UA75957C2 - Alkynarylnaphthyridine-4(1h) as an phosphodiesterase iv inhibitor - Google Patents
Alkynarylnaphthyridine-4(1h) as an phosphodiesterase iv inhibitor Download PDFInfo
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- UA75957C2 UA75957C2 UA2004032266A UA2004032266A UA75957C2 UA 75957 C2 UA75957 C2 UA 75957C2 UA 2004032266 A UA2004032266 A UA 2004032266A UA 2004032266 A UA2004032266 A UA 2004032266A UA 75957 C2 UA75957 C2 UA 75957C2
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- Prior art keywords
- alkyl
- dihydro
- phenyl
- carboxamide
- isopropyl
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Psychiatry (AREA)
- Virology (AREA)
- Toxicology (AREA)
- Psychology (AREA)
- Ophthalmology & Optometry (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Otolaryngology (AREA)
- Transplantation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31609301P | 2001-08-29 | 2001-08-29 | |
| PCT/CA2002/001324 WO2003018579A1 (fr) | 2001-08-29 | 2002-08-27 | Derives d'alkyne-aryle-naphthyridine-4-one (1h) tenant lieu d'inhibiteurs de phosphodiesterase-4 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA75957C2 true UA75957C2 (en) | 2006-06-15 |
Family
ID=23227432
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UA2004032266A UA75957C2 (en) | 2001-08-29 | 2002-08-27 | Alkynarylnaphthyridine-4(1h) as an phosphodiesterase iv inhibitor |
Country Status (28)
| Country | Link |
|---|---|
| US (2) | US6743802B2 (fr) |
| EP (2) | EP1436290B8 (fr) |
| JP (1) | JP4157035B2 (fr) |
| KR (1) | KR100928849B1 (fr) |
| CN (1) | CN100338061C (fr) |
| AR (1) | AR036365A1 (fr) |
| AU (1) | AU2002322940B2 (fr) |
| BR (1) | BR0212042A (fr) |
| CA (1) | CA2456817C (fr) |
| DO (1) | DOP2002000456A (fr) |
| EA (1) | EA006800B1 (fr) |
| EC (1) | ECSP044992A (fr) |
| GE (1) | GEP20063805B (fr) |
| HK (1) | HK1080073B (fr) |
| HR (1) | HRP20040151A2 (fr) |
| HU (1) | HUP0401729A3 (fr) |
| IL (1) | IL160213A0 (fr) |
| IS (1) | IS7138A (fr) |
| JO (1) | JO2311B1 (fr) |
| MX (1) | MXPA04001889A (fr) |
| NO (1) | NO330521B1 (fr) |
| NZ (1) | NZ530931A (fr) |
| PE (1) | PE20030416A1 (fr) |
| PL (1) | PL367716A1 (fr) |
| RS (1) | RS17004A (fr) |
| UA (1) | UA75957C2 (fr) |
| WO (1) | WO2003018579A1 (fr) |
| ZA (1) | ZA200400952B (fr) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JO2311B1 (en) * | 2001-08-29 | 2005-09-12 | ميرك فروست كندا ليمتد | Alkyl inhibitors Ariel phosphodiesterase-4 |
| DE10250708A1 (de) * | 2002-10-31 | 2004-05-19 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Alkin-Verbindungen mit MCH-antagonistischer Wirkung und diese Verbindungen enthaltende Arzneimittel |
| US7452911B2 (en) | 2002-10-31 | 2008-11-18 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Alkyne compounds with MCH antagonistic activity and medicaments comprising these compounds |
| US7351719B2 (en) | 2002-10-31 | 2008-04-01 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Amide compounds having MCH-antagonistic activity and medicaments comprising these compounds |
| EP1562588A4 (fr) * | 2002-11-15 | 2007-10-31 | Merck & Co Inc | Utilisation d'inhibiteurs de pde4 comme traitement d'appoint de troubles psychiatriques |
| EP1592419A1 (fr) * | 2002-11-22 | 2005-11-09 | Merck Frosst Canada & Co. | Inhibiteurs de phosphodiesterase-4 nootropes |
| AR042194A1 (es) * | 2002-11-22 | 2005-06-15 | Merck & Co Inc | Metodo para preparar inhibidores de fosfodiesterasa - 4 |
| GB0307863D0 (en) * | 2003-04-04 | 2003-05-14 | Merck Sharp & Dohme | Therapeutic treatment |
| GB0322726D0 (en) * | 2003-09-27 | 2003-10-29 | Glaxo Group Ltd | Compounds |
| GB0322722D0 (en) * | 2003-09-27 | 2003-10-29 | Glaxo Group Ltd | Compounds |
| US7592373B2 (en) | 2003-12-23 | 2009-09-22 | Boehringer Ingelheim International Gmbh | Amide compounds with MCH antagonistic activity and medicaments comprising these compounds |
| DE102004017930A1 (de) * | 2004-04-14 | 2005-11-03 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Alkin-Verbindungen mit MCH-antagonistischer Wirkung und diese Verbindungen enthaltende Arzneimittel |
| US7524862B2 (en) | 2004-04-14 | 2009-04-28 | Boehringer Ingelheim International Gmbh | Alkyne compounds with MCH antagonistic activity and medicaments comprising these compounds |
| DE102004017934A1 (de) | 2004-04-14 | 2005-11-03 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Alkin-Verbindungen mit MCH-antagonistischer Wirkung und diese Verbindungen enthaltende Arzneimittel |
| US20080119509A1 (en) * | 2004-04-26 | 2008-05-22 | Sophie-Dorothee Clas | Altenrative Forms Of The Phosphodeisterase -4 Inhibitor N-Cyclopropyl-1- -3{3-[(1-Oxidopyryidin-3-Yl) Phenyl]-4-Oxo-1,4-Dihydro-1,8-Naphthyridine-3-Carboxyamide |
| JP4264388B2 (ja) * | 2004-07-01 | 2009-05-13 | 富士通株式会社 | 半導体チップの接合方法および接合装置 |
| WO2006004191A1 (fr) * | 2004-07-05 | 2006-01-12 | Astellas Pharma Inc. | Derivés de pyrrolopyridazine qui inhibent la pde iv et le tnf alpha |
| US7687490B2 (en) * | 2005-04-12 | 2010-03-30 | Meiji Seika Kaisha, Ltd. | 2-thioethenyl substituted carbapenem derivatives |
| JP2006016407A (ja) * | 2005-06-15 | 2006-01-19 | Yamaha Motor Co Ltd | ホスホジエステラーゼ阻害剤 |
| EP2258359A3 (fr) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenèse par modulation des récepteurs muscariniques avec sabcomeline |
| EP2275095A3 (fr) | 2005-08-26 | 2011-08-17 | Braincells, Inc. | Neurogenese par modulation des recepteurs muscariniques |
| EP1931338A4 (fr) * | 2005-09-28 | 2009-05-27 | Merck Frosst Canada Inc | Formulation de poudre aerosol comprenant un lactose tamise |
| EP2377530A3 (fr) | 2005-10-21 | 2012-06-20 | Braincells, Inc. | Modulation de neurogénèse par inhibition PDE |
| EP2314289A1 (fr) | 2005-10-31 | 2011-04-27 | Braincells, Inc. | Modulation de la neurogenese dont la médiation est assurée par récepteur gaba |
| WO2007070319A2 (fr) * | 2005-12-13 | 2007-06-21 | Wyeth | Derives de dibenzonaphtyridine et leurs procedes d'utilisation |
| US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
| WO2007134077A2 (fr) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | Neurogenèse induite par le récepteur 5ht |
| CA2651813A1 (fr) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | Neurogenese par modulation de l'angiotensine |
| AU2007292848A1 (en) | 2006-09-08 | 2008-03-13 | Braincells, Inc. | Combinations containing a 4-acylaminopyridine derivative |
| US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
| EP2121633A2 (fr) | 2007-02-12 | 2009-11-25 | Merck & Co., Inc. | Dérivés de pipérazine pour le traitement de la maladie d'alzheimer et des conditions apparentées |
| JP2010523695A (ja) * | 2007-04-11 | 2010-07-15 | アルコン リサーチ， リミテッド | アレルギー性鼻炎およびアレルギー性結膜炎を処置するためのＴＮＦαのインヒビターおよび抗ヒスタミン薬の使用 |
| US20090182035A1 (en) * | 2007-04-11 | 2009-07-16 | Alcon Research, Ltd. | Use of a combination of olopatadine and cilomilast to treat non-infectious rhinitis and allergic conjunctivitis |
| CA2707360A1 (fr) | 2007-06-20 | 2008-12-24 | Merck Sharp & Dohme Corp. | Alcanes diphenyl-substitues |
| WO2009052624A1 (fr) * | 2007-10-25 | 2009-04-30 | Merck Frosst Canada Ltd. | Polythérapie |
| WO2009128057A2 (fr) | 2008-04-18 | 2009-10-22 | UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN et al | Produits psycho-pharmaceutiques |
| US20100216805A1 (en) | 2009-02-25 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
| AU2010300421B2 (en) * | 2009-10-01 | 2014-01-23 | Alcon Research, Ltd. | Olopatadine compositions and uses thereof |
| FR2952934B1 (fr) * | 2009-11-23 | 2012-06-22 | Sanofi Aventis | Derives de pyridino-pyridinones, leur preparation et leur application en therapeutique |
| US8980922B2 (en) | 2010-02-12 | 2015-03-17 | Raqualia Pharma Inc. | 5-HT4 receptor agonists for the treatment of dementia |
| US20140051701A1 (en) * | 2011-03-02 | 2014-02-20 | Bionomics Limited | Methods of treating a disease or condition of the central nervous system |
| CN103183675A (zh) * | 2011-12-27 | 2013-07-03 | 山东轩竹医药科技有限公司 | 磷酸二酯酶-4抑制剂 |
| CN102643268B (zh) * | 2011-12-30 | 2014-05-21 | 沈阳药科大学 | 喹啉类及噌啉类化合物及其应用 |
| EP2804603A1 (fr) | 2012-01-10 | 2014-11-26 | President and Fellows of Harvard College | Composés promoteurs de réplication des cellules bêta et leurs procédés d'utilisation |
| CN103214478B (zh) * | 2012-01-19 | 2015-07-15 | 山东轩竹医药科技有限公司 | 吡啶并氧代哒嗪衍生物 |
| BR112015019276A2 (pt) | 2013-02-19 | 2017-07-18 | Pfizer | compostos de azabenzimidazol como inibidores de isoenzimas de pde4 para o tratamento de distúrbios do snc e outros distúrbios |
| JP6713982B2 (ja) | 2014-07-24 | 2020-06-24 | ファイザー・インク | ピラゾロピリミジン化合物 |
| ES2733502T3 (es) | 2014-08-06 | 2019-11-29 | Pfizer | Compuestos de imidazopiridazina |
| US20200254070A1 (en) | 2018-12-28 | 2020-08-13 | Regeneron Pharmaceuticals, Inc. | Treatment Of Respiratory Disorders With Arachidonate 15-Lipoxygenase (ALOX15) Inhibitors |
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| GB9212693D0 (en) | 1992-06-15 | 1992-07-29 | Celltech Ltd | Chemical compounds |
| GB9212673D0 (en) | 1992-06-15 | 1992-07-29 | Celltech Ltd | Chemical compounds |
| ES2092729T3 (es) | 1992-07-01 | 1996-12-01 | Hoechst Ag | Benzoilguanidinas 3,4,5-sustituidas, procedimiento para su preparacion, su empleo como medicamento o agente de diagnostico, asi como medicamento que las contiene. |
| GB9222253D0 (en) | 1992-10-23 | 1992-12-09 | Celltech Ltd | Chemical compounds |
| GB9226830D0 (en) | 1992-12-23 | 1993-02-17 | Celltech Ltd | Chemical compounds |
| US5622977A (en) | 1992-12-23 | 1997-04-22 | Celltech Therapeutics Limited | Tri-substituted (aryl or heteroaryl) derivatives and pharmaceutical compositions containing the same |
| DE4306152A1 (de) | 1993-02-27 | 1994-09-01 | Hoechst Ag | Positiv arbeitendes strahlungsempfindliches Gemisch und damit hergestelltes Aufzeichnungsmaterial |
| GB9304919D0 (en) | 1993-03-10 | 1993-04-28 | Celltech Ltd | Chemical compounds |
| GB9304920D0 (en) | 1993-03-10 | 1993-04-28 | Celltech Ltd | Chemical compounds |
| US5455252A (en) | 1993-03-31 | 1995-10-03 | Syntex (U.S.A.) Inc. | Optionally substituted 6,8-quinolines |
| DE4318756A1 (de) | 1993-06-05 | 1994-12-08 | Hoechst Ag | Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| GB9326600D0 (en) | 1993-12-22 | 1994-03-02 | Celltech Ltd | Chemical compounds |
| GB9326173D0 (en) | 1993-12-22 | 1994-02-23 | Celltech Ltd | Chemical compounds and process |
| DE69433594T2 (de) | 1993-12-22 | 2004-08-05 | Celltech R&D Ltd., Slough | Trisubstituierte phenyl-derivate, verfahren zu deren herstellung und deren verwendung als phosphodiesterase (typ iv) hemmstoffe |
| US6245774B1 (en) | 1994-06-21 | 2001-06-12 | Celltech Therapeutics Limited | Tri-substituted phenyl or pyridine derivatives |
| US5786354A (en) | 1994-06-21 | 1998-07-28 | Celltech Therapeutics, Limited | Tri-substituted phenyl derivatives and processes for their preparation |
| GB9412571D0 (en) | 1994-06-22 | 1994-08-10 | Celltech Ltd | Chemical compounds |
| GB9412573D0 (en) | 1994-06-22 | 1994-08-10 | Celltech Ltd | Chemical compounds |
| GB9412672D0 (en) | 1994-06-23 | 1994-08-10 | Celltech Ltd | Chemical compounds |
| EP0765867A1 (fr) | 1995-09-27 | 1997-04-02 | Hoechst Aktiengesellschaft | Benzoylguanidines substituées, procédé de leur préparation, leur utilisation comme agent antiarythmique ou diagnostique ainsi que le médicament les contenant |
| GB9526243D0 (en) | 1995-12-21 | 1996-02-21 | Celltech Therapeutics Ltd | Chemical compounds |
| GB9526246D0 (en) | 1995-12-21 | 1996-02-21 | Celltech Therapeutics Ltd | Chemical compounds |
| GB9526245D0 (en) | 1995-12-21 | 1996-02-21 | Celltech Therapeutics Ltd | Chemical compounds |
| DE19622370A1 (de) | 1996-06-04 | 1997-12-11 | Hoechst Ag | Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| GB9625184D0 (en) | 1996-12-04 | 1997-01-22 | Celltech Therapeutics Ltd | Chemical compounds |
| AU721620B2 (en) | 1996-12-11 | 2000-07-13 | Basf Aktiengesellschaft | Novel ketobenzamides and their use |
| HUP0001054A3 (en) | 1997-08-06 | 2001-01-29 | Daiichi Asubio Pharma Co Ltd | 1-aryl-1,8-naphthyridin-4-one derivative as type iv phosphodiesterase inhibitor |
| AU8780898A (en) | 1997-08-20 | 1999-03-08 | First Data Corporation | Interactive tax payment system |
| US6331548B1 (en) | 1998-01-29 | 2001-12-18 | Suntory Limited | 1-cycloalkyl-1,8-naphthyridin-4-one derivative as type IV phosphodiesterase inhibitor |
| IL140868A0 (en) * | 1998-08-11 | 2002-02-10 | Pfizer Prod Inc | Substituted 1,8-naphthyridin-4(1h)-ones as phosphodiesterase 4 inhibitors |
| JO2311B1 (en) * | 2001-08-29 | 2005-09-12 | ميرك فروست كندا ليمتد | Alkyl inhibitors Ariel phosphodiesterase-4 |
| IS7839A (is) * | 2002-11-22 | 2004-05-23 | Merck Frosst Canada Ltd. | 4-oxó-1-(3-setið fenýl-1,4-díhýdró-1,8-naftýridín-3-karboxamíð fosfódíesterasa-4 hindrar |
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2002
- 2002-08-22 JO JO200289A patent/JO2311B1/en active
- 2002-08-23 US US10/226,980 patent/US6743802B2/en not_active Expired - Lifetime
- 2002-08-26 PE PE2002000819A patent/PE20030416A1/es not_active Application Discontinuation
- 2002-08-27 IL IL16021302A patent/IL160213A0/xx unknown
- 2002-08-27 AU AU2002322940A patent/AU2002322940B2/en not_active Ceased
- 2002-08-27 AR ARP020103210A patent/AR036365A1/es not_active Application Discontinuation
- 2002-08-27 KR KR1020047002912A patent/KR100928849B1/ko not_active IP Right Cessation
- 2002-08-27 GE GE5495A patent/GEP20063805B/en unknown
- 2002-08-27 HU HU0401729A patent/HUP0401729A3/hu unknown
- 2002-08-27 PL PL02367716A patent/PL367716A1/xx not_active Application Discontinuation
- 2002-08-27 BR BR0212042-9A patent/BR0212042A/pt not_active Application Discontinuation
- 2002-08-27 CN CNB028213270A patent/CN100338061C/zh not_active Expired - Fee Related
- 2002-08-27 JP JP2003523241A patent/JP4157035B2/ja not_active Expired - Fee Related
- 2002-08-27 EP EP02754079.8A patent/EP1436290B8/fr not_active Expired - Lifetime
- 2002-08-27 EA EA200400361A patent/EA006800B1/ru not_active IP Right Cessation
- 2002-08-27 MX MXPA04001889A patent/MXPA04001889A/es active IP Right Grant
- 2002-08-27 EP EP10191086A patent/EP2305677A1/fr not_active Withdrawn
- 2002-08-27 US US10/487,047 patent/US20050070569A1/en not_active Abandoned
- 2002-08-27 NZ NZ530931A patent/NZ530931A/en not_active IP Right Cessation
- 2002-08-27 CA CA2456817A patent/CA2456817C/fr not_active Expired - Fee Related
- 2002-08-27 RS YUP-170/04A patent/RS17004A/sr unknown
- 2002-08-27 UA UA2004032266A patent/UA75957C2/uk unknown
- 2002-08-27 WO PCT/CA2002/001324 patent/WO2003018579A1/fr active IP Right Grant
- 2002-08-29 DO DO2002000456A patent/DOP2002000456A/es unknown
-
2004
- 2004-01-30 IS IS7138A patent/IS7138A/is unknown
- 2004-02-05 ZA ZA200400952A patent/ZA200400952B/en unknown
- 2004-02-16 HR HR20040151A patent/HRP20040151A2/hr not_active Application Discontinuation
- 2004-02-27 EC EC2004004992A patent/ECSP044992A/es unknown
- 2004-03-26 NO NO20041293A patent/NO330521B1/no not_active IP Right Cessation
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2006
- 2006-01-03 HK HK06100008.4A patent/HK1080073B/zh not_active IP Right Cessation
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