UA78275C2 - Oxa- and thiadiasols and their use as inhibitors of matrix metalloproteinases - Google Patents
Oxa- and thiadiasols and their use as inhibitors of matrix metalloproteinases Download PDFInfo
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- UA78275C2 UA78275C2 UA20040806941A UA20040806941A UA78275C2 UA 78275 C2 UA78275 C2 UA 78275C2 UA 20040806941 A UA20040806941 A UA 20040806941A UA 20040806941 A UA20040806941 A UA 20040806941A UA 78275 C2 UA78275 C2 UA 78275C2
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- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
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- C07—ORGANIC CHEMISTRY
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- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
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- Urology & Nephrology (AREA)
- Virology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Communicable Diseases (AREA)
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- Heart & Thoracic Surgery (AREA)
- Molecular Biology (AREA)
- Cardiology (AREA)
- Transplantation (AREA)
- Vascular Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0204159.8A GB0204159D0 (en) | 2002-02-22 | 2002-02-22 | Metalloproteinase inhibitors |
| PCT/GB2003/000741 WO2003070711A1 (en) | 2002-02-22 | 2003-02-20 | Oxa- and thiadiazoles and their use as metalloproteinase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA78275C2 true UA78275C2 (en) | 2007-03-15 |
Family
ID=9931543
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UA20040806941A UA78275C2 (en) | 2002-02-22 | 2003-02-20 | Oxa- and thiadiasols and their use as inhibitors of matrix metalloproteinases |
Country Status (27)
| Country | Link |
|---|---|
| US (4) | US7358265B2 (es) |
| EP (1) | EP1476438B1 (es) |
| JP (1) | JP4615864B2 (es) |
| KR (1) | KR101098614B1 (es) |
| CN (1) | CN100351245C (es) |
| AT (1) | ATE360007T1 (es) |
| AU (1) | AU2003205910B2 (es) |
| BR (1) | BR0307899A (es) |
| CA (1) | CA2475867C (es) |
| CY (1) | CY1106730T1 (es) |
| DE (1) | DE60313292T2 (es) |
| DK (1) | DK1476438T3 (es) |
| EA (1) | EA007609B1 (es) |
| ES (1) | ES2286404T3 (es) |
| GB (1) | GB0204159D0 (es) |
| HK (1) | HK1078583A1 (es) |
| HR (1) | HRP20040725A2 (es) |
| IL (1) | IL163413A (es) |
| MX (1) | MXPA04008132A (es) |
| NO (1) | NO330772B1 (es) |
| PL (1) | PL210773B1 (es) |
| PT (1) | PT1476438E (es) |
| RS (1) | RS51354B (es) |
| SI (1) | SI1476438T1 (es) |
| UA (1) | UA78275C2 (es) |
| WO (1) | WO2003070711A1 (es) |
| ZA (1) | ZA200406755B (es) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2004101537A1 (en) * | 2003-05-17 | 2004-11-25 | British Biotech Pharmaceuticals Ltd | Metalloproteinase inhibitors |
| PL1660471T3 (pl) * | 2003-08-23 | 2011-10-31 | Vernalis R&D Ltd | Pochodne kwasu hydroksamowego jako inhibitory metaloproteinaz |
| US7838522B2 (en) | 2004-11-17 | 2010-11-23 | Ares Trading S.A. | Benzothiazole formulations and use thereof |
| DK1828160T3 (da) | 2004-12-21 | 2012-02-13 | Merck Serono Sa | Cykliske sulfonylaminoderivater og anvendelse deraf som MMP-hæmmere |
| JP4950070B2 (ja) | 2005-01-31 | 2012-06-13 | メルク セローノ ソシエテ アノニム | Ｎ−ヒドロキシアミド誘導体及びその使用 |
| KR20080044836A (ko) | 2005-07-15 | 2008-05-21 | 라보라뚜와르 세로노 에스. 에이. | 자궁내막증 치료용 ｊｎｋ 억제제 |
| BRPI0613042A2 (pt) | 2005-07-15 | 2010-12-14 | Serono Lab | inibidores de jnk para o tratamento de endometriose |
| EP1933860A2 (en) | 2005-09-01 | 2008-06-25 | Ares Trading S.A. | Treatment of optic neuritis |
| US8153166B2 (en) * | 2006-06-08 | 2012-04-10 | Chih-Hsiung Lin | Composition for prophylaxis or treatment of urinary system infection and method thereof |
| ES2788848T3 (es) | 2013-09-06 | 2020-10-23 | Aurigene Discovery Tech Ltd | Derivados de 1,2,4-oxadiazol como inmunomoduladores |
| EA034708B1 (ru) | 2015-03-10 | 2020-03-10 | Ауриджен Дискавери Текнолоджис Лимитед | 1,2,4-оксадиазольные и тиадиазольные соединения в качестве иммуномодуляторов |
| CA2979161A1 (en) * | 2015-03-10 | 2016-09-15 | Aurigene Discovery Technologies Limited | 3-substituted-1,2,4-oxadiazole and thiadiazole compounds as immunomodulators |
| CN105384736B (zh) * | 2015-10-28 | 2018-11-02 | 南昌大学 | 一种ⅳ型胶原酶抑制剂及合成方法 |
| WO2019061324A1 (en) | 2017-09-29 | 2019-04-04 | Curis Inc. | CRYSTALLINE FORMS OF IMMUNOMODULATORS |
| KR20200068659A (ko) | 2017-10-11 | 2020-06-15 | 오리진 디스커버리 테크놀로지스 리미티드 | 3-치환된 1,2,4-옥사다이아졸의 결정질 형태 |
| JP7378394B2 (ja) | 2017-11-03 | 2023-11-13 | オーリジーン オンコロジー リミテッド | Ｔｉｍ－３およびｐｄ－１経路の二重阻害剤 |
| EP3706798A1 (en) | 2017-11-06 | 2020-09-16 | Aurigene Discovery Technologies Limited | Conjoint therapies for immunomodulation |
| CN108530378B (zh) * | 2018-05-29 | 2021-09-14 | 济南大学 | 一类含有噁二唑结构的氮原子双取代异羟肟酸类化合物、用途及其制备方法 |
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| GB9404046D0 (en) * | 1994-03-03 | 1994-04-20 | Smithkline Beecham Corp | Novel compounds |
| US5665753A (en) * | 1994-03-03 | 1997-09-09 | Smithkline Beecham Corporation | Cytokine inhibiting imidazole substituted hydroxamic acid derivatives |
| US5703092A (en) | 1995-04-18 | 1997-12-30 | The Dupont Merck Pharmaceutical Company | Hydroxamic acid compounds as metalloprotease and TNF inhibitors |
| DK0946166T3 (da) * | 1996-12-17 | 2004-05-03 | Warner Lambert Co | Anvendelse af matrixmetalloproteinaseinhibitorer til fremme af sårheling |
| JP2002506873A (ja) * | 1998-03-18 | 2002-03-05 | アリアド・ファーマシューティカルズ・インコーポレイテッド | 複素環式シグナル伝達阻害剤、それを含む組成物 |
| JP2001031637A (ja) * | 1999-05-17 | 2001-02-06 | Fuji Chemical Industries Ltd | 新規なヒドロキサム酸誘導体 |
| US6448278B2 (en) | 1999-12-23 | 2002-09-10 | Pfizer Inc. | Procollagen C-proteinase inhibitors |
| GB9930570D0 (en) * | 1999-12-23 | 2000-02-16 | Pfizer Ltd | Therapy |
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2002
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2003
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- 2003-02-20 WO PCT/GB2003/000741 patent/WO2003070711A1/en active IP Right Grant
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- 2003-02-20 RS YUP-716/04A patent/RS51354B/sr unknown
- 2003-02-20 SI SI200330870T patent/SI1476438T1/sl unknown
- 2003-02-20 KR KR1020047012821A patent/KR101098614B1/ko not_active IP Right Cessation
- 2003-02-20 US US10/504,317 patent/US7358265B2/en not_active Expired - Fee Related
- 2003-02-20 JP JP2003569618A patent/JP4615864B2/ja not_active Expired - Fee Related
- 2003-02-20 EP EP03702791A patent/EP1476438B1/en not_active Expired - Lifetime
- 2003-02-20 PT PT03702791T patent/PT1476438E/pt unknown
- 2003-02-20 CA CA2475867A patent/CA2475867C/en not_active Expired - Fee Related
- 2003-02-20 UA UA20040806941A patent/UA78275C2/uk unknown
- 2003-02-20 ES ES03702791T patent/ES2286404T3/es not_active Expired - Lifetime
- 2003-02-20 AT AT03702791T patent/ATE360007T1/de active
- 2003-02-20 AU AU2003205910A patent/AU2003205910B2/en not_active Ceased
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2004
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- 2004-08-25 ZA ZA200406755A patent/ZA200406755B/en unknown
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2006
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2007
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2008
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2009
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2010
- 2010-10-07 US US12/900,262 patent/US20110086893A1/en not_active Abandoned
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