MX2009005043A - Polimorfos de intermedios nicotinicos. - Google Patents

Polimorfos de intermedios nicotinicos.

Info

Publication number
MX2009005043A
MX2009005043A MX2009005043A MX2009005043A MX2009005043A MX 2009005043 A MX2009005043 A MX 2009005043A MX 2009005043 A MX2009005043 A MX 2009005043A MX 2009005043 A MX2009005043 A MX 2009005043A MX 2009005043 A MX2009005043 A MX 2009005043A
Authority
MX
Mexico
Prior art keywords
polymorphs
nicotinic
intermediates
iii
compounds
Prior art date
Application number
MX2009005043A
Other languages
English (en)
Inventor
Douglas J M Allen
Melissa Jean Casteel
David Burns Damon
Travis Lee Houston
Lien Helen Koztecki
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of MX2009005043A publication Critical patent/MX2009005043A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Addiction (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)

Abstract

Se proporcionan formas cristalinas de los compuestos II, III y IV y procedimientos para producir las mismas. (ver fórmulas).
MX2009005043A 2006-11-09 2007-11-09 Polimorfos de intermedios nicotinicos. MX2009005043A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US86507706P 2006-11-09 2006-11-09
US98540607P 2007-11-05 2007-11-05
PCT/US2007/023683 WO2008060487A2 (en) 2006-11-09 2007-11-09 Polymorphs of nicotinic intermediates

Publications (1)

Publication Number Publication Date
MX2009005043A true MX2009005043A (es) 2009-05-25

Family

ID=39204744

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009005043A MX2009005043A (es) 2006-11-09 2007-11-09 Polimorfos de intermedios nicotinicos.

Country Status (11)

Country Link
US (1) US20100062046A1 (es)
EP (1) EP2086977A2 (es)
JP (1) JP2010527907A (es)
KR (1) KR20090086071A (es)
AU (1) AU2007319951A1 (es)
BR (1) BRPI0718600A2 (es)
CA (1) CA2666327A1 (es)
IL (1) IL197956A0 (es)
MX (1) MX2009005043A (es)
RU (1) RU2009116260A (es)
WO (1) WO2008060487A2 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009065872A2 (en) * 2007-11-20 2009-05-28 Medichem, S.A. Improved processes for the synthesis of varenicline l-tartrate
JP5485135B2 (ja) * 2008-02-27 2014-05-07 久光製薬株式会社 貼付製剤
WO2009107478A1 (ja) 2008-02-27 2009-09-03 久光製薬株式会社 貼付剤及び包装体
CA2709774C (en) 2008-05-22 2012-10-02 Teva Pharmaceutical Industries Ltd. Varenicline tosylate, an intermediate in the preparation process of varenicline l-tartrate
WO2010005643A1 (en) * 2008-07-10 2010-01-14 Teva Pharmaceutical Industries Ltd. Processes for purifying varenicline l-tartrate salt and preparing crystalline forms of varenicline l-tartrate salt
WO2010023561A1 (en) 2008-09-01 2010-03-04 Actavis Group Ptc Ehf Process for preparing varenicline, varenicline intermediates, and pharmaceutically acceptable salts thereof
CA2801842A1 (en) 2009-06-10 2010-12-16 Actavis Group Ptc Ehf Amorphous varenicline tartrate co-precipitates
EP2438054A1 (en) 2009-06-22 2012-04-11 Teva Pharmaceutical Industries Ltd. Solid states forms of varenicline salts and processes for preparation thereof
CA2791460A1 (en) 2010-03-09 2011-09-15 Actavis Group Ptc Ehf Highly pure varenicline or a pharmaceutically acceptable salt thereof substantially free of methylvarenicline impurity
KR101724301B1 (ko) 2016-11-22 2017-04-10 주식회사 한서켐 바레니클린 살리실산염의 i형 결정 및 그 제조방법
EP4241775A1 (en) 2022-03-11 2023-09-13 Par Pharmaceutical, Inc. Tablet comprising varenicline and process of preparation thereof
US11602537B2 (en) 2022-03-11 2023-03-14 Par Pharmaceutical, Inc. Varenicline compound and process of manufacture thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2301210T5 (es) * 1997-12-31 2015-05-07 Pfizer Products Inc. Compuestos azapolicíclicos condensados con un arilo
US6605610B1 (en) * 1997-12-31 2003-08-12 Pfizer Inc Aryl fused azapolycyclic compounds
ME00466B (me) * 2001-05-14 2011-10-10 Pfizer Prod Inc Tartaratne soli 5,8,14-triazatetraciklo( 10.3.1.02,11.04,9)-heksadeka-2 (11),3,5,7,9-pentaena
OA12600A (en) * 2001-05-14 2006-06-09 Pfizer Prod Inc The citrate salt of 5,8,14-triazatetracyclo 10.3.1.o2,11.o49)-hexadeca-2(11)3,5,7,9-pentaene and pharmaceutical compositions thereof.
AU2002341327A1 (en) * 2001-11-29 2003-06-10 Pfizer Products Inc. Succinic acid salts of 5,8,14-triazatetracyclo'10.3.1.0<2,11>.0<4,9>-hexadeca-2(11),3,5,7,9-pentaene and pharmaceutical compositions thereof
KR101228376B1 (ko) * 2002-07-18 2013-01-31 사이토스 바이오테크놀로지 아게 합텐-캐리어 컨쥬게이트 및 그의 용도
US20080275051A1 (en) 2005-02-24 2008-11-06 Busch Frank R Preparation of High Purity Substituted Quinoxalines
MX2008011549A (es) 2006-03-27 2008-09-22 Pfizer Prod Inc Patrones de vareniclina y controles de impureza.

Also Published As

Publication number Publication date
CA2666327A1 (en) 2008-05-22
US20100062046A1 (en) 2010-03-11
EP2086977A2 (en) 2009-08-12
RU2009116260A (ru) 2010-11-10
WO2008060487B1 (en) 2008-09-18
AU2007319951A1 (en) 2008-05-22
BRPI0718600A2 (pt) 2013-12-10
WO2008060487A8 (en) 2009-05-14
IL197956A0 (en) 2009-12-24
KR20090086071A (ko) 2009-08-10
WO2008060487A2 (en) 2008-05-22
WO2008060487A3 (en) 2008-08-07
JP2010527907A (ja) 2010-08-19

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