UA75907C2 - Androgenic 7-substituted-11-halogenated steroids - Google Patents

Androgenic 7-substituted-11-halogenated steroids Download PDF

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Publication number
UA75907C2
UA75907C2 UA2003087912A UA2003087912A UA75907C2 UA 75907 C2 UA75907 C2 UA 75907C2 UA 2003087912 A UA2003087912 A UA 2003087912A UA 2003087912 A UA2003087912 A UA 2003087912A UA 75907 C2 UA75907 C2 UA 75907C2
Authority
UA
Ukraine
Prior art keywords
group
halogenosteroids
methylestr
fluoro
groups
Prior art date
Application number
UA2003087912A
Other languages
English (en)
Ukrainian (uk)
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of UA75907C2 publication Critical patent/UA75907C2/uk

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J1/00Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J1/00Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051Estrane derivatives
    • C07J1/0066Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
    • C07J1/007Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • C07J1/0074Esters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10Drugs for genital or sexual disorders; Contraceptives for impotence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/16Masculine contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/24Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/26Androgens
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J1/00Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003Androstane derivatives
    • C07J1/0018Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa
    • C07J1/0022Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J1/00Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003Androstane derivatives
    • C07J1/0018Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa
    • C07J1/0022Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • C07J1/0025Esters
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J1/00Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051Estrane derivatives
    • C07J1/0066Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
    • C07J1/007Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Endocrinology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Gynecology & Obstetrics (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
UA2003087912A 2001-01-24 2002-01-24 Androgenic 7-substituted-11-halogenated steroids UA75907C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10104327A DE10104327A1 (de) 2001-01-24 2001-01-24 11beta-Halogensteroide, deren Herstellung und Verwendung zur Herstellung von Arzneimitteln sowie 11beta-Halogensteroide enthaltende pharmazeutische Präparate
PCT/EP2002/000722 WO2002059139A1 (en) 2001-01-24 2002-01-24 Androgenic 7-substituted 11-halogen steroids

Publications (1)

Publication Number Publication Date
UA75907C2 true UA75907C2 (en) 2006-06-15

Family

ID=7672351

Family Applications (1)

Application Number Title Priority Date Filing Date
UA2003087912A UA75907C2 (en) 2001-01-24 2002-01-24 Androgenic 7-substituted-11-halogenated steroids

Country Status (34)

Country Link
US (1) US7361645B2 (cs)
EP (1) EP1353938B1 (cs)
JP (1) JP4339591B2 (cs)
KR (1) KR100728088B1 (cs)
CN (1) CN1234721C (cs)
AR (1) AR053299A1 (cs)
AT (1) ATE386045T1 (cs)
AU (1) AU2002238516B2 (cs)
BG (1) BG66133B1 (cs)
BR (1) BR0206653A (cs)
CA (1) CA2434187C (cs)
CY (1) CY1110377T1 (cs)
CZ (1) CZ303553B6 (cs)
DE (2) DE10104327A1 (cs)
DK (1) DK1353938T3 (cs)
EA (1) EA006674B1 (cs)
EE (1) EE05274B1 (cs)
ES (1) ES2300431T3 (cs)
HR (1) HRP20030661B1 (cs)
HU (1) HUP0303020A3 (cs)
IL (2) IL156807A0 (cs)
MX (1) MXPA03006578A (cs)
NO (1) NO325754B1 (cs)
NZ (1) NZ527041A (cs)
PE (1) PE20020848A1 (cs)
PL (1) PL207582B1 (cs)
PT (1) PT1353938E (cs)
RS (1) RS50740B (cs)
SK (1) SK287444B6 (cs)
TW (1) TWI333494B (cs)
UA (1) UA75907C2 (cs)
UY (1) UY27133A1 (cs)
WO (1) WO2002059139A1 (cs)
ZA (1) ZA200306537B (cs)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10234525A1 (de) * 2002-07-25 2004-02-05 Schering Ag Zusammensetzung, enthaltend ein androgenes 11ß-Halogensteroid und ein Gestagen sowie männliches Kontrazeptivum auf Basis dieser Zusammensetzung
CA2492079C (en) * 2002-07-24 2012-01-10 Schering Aktiengesellschaft Microbiological processes for the production of 7 alpha-substituted 11 alpha-hydroxy steroids
DE10233723A1 (de) 2002-07-24 2004-02-12 Schering Ag Mikrobiologische Verfahren zur Herstellung von 7α-substituierten 11α-Hydroxysteroiden, daraus herstellbare 7α,17α-substituierte 11β-Halogensteroide, deren Herstellungsverfahren und Verwendung sowie pharmazeutische Präparate, die diese Verbindungen enthalten, sowie daraus herstellbare 7α-substituierte Estra-1,3,5(10)-triene
WO2004011008A1 (de) * 2002-07-25 2004-02-05 Schering Aktiengesellschaft ZUSAMMENSETZUNG, ENTHALTEND EIN ANDROGENES 11β-HALOGENSTEROID UND EIN GESTAGEN SOWIE MÄNNLICHES KONTRAZEPTIVUM AUF BASIS DIESER ZUSAMMENSETZUNG
US7879357B2 (en) * 2003-04-28 2011-02-01 Bayer Schering Pharma Ag Pharmaceutical composition in the form of a hydrogel for transdermal administration of active ingredients
JO2492B1 (en) * 2003-04-28 2009-10-05 شيرينج ايه جي A pharmaceutical formula in the form of aqueous gel for the skin use of its active ingredients
CN106188203B (zh) * 2014-10-08 2017-10-24 常州大学 一种可提高睾酮的收率及大幅减少杂质的合成睾酮方法
TWI530504B (zh) * 2014-12-01 2016-04-21 臺灣永光化學工業股份有限公司 烷基酸睾酮化合物之合成方法
US12410209B2 (en) * 2021-06-29 2025-09-09 Board Of Regents, The University Of Texas System Modified glucocorticoids

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB863661A (en) 1958-06-06 1961-03-22 Upjohn Co Improvements in or relating to steroids and the manufacture thereof
CH380118A (de) * 1959-06-17 1964-07-31 Ciba Geigy Neue Halogenandrostenverbindungen und Verfahren zu deren Herstellung
GB1159434A (en) * 1965-08-16 1969-07-23 Glaxo Lab Ltd 11beta&;-Fluoro-19-nor-Steroids
FR1489519A (fr) 1965-08-16 1967-07-21 Glaxo Lab Ltd Procédé de préparation de nouveaux 19-nor-stéroïdes et produits obtenus
US3665021A (en) * 1966-07-29 1972-05-23 Glaxo Lab Ltd 9alpha-unsubstituted-11beta-chloro-l9 nos-steroids
GB1260463A (en) 1968-01-29 1972-01-19 Glaxo Lab Ltd 11beta-BROMO-19-NOR-STEROIDS
DE2410442A1 (de) 1974-03-01 1975-09-11 Schering Ag Verfahren zur herstellung von 11-fluorandrostenen
DE2410443A1 (de) * 1974-03-01 1975-09-11 Schering Ag 11beta-fluor-androstene
DE3214690A1 (de) * 1982-04-16 1983-10-27 Schering AG, 1000 Berlin und 4709 Bergkamen 11ss-chlor-(delta)(pfeil hoch)1(pfeil hoch)(pfeil hoch)5(pfeil hoch)-steroide, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
GB8721384D0 (en) * 1987-09-11 1987-10-21 Erba Farmitalia 17-substituted andro-sta-1 4-dien-3-one derivatives
US5342834A (en) * 1989-04-07 1994-08-30 The Population Council, Inc. Method for androgen supplementation
US20020012694A1 (en) * 1997-09-17 2002-01-31 Alfred J. Moo-Young Transdermal administration of ment
US6767902B2 (en) * 1997-09-17 2004-07-27 The Population Council, Inc. Androgen as a male contraceptive and non-contraceptive androgen replacement
US5952319A (en) * 1997-11-26 1999-09-14 Research Triangle Institute Androgenic steroid compounds and a method of making and using the same
EP1163259B1 (en) * 1999-03-08 2002-11-20 Akzo Nobel N.V. 14.beta.,17-alpha-hydroxymethylandrostane derivatives as androgens
ES2204613T3 (es) * 1999-04-06 2004-05-01 Akzo Nobel N.V. Androgenos 7-alfa alquilo oralmente activos.
DE19959696A1 (de) * 1999-12-08 2001-06-21 Jenapharm Gmbh Ungesättigte 14,15-Cyclopropano-Androstane, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen

Also Published As

Publication number Publication date
BR0206653A (pt) 2004-02-03
SK9542003A3 (en) 2003-12-02
JP4339591B2 (ja) 2009-10-07
DK1353938T3 (da) 2008-05-26
EP1353938A1 (en) 2003-10-22
KR100728088B1 (ko) 2007-06-14
EP1353938B1 (en) 2008-02-13
NO20033321L (no) 2003-09-24
CZ303553B6 (cs) 2012-12-05
HK1064678A1 (en) 2005-02-04
DE60224982T2 (de) 2009-04-09
ES2300431T3 (es) 2008-06-16
EE05274B1 (et) 2010-02-15
PL207582B1 (pl) 2011-01-31
BG66133B1 (bg) 2011-06-30
JP2004517153A (ja) 2004-06-10
RS50740B (sr) 2010-08-31
ZA200306537B (en) 2004-09-08
HUP0303020A2 (hu) 2003-12-29
NO325754B1 (no) 2008-07-14
AR053299A1 (es) 2007-05-02
KR20030081391A (ko) 2003-10-17
EA200300756A1 (ru) 2004-02-26
CN1487950A (zh) 2004-04-07
DE60224982D1 (de) 2008-03-27
US20050075322A1 (en) 2005-04-07
CN1234721C (zh) 2006-01-04
HUP0303020A3 (en) 2012-03-28
ATE386045T1 (de) 2008-03-15
PE20020848A1 (es) 2002-10-26
EA006674B1 (ru) 2006-02-24
MXPA03006578A (es) 2003-09-22
EE200300346A (et) 2003-12-15
CA2434187C (en) 2009-06-16
PT1353938E (pt) 2008-04-29
NO20033321D0 (no) 2003-07-23
CA2434187A1 (en) 2002-08-01
TWI333494B (en) 2010-11-21
UY27133A1 (es) 2002-07-31
NZ527041A (en) 2005-02-25
IL156807A0 (en) 2004-02-08
AU2002238516B2 (en) 2007-08-23
US7361645B2 (en) 2008-04-22
PL361730A1 (en) 2004-10-04
IL156807A (en) 2008-08-07
BG108023A (bg) 2004-02-27
CZ20032006A3 (cs) 2004-01-14
HRP20030661A2 (en) 2005-06-30
HRP20030661B1 (en) 2011-10-31
WO2002059139A1 (en) 2002-08-01
CY1110377T1 (el) 2015-04-29
SK287444B6 (sk) 2010-09-07
DE10104327A1 (de) 2002-07-25
YU59403A (sh) 2006-08-17

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