UA74826C2 - ?-carboline derivatives as phosphodiesterase inhibitors - Google Patents
?-carboline derivatives as phosphodiesterase inhibitors Download PDFInfo
- Publication number
- UA74826C2 UA74826C2 UA2002119179A UA2002119179A UA74826C2 UA 74826 C2 UA74826 C2 UA 74826C2 UA 2002119179 A UA2002119179 A UA 2002119179A UA 2002119179 A UA2002119179 A UA 2002119179A UA 74826 C2 UA74826 C2 UA 74826C2
- Authority
- UA
- Ukraine
- Prior art keywords
- group
- phenyl
- nitro
- furyl
- substituted
- Prior art date
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- 239000002571 phosphodiesterase inhibitor Substances 0.000 title abstract description 5
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- 238000011282 treatment Methods 0.000 claims abstract description 40
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- 238000000034 method Methods 0.000 claims description 47
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- 229910052736 halogen Inorganic materials 0.000 claims description 26
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- 125000000217 alkyl group Chemical group 0.000 claims description 17
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Classifications
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20466700P | 2000-05-17 | 2000-05-17 | |
| PCT/US2001/014357 WO2001087038A2 (en) | 2000-05-17 | 2001-05-03 | β-CARBOLINE DERIVATIVES USEFUL AS INHIBITORS OF PHOSPHODIESTERASE |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA74826C2 true UA74826C2 (en) | 2006-02-15 |
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| Application Number | Title | Priority Date | Filing Date |
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| UA2002119179A UA74826C2 (en) | 2000-05-17 | 2001-03-05 | ?-carboline derivatives as phosphodiesterase inhibitors |
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| EP (1) | EP1289985B1 (no) |
| JP (1) | JP5014551B2 (no) |
| KR (1) | KR20030031482A (no) |
| CN (1) | CN1255403C (no) |
| AR (1) | AR028576A1 (no) |
| AT (1) | ATE256127T1 (no) |
| AU (2) | AU2001261167B2 (no) |
| BG (1) | BG66141B1 (no) |
| CA (1) | CA2409715C (no) |
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| DK (1) | DK1289985T3 (no) |
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| HK (1) | HK1051368A1 (no) |
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| HU (1) | HUP0302412A3 (no) |
| IL (2) | IL152873A0 (no) |
| MX (1) | MXPA02011426A (no) |
| MY (1) | MY128479A (no) |
| NO (1) | NO324251B1 (no) |
| NZ (1) | NZ522731A (no) |
| PL (1) | PL205507B1 (no) |
| PT (1) | PT1289985E (no) |
| RU (1) | RU2271358C2 (no) |
| SK (1) | SK16972002A3 (no) |
| TR (1) | TR200302309T4 (no) |
| TW (1) | TWI286553B (no) |
| UA (1) | UA74826C2 (no) |
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| ZA (1) | ZA200210111B (no) |
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| US6987115B2 (en) * | 2000-12-08 | 2006-01-17 | Smithkline Beecham Corporation | Antibacterial compounds |
| US6900220B2 (en) * | 2001-01-02 | 2005-05-31 | Syntex (U.S.A.) Llc | Quinazolone derivatives as alpha 1A/B adrenergic receptor antagonists |
| DE60216233T2 (de) * | 2001-02-12 | 2007-09-27 | Lilly Icos Llc, Wilmington | Carbolinderivate |
| DE60112974T2 (de) * | 2001-02-12 | 2006-02-16 | Lilly Icos Llc, Wilmington | Carbolinderivate |
| US7115621B2 (en) * | 2001-04-25 | 2006-10-03 | Lilly Icos Llc | Chemical compounds |
| CA2445460A1 (en) | 2001-06-05 | 2002-12-12 | Lilly Icos Llc | Carboline derivatives as pde-5 inhibitors |
| ES2269679T3 (es) * | 2001-06-21 | 2007-04-01 | Lilly Icos Llc | Derivados de carbolina como inhibidores de pdev. |
| JP4484517B2 (ja) | 2001-11-14 | 2010-06-16 | オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド | ホスホジエステラーゼ阻害剤として有用な置換された四環式ピロロキノロン誘導体 |
| WO2003065992A2 (en) * | 2002-02-07 | 2003-08-14 | Gtx, Inc. | Treating benign prostate hyperplasia with sarms |
| DE60317684D1 (de) * | 2002-06-19 | 2008-01-03 | Janssen Pharmaceutica Nv | SUBSTITUIERTE 2,4-DIHYDROPYRROLOc3,4BÜCHINOLIN-9-ONDERIVATE, DIE SICH ALS PHOSPHODIESTERASEINHIBITOREN EIGNEN |
| EP1637521B1 (en) * | 2003-06-23 | 2013-06-19 | Ono Pharmaceutical Co., Ltd. | Novel tricyclic heterocycle compound |
| BRPI0506977A (pt) | 2004-01-23 | 2007-07-03 | Chiron Corp | composto de tetrahidrocarbolina como agentes anticáncer |
| US7767689B2 (en) | 2004-03-15 | 2010-08-03 | Ptc Therapeutics, Inc. | Carboline derivatives useful in the treatment of cancer |
| US8076352B2 (en) | 2004-03-15 | 2011-12-13 | Ptc Therapeutics, Inc. | Administration of carboline derivatives useful in the treatment of cancer and other diseases |
| CN102408425A (zh) | 2004-03-15 | 2012-04-11 | Ptc医疗公司 | 用于抑制血管生成的咔啉衍生物及其应用 |
| US8076353B2 (en) | 2004-03-15 | 2011-12-13 | Ptc Therapeutics, Inc. | Inhibition of VEGF translation |
| AR051780A1 (es) * | 2004-11-29 | 2007-02-07 | Japan Tobacco Inc | Compuestos en anillo fusionados que contienen nitrogeno y utilizacion de los mismos |
| DK1829874T3 (da) | 2004-12-22 | 2014-05-12 | Ono Pharmaceutical Co | Tricyklisk forbindelse og anvendelse deraf |
| GB2422828A (en) * | 2005-02-03 | 2006-08-09 | Hunter Fleming Ltd | Tricyclic cytoprotective compounds comprising an indole residue |
| CA2616366A1 (en) * | 2005-07-29 | 2007-02-08 | Concert Pharmaceuticals Inc. | Novel pharmaceutical compounds |
| US7678363B2 (en) | 2005-08-26 | 2010-03-16 | Braincells Inc | Methods of treating psychiatric conditions comprising administration of muscarinic agents in combination with SSRIs |
| EP2258358A3 (en) | 2005-08-26 | 2011-09-07 | Braincells, Inc. | Neurogenesis with acetylcholinesterase inhibitor |
| EP1940389A2 (en) | 2005-10-21 | 2008-07-09 | Braincells, Inc. | Modulation of neurogenesis by pde inhibition |
| US20070112017A1 (en) | 2005-10-31 | 2007-05-17 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
| US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
| AU2007249399A1 (en) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
| MX2008014320A (es) | 2006-05-09 | 2009-03-25 | Braincells Inc | Neurogenesis mediada por el receptor de 5-hidroxitriptamina. |
| JP2010502722A (ja) * | 2006-09-08 | 2010-01-28 | ブレインセルス，インコーポレイティド | ４−アシルアミノピリジン誘導体を含む組み合わせ |
| US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
| EP2178537A4 (en) * | 2007-07-19 | 2011-08-17 | Merck Sharp & Dohme | BETA-CARBOLIN DERIVATIVES AS ANTIDIBLE COMPOUNDS |
| EP2225250A2 (en) | 2007-11-30 | 2010-09-08 | Biota Scientific Management Pty Ltd | Bicyclic ppat inhibitors as antibacterial agents |
| MX2010007430A (es) | 2008-01-11 | 2010-12-21 | Albany Molecular Res Inc | Piridoindoles (1-azinona)-sustituidos como antagonistas de la hormona de concentracion melanina humana. |
| WO2009120717A2 (en) | 2008-03-24 | 2009-10-01 | Medivation Technologies, Inc. | Pyrido [3, 4-b] indoles and methods of use |
| MD4009C2 (ro) * | 2008-07-15 | 2010-08-31 | Институт Химии Академии Наук Молдовы | Utilizarea 1-metil-4-(N-metilaminobutil-4)-β-carbolinei în calitate de remediu antituberculos |
| WO2010099217A1 (en) | 2009-02-25 | 2010-09-02 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
| WO2010107485A1 (en) * | 2009-03-17 | 2010-09-23 | The Trustees Of Columbia University In The City Of New York | E3 ligase inhibitors |
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| WO2011003007A1 (en) | 2009-07-01 | 2011-01-06 | Albany Molecular Research, Inc. | Azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine mch-1 antagonists, methods of making, and use thereof |
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| RU2572818C2 (ru) | 2010-07-06 | 2016-01-20 | Оно Фармасьютикал Ко., Лтд. | Производное тетрагидрокарболина |
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| US20150119399A1 (en) | 2012-01-10 | 2015-04-30 | President And Fellows Of Harvard College | Beta-cell replication promoting compounds and methods of their use |
| US10092574B2 (en) | 2012-09-26 | 2018-10-09 | Valorisation-Recherche, Limited Partnership | Inhibitors of polynucleotide repeat-associated RNA foci and uses thereof |
| WO2017168174A1 (en) | 2016-04-02 | 2017-10-05 | N4 Pharma Uk Limited | New pharmaceutical forms of sildenafil |
| CN107216327A (zh) * | 2017-06-27 | 2017-09-29 | 山东大学 | 5型磷酸二酯酶抑制剂及其制备方法和用途 |
| US20220402914A1 (en) * | 2019-09-03 | 2022-12-22 | The Regents Of The University Of Colorado, A Body Corporate | Tryptoline-Based Benzothiazoles and their use as Antibiotics and Antibiotic Resistance-Modifying Agents |
| EP4011877A3 (en) * | 2020-12-11 | 2023-01-11 | Institut de Cardiologie de Montréal | Method of treating elevated plasma cholesterol |
| WO2022140744A1 (en) | 2020-12-23 | 2022-06-30 | Recurium Ip Holdings, Llc | Estrogen receptor modulators |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1055203A (en) | 1964-09-16 | 1967-01-18 | Ici Ltd | -ß-carboline derivatives, a process for their manufacture, and compositions containing them |
| US4228168A (en) | 1978-11-22 | 1980-10-14 | Tanabe Seiyaku Co., Ltd. | Azepino [1,2,3-lm]-β-carboline compounds and pharmaceutical composition thereof |
| NZ194747A (en) | 1979-08-29 | 1988-11-29 | Schering Ag | 9h-pyrido(3,4-b)indol-3-ylcarboxylic acid derivatives |
| WO1988002751A1 (en) | 1986-10-13 | 1988-04-21 | Asahi Kasei Kogyo Kabushiki Kaisha | Pyridine derivatives |
| CS262100B1 (cs) * | 1987-07-17 | 1989-02-10 | Protiva Miroslav | 1-substituované 2- [ (4-methyl-l-piperazinyl)acetyl ] -2,3,4,9- -tetrahydro-lH-pyrido( 3,4-b)indoly a jejich hydrochloridy |
| DE3855147D1 (de) | 1987-07-20 | 1996-05-02 | Duphar Int Res | 8,9-Anellierte 1,2,3,4-Tetrahydro-beta-carbolin-Derivate |
| FR2619112B1 (fr) * | 1987-08-07 | 1989-11-17 | Synthelabo | Derives de (piperidinyl-4)methyl-2 benzo(b)furo(2,3-c) pyridines, leur preparation et leur application en therapeutique |
| US4971974A (en) | 1988-06-16 | 1990-11-20 | Neurex Corporation | Benzothiophenes as appetite suppressants |
| WO1990001483A1 (en) | 1988-08-11 | 1990-02-22 | Asahi Kasei Kogyo Kabushiki Kaisha | Tetrahydropyridine derivatives |
| US5250534A (en) * | 1990-06-20 | 1993-10-05 | Pfizer Inc. | Pyrazolopyrimidinone antianginal agents |
| FR2663935A1 (fr) | 1990-06-27 | 1992-01-03 | Adir | Nouveaux 1,2,3,4,5,6-hexahydroazepino [4,5-b] indoles et 1,2,3,4-tetrahydrobethacarbolines, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent. |
| GB9301192D0 (en) | 1993-06-09 | 1993-06-09 | Trott Francis W | Flower shaped mechanised table |
| GB9401090D0 (en) | 1994-01-21 | 1994-03-16 | Glaxo Lab Sa | Chemical compounds |
| US5403851A (en) | 1994-04-05 | 1995-04-04 | Interneuron Pharmaceuticals, Inc. | Substituted tryptamines, phenalkylamines and related compounds |
| DE69531476T2 (de) * | 1994-09-12 | 2004-06-09 | Lilly Industries Ltd., Basingstoke | Serotonergische Modulatoren |
| FR2724384B1 (fr) | 1994-09-14 | 1999-04-16 | Cemaf | Nouveaux derives de la 3,4-dihydro beta-carboline agonistes de la melatonine, leur procede de preparation et leur utilisation a titre de medicament |
| DE4436190A1 (de) | 1994-10-10 | 1996-04-11 | Gerhard Prof Dr Bringmann | Halogenierte ß-Carbolin-Derivate, Verfahren zu ihrer Herstellung und Verwendung dieser Substanzen zur Hemmung der Atmungskette |
| DE4436509A1 (de) | 1994-10-13 | 1996-04-18 | Hoechst Schering Agrevo Gmbh | Substituierte Spiroalkylamino- und alkoxy-Heterocyclen, Verfahren zu ihrer Herstellung und ihre Verwendung als Schädlingsbekämpfungsmittel und Fungizide |
| GB9423911D0 (en) | 1994-11-26 | 1995-01-11 | Pfizer Ltd | Therapeutic agents |
| GB9423910D0 (en) | 1994-11-26 | 1995-01-11 | Pfizer Ltd | Therapeutic agents |
| US5968910A (en) * | 1994-11-30 | 1999-10-19 | Jan M. R. Balzarini | Compositions containing two or three inhibitors of different HIV reverse transcriptases |
| GB9514464D0 (en) | 1995-07-14 | 1995-09-13 | Glaxo Lab Sa | Medicaments |
| FR2748026B1 (fr) | 1996-04-26 | 1998-06-05 | Adir | Nouveaux inhibiteurs de metalloproteases, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| BR9709230A (pt) * | 1996-05-10 | 1999-08-10 | Icos Corp | Composto |
| ATE236156T1 (de) | 1996-05-31 | 2003-04-15 | Mochida Pharm Co Ltd | Pyridocarbazol derivate die einen cgmp-pde inhibilierenden effekt haben |
| WO1998040385A1 (en) | 1997-03-07 | 1998-09-17 | Novo Nordisk A/S | 4,5,6,7-TETRAHYDRO-THIENO[3,2-c]PYRIDINE DERIVATIVES, THEIR PREPARATION AND USE |
| US6043252A (en) | 1997-05-05 | 2000-03-28 | Icos Corporation | Carboline derivatives |
| AU4919099A (en) | 1998-07-11 | 2000-02-01 | University Of Bristol, The | Compounds having activity at imidazoline receptors |
| FR2796644B1 (fr) * | 1999-07-23 | 2001-09-07 | Adir | Nouveaux derives de beta-carboline, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
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2001
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- 2001-05-02 US US09/847,767 patent/US6492358B2/en not_active Expired - Lifetime
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- 2001-05-03 AT AT01935038T patent/ATE256127T1/de active
- 2001-05-03 HU HU0302412A patent/HUP0302412A3/hu unknown
- 2001-05-03 PL PL365445A patent/PL205507B1/pl unknown
- 2001-05-03 CN CNB018128432A patent/CN1255403C/zh not_active Expired - Fee Related
- 2001-05-03 DK DK01935038T patent/DK1289985T3/da active
- 2001-05-03 WO PCT/US2001/014357 patent/WO2001087038A2/en active IP Right Grant
- 2001-05-03 KR KR1020027015581A patent/KR20030031482A/ko not_active Application Discontinuation
- 2001-05-03 AU AU6116701A patent/AU6116701A/xx active Pending
- 2001-05-03 SK SK1697-2002A patent/SK16972002A3/sk unknown
- 2001-05-03 MX MXPA02011426A patent/MXPA02011426A/es active IP Right Grant
- 2001-05-03 DE DE60101479T patent/DE60101479T2/de not_active Expired - Lifetime
- 2001-05-03 EP EP01935038A patent/EP1289985B1/en not_active Expired - Lifetime
- 2001-05-03 ES ES01935038T patent/ES2211806T3/es not_active Expired - Lifetime
- 2001-05-03 PT PT01935038T patent/PT1289985E/pt unknown
- 2001-05-03 CA CA2409715A patent/CA2409715C/en not_active Expired - Fee Related
- 2001-05-03 GE GE5003A patent/GEP20053511B/en unknown
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- 2001-05-03 NZ NZ522731A patent/NZ522731A/en not_active IP Right Cessation
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- 2001-05-03 RU RU2002133867/04A patent/RU2271358C2/ru not_active IP Right Cessation
- 2001-05-03 TR TR2003/02309T patent/TR200302309T4/xx unknown
- 2001-05-03 JP JP2001583517A patent/JP5014551B2/ja not_active Expired - Fee Related
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- 2002-11-15 IL IL152873A patent/IL152873A/en not_active IP Right Cessation
- 2002-11-15 HR HR20020910A patent/HRP20020910B1/xx not_active IP Right Cessation
- 2002-11-18 BG BG107285A patent/BG66141B1/bg unknown
- 2002-11-18 NO NO20025527A patent/NO324251B1/no not_active IP Right Cessation
- 2002-12-12 ZA ZA200210111A patent/ZA200210111B/en unknown
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