UA78693C2 - Use of eicosapentaenoic acid ethyl ester and docosahexaenoic acid ethyl ester for treating heart failure - Google Patents
Use of eicosapentaenoic acid ethyl ester and docosahexaenoic acid ethyl ester for treating heart failure Download PDFInfo
- Publication number
- UA78693C2 UA78693C2 UA2003087938A UA2003087938A UA78693C2 UA 78693 C2 UA78693 C2 UA 78693C2 UA 2003087938 A UA2003087938 A UA 2003087938A UA 2003087938 A UA2003087938 A UA 2003087938A UA 78693 C2 UA78693 C2 UA 78693C2
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- Ukraine
- Prior art keywords
- heart failure
- ethyl ester
- item
- use according
- dha
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- 206010019280 Heart failures Diseases 0.000 title claims abstract description 42
- 229920000064 Ethyl eicosapentaenoic acid Polymers 0.000 title abstract description 22
- SSQPWTVBQMWLSZ-AAQCHOMXSA-N ethyl (5Z,8Z,11Z,14Z,17Z)-icosapentaenoate Chemical compound CCOC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CC SSQPWTVBQMWLSZ-AAQCHOMXSA-N 0.000 title abstract description 22
- TYLNXKAVUJJPMU-DNKOKRCQSA-N Docosahexaenoic acid ethyl ester Chemical compound CCCCCCCCC\C=C\C=C\C=C\C=C\C=C\C=C\C(=O)OCC TYLNXKAVUJJPMU-DNKOKRCQSA-N 0.000 title abstract description 6
- MBMBGCFOFBJSGT-KUBAVDMBSA-N docosahexaenoic acid Natural products CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCC(O)=O MBMBGCFOFBJSGT-KUBAVDMBSA-N 0.000 claims abstract description 45
- 239000003814 drug Substances 0.000 claims abstract description 33
- 235000020673 eicosapentaenoic acid Nutrition 0.000 claims abstract description 27
- 235000020669 docosahexaenoic acid Nutrition 0.000 claims abstract description 26
- 235000004626 essential fatty acids Nutrition 0.000 claims abstract description 19
- 239000000203 mixture Substances 0.000 claims abstract description 18
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- 230000002265 prevention Effects 0.000 claims abstract description 14
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- 206010007559 Cardiac failure congestive Diseases 0.000 claims description 22
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- 230000001154 acute effect Effects 0.000 claims description 8
- JAZBEHYOTPTENJ-JLNKQSITSA-N all-cis-5,8,11,14,17-icosapentaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O JAZBEHYOTPTENJ-JLNKQSITSA-N 0.000 claims description 8
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- 229960005135 eicosapentaenoic acid Drugs 0.000 claims description 8
- JAZBEHYOTPTENJ-UHFFFAOYSA-N eicosapentaenoic acid Natural products CCC=CCC=CCC=CCC=CCC=CCCCC(O)=O JAZBEHYOTPTENJ-UHFFFAOYSA-N 0.000 claims description 8
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- 125000004494 ethyl ester group Chemical group 0.000 claims description 5
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- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
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- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Organic Chemistry (AREA)
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- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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IT2001MI000129A ITMI20010129A1 (it) | 2001-01-25 | 2001-01-25 | Acidi grassi essenziali nella terapia di insufficienza cardiaca e scompenso cardiaco |
PCT/EP2002/000507 WO2002058793A1 (fr) | 2001-01-25 | 2002-01-16 | Utilisation d'acides gras n-3 essentiels dans le traitement de l'insuffisance cardiaque et de l'arret cardiaque |
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UA78693C2 true UA78693C2 (en) | 2007-04-25 |
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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UA2003087938A UA78693C2 (en) | 2001-01-25 | 2002-01-16 | Use of eicosapentaenoic acid ethyl ester and docosahexaenoic acid ethyl ester for treating heart failure |
Country Status (21)
Country | Link |
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US (3) | US20040077723A1 (fr) |
EP (2) | EP1365841A1 (fr) |
JP (1) | JP2004517148A (fr) |
AU (1) | AU2002225026B2 (fr) |
BG (1) | BG108071A (fr) |
CA (1) | CA2433762A1 (fr) |
CZ (1) | CZ20031947A3 (fr) |
EA (1) | EA200300830A1 (fr) |
EE (1) | EE05320B1 (fr) |
HR (1) | HRP20030561A2 (fr) |
HU (1) | HUP0303019A2 (fr) |
IS (1) | IS6862A (fr) |
IT (1) | ITMI20010129A1 (fr) |
MX (1) | MX282405B (fr) |
NO (1) | NO20033304L (fr) |
NZ (1) | NZ526609A (fr) |
PL (1) | PL363269A1 (fr) |
SK (1) | SK8332003A3 (fr) |
UA (1) | UA78693C2 (fr) |
WO (1) | WO2002058793A1 (fr) |
YU (1) | YU59303A (fr) |
Families Citing this family (58)
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GB9901809D0 (en) * | 1999-01-27 | 1999-03-17 | Scarista Limited | Highly purified ethgyl epa and other epa derivatives for psychiatric and neurological disorderes |
ITMI20010129A1 (it) * | 2001-01-25 | 2002-07-25 | Pharmacia & Upjohn Spa | Acidi grassi essenziali nella terapia di insufficienza cardiaca e scompenso cardiaco |
ITMI20012384A1 (it) * | 2001-11-12 | 2003-05-12 | Quatex Nv | Uso di acidi grassi poliinsaturi per la prevenzione primaria di eventi cardiovascolari maggiori |
ITMI20020269A1 (it) * | 2002-02-12 | 2003-08-12 | Victorix Assets Ltd | Uso di steri etilici di acidi poliinsaturi omega-3 in pazienti con insufficienza cardiaca |
CN100352889C (zh) * | 2002-11-22 | 2007-12-05 | 日本水产株式会社 | 高氧化稳定性的含有双键有机物的组合物 |
ITMI20022511A1 (it) * | 2002-11-26 | 2004-05-27 | Victorix Assets Ltd | Uso di composizioni farmaceutiche contenenti esteri etilici di acidi poliinsaturi omega-3 nella orevenzione della fibrillazione atriale. |
DE602004021573D1 (de) * | 2003-04-07 | 2009-07-30 | Pharmacyclics Inc | Hydroxamate als therapeutische mittel |
WO2004091603A1 (fr) * | 2003-04-07 | 2004-10-28 | Clinigenetics | Utilisation d’un ester de dha pour le traitement des malades cardiovasculaires |
SE0303513D0 (sv) * | 2003-12-19 | 2003-12-19 | Pronova Biocare As | Use of a fatty acid composition comprising at least one of epa and dha or any combinations thereof |
AU2005249794A1 (en) | 2004-06-04 | 2005-12-15 | Teva Pharmaceutical Industries, Ltd. | Pharmaceutical composition containing irbesartan |
EP1865770A4 (fr) * | 2005-04-07 | 2010-12-29 | Nitromed Inc | Evaluation du risque genetique d'insuffisance cardiaque: impact de la variation genetique de nos3 |
FR2902659A1 (fr) * | 2006-06-23 | 2007-12-28 | Pierre Fabre Medicament Sa | Ester de dha et son utilisation dans le traitement et la prevention des maladies cardiovasculaires |
US20090011012A1 (en) * | 2007-07-06 | 2009-01-08 | Baum Seth J | Fatty acid compositions and methods of use |
US9468668B2 (en) | 2011-08-11 | 2016-10-18 | Allergy Research Group, Llc | Flavored chewable lipid supplements for maintaining health and the treatment of acute and chronic disorders |
US8877239B2 (en) | 2010-08-12 | 2014-11-04 | Nutritional Therapeutics, Inc. | Lipid supplements for maintaining health and treatment of acute and chronic disorders |
US8343753B2 (en) | 2007-11-01 | 2013-01-01 | Wake Forest University School Of Medicine | Compositions, methods, and kits for polyunsaturated fatty acids from microalgae |
AU2009278317B2 (en) | 2008-08-07 | 2014-12-18 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Long-term treatment of symptomatic heart failure |
WO2010018856A1 (fr) * | 2008-08-13 | 2010-02-18 | 持田製薬株式会社 | Agent prophylactique/d’amélioration ou thérapeutique destiné aux maladies associées au récepteur des cannabinoïdes |
WO2010028067A1 (fr) | 2008-09-02 | 2010-03-11 | Amarin Corporation Plc | Composition pharmaceutique comprenant de l'acide eïcosapentaénoïque et de l'acide nicotinique et ses procédés d'utilisation |
ES2426132T3 (es) | 2009-02-10 | 2013-10-21 | Amarin Pharmaceuticals Ireland Limited | Uso del éster etílico del ácido eicosapentaenoico para tratar la hipertrigliceridemia |
CA2795907A1 (fr) | 2009-04-09 | 2010-10-14 | The Regents Of The University Of Colorado, A Body Corporate | Procedes et compositions pour induire une hypertrophie physiologique |
LT2424356T (lt) | 2009-04-29 | 2017-11-27 | Amarin Pharmaceuticals Ireland Limited | Stabili farmacinė kompozicija ir jos panaudojimo būdai |
MY198422A (en) | 2009-04-29 | 2023-08-29 | Amarin Pharmaceuticals Ie Ltd | Pharmaceutical compositions comprising epa and a cardiovascular agent and methods of using the same |
NZ597193A (en) | 2009-06-15 | 2014-01-31 | Amarin Pharmaceuticals Ie Ltd | Compositions and methods for lowering triglycerides without raising ldl-c levels in a subject on concomitant statin therapy |
US20110071176A1 (en) | 2009-09-23 | 2011-03-24 | Amarin Pharma, Inc. | Pharmaceutical composition comprising omega-3 fatty acid and hydroxy-derivative of a statin and methods of using same |
WO2011109724A1 (fr) * | 2010-03-04 | 2011-09-09 | Amarin Pharma, Inc. | Compositions et méthodes pour le traitement et/ou la prévention de maladies cardio-vasculaires |
WO2012074930A2 (fr) | 2010-11-29 | 2012-06-07 | Amarin Pharma, Inc. | Composition à faible éructation et méthodes de traitement et/ou de prévention de maladie cardiovasculaire chez un sujet présentant une allergie/hypersensibilité aux poissons |
US11712429B2 (en) | 2010-11-29 | 2023-08-01 | Amarin Pharmaceuticals Ireland Limited | Low eructation composition and methods for treating and/or preventing cardiovascular disease in a subject with fish allergy/hypersensitivity |
CA2826663A1 (fr) | 2011-02-07 | 2012-08-16 | Mochida Pharmaceutical Co., Ltd. | Agent therapeutique pour l'insuffisance cardiaque congestive diastolique |
US8951514B2 (en) | 2011-02-16 | 2015-02-10 | Pivotal Therapeutics Inc. | Statin and omega 3 fatty acids for reduction of apolipoprotein-B levels |
US8952000B2 (en) | 2011-02-16 | 2015-02-10 | Pivotal Therapeutics Inc. | Cholesterol absorption inhibitor and omega 3 fatty acids for the reduction of cholesterol and for the prevention or reduction of cardiovascular, cardiac and vascular events |
US9119826B2 (en) | 2011-02-16 | 2015-09-01 | Pivotal Therapeutics, Inc. | Omega 3 fatty acid for use as a prescription medical food and omega 3 fatty acid diagniostic assay for the dietary management of cardiovascular patients with cardiovascular disease (CVD) who are deficient in blood EPA and DHA levels |
US8715648B2 (en) | 2011-02-16 | 2014-05-06 | Pivotal Therapeutics Inc. | Method for treating obesity with anti-obesity formulations and omega 3 fatty acids for the reduction of body weight in cardiovascular disease patients (CVD) and diabetics |
US10117885B2 (en) | 2011-08-11 | 2018-11-06 | Allergy Research Group, Llc | Chewable lipid supplements for treating pain and fibromyalgia |
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- 2002-01-16 AU AU2002225026A patent/AU2002225026B2/en not_active Ceased
- 2002-01-16 HU HU0303019A patent/HUP0303019A2/hu unknown
- 2002-01-16 MX MXPA03006480 patent/MX282405B/es active IP Right Grant
- 2002-01-16 SK SK833-2003A patent/SK8332003A3/sk not_active Application Discontinuation
- 2002-01-16 CA CA002433762A patent/CA2433762A1/fr not_active Abandoned
- 2002-01-16 UA UA2003087938A patent/UA78693C2/uk unknown
- 2002-01-16 YU YU59303A patent/YU59303A/sh unknown
- 2002-01-16 WO PCT/EP2002/000507 patent/WO2002058793A1/fr active IP Right Grant
- 2002-01-16 NZ NZ526609A patent/NZ526609A/en not_active IP Right Cessation
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YU59303A (sh) | 2006-08-17 |
US7439267B2 (en) | 2008-10-21 |
JP2004517148A (ja) | 2004-06-10 |
EP2258447A3 (fr) | 2012-07-25 |
HRP20030561A2 (en) | 2005-06-30 |
US20060205814A1 (en) | 2006-09-14 |
PL363269A1 (en) | 2004-11-15 |
HUP0303019A2 (hu) | 2003-12-29 |
NZ526609A (en) | 2005-10-28 |
AU2002225026B2 (en) | 2007-09-13 |
EP1365841A1 (fr) | 2003-12-03 |
NO20033304D0 (no) | 2003-07-22 |
CA2433762A1 (fr) | 2002-08-01 |
EP2258447A2 (fr) | 2010-12-08 |
MX282405B (es) | 2010-12-21 |
CZ20031947A3 (cs) | 2003-12-17 |
NO20033304L (no) | 2003-07-22 |
US20040077723A1 (en) | 2004-04-22 |
SK8332003A3 (en) | 2003-11-04 |
EE200300297A (et) | 2003-10-15 |
IS6862A (is) | 2003-06-27 |
EA200300830A1 (ru) | 2003-12-25 |
MXPA03006480A (es) | 2003-09-22 |
ITMI20010129A1 (it) | 2002-07-25 |
US20090005327A1 (en) | 2009-01-01 |
EE05320B1 (et) | 2010-08-16 |
BG108071A (bg) | 2005-04-30 |
WO2002058793A1 (fr) | 2002-08-01 |
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