз, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39315133&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA94129(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Милленниум Фармасьютикалз, Инк. filed Critical Милленниум Фармасьютикалз, Инк.
Publication of UA94129C2 publication Critical patent/UA94129C2/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
UAA200906211A 2006-11-16 2007-11-14 Соединения для ингибирования митоза UA94129C2 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US85934006P 2006-11-16 2006-11-16

Publications (1)

Publication Number Publication Date
UA94129C2 true UA94129C2 (ru) 2011-04-11

Family

ID=39315133

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200906211A UA94129C2 (ru) 2006-11-16 2007-11-14 Соединения для ингибирования митоза

Country Status (34)

Country Link
US (7) US8026246B2 (https=)
EP (4) EP2086981B1 (https=)
JP (3) JP5102839B2 (https=)
KR (2) KR101342014B1 (https=)
CN (2) CN103483343B (https=)
AR (1) AR064246A1 (https=)
AT (1) ATE556076T1 (https=)
AU (1) AU2007322046B2 (https=)
BR (1) BRPI0718803B8 (https=)
CA (1) CA2669680C (https=)
CL (1) CL2007003244A1 (https=)
CR (3) CR10782A (https=)
CY (1) CY1112828T1 (https=)
DK (2) DK2497772T3 (https=)
EA (1) EA015779B1 (https=)
ES (3) ES2528793T3 (https=)
GE (1) GEP20125459B (https=)
HR (2) HRP20120490T1 (https=)
IL (1) IL198690A0 (https=)
MA (1) MA30988B1 (https=)
MX (3) MX343391B (https=)
MY (1) MY153243A (https=)
NO (1) NO343338B1 (https=)
NZ (3) NZ577042A (https=)
PH (1) PH12012502057B1 (https=)
PL (2) PL2086981T3 (https=)
PT (2) PT2086981E (https=)
RS (2) RS52313B (https=)
SG (2) SG176443A1 (https=)
SI (2) SI2497772T1 (https=)
TW (1) TWI401255B (https=)
UA (1) UA94129C2 (https=)
WO (1) WO2008063525A1 (https=)
ZA (1) ZA200903279B (https=)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2540987T3 (es) * 2004-05-14 2015-07-15 Millennium Pharmaceuticals, Inc. Métodos para preparar inhibidores de la aurora cinasa
CL2007003244A1 (es) * 2006-11-16 2008-04-04 Millennium Pharm Inc Compuestos derivados de pirimido[5,4-d][2]benzazepina; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento del cancer.
US7998952B2 (en) * 2008-12-05 2011-08-16 Millennium Pharmaceuticals, Inc. Thiolactams and uses thereof
RU2535032C2 (ru) * 2008-12-22 2014-12-10 Милленниум Фармасьютикалз, Инк. Сочетание ингибиторов аврора киназы и анти-cd 20 антител
JO3635B1 (ar) * 2009-05-18 2020-08-27 Millennium Pharm Inc مركبات صيدلانية صلبة وطرق لانتاجها
JO3434B1 (ar) 2009-07-31 2019-10-20 Millennium Pharm Inc مركبات صيدلانية لمعالجة السرطان وامراض واضطرابات اخري
CA2788774A1 (en) * 2010-02-19 2011-08-25 Millennium Pharmaceuticals, Inc. Crystalline forms of sodium 4-{[9-chloro-7-(2-fluoro-6-methoxyphenyl)-5h-pyrimido[5,4-d][2]benzazepin-2-yl]amino}-2-methoxybenzoate
US20120107304A1 (en) 2010-04-27 2012-05-03 Boehringer Ingelheim International Gmbh Combination therapy in treatment of oncological and fibrotic diseases
US9085582B2 (en) * 2010-06-22 2015-07-21 Glaxosmithkline Llc Benzotriazolodiazepine compounds inhibitors of bromodomains
AR086656A1 (es) 2011-06-03 2014-01-15 Millennium Pharm Inc Combinacion de inhibidores de mek e inhibidores selectivos de la quinasa aurora a
US20130303519A1 (en) * 2012-03-20 2013-11-14 Millennium Pharmaceuticals, Inc. Methods of treating cancer using aurora kinase inhibitors
CN103772391A (zh) * 2012-10-23 2014-05-07 杨子娇 一类治疗房角狭窄的化合物及其用途
WO2014153509A1 (en) 2013-03-22 2014-09-25 Millennium Pharmaceuticals, Inc. Combination of catalytic mtorc 1/2 inhibitors and selective inhibitors of aurora a kinase
EP3076963A4 (en) 2013-12-06 2017-09-13 Millennium Pharmaceuticals, Inc. Combination of aurora kinase inhibitors and anti-cd30 antibodies
WO2016106357A1 (en) * 2014-12-23 2016-06-30 Millennnium Pharmaceuticals, Inc. Combination of raf inhibitors and aurora kinase inhibitors
JP2018524292A (ja) 2015-07-21 2018-08-30 ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． オーロラキナーゼインヒビターと化学療法剤の投与
CA2997769A1 (en) 2015-09-09 2017-03-16 Icahn School Of Medicine At Mount Sinai Heterocyclic constrained tricyclic sulfonamides as anti-cancer agents
CA2997784A1 (en) 2015-09-09 2017-03-16 Icahn School Of Medicine At Mount Sinai Heterocyclic constrained tricyclic sulfonamides as anti-cancer agents
JP6591036B2 (ja) 2016-02-26 2019-10-16 公益財団法人がん研究会 Ｈｐ１の機能に着目した抗癌剤のスクリーニング方法及び評価系
ES3057783T3 (en) 2016-03-15 2026-03-04 Oryzon Genomics Sa Combinations of lsd1 inhibitors for use in the treatment of neoplastic diseases
JP6188986B1 (ja) * 2017-03-23 2017-08-30 株式会社ノエビア 時計遺伝子発現量調整剤及びエラスチン産生促進剤
US11874276B2 (en) 2018-04-05 2024-01-16 Dana-Farber Cancer Institute, Inc. STING levels as a biomarker for cancer immunotherapy
WO2020049208A1 (es) 2018-09-09 2020-03-12 Fundacio Privada Institut De Recerca De La Sida - Caixa Aurora cinasa como diana para tratar, prevenir o curar una infección por vih o sida
US20220305048A1 (en) 2019-08-26 2022-09-29 Dana-Farber Cancer Institute, Inc. Use of heparin to promote type 1 interferon signaling
JP2025511697A (ja) 2022-04-07 2025-04-16 イーライ リリー アンド カンパニー Ｋｒａｓ ｇ１２ｃ阻害剤を作製するための方法
CA3247183A1 (en) 2022-04-08 2023-10-12 Eli Lilly And Company TREATMENT METHOD INCLUDING KRAS G12C INHIBITORS AND AURORA A INHIBITORS
EP4547251A1 (en) 2022-06-30 2025-05-07 Eli Lilly and Company Kras g12c inhibitor for treating cancer
AU2024355871A1 (en) 2023-10-03 2026-04-16 Takeda Pharmaceutical Company Limited Alisertib and paclitaxel for treating small cell lung cancer
WO2025245045A1 (en) 2024-05-21 2025-11-27 The Regents Of The University Of California Methods of treating lung cancer

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4099012A (en) * 1975-08-28 1978-07-04 Ciba-Geigy Corporation 2-pyrazolyl-benzophenones
US4481142A (en) * 1979-02-07 1984-11-06 Hoffmann-La Roche Inc. Pyrimido-2-benzazepines
CA1138863A (en) 1979-02-07 1983-01-04 Norman W. Gilman Benzazepine-derivatives
US4469633A (en) * 1980-05-16 1984-09-04 Hoffmann-La Roche Inc. N-oxides of 5-oxo-1-phenyl-2-benzazepines
EP0273697A3 (en) 1986-12-30 1989-11-29 Merck & Co. Inc. 2-benzazepines with 5- and 6- membered heterocyclic rings
US5166151A (en) * 1988-03-25 1992-11-24 Merck & Co., Inc. 2-Benzazepines with 5- and 6-membered heterocyclic rings, compositions and medical methods of use thereof
US5210082A (en) * 1991-05-16 1993-05-11 Merck & Co., Inc. 2-benzazepines with 5- and 6-membered heterocyclic rings to treat pain and anxiety disorders
GB9523675D0 (en) 1995-11-20 1996-01-24 Celltech Therapeutics Ltd Chemical compounds
KR19990087585A (ko) * 1996-03-08 1999-12-27 돈 리사 로얄 신경학적 활성제로서의 아졸로벤즈아제핀 유도체
US6057329A (en) * 1996-12-23 2000-05-02 Celltech Therapeutics Limited Fused polycyclic 2-aminopyrimidine derivatives
GB9713087D0 (en) 1997-06-20 1997-08-27 Celltech Therapeutics Ltd Chemical compounds
DK1026167T3 (da) 1997-09-29 2003-05-26 Meiji Seika Kaisha Tricykliske triazolobenzazepinderivater, fremgangsmåde til fremstilling af disse samt antiallergiske midler
US6277844B1 (en) * 1998-09-14 2001-08-21 Sydney Spector Compound for selective treatment of malignant cells by inhibiting cell cycle progression, decreasing Bcl2, and increasing apoptosis
US6417207B1 (en) 1999-05-12 2002-07-09 Nitromed, Inc. Nitrosated and nitrosylated potassium channel activators, compositions and methods of use
DE60039782D1 (de) 1999-12-06 2008-09-18 Ajinomoto Kk Amidinophenylbrenztraubensäure-derivat
NZ526472A (en) * 2000-12-21 2004-04-30 Vertex Pharma Pyrazole compounds useful as protein kinase inhibitors
US6686352B2 (en) 2001-05-18 2004-02-03 Hoffmann-La Roche Inc. Substituted imidazo [1,5-a] pyrimido [5,4-d] [1] benzazepine derivatives
DE10135457A1 (de) * 2001-07-20 2003-02-06 Adc Automotive Dist Control Optische Sensoranordnung
JP4364637B2 (ja) 2001-08-09 2009-11-18 アクテリオン ファーマシューティカルズ リミテッド 新規なベンゾ縮合へテロ環化合物
CN1897950A (zh) 2003-10-14 2007-01-17 惠氏公司 稠合芳基和杂芳基衍生物及其使用方法
ES2540987T3 (es) * 2004-05-14 2015-07-15 Millennium Pharmaceuticals, Inc. Métodos para preparar inhibidores de la aurora cinasa
JP2008520713A (ja) 2004-11-17 2008-06-19 ミイカナ セラピューティクス インコーポレイテッド キナーゼ阻害剤
US20100160324A1 (en) 2004-12-30 2010-06-24 Astex Therapeutics Limited Pyrazole derivatives as that modulate the activity of cdk, gsk and aurora kinases
SI1962830T1 (sl) 2005-12-23 2013-07-31 Glaxosmithkline Llc Azaindolni inhibitorji kinaz Aurora
US7718648B2 (en) 2006-08-09 2010-05-18 Millennium Pharmaceuticals, Inc. Pyridobenzazepine compounds and methods for inhibiting mitotic progression
CL2007003244A1 (es) 2006-11-16 2008-04-04 Millennium Pharm Inc Compuestos derivados de pirimido[5,4-d][2]benzazepina; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento del cancer.
JO3635B1 (ar) 2009-05-18 2020-08-27 Millennium Pharm Inc مركبات صيدلانية صلبة وطرق لانتاجها

Also Published As

Publication number Publication date
US20110312942A1 (en) 2011-12-22
PH12012502057B1 (en) 2018-10-24
BRPI0718803B8 (pt) 2021-05-25
NZ611898A (en) 2015-01-30
CR20140154A (es) 2014-07-23
PH12012502057A1 (en) 2015-09-14
JP2012006965A (ja) 2012-01-12
CN103483343A (zh) 2014-01-01
US8026246B2 (en) 2011-09-27
MX2009004670A (es) 2009-05-15
PT2086981E (pt) 2012-06-20
MY153243A (en) 2015-01-29
US20150166545A1 (en) 2015-06-18
CY1112828T1 (el) 2016-02-10
JP5452811B2 (ja) 2014-03-26
CA2669680A1 (en) 2008-05-29
EP2086981B1 (en) 2012-05-02
EP2497773B1 (en) 2015-02-25
MX343391B (es) 2016-11-04
WO2008063525A1 (en) 2008-05-29
SG176443A1 (en) 2011-12-29
KR101342014B1 (ko) 2013-12-19
PL2497772T3 (pl) 2015-05-29
US20110312943A1 (en) 2011-12-22
JP5102839B2 (ja) 2012-12-19
HK1175777A1 (en) 2013-07-12
US9765076B2 (en) 2017-09-19
KR20090091173A (ko) 2009-08-26
CA2669680C (en) 2012-04-10
PL2086981T3 (pl) 2012-09-28
CN101547924A (zh) 2009-09-30
ES2384123T3 (es) 2012-06-29
AU2007322046B2 (en) 2012-04-05
SG10201503350TA (en) 2015-06-29
CN101547924B (zh) 2013-09-25
NZ597252A (en) 2013-06-28
KR20110113210A (ko) 2011-10-14
EA015779B1 (ru) 2011-12-30
KR101110458B1 (ko) 2012-03-13
HK1217699A1 (en) 2017-01-20
EP2497772B1 (en) 2014-10-29
JP2010510215A (ja) 2010-04-02
ES2528793T3 (es) 2015-02-12
NO343338B1 (no) 2019-02-04
US10836766B2 (en) 2020-11-17
PT2497772E (pt) 2015-02-05
CL2007003244A1 (es) 2008-04-04
HK1134672A1 (en) 2010-05-07
US20210214361A1 (en) 2021-07-15
EP2086981A1 (en) 2009-08-12
EP2497773A1 (en) 2012-09-12
US9988384B2 (en) 2018-06-05
US20080167292A1 (en) 2008-07-10
AR064246A1 (es) 2009-03-25
HRP20120490T1 (hr) 2012-07-31
RS53788B1 (sr) 2015-06-30
DK2086981T3 (da) 2012-08-06
CN103483343B (zh) 2016-06-01
TW200829589A (en) 2008-07-16
JP2014055166A (ja) 2014-03-27
US20190031662A1 (en) 2019-01-31
SI2497772T1 (sl) 2015-03-31
ATE556076T1 (de) 2012-05-15
AU2007322046A1 (en) 2008-05-29
SI2086981T1 (sl) 2012-12-31
US20240400567A1 (en) 2024-12-05
GEP20125459B (en) 2012-03-26
HRP20150047T1 (en) 2015-03-13
TWI401255B (zh) 2013-07-11
CR20140544A (es) 2015-01-12
NZ577042A (en) 2012-03-30
BRPI0718803B1 (pt) 2020-11-17
HK1175778A1 (en) 2013-07-12
MA30988B1 (fr) 2009-12-01
ES2537451T3 (es) 2015-06-08
CR10782A (es) 2009-06-24
US11958855B2 (en) 2024-04-16
EP2944639A1 (en) 2015-11-18
ZA200903279B (en) 2010-07-28
EP2944639B1 (en) 2017-01-04
MX348568B (es) 2017-06-20
NO20091864L (no) 2009-06-15
BRPI0718803A2 (pt) 2013-12-03
RS52313B (sr) 2012-12-31
DK2497772T3 (en) 2015-01-19
IL198690A0 (en) 2010-02-17
EA200970486A1 (ru) 2009-10-30
EP2497772A1 (en) 2012-09-12

Similar Documents

Publication Publication Date Title
UA94129C2 (ru) Соединения для ингибирования митоза
MY149512A (en) Pyrazolylaminopyridine derivatives useful as kinase inhibitors
WO2006123113A3 (en) Pyrazolylaminopyrimidine derivatives useful as tyrosine kinase inhibitors
MA33803B1 (fr) Inhibiteur de bromodomaine de benzodiazépine
MX2009000884A (es) Derivados de piridizinona.
DK1853602T3 (da) Kemiske forbindelser
CY1108275T1 (el) Χημικες ενωσεις
WO2007095124A3 (en) Benzazole derivatives, compositions, and methods of use as aurora kinase inhibitors
MX2008005398A (es) Derivados de 4-(3-amino-pirazol)-pirimidina para uso como inhibidores de tirosina cinasa en el tratamiento de cancer.
CY1113192T1 (el) Ενωσεις και μεθοδοι για την αναστολη της μιτωτικης προοδου μεσω αναστολης της κινασης aurora
MX2012000709A (es) Inhibidores de pirrolopiridina de cinasas.
SG179418A1 (en) Inhibitors of the hedgehog pathway
EA201170832A1 (ru) Пуриновые соединения
EA201070327A1 (ru) Катехоламиновые производные и их пролекарства
MA32776B1 (fr) Inhibiteurs de l'akt et de la p70 s6 kinase
EA201000703A1 (ru) Производные пиразола в качестве ингибиторов 5-lo
ATE502935T1 (de) C-met-proteinkinasehemmer
MX2009005916A (es) Nuevos derivados de cromen-2-ona y su uso como inhibidores de la reabsorcion del neurotransmisor de monoamina.
IL191670A0 (en) Compounds for the inhibition of apoptosis
MX2009012079A (es) Compuestos heterociclicos condensados como inhibidores de proteina cinasas.
MX2009006213A (es) Nuevos derivados de cromen-2-ona y su uso como inhibidores de reabsorcion del neurotransmisor monoamina.
CY1117072T1 (el) Ενωσεις αναστολης της μιτωτικης διαδικασιας
UA95260C2 (ru) Производное 4-(3-аминопиразол)пиримидина и его применение для лечения злокачественного новообразования