PE20030416A1 - 1,8-naftiridin-4(1h)-onas alquin aril sustituidas como inhibidores de fosfodiesterasa-4 - Google Patents

1,8-naftiridin-4(1h)-onas alquin aril sustituidas como inhibidores de fosfodiesterasa-4

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Publication number
PE20030416A1
PE20030416A1 PE2002000819A PE2002000819A PE20030416A1 PE 20030416 A1 PE20030416 A1 PE 20030416A1 PE 2002000819 A PE2002000819 A PE 2002000819A PE 2002000819 A PE2002000819 A PE 2002000819A PE 20030416 A1 PE20030416 A1 PE 20030416A1
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Peru
Prior art keywords
alkyl
phenyl
naphthyridin
pyridinyletinyl
ona
Prior art date
Application number
PE2002000819A
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English (en)
Inventor
Richard Friesen
Mario Girard
Sebastien Laliberte
Pierre Hamel
Daniel Guay
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Merck Frosst Canada Ltd
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Publication date
Application filed by Merck Frosst Canada Ltd filed Critical Merck Frosst Canada Ltd
Publication of PE20030416A1 publication Critical patent/PE20030416A1/es

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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Abstract

SE REFIERE A 1,8-NAFTIRIDIN-4(1H)-ONAS ALQUIN ARIL SUSTITUIDAS DE FORMULA I, DONDE R ES H, ALQUILO C1-C6, CICLOALQUILO C3-C6; R1 ES H, ALQUILO C1-C6, CICLOALQUILO C3-C6, ALCOXI C1-C6, ALQUENILO C2-C6, ENTRE OTROS; R2 ESTA AUSENTE, H, HALOGENO, ALQUILO C1-C6, CICLOALQUILO C3-C6, FENILO, HETEROARILO, ENTRE OTROS; R3 ESTA AUSENTE, H, OH, N-(ALQUIL C0-C6)(ALQUILO C0-C6), HALOGENO, ENTRE OTROS; R4, R5, R6, R7 SON H, HALOGENO, ALQUILO C1-C6-ALCOXI C1-C6, SOn(ALQUILO C1-C6), NITRO, CN, ENTRE OTROS; R8 ES FENILO, PIRIDILO, PIRIMIDILO, INDOLILO, QUINOLILO, TIENILO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS N-ISOPROPIL-1-[3-(2-PIRIDINILETINIL)FENIL]-1,4-DIHIDRO[1,8]NAFTIRIDIN-4-ONA-3-CARBOXAMIDA; N-CICLOPROPIL-1-[3-(3-PIRIDINILETINIL)FENIL]-1,4-DIHIDRO[1,8]NAFTIRIDIN-4-ONA-3-CARBOXAMIDA; N-ISOPROPIL-1-[3-(3-PIRIDINILOETINIL)FENIL]-1,4-DIHIDRO[1,8]NAFTIRIDIN-4-ONA-3-CARBOXAMIDA; ENTRE OTROS. LA COMPOSICION QUE COMPRENDE ADEMAS UN ANTAGONISTA DEL RECEPTOR DE LEUCOTRIENO, INHIBIDOR DE SINTESIS DE LEUCOTRIENO, ANTAGONISTA DE M2/M3, CORTICOSTEROIDE, ANTAGONISTA DE RECEPTOR H1, AGONISTA DE RECEPTOR BETA-2-ADRENERGICO, INHIBIDOR COX2, ESTATINA, FAINE. LOS COMPUESTOS SON INHIBIDORES DE FOSFODIESTERASA 4 Y PUEDEN SER UTILES PARA TRATAMIENTO DE ASMA, BRONQUITIS CRONICA, ENFERMEDAD PULMONAR OBSTRUCTIVA CRONICA, SINDROME DISNEICO AGUDO DEL ADULTO, TOS, ENFERMEDAD PULMONAR OBSTRUCTIVA CRONICA, RINITIS ALERGICA, DEPRESION
PE2002000819A 2001-08-29 2002-08-26 1,8-naftiridin-4(1h)-onas alquin aril sustituidas como inhibidores de fosfodiesterasa-4 PE20030416A1 (es)

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US31609301P 2001-08-29 2001-08-29

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PE20030416A1 true PE20030416A1 (es) 2003-05-15

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US (2) US6743802B2 (es)
EP (2) EP1436290B8 (es)
JP (1) JP4157035B2 (es)
KR (1) KR100928849B1 (es)
CN (1) CN100338061C (es)
AR (1) AR036365A1 (es)
AU (1) AU2002322940B2 (es)
BR (1) BR0212042A (es)
CA (1) CA2456817C (es)
DO (1) DOP2002000456A (es)
EA (1) EA006800B1 (es)
EC (1) ECSP044992A (es)
GE (1) GEP20063805B (es)
HK (1) HK1080073B (es)
HR (1) HRP20040151A2 (es)
HU (1) HUP0401729A3 (es)
IL (1) IL160213A0 (es)
IS (1) IS7138A (es)
JO (1) JO2311B1 (es)
MX (1) MXPA04001889A (es)
NO (1) NO330521B1 (es)
NZ (1) NZ530931A (es)
PE (1) PE20030416A1 (es)
PL (1) PL367716A1 (es)
RS (1) RS17004A (es)
UA (1) UA75957C2 (es)
WO (1) WO2003018579A1 (es)
ZA (1) ZA200400952B (es)

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