UA74813C2 - Azapolycyclic compounds condensated with aryl - Google Patents
Azapolycyclic compounds condensated with aryl Download PDFInfo
- Publication number
- UA74813C2 UA74813C2 UA2002075792A UA2002075792A UA74813C2 UA 74813 C2 UA74813 C2 UA 74813C2 UA 2002075792 A UA2002075792 A UA 2002075792A UA 2002075792 A UA2002075792 A UA 2002075792A UA 74813 C2 UA74813 C2 UA 74813C2
- Authority
- UA
- Ukraine
- Prior art keywords
- dodeca
- diazatetracyclo
- triene
- azatricyclo
- tetraene
- Prior art date
Links
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- 125000003118 aryl group Chemical group 0.000 title description 15
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Classifications
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
- C07D221/24—Camphidines
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/514,002 US6605610B1 (en) | 1997-12-31 | 2000-02-25 | Aryl fused azapolycyclic compounds |
| PCT/IB2001/000153 WO2001062736A1 (en) | 2000-02-25 | 2001-02-08 | Aryl fused azapolycyclic compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA74813C2 true UA74813C2 (en) | 2006-02-15 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UA2002075792A UA74813C2 (en) | 2000-02-25 | 2001-08-02 | Azapolycyclic compounds condensated with aryl |
Country Status (39)
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG102686A1 (en) * | 1997-12-31 | 2004-03-26 | Pfizer Prod Inc | Aryl fused azapolycyclic compounds |
| PT1383733E (pt) * | 2001-04-20 | 2008-04-15 | Pfizer Prod Inc | Processo para a preparação de indenos 1,3-substituídos e compostos azapolicíclicos fundidos com arilo |
| JP2005507411A (ja) * | 2001-10-31 | 2005-03-17 | ファイザー・プロダクツ・インク | 下肢静止不能症候群の治療における、ニコチン性アセチルコリン受容体アゴニスト。 |
| KR20040063939A (ko) * | 2001-11-30 | 2004-07-14 | 화이자 프로덕츠 인크. | 아릴 융합된 아자폴리시클릭 화합물 |
| SI1448235T1 (sl) * | 2001-11-30 | 2007-08-31 | Pfizer Prod Inc | Peroralni farmacevtski sestavki s podaljšanim sproščanjem 5,8,14-triazatetraciklo (10.3.1.0(2,11).0(4,9)) -heksadeka-2(11)3,5,7,9-pentaena |
| EP2392345A3 (en) | 2002-07-18 | 2012-03-07 | Cytos Biotechnology AG | Hapten-carrier conjugates comprising virus like particles and uses thereof |
| US7309458B2 (en) * | 2002-10-22 | 2007-12-18 | Millipore Corporation | Multi-sided immersion formation of composite structures and method |
| CN1714075A (zh) * | 2002-11-25 | 2005-12-28 | 辉瑞产品公司 | 1,3－取代的茚类的改进制备方法 |
| EP1587794A1 (en) * | 2003-01-15 | 2005-10-26 | Pfizer Products Inc. | Process for the preparation of aryl fused polycyclic lactams |
| WO2004103372A1 (en) * | 2003-05-20 | 2004-12-02 | Pfizer Products Inc. | Pharmaceutical compositions of varenicline |
| ES2310730T3 (es) * | 2003-06-04 | 2009-01-16 | Pfizer Products Inc. | Preparacion de quinoxalinas sustituidas a partir de la dianilina con 2,3-dihidroxi-1,4-dioxano. |
| EP1648872A2 (en) * | 2003-07-21 | 2006-04-26 | Pfizer Products Inc. | Aryl fused azapolycyclic compounds |
| US8580842B2 (en) | 2003-09-30 | 2013-11-12 | Abbott Gmbh & Co. Kg | Heteroaryl-substituted 1,3-dihydroindol-2-one derivatives and medicaments containing them |
| CA2541752C (en) | 2003-10-14 | 2012-01-03 | Xenoport, Inc. | Crystalline form of gamma-aminobutyric acid analog |
| CA2549638A1 (en) * | 2003-12-23 | 2005-07-14 | Pfizer Products Inc. | Therapeutic combination for cognition enhancement and psychotic disorders |
| WO2006006071A1 (en) * | 2004-07-07 | 2006-01-19 | Pfizer Products Inc. | Resolution of an aryl-fused azapolycyclic compound |
| RU2007131535A (ru) * | 2005-02-24 | 2009-03-27 | Пфайзер Продактс Инк. (Us) | Получение замещенного хиноксалина высокой чистоты |
| EP2012757A2 (en) * | 2006-04-24 | 2009-01-14 | Pfizer Products Incorporated | Asymmetric membranes for drug delivery devices |
| MX2009005043A (es) * | 2006-11-09 | 2009-05-25 | Pfizer Prod Inc | Polimorfos de intermedios nicotinicos. |
| US20080167286A1 (en) * | 2006-12-12 | 2008-07-10 | Abbott Laboratories | Pharmaceutical compositions and their methods of use |
| US8486979B2 (en) * | 2006-12-12 | 2013-07-16 | Abbvie Inc. | 1,2,4 oxadiazole compounds and methods of use thereof |
| UY30846A1 (es) | 2006-12-30 | 2008-07-31 | Abbott Gmbh & Amp | Derivados de oxindol sustituidos, medicamentos que los comprenden y uso de los mismos |
| US20090062257A1 (en) * | 2007-08-29 | 2009-03-05 | Protia, Llc | Deuterium-enriched varenicline |
| WO2009034431A2 (en) | 2007-09-10 | 2009-03-19 | Pfizer Inc. | Controlled-release dosage forms for varenicline |
| WO2009065872A2 (en) * | 2007-11-20 | 2009-05-28 | Medichem, S.A. | Improved processes for the synthesis of varenicline l-tartrate |
| US8703774B2 (en) * | 2007-12-07 | 2014-04-22 | AbbVie Deutschland GmbH & Co. KG | Carbamate-substituted oxindole derivatives and use thereof for the treatment of vasopressin-dependent diseases |
| CA2707667C (en) * | 2007-12-07 | 2016-02-23 | Abbott Gmbh & Co. Kg | Amidomethyl-substituted oxindole derivatives and the use thereof for the treatment of vasopressin-dependent illnesses |
| US8546401B2 (en) * | 2007-12-07 | 2013-10-01 | AbbVie Deutschland GmbH & Co. KG | 5,6-disubstituted oxindole-derivatives and use thereof for treating vasopressin-dependent diseases |
| MX2010006206A (es) * | 2007-12-07 | 2011-03-04 | Abbott Gmbh & Co Kg | Derivados de oxindol substituidos por 5-halogeno y el uso de los mismos para el tratamiento de enfermedades dependientes de la vasopresina. |
| US8383657B2 (en) | 2007-12-21 | 2013-02-26 | Abbott Laboratories | Thiazolylidine urea and amide derivatives and methods of use thereof |
| WO2009146031A1 (en) | 2008-03-31 | 2009-12-03 | University Of South Florida | Methods of treating disease-induced ataxia and non-ataxic imbalance |
| WO2009143347A2 (en) * | 2008-05-22 | 2009-11-26 | Teva Pharmaceutical Industries Ltd. | Varenicline tosylate, an intermediate in the preparation process of varenicline l-tartrate |
| US20090318695A1 (en) * | 2008-06-19 | 2009-12-24 | Vinod Kumar Kansal | Processes for the preparation of varenicline and intermediates thereof |
| US20100010221A1 (en) * | 2008-07-10 | 2010-01-14 | Revital Lifshitz-Liron | Processes for purifying varenicline l-tartrate salt and preparing crystalline forms of varenicline l-tartrate salt |
| US8314235B2 (en) * | 2008-09-01 | 2012-11-20 | Actavis Group Ptc Ehf | Process for preparing varenicline, varenicline intermediates, pharmaceutically acceptable salts thereof |
| EP2396327A1 (en) * | 2009-02-11 | 2011-12-21 | Sunovion Pharmaceuticals Inc. | Histamine h3 inverse agonists and antagonists and methods of use thereof |
| US9040568B2 (en) | 2009-05-29 | 2015-05-26 | Abbvie Inc. | Pharmaceutical compositions for the treatment of pain |
| US8178537B2 (en) * | 2009-06-22 | 2012-05-15 | Teva Pharmaceutical Industries Ltd. | Solid state forms of varenicline salts and processes for preparation thereof |
| EP3590498A4 (en) | 2017-03-03 | 2020-12-16 | CTC Bio, Inc. | PREPARATION WITH INCLUDING COMPLEX OF VARENICLINE OR PHARMACEUTICAL SAFE SALT THEREOF FOR ORAL ADMINISTRATION |
| US20230116114A1 (en) * | 2020-01-03 | 2023-04-13 | Blue Oak Pharmaceuticals, Inc. | Compounds and compositions for treating cns disorders |
| CN115322105A (zh) * | 2021-05-11 | 2022-11-11 | 江苏润安制药有限公司 | 一种合成艾拉莫德关键中间体的方法 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US3471503A (en) | 1967-05-05 | 1969-10-07 | Mcneilab Inc | 1,2,3,5,6,7-hexahydro-4-phenethyl-2,6-methano-4h-4- benzazonin-12-ols |
| SG102686A1 (en) * | 1997-12-31 | 2004-03-26 | Pfizer Prod Inc | Aryl fused azapolycyclic compounds |
| EP0955301A3 (en) | 1998-04-27 | 2001-04-18 | Pfizer Products Inc. | 7-aza-bicyclo[2.2.1]-heptane derivatives, their preparation and use according to their affinity for neuronal nicotinic acetylcholine receptors |
| JP2002513007A (ja) | 1998-04-29 | 2002-05-08 | ファイザー・プロダクツ・インク | アリール縮合アザ多環式化合物 |
| HUP0200332A3 (en) * | 1999-01-29 | 2002-09-30 | Abbott Lab | Diazabicyclic derivatives as nicotinic acetylcholine receptor ligands pharmaceutical compositions comprising thereof and their use |
| FR2788982B1 (fr) * | 1999-02-02 | 2002-08-02 | Synthelabo | Compositions pharmaceutiques contenant de la nicotine et leur application dans le sevrage tabagique |
| IL137937A0 (en) * | 1999-08-27 | 2001-10-31 | Pfizer Prod Inc | A pharmaceutical composition for the prevention and treatment of nicotine addiction in a mammal |
| WO2002074050A2 (en) * | 2001-03-19 | 2002-09-26 | Sloan Kettering Institute For Cancer Research | Asymmetric synthesis of (s, s, r)-(-)-actinonin and its analogs and uses therefor |
| EP1648872A2 (en) * | 2003-07-21 | 2006-04-26 | Pfizer Products Inc. | Aryl fused azapolycyclic compounds |
| US8123947B2 (en) | 2007-10-22 | 2012-02-28 | Baxter International Inc. | Priming and air removal systems and methods for dialysis |
-
2000
- 2000-02-25 US US09/514,002 patent/US6605610B1/en not_active Expired - Fee Related
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2001
- 2001-02-08 EE EEP200200475A patent/EE200200475A/xx unknown
- 2001-02-08 OA OA1200200256A patent/OA12181A/en unknown
- 2001-02-08 ES ES05106835T patent/ES2336800T3/es not_active Expired - Lifetime
- 2001-02-08 DE DE60140965T patent/DE60140965D1/de not_active Expired - Lifetime
- 2001-02-08 JP JP2001562518A patent/JP2003524002A/ja active Pending
- 2001-02-08 AT AT05106835T patent/ATE453643T1/de not_active IP Right Cessation
- 2001-02-08 SI SI200130584T patent/SI1259489T1/sl unknown
- 2001-02-08 BR BR0108610-3A patent/BR0108610A/pt not_active Application Discontinuation
- 2001-02-08 GE GE4911A patent/GEP20053454B/en unknown
- 2001-02-08 NZ NZ519973A patent/NZ519973A/en not_active IP Right Cessation
- 2001-02-08 DK DK05106835.1T patent/DK1619192T3/da active
- 2001-02-08 IL IL15063901A patent/IL150639A0/xx active IP Right Grant
- 2001-02-08 KR KR10-2002-7011140A patent/KR100537976B1/ko not_active Expired - Fee Related
- 2001-02-08 AP APAP/P/2002/002604A patent/AP1860A/en active
- 2001-02-08 MX MXPA02008311A patent/MXPA02008311A/es active IP Right Grant
- 2001-02-08 HU HU0204580A patent/HU229482B1/hu not_active IP Right Cessation
- 2001-02-08 HR HRP20020700 patent/HRP20020700A2/hr not_active Application Discontinuation
- 2001-02-08 AT AT01953630T patent/ATE328872T1/de active
- 2001-02-08 DK DK01953630T patent/DK1259489T3/da active
- 2001-02-08 EA EA200200716A patent/EA005316B1/ru not_active IP Right Cessation
- 2001-02-08 CZ CZ20022778A patent/CZ303203B6/cs not_active IP Right Cessation
- 2001-02-08 EP EP05106835A patent/EP1619192B1/en not_active Expired - Lifetime
- 2001-02-08 ES ES01953630T patent/ES2263640T3/es not_active Expired - Lifetime
- 2001-02-08 SK SK1204-2002A patent/SK12042002A3/sk not_active Application Discontinuation
- 2001-02-08 DZ DZ013328A patent/DZ3328A1/fr active
- 2001-02-08 WO PCT/IB2001/000153 patent/WO2001062736A1/en not_active Ceased
- 2001-02-08 DE DE60120366T patent/DE60120366T2/de not_active Expired - Lifetime
- 2001-02-08 RS YUP-596/02A patent/RS51123B/sr unknown
- 2001-02-08 AU AU28748/01A patent/AU784081B2/en not_active Ceased
- 2001-02-08 PL PL01365163A patent/PL365163A1/xx not_active Application Discontinuation
- 2001-02-08 CN CNB018055737A patent/CN1263745C/zh not_active Expired - Fee Related
- 2001-02-08 PT PT01953630T patent/PT1259489E/pt unknown
- 2001-02-08 CA CA002401229A patent/CA2401229C/en not_active Expired - Fee Related
- 2001-02-08 EP EP01953630A patent/EP1259489B1/en not_active Expired - Lifetime
- 2001-08-02 UA UA2002075792A patent/UA74813C2/uk unknown
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2002
- 2002-07-05 IS IS6459A patent/IS2293B/is unknown
- 2002-07-05 BG BG106908A patent/BG65891B1/bg unknown
- 2002-07-08 IL IL150639A patent/IL150639A/en not_active IP Right Cessation
- 2002-08-09 CR CR6726A patent/CR6726A/es unknown
- 2002-08-13 MA MA26775A patent/MA26875A1/fr unknown
- 2002-08-21 CU CU177A patent/CU23148A3/es not_active IP Right Cessation
- 2002-08-22 ZA ZA200206768A patent/ZA200206768B/xx unknown
- 2002-08-23 NO NO20024042A patent/NO323608B1/no not_active IP Right Cessation
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2003
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2005
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