ZA200400952B - Alkyne-aryl phosphodiesterase-4 inhibitors. - Google Patents
Alkyne-aryl phosphodiesterase-4 inhibitors. Download PDFInfo
- Publication number
- ZA200400952B ZA200400952B ZA200400952A ZA200400952A ZA200400952B ZA 200400952 B ZA200400952 B ZA 200400952B ZA 200400952 A ZA200400952 A ZA 200400952A ZA 200400952 A ZA200400952 A ZA 200400952A ZA 200400952 B ZA200400952 B ZA 200400952B
- Authority
- ZA
- South Africa
- Prior art keywords
- 6alkyl
- phenyl
- carboxamide
- naphthyridin
- dihydro
- Prior art date
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- Physical Education & Sports Medicine (AREA)
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- Oncology (AREA)
- Communicable Diseases (AREA)
- Psychiatry (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
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- Virology (AREA)
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- Toxicology (AREA)
- Ophthalmology & Optometry (AREA)
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Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
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| US31609301P | 2001-08-29 | 2001-08-29 |
Publications (1)
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|---|---|
| ZA200400952B true ZA200400952B (en) | 2004-10-22 |
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| ZA200400952A ZA200400952B (en) | 2001-08-29 | 2004-02-05 | Alkyne-aryl phosphodiesterase-4 inhibitors. |
Country Status (28)
| Country | Link |
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| US (2) | US6743802B2 (fr) |
| EP (2) | EP2305677A1 (fr) |
| JP (1) | JP4157035B2 (fr) |
| KR (1) | KR100928849B1 (fr) |
| CN (1) | CN100338061C (fr) |
| AR (1) | AR036365A1 (fr) |
| AU (1) | AU2002322940B2 (fr) |
| BR (1) | BR0212042A (fr) |
| CA (1) | CA2456817C (fr) |
| DO (1) | DOP2002000456A (fr) |
| EA (1) | EA006800B1 (fr) |
| EC (1) | ECSP044992A (fr) |
| GE (1) | GEP20063805B (fr) |
| HK (1) | HK1080073B (fr) |
| HR (1) | HRP20040151A2 (fr) |
| HU (1) | HUP0401729A3 (fr) |
| IL (1) | IL160213A0 (fr) |
| IS (1) | IS7138A (fr) |
| JO (1) | JO2311B1 (fr) |
| MX (1) | MXPA04001889A (fr) |
| NO (1) | NO330521B1 (fr) |
| NZ (1) | NZ530931A (fr) |
| PE (1) | PE20030416A1 (fr) |
| PL (1) | PL367716A1 (fr) |
| RS (1) | RS17004A (fr) |
| UA (1) | UA75957C2 (fr) |
| WO (1) | WO2003018579A1 (fr) |
| ZA (1) | ZA200400952B (fr) |
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| JO2311B1 (en) * | 2001-08-29 | 2005-09-12 | ميرك فروست كندا ليمتد | Alkyl inhibitors Ariel phosphodiesterase-4 |
| US7351719B2 (en) | 2002-10-31 | 2008-04-01 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Amide compounds having MCH-antagonistic activity and medicaments comprising these compounds |
| DE10250708A1 (de) * | 2002-10-31 | 2004-05-19 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Alkin-Verbindungen mit MCH-antagonistischer Wirkung und diese Verbindungen enthaltende Arzneimittel |
| US7452911B2 (en) | 2002-10-31 | 2008-11-18 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Alkyne compounds with MCH antagonistic activity and medicaments comprising these compounds |
| US20060069115A1 (en) * | 2002-11-15 | 2006-03-30 | Scolnick Edward M | Use of pde4 inhibitors as adjunct therapy for psychiatric disorders |
| WO2004047836A1 (fr) * | 2002-11-22 | 2004-06-10 | Merck Frosst Canada & Co. | Inhibiteurs de phosphodiesterase-4 nootropes |
| AR042194A1 (es) * | 2002-11-22 | 2005-06-15 | Merck & Co Inc | Metodo para preparar inhibidores de fosfodiesterasa - 4 |
| GB0307863D0 (en) * | 2003-04-04 | 2003-05-14 | Merck Sharp & Dohme | Therapeutic treatment |
| GB0322722D0 (en) * | 2003-09-27 | 2003-10-29 | Glaxo Group Ltd | Compounds |
| GB0322726D0 (en) * | 2003-09-27 | 2003-10-29 | Glaxo Group Ltd | Compounds |
| US7592373B2 (en) | 2003-12-23 | 2009-09-22 | Boehringer Ingelheim International Gmbh | Amide compounds with MCH antagonistic activity and medicaments comprising these compounds |
| US7524862B2 (en) | 2004-04-14 | 2009-04-28 | Boehringer Ingelheim International Gmbh | Alkyne compounds with MCH antagonistic activity and medicaments comprising these compounds |
| DE102004017934A1 (de) | 2004-04-14 | 2005-11-03 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Alkin-Verbindungen mit MCH-antagonistischer Wirkung und diese Verbindungen enthaltende Arzneimittel |
| DE102004017930A1 (de) * | 2004-04-14 | 2005-11-03 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Alkin-Verbindungen mit MCH-antagonistischer Wirkung und diese Verbindungen enthaltende Arzneimittel |
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| JP4264388B2 (ja) * | 2004-07-01 | 2009-05-13 | 富士通株式会社 | 半導体チップの接合方法および接合装置 |
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| JP2006016407A (ja) * | 2005-06-15 | 2006-01-19 | Yamaha Motor Co Ltd | ホスホジエステラーゼ阻害剤 |
| EP2258358A3 (fr) | 2005-08-26 | 2011-09-07 | Braincells, Inc. | Neurogenèse avec un inhibiteur de l'acetylcholinestérase |
| CA2620333A1 (fr) | 2005-08-26 | 2007-03-01 | Braincells, Inc. | Neurogenese par modulation du recepteur muscarinique |
| EP1931338A4 (fr) * | 2005-09-28 | 2009-05-27 | Merck Frosst Canada Inc | Formulation de poudre aerosol comprenant un lactose tamise |
| EP1940389A2 (fr) | 2005-10-21 | 2008-07-09 | Braincells, Inc. | Modulation de la neurogenese par inhibition de la pde |
| WO2007053596A1 (fr) | 2005-10-31 | 2007-05-10 | Braincells, Inc. | Modulation de la neurogenese dont la mediation est assuree par recepteur gaba |
| WO2007070319A2 (fr) * | 2005-12-13 | 2007-06-21 | Wyeth | Derives de dibenzonaphtyridine et leurs procedes d'utilisation |
| US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
| EP2026813A2 (fr) | 2006-05-09 | 2009-02-25 | Braincells, Inc. | Neurogenèse induite par le récepteur 5ht |
| CA2651813A1 (fr) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | Neurogenese par modulation de l'angiotensine |
| EP2068872A1 (fr) | 2006-09-08 | 2009-06-17 | Braincells, Inc. | Combinaisons contenant un dérivé de 4-acylaminopyridine |
| US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
| US20100204230A1 (en) | 2007-02-12 | 2010-08-12 | Peter Blurton | Piperazine derivatives for treatment of ad and related conditions |
| US20090182035A1 (en) * | 2007-04-11 | 2009-07-16 | Alcon Research, Ltd. | Use of a combination of olopatadine and cilomilast to treat non-infectious rhinitis and allergic conjunctivitis |
| WO2008127975A2 (fr) * | 2007-04-11 | 2008-10-23 | Alcon Research, Ltd. | Utilisation d'un inhibiteur de tnfa et d'une anti-histamine pour traiter la rhinite allergique et la conjonctivite allergique |
| WO2008156721A1 (fr) | 2007-06-20 | 2008-12-24 | Merck & Co., Inc. | Alcanes diphényl-substitués |
| RU2470639C2 (ru) * | 2007-10-25 | 2012-12-27 | Мерк Фросст Кэнада Лтд. | Композиции для ингаляции, содержащие кислоту монтелукаст и ингибитор pde-4 или ингаляционный кортикостероид |
| EP2291181B9 (fr) | 2008-04-18 | 2013-09-11 | University College Dublin National University Of Ireland, Dublin | Utilisation de la captodiamine pour le traitement des symptômes de la dépression |
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| GB9212673D0 (en) | 1992-06-15 | 1992-07-29 | Celltech Ltd | Chemical compounds |
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| EP0765867A1 (fr) | 1995-09-27 | 1997-04-02 | Hoechst Aktiengesellschaft | Benzoylguanidines substituées, procédé de leur préparation, leur utilisation comme agent antiarythmique ou diagnostique ainsi que le médicament les contenant |
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2002
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- 2002-08-23 US US10/226,980 patent/US6743802B2/en not_active Expired - Lifetime
- 2002-08-26 PE PE2002000819A patent/PE20030416A1/es not_active Application Discontinuation
- 2002-08-27 KR KR1020047002912A patent/KR100928849B1/ko not_active IP Right Cessation
- 2002-08-27 US US10/487,047 patent/US20050070569A1/en not_active Abandoned
- 2002-08-27 MX MXPA04001889A patent/MXPA04001889A/es active IP Right Grant
- 2002-08-27 EA EA200400361A patent/EA006800B1/ru not_active IP Right Cessation
- 2002-08-27 IL IL16021302A patent/IL160213A0/xx unknown
- 2002-08-27 AR ARP020103210A patent/AR036365A1/es not_active Application Discontinuation
- 2002-08-27 UA UA2004032266A patent/UA75957C2/uk unknown
- 2002-08-27 HU HU0401729A patent/HUP0401729A3/hu unknown
- 2002-08-27 AU AU2002322940A patent/AU2002322940B2/en not_active Ceased
- 2002-08-27 NZ NZ530931A patent/NZ530931A/en not_active IP Right Cessation
- 2002-08-27 GE GE5495A patent/GEP20063805B/en unknown
- 2002-08-27 CN CNB028213270A patent/CN100338061C/zh not_active Expired - Fee Related
- 2002-08-27 EP EP10191086A patent/EP2305677A1/fr not_active Withdrawn
- 2002-08-27 BR BR0212042-9A patent/BR0212042A/pt not_active Application Discontinuation
- 2002-08-27 WO PCT/CA2002/001324 patent/WO2003018579A1/fr active IP Right Grant
- 2002-08-27 RS YUP-170/04A patent/RS17004A/sr unknown
- 2002-08-27 PL PL02367716A patent/PL367716A1/xx not_active Application Discontinuation
- 2002-08-27 EP EP02754079.8A patent/EP1436290B8/fr not_active Expired - Lifetime
- 2002-08-27 JP JP2003523241A patent/JP4157035B2/ja not_active Expired - Fee Related
- 2002-08-27 CA CA2456817A patent/CA2456817C/fr not_active Expired - Fee Related
- 2002-08-29 DO DO2002000456A patent/DOP2002000456A/es unknown
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- 2004-01-30 IS IS7138A patent/IS7138A/is unknown
- 2004-02-05 ZA ZA200400952A patent/ZA200400952B/en unknown
- 2004-02-16 HR HR20040151A patent/HRP20040151A2/hr not_active Application Discontinuation
- 2004-02-27 EC EC2004004992A patent/ECSP044992A/es unknown
- 2004-03-26 NO NO20041293A patent/NO330521B1/no not_active IP Right Cessation
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