UA77937C2 - Antagonists of adenosine receptor, method for production and use thereof - Google Patents
Antagonists of adenosine receptor, method for production and use thereof Download PDFInfo
- Publication number
- UA77937C2 UA77937C2 UA2002064854A UA2002064854A UA77937C2 UA 77937 C2 UA77937 C2 UA 77937C2 UA 2002064854 A UA2002064854 A UA 2002064854A UA 2002064854 A UA2002064854 A UA 2002064854A UA 77937 C2 UA77937 C2 UA 77937C2
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- Ukraine
- Prior art keywords
- dipropyl
- compound according
- group
- dihydropurine
- dione
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- CTSAXXHOGZNKJR-UHFFFAOYSA-N methyl 2-diethoxyphosphorylacetate Chemical compound CCOP(=O)(OCC)CC(=O)OC CTSAXXHOGZNKJR-UHFFFAOYSA-N 0.000 description 1
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- FAXGPCHRFPCXOO-LXTPJMTPSA-N pepstatin A Chemical compound OC(=O)C[C@H](O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)C[C@H](O)[C@H](CC(C)C)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C(C)C)NC(=O)CC(C)C FAXGPCHRFPCXOO-LXTPJMTPSA-N 0.000 description 1
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- BEOOHQFXGBMRKU-UHFFFAOYSA-N sodium cyanoborohydride Chemical compound [Na+].[B-]C#N BEOOHQFXGBMRKU-UHFFFAOYSA-N 0.000 description 1
- BBMHARZCALWXSL-UHFFFAOYSA-M sodium dihydrogenphosphate monohydrate Chemical compound O.[Na+].OP(O)([O-])=O BBMHARZCALWXSL-UHFFFAOYSA-M 0.000 description 1
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Classifications
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Pulmonology (AREA)
- Hematology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Emergency Medicine (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16528399P | 1999-11-12 | 1999-11-12 | |
| PCT/US2000/031100 WO2001034604A2 (en) | 1999-11-12 | 2000-11-13 | Adenosine receptor antagonists and methods of making and using the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA77937C2 true UA77937C2 (en) | 2007-02-15 |
Family
ID=22598257
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UA2002064854A UA77937C2 (en) | 1999-11-12 | 2000-11-13 | Antagonists of adenosine receptor, method for production and use thereof |
Country Status (33)
| Country | Link |
|---|---|
| US (4) | US6605600B1 (de) |
| EP (2) | EP1230241B1 (de) |
| JP (1) | JP2003513976A (de) |
| KR (1) | KR100845488B1 (de) |
| CN (1) | CN1187354C (de) |
| AT (1) | ATE353328T1 (de) |
| AU (1) | AU784528B2 (de) |
| BG (1) | BG106693A (de) |
| BR (1) | BR0015540A (de) |
| CA (1) | CA2390590C (de) |
| CY (1) | CY1106560T1 (de) |
| CZ (1) | CZ20021615A3 (de) |
| DE (1) | DE60033310T2 (de) |
| DK (1) | DK1230241T3 (de) |
| EA (1) | EA010260B1 (de) |
| EE (1) | EE200200248A (de) |
| ES (1) | ES2281367T3 (de) |
| GE (1) | GEP20043267B (de) |
| HK (1) | HK1049153B (de) |
| HU (1) | HUP0203371A3 (de) |
| IL (1) | IL149486A0 (de) |
| IS (1) | IS6380A (de) |
| MX (1) | MXPA02004795A (de) |
| NO (1) | NO20022237L (de) |
| NZ (2) | NZ519427A (de) |
| PL (1) | PL198156B1 (de) |
| PT (1) | PT1230241E (de) |
| SK (1) | SK6622002A3 (de) |
| TR (1) | TR200301062T2 (de) |
| UA (1) | UA77937C2 (de) |
| WO (1) | WO2001034604A2 (de) |
| YU (1) | YU33702A (de) |
| ZA (1) | ZA200203702B (de) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI229674B (en) | 1998-12-04 | 2005-03-21 | Astra Pharma Prod | Novel triazolo[4,5-d]pyrimidine compounds, pharmaceutical composition containing the same, their process for preparation and uses |
| TR200301062T2 (tr) * | 1999-11-12 | 2003-09-22 | Biogen, Inc. | Adenosin reseptörü antagonistleri ve bu antagonistlerin yapım ve kullanım yöntemleri |
| DE60041710D1 (de) * | 1999-11-12 | 2009-04-16 | Biogen Idec Inc | Polycycloalkylpurine als adenosinrezeptorantagonisten |
| SG131115A1 (en) * | 2002-06-12 | 2007-04-26 | Biogen Idec Inc | Method of treating ischemia reperfusion injury using adenosine receptor antagonists |
| US20040106797A1 (en) * | 2002-07-19 | 2004-06-03 | Pascal Druzgala | Novel xanthines having adenosine A1-receptor antagonist properties |
| US20040229901A1 (en) * | 2003-02-24 | 2004-11-18 | Lauren Otsuki | Method of treatment of disease using an adenosine A1 receptor antagonist |
| BRPI0409307A (pt) * | 2003-04-14 | 2006-04-25 | Pfizer Prod Inc | derivados de 3-azabiciclo[3.2.1]octano |
| WO2004096228A1 (en) * | 2003-04-25 | 2004-11-11 | Novacardia, Inc. | Method of improved diuresis in individuals with impaired renal function |
| EP1636229A4 (de) * | 2003-06-06 | 2008-07-30 | Endacea Inc | A1-adenosinrezeptorantagonisten |
| US20070208040A1 (en) * | 2006-03-02 | 2007-09-06 | Elfatih Elzein | A2a adenosine receptor antagonists |
| WO2007117549A2 (en) * | 2006-04-06 | 2007-10-18 | Novacardia, Inc. | Co-administration of adenosine a1 receptor antagonists and anticonvulsants |
| CN102516241B (zh) | 2006-05-19 | 2015-07-29 | 艾伯维巴哈马有限公司 | Cns活性的稠合的双环杂环取代的氮杂双环烷烃衍生物 |
| CN101466383A (zh) * | 2006-06-16 | 2009-06-24 | 美国诺华卡迪亚公司 | 包含低频率投与aa1ra的肾功能延长改善 |
| WO2008121882A1 (en) * | 2007-03-29 | 2008-10-09 | Novacardia, Inc. | Improved methods of administration of adenosine a1 receptor antagonists |
| US20090197900A1 (en) * | 2007-03-29 | 2009-08-06 | Howard Dittrich | Methods of treating heart failure and renal dysfunction in individuals with an adenosine a1 receptor antagonist |
| US20090228097A1 (en) * | 2008-03-07 | 2009-09-10 | Abbott Cardiovascular Systems Inc. | A1 Adenosine Receptor Antagonist-Coated Implantable Medical Device |
| CN114790164B (zh) | 2021-08-13 | 2022-12-27 | 苏州璞正医药有限公司 | 一种取代的异吲哚啉-1,3-二酮类pde4抑制剂及其药物用途 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3155664A (en) * | 1959-11-13 | 1964-11-03 | Endo Lab | Derivatives of theophylline |
| DE8817122U1 (de) | 1988-12-22 | 1993-02-04 | Boehringer Ingelheim Kg, 55218 Ingelheim | Neue Xanthinderivate mit Adenosinantogenistischer Wirkung |
| JPH06102662B2 (ja) * | 1989-09-01 | 1994-12-14 | 協和醗酵工業株式会社 | キサンチン誘導体 |
| US5290782A (en) | 1989-09-01 | 1994-03-01 | Kyowa Hakko Kogyo Co., Ltd. | Xanthine derivatives |
| ATE195739T1 (de) | 1989-10-20 | 2000-09-15 | Kyowa Hakko Kogyo Kk | Kondensierte purinderivate |
| DE4019892A1 (de) * | 1990-06-22 | 1992-01-02 | Boehringer Ingelheim Kg | Neue xanthinderivate |
| CA2061544A1 (en) | 1991-02-25 | 1992-08-26 | Fumio Suzuki | Xanthine compounds |
| EP0541120B1 (de) | 1991-11-08 | 1999-05-26 | Kyowa Hakko Kogyo Co., Ltd. | Xanthinderivate zur Behandlung der Demenz |
| JPH05294966A (ja) | 1992-02-17 | 1993-11-09 | Kyowa Hakko Kogyo Co Ltd | キサンチン誘導体 |
| US5342841A (en) | 1992-03-12 | 1994-08-30 | Kyowa Hakko Kogyo Co., Ltd. | Xanthine derivatives |
| TW252044B (de) | 1992-08-10 | 1995-07-21 | Boehringer Ingelheim Kg | |
| WO1994016702A1 (en) | 1993-01-26 | 1994-08-04 | Kyowa Hakko Kogyo Co., Ltd. | Remedy for irregular bowel movement |
| US5395836A (en) | 1993-04-07 | 1995-03-07 | Kyowa Hakko Kogyo Co., Ltd. | 8-tricycloalkyl xanthine derivatives |
| US5446046A (en) * | 1993-10-28 | 1995-08-29 | University Of Florida Research Foundation | A1 adenosine receptor agonists and antagonists as diuretics |
| WO1998057645A1 (fr) | 1997-06-16 | 1998-12-23 | Kyowa Hakko Kogyo Co., Ltd. | Medicament contre l'oedeme hepatique |
| WO1998057644A1 (fr) | 1997-06-16 | 1998-12-23 | Kyowa Hakko Kogyo Co., Ltd. | Agent de prevention et remede contre la nephropathie induite par les medicaments |
| DE19816857A1 (de) | 1998-04-16 | 1999-10-21 | Boehringer Ingelheim Pharma | Neue unsymmetrisch substituierte Xanthin-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| EP0955301A3 (de) * | 1998-04-27 | 2001-04-18 | Pfizer Products Inc. | 7-Aza-bicyclo[2.2.1]-heptan Derivate, deren Herstellung und Verwendung aufgrund ihrer Affinität für neuronale nikotinische Acetylcholin Rezeptoren |
| ATE358484T1 (de) | 1998-07-02 | 2007-04-15 | Kyowa Hakko Kogyo Kk | Antidiabetische medikamente |
| DE60041710D1 (de) * | 1999-11-12 | 2009-04-16 | Biogen Idec Inc | Polycycloalkylpurine als adenosinrezeptorantagonisten |
| TR200301062T2 (tr) * | 1999-11-12 | 2003-09-22 | Biogen, Inc. | Adenosin reseptörü antagonistleri ve bu antagonistlerin yapım ve kullanım yöntemleri |
-
2000
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- 2000-11-13 US US09/711,554 patent/US6605600B1/en not_active Expired - Fee Related
- 2000-11-13 KR KR1020027006022A patent/KR100845488B1/ko not_active IP Right Cessation
- 2000-11-13 CA CA2390590A patent/CA2390590C/en not_active Expired - Fee Related
- 2000-11-13 HU HU0203371A patent/HUP0203371A3/hu unknown
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2002
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2003
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2005
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