WO2008060487A8 - Polymorphs of nicotinic intermediates - Google Patents

Polymorphs of nicotinic intermediates Download PDF

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Publication number
WO2008060487A8
WO2008060487A8 PCT/US2007/023683 US2007023683W WO2008060487A8 WO 2008060487 A8 WO2008060487 A8 WO 2008060487A8 US 2007023683 W US2007023683 W US 2007023683W WO 2008060487 A8 WO2008060487 A8 WO 2008060487A8
Authority
WO
WIPO (PCT)
Prior art keywords
polymorphs
nicotinic
intermediates
iii
compounds
Prior art date
Application number
PCT/US2007/023683
Other languages
French (fr)
Other versions
WO2008060487A2 (en
WO2008060487A3 (en
WO2008060487B1 (en
Inventor
Douglas J M Allen
Melissa Jean Casteel
David Burns Damon
Travis Lee Houston
Lien Helen Koztecki
Original Assignee
Pfizer Prod Inc
Douglas J M Allen
Melissa Jean Casteel
David Burns Damon
Travis Lee Houston
Lien Helen Koztecki
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to CA002666327A priority Critical patent/CA2666327A1/en
Priority to BRPI0718600-2A priority patent/BRPI0718600A2/en
Priority to MX2009005043A priority patent/MX2009005043A/en
Priority to JP2009536323A priority patent/JP2010527907A/en
Priority to EP07861908A priority patent/EP2086977A2/en
Priority to AU2007319951A priority patent/AU2007319951A1/en
Application filed by Pfizer Prod Inc, Douglas J M Allen, Melissa Jean Casteel, David Burns Damon, Travis Lee Houston, Lien Helen Koztecki filed Critical Pfizer Prod Inc
Priority to US12/447,516 priority patent/US20100062046A1/en
Publication of WO2008060487A2 publication Critical patent/WO2008060487A2/en
Publication of WO2008060487A3 publication Critical patent/WO2008060487A3/en
Publication of WO2008060487B1 publication Critical patent/WO2008060487B1/en
Priority to IL197956A priority patent/IL197956A0/en
Publication of WO2008060487A8 publication Critical patent/WO2008060487A8/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems

Abstract

Crystalline forms of compounds (II), (III) and (IV) and processes to produce them are provided.
PCT/US2007/023683 2006-11-09 2007-11-09 Polymorphs of nicotinic intermediates WO2008060487A2 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
BRPI0718600-2A BRPI0718600A2 (en) 2006-11-09 2007-11-09 POLICORPHS OF NICOTINE INTERMEDIARIES.
MX2009005043A MX2009005043A (en) 2006-11-09 2007-11-09 Polymorphs of nicotinic intermediates.
JP2009536323A JP2010527907A (en) 2006-11-09 2007-11-09 Polymorphs of nicotine-like intermediates
EP07861908A EP2086977A2 (en) 2006-11-09 2007-11-09 Polymorphs of nicotinic intermediates
AU2007319951A AU2007319951A1 (en) 2006-11-09 2007-11-09 Polymorphs of nicotinic intermediates
CA002666327A CA2666327A1 (en) 2006-11-09 2007-11-09 Polymorphs of nicotinic intermediates
US12/447,516 US20100062046A1 (en) 2006-11-09 2007-11-09 Polymorphs of nicotinic intermediates
IL197956A IL197956A0 (en) 2006-11-09 2009-04-05 Polymorphs of nicotinic intermediates

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US86507706P 2006-11-09 2006-11-09
US60/865,077 2006-11-09
US98540607P 2007-11-05 2007-11-05
US60/985,406 2007-11-05

Publications (4)

Publication Number Publication Date
WO2008060487A2 WO2008060487A2 (en) 2008-05-22
WO2008060487A3 WO2008060487A3 (en) 2008-08-07
WO2008060487B1 WO2008060487B1 (en) 2008-09-18
WO2008060487A8 true WO2008060487A8 (en) 2009-05-14

Family

ID=39204744

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/023683 WO2008060487A2 (en) 2006-11-09 2007-11-09 Polymorphs of nicotinic intermediates

Country Status (11)

Country Link
US (1) US20100062046A1 (en)
EP (1) EP2086977A2 (en)
JP (1) JP2010527907A (en)
KR (1) KR20090086071A (en)
AU (1) AU2007319951A1 (en)
BR (1) BRPI0718600A2 (en)
CA (1) CA2666327A1 (en)
IL (1) IL197956A0 (en)
MX (1) MX2009005043A (en)
RU (1) RU2009116260A (en)
WO (1) WO2008060487A2 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009065872A2 (en) * 2007-11-20 2009-05-28 Medichem, S.A. Improved processes for the synthesis of varenicline l-tartrate
WO2009107479A1 (en) * 2008-02-27 2009-09-03 久光製薬株式会社 Patch
EP2255802B1 (en) 2008-02-27 2018-01-17 Hisamitsu Pharmaceutical Co., Inc. Adhesive skin patch and packaged product
WO2009143347A2 (en) 2008-05-22 2009-11-26 Teva Pharmaceutical Industries Ltd. Varenicline tosylate, an intermediate in the preparation process of varenicline l-tartrate
US20100010221A1 (en) * 2008-07-10 2010-01-14 Revital Lifshitz-Liron Processes for purifying varenicline l-tartrate salt and preparing crystalline forms of varenicline l-tartrate salt
EP2334679A1 (en) 2008-09-01 2011-06-22 Actavis Group PTC EHF Process for preparing varenicline, varenicline intermediates, and pharmaceutically acceptable salts thereof
CA2801842A1 (en) 2009-06-10 2010-12-16 Actavis Group Ptc Ehf Amorphous varenicline tartrate co-precipitates
RU2012102052A (en) 2009-06-22 2013-11-20 Тева Фармасьютикал Индастриз Лтд. SOLID FORMS OF VARENIKLIN SALTS AND METHODS FOR THEIR PRODUCTION
WO2011110954A1 (en) 2010-03-09 2011-09-15 Actavis Group Ptc Ehf Highly pure varenicline or a pharmaceutically acceptable salt thereof substantially free of methylvarenicline impurity
KR101724301B1 (en) 2016-11-22 2017-04-10 주식회사 한서켐 Novel crystal form I of varenicline salicylate and its preparing method
EP4241775A1 (en) 2022-03-11 2023-09-13 Par Pharmaceutical, Inc. Tablet comprising varenicline and process of preparation thereof
US11602537B2 (en) 2022-03-11 2023-03-14 Par Pharmaceutical, Inc. Varenicline compound and process of manufacture thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6605610B1 (en) * 1997-12-31 2003-08-12 Pfizer Inc Aryl fused azapolycyclic compounds
BR9814592B1 (en) * 1997-12-31 2010-06-01 azapolicolytic compound condensed with aryl, a pharmaceutical composition containing aryl and its use in the manufacture of a medicament.
CZ20032917A3 (en) * 2001-05-14 2004-07-14 Pfizer Products Inc. Citrate salt of 5, 8, 14-triazatetracyclo(10.3.1.0e2,e11,0e4,e9)-hexadeca-2.(11),3,5,7,9-pentaene
BR0209605A (en) * 2001-05-14 2004-03-23 Pfizer Prod Inc Salts of 5,8,14-triazatetracyclo [10.3.1.0.², ¹¹.04,9] -hexadeca-2 (11), 3,5,7,9-pentaene
IL161326A0 (en) * 2001-11-29 2004-09-27 Pfizer Prod Inc Succinic acid salts of 5,8,14-triazatetracyclo'10.3.1.0<2,11>.0<4,9>-hexadeca-2 (11),3,5,7,9-pentaene and pharmaceutical compositions thereof
EP2392345A3 (en) * 2002-07-18 2012-03-07 Cytos Biotechnology AG Hapten-carrier conjugates comprising virus like particles and uses thereof
EP1866308B1 (en) 2005-02-24 2008-10-22 Pfizer Products Incorporated Preparation of a high purity substituted quinoxaline
CA2644448A1 (en) 2006-03-27 2007-10-04 Pfizer Products Inc. Varenicline standards and impurity controls

Also Published As

Publication number Publication date
WO2008060487A2 (en) 2008-05-22
JP2010527907A (en) 2010-08-19
AU2007319951A1 (en) 2008-05-22
WO2008060487A3 (en) 2008-08-07
BRPI0718600A2 (en) 2013-12-10
EP2086977A2 (en) 2009-08-12
RU2009116260A (en) 2010-11-10
IL197956A0 (en) 2009-12-24
KR20090086071A (en) 2009-08-10
WO2008060487B1 (en) 2008-09-18
MX2009005043A (en) 2009-05-25
US20100062046A1 (en) 2010-03-11
CA2666327A1 (en) 2008-05-22

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