UA68407C2 - Antagonistic analogues of growth hormone releasing hormone (gh-rh) inhibiting activity of endogenous insulin-like growth factors - Google Patents
Antagonistic analogues of growth hormone releasing hormone (gh-rh) inhibiting activity of endogenous insulin-like growth factors Download PDFInfo
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- UA68407C2 UA68407C2 UA2001064393A UA2001064393A UA68407C2 UA 68407 C2 UA68407 C2 UA 68407C2 UA 2001064393 A UA2001064393 A UA 2001064393A UA 2001064393 A UA2001064393 A UA 2001064393A UA 68407 C2 UA68407 C2 UA 68407C2
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- 230000002194 synthesizing effect Effects 0.000 description 1
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- 229920003002 synthetic resin Polymers 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- WROMPOXWARCANT-UHFFFAOYSA-N tfa trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.OC(=O)C(F)(F)F WROMPOXWARCANT-UHFFFAOYSA-N 0.000 description 1
- 229940104230 thymidine Drugs 0.000 description 1
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- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
- A61P5/04—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin for decreasing, blocking or antagonising the activity of the hypothalamic hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
- A61P5/08—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH for decreasing, blocking or antagonising the activity of the anterior pituitary hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Endocrinology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/199,381 US6057422A (en) | 1998-11-25 | 1998-11-25 | Antagonistic analogs of GH-RH inhibiting IGF-I and -II |
| PCT/US1999/027822 WO2000031136A1 (fr) | 1998-11-25 | 1999-11-23 | Analogues antagonistes de gh-rh inhibant igf-i et igf-ii |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA68407C2 true UA68407C2 (en) | 2004-08-16 |
Family
ID=22737273
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UA2001064393A UA68407C2 (en) | 1998-11-25 | 1999-11-23 | Antagonistic analogues of growth hormone releasing hormone (gh-rh) inhibiting activity of endogenous insulin-like growth factors |
Country Status (29)
| Country | Link |
|---|---|
| US (2) | US6057422A (fr) |
| EP (1) | EP1133522B1 (fr) |
| JP (1) | JP2002530432A (fr) |
| KR (1) | KR100629013B1 (fr) |
| CN (1) | CN100422211C (fr) |
| AR (1) | AR022392A1 (fr) |
| AT (1) | ATE332310T1 (fr) |
| AU (1) | AU757222B2 (fr) |
| BG (1) | BG65137B1 (fr) |
| BR (1) | BR9915512A (fr) |
| CA (1) | CA2351665C (fr) |
| CO (1) | CO5180565A1 (fr) |
| CZ (1) | CZ20011794A3 (fr) |
| DE (1) | DE69932255T2 (fr) |
| DK (1) | DK1133522T3 (fr) |
| ES (1) | ES2264279T3 (fr) |
| HK (1) | HK1036461A1 (fr) |
| HU (1) | HUP0105094A3 (fr) |
| IL (1) | IL142899A0 (fr) |
| NO (1) | NO20012489L (fr) |
| NZ (1) | NZ511307A (fr) |
| PL (1) | PL197471B1 (fr) |
| PT (1) | PT1133522E (fr) |
| RU (1) | RU2235099C2 (fr) |
| SK (1) | SK7252001A3 (fr) |
| TR (1) | TR200101492T2 (fr) |
| TW (1) | TW585873B (fr) |
| UA (1) | UA68407C2 (fr) |
| WO (1) | WO2000031136A1 (fr) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003006611A2 (fr) * | 2001-07-12 | 2003-01-23 | Exelixis, Inc. | Glypicanes (gpc) utiles en tant que modificateurs des mecanismes de irrtk et de p21, methodes d'utilisation correspondantes |
| US20040121407A1 (en) * | 2002-09-06 | 2004-06-24 | Elixir Pharmaceuticals, Inc. | Regulation of the growth hormone/IGF-1 axis |
| BR0314619A (pt) * | 2002-09-18 | 2005-08-02 | Univ Montreal Ct Hospitalier Chum | Análogos de ghrh |
| TW200517400A (en) * | 2003-08-05 | 2005-06-01 | Univ Tulane | Antagonistic analogs of GH-RH (2003) |
| EP2288374B1 (fr) * | 2008-03-28 | 2017-02-01 | The University of Miami | Nouveaux analogues antagonistes substitués n- et c-terminaux de gh-rh |
| US8691942B2 (en) | 2008-03-28 | 2014-04-08 | University Of Miami | N- and C- terminal substituted antagonistic analogs of GH-RH |
| ES2732205T3 (es) | 2008-06-12 | 2019-11-21 | Ipsen Bioinnovation Ltd | Proteínas de fusión para uso en el tratamiento del cáncer |
| EP2719392B1 (fr) | 2008-06-12 | 2019-07-24 | Ipsen Bioinnovation Limited | Protéines de fusion pour leur utilisation dans le traitement de l'acromégalie |
| GB0820970D0 (en) | 2008-11-17 | 2008-12-24 | Syntaxin Ltd | Suppression of cancer |
| US8227421B2 (en) | 2009-09-17 | 2012-07-24 | University Of Miami | Fluorinated GHRH antagonists |
| WO2012142706A1 (fr) | 2011-04-21 | 2012-10-26 | Theratechnologies Inc. | Analogues du facteur de libération de l'hormone de croissance (grf) et leurs utilisations |
| US9079974B2 (en) * | 2011-12-21 | 2015-07-14 | The University Of Miami | GH-RH analogs with potent agonistic effects |
| EP2934565B1 (fr) | 2012-12-21 | 2019-03-13 | University of Miami | Agonistes de ghrh pour le traitement de troubles ischémiques |
| WO2014100816A2 (fr) | 2012-12-21 | 2014-06-26 | University Of Miami | Agonistes de ghrh pour la greffe et fonction de cellules d'îlot et le traitement du diabète |
| US10350273B2 (en) | 2014-11-12 | 2019-07-16 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Treatment of hormonal disorders of growth |
| AU2020218272A1 (en) | 2019-02-08 | 2021-09-02 | United States Government As Represented By The Department Of Veterans Affairs | Growth hormone-releasing hormone antagonists and uses thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4659693A (en) * | 1984-04-30 | 1987-04-21 | Syntex (U.S.A.) Inc. | N,N'-dialkyl substituted guanidino amino acyl residue substituted GRF-analog peptides |
| AU651976B2 (en) * | 1990-05-04 | 1994-08-11 | The Administrators Of The Tulane Eductional Fund | Novel synthetic GRF analogs |
| US5550212A (en) * | 1993-12-17 | 1996-08-27 | The Administrators Of The Tulane Educational Fund | Analogues of hGH-RH(1-29)NH2 having antagonistic activity |
| US5942489A (en) * | 1996-05-03 | 1999-08-24 | The Administrators Of The Tulane Educational Fund | HGH-RH(1-29)NH2 analogues having antagonistic activity |
-
1998
- 1998-11-25 US US09/199,381 patent/US6057422A/en not_active Expired - Fee Related
-
1999
- 1999-11-16 CO CO99072002A patent/CO5180565A1/es not_active Application Discontinuation
- 1999-11-23 AT AT99963962T patent/ATE332310T1/de not_active IP Right Cessation
- 1999-11-23 IL IL14289999A patent/IL142899A0/xx not_active IP Right Cessation
- 1999-11-23 WO PCT/US1999/027822 patent/WO2000031136A1/fr active IP Right Grant
- 1999-11-23 RU RU2001117218/04A patent/RU2235099C2/ru not_active IP Right Cessation
- 1999-11-23 NZ NZ511307A patent/NZ511307A/en unknown
- 1999-11-23 KR KR1020017006568A patent/KR100629013B1/ko not_active IP Right Cessation
- 1999-11-23 CA CA002351665A patent/CA2351665C/fr not_active Expired - Fee Related
- 1999-11-23 JP JP2000583962A patent/JP2002530432A/ja not_active Ceased
- 1999-11-23 AU AU20291/00A patent/AU757222B2/en not_active Ceased
- 1999-11-23 DK DK99963962T patent/DK1133522T3/da active
- 1999-11-23 HU HU0105094A patent/HUP0105094A3/hu unknown
- 1999-11-23 BR BR9915512-5A patent/BR9915512A/pt not_active Application Discontinuation
- 1999-11-23 TR TR2001/01492T patent/TR200101492T2/xx unknown
- 1999-11-23 PT PT99963962T patent/PT1133522E/pt unknown
- 1999-11-23 DE DE69932255T patent/DE69932255T2/de not_active Expired - Fee Related
- 1999-11-23 CN CNB998137359A patent/CN100422211C/zh not_active Expired - Fee Related
- 1999-11-23 UA UA2001064393A patent/UA68407C2/uk unknown
- 1999-11-23 CZ CZ20011794A patent/CZ20011794A3/cs unknown
- 1999-11-23 SK SK725-2001A patent/SK7252001A3/sk unknown
- 1999-11-23 ES ES99963962T patent/ES2264279T3/es not_active Expired - Lifetime
- 1999-11-23 EP EP99963962A patent/EP1133522B1/fr not_active Expired - Lifetime
- 1999-11-23 PL PL349877A patent/PL197471B1/pl unknown
- 1999-11-24 AR ARP990105977A patent/AR022392A1/es active IP Right Grant
- 1999-11-24 TW TW088120503A patent/TW585873B/zh not_active IP Right Cessation
-
2000
- 2000-04-11 US US09/547,215 patent/US7026281B1/en not_active Expired - Fee Related
-
2001
- 2001-05-21 NO NO20012489A patent/NO20012489L/no not_active Application Discontinuation
- 2001-06-22 BG BG105638A patent/BG65137B1/bg unknown
- 2001-10-29 HK HK01107515A patent/HK1036461A1/xx not_active IP Right Cessation
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