UA26137C2 - Імплаhтат для пареhтеральhого введеhhя з коhтрольоваhою доставкою - Google Patents
Імплаhтат для пареhтеральhого введеhhя з коhтрольоваhою доставкою Download PDFInfo
- Publication number
- UA26137C2 UA26137C2 UA93002879A UA93002879A UA26137C2 UA 26137 C2 UA26137 C2 UA 26137C2 UA 93002879 A UA93002879 A UA 93002879A UA 93002879 A UA93002879 A UA 93002879A UA 26137 C2 UA26137 C2 UA 26137C2
- Authority
- UA
- Ukraine
- Prior art keywords
- composition
- introduction
- recess
- parecheral
- implement
- Prior art date
Links
- 239000000203 mixture Substances 0.000 abstract description 30
- 239000007943 implant Substances 0.000 abstract description 10
- 108090000765 processed proteins & peptides Proteins 0.000 abstract description 10
- 102000004196 processed proteins & peptides Human genes 0.000 abstract description 6
- 102000004169 proteins and genes Human genes 0.000 abstract description 6
- 108090000623 proteins and genes Proteins 0.000 abstract description 6
- 229920001184 polypeptide Polymers 0.000 abstract description 5
- 239000000872 buffer Substances 0.000 abstract description 4
- 239000000945 filler Substances 0.000 abstract description 3
- 230000007774 longterm Effects 0.000 abstract description 2
- 238000007911 parenteral administration Methods 0.000 abstract description 2
- 238000012377 drug delivery Methods 0.000 abstract 1
- 239000000843 powder Substances 0.000 description 10
- 102000018997 Growth Hormone Human genes 0.000 description 9
- 108010051696 Growth Hormone Proteins 0.000 description 9
- 239000008280 blood Substances 0.000 description 8
- 210000004369 blood Anatomy 0.000 description 8
- 241001465754 Metazoa Species 0.000 description 7
- 239000000126 substance Substances 0.000 description 7
- 230000029142 excretion Effects 0.000 description 6
- 241000282887 Suidae Species 0.000 description 5
- 239000004480 active ingredient Substances 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 description 4
- 239000000654 additive Substances 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 239000003826 tablet Substances 0.000 description 4
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 3
- JIGUQPWFLRLWPJ-UHFFFAOYSA-N Ethyl acrylate Chemical compound CCOC(=O)C=C JIGUQPWFLRLWPJ-UHFFFAOYSA-N 0.000 description 3
- 235000013336 milk Nutrition 0.000 description 3
- 239000008267 milk Substances 0.000 description 3
- 210000004080 milk Anatomy 0.000 description 3
- 229940045641 monobasic sodium phosphate Drugs 0.000 description 3
- PNJWIWWMYCMZRO-UHFFFAOYSA-N pent‐4‐en‐2‐one Natural products CC(=O)CC=C PNJWIWWMYCMZRO-UHFFFAOYSA-N 0.000 description 3
- 229920000642 polymer Polymers 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 3
- 239000000454 talc Substances 0.000 description 3
- 229910052623 talc Inorganic materials 0.000 description 3
- BAPJBEWLBFYGME-UHFFFAOYSA-N Methyl acrylate Chemical compound COC(=O)C=C BAPJBEWLBFYGME-UHFFFAOYSA-N 0.000 description 2
- 239000001913 cellulose Substances 0.000 description 2
- 229920002678 cellulose Polymers 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 229940061607 dibasic sodium phosphate Drugs 0.000 description 2
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
- 230000008030 elimination Effects 0.000 description 2
- 238000003379 elimination reaction Methods 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 239000008055 phosphate buffer solution Substances 0.000 description 2
- 239000004014 plasticizer Substances 0.000 description 2
- 235000017788 Cydonia oblonga Nutrition 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 description 1
- 101710094568 Somatotropin-A Proteins 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 150000001540 azides Chemical class 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 229910021538 borax Inorganic materials 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 230000001054 cortical effect Effects 0.000 description 1
- 235000013365 dairy product Nutrition 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- ZAFFWOKULJCCSA-UHFFFAOYSA-N ethyl 2-methylprop-2-enoate;trimethylazanium;chloride Chemical compound [Cl-].C[NH+](C)C.CCOC(=O)C(C)=C ZAFFWOKULJCCSA-UHFFFAOYSA-N 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000004519 grease Substances 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 239000008240 homogeneous mixture Substances 0.000 description 1
- 235000012907 honey Nutrition 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- QPNHNCISNUAHNE-UHFFFAOYSA-N methyl 2-methylprop-2-enoate;trimethylazanium;chloride Chemical compound [Cl-].C[NH+](C)C.COC(=O)C(C)=C QPNHNCISNUAHNE-UHFFFAOYSA-N 0.000 description 1
- 229910000403 monosodium phosphate Inorganic materials 0.000 description 1
- 235000019799 monosodium phosphate Nutrition 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 238000003127 radioimmunoassay Methods 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 235000010339 sodium tetraborate Nutrition 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- DUXYWXYOBMKGIN-UHFFFAOYSA-N trimyristin Chemical compound CCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCC DUXYWXYOBMKGIN-UHFFFAOYSA-N 0.000 description 1
- BSVBQGMMJUBVOD-UHFFFAOYSA-N trisodium borate Chemical compound [Na+].[Na+].[Na+].[O-]B([O-])[O-] BSVBQGMMJUBVOD-UHFFFAOYSA-N 0.000 description 1
- DCXXMTOCNZCJGO-UHFFFAOYSA-N tristearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCCCC DCXXMTOCNZCJGO-UHFFFAOYSA-N 0.000 description 1
- 238000012800 visualization Methods 0.000 description 1
- 230000004584 weight gain Effects 0.000 description 1
- 235000019786 weight gain Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/07—Stiffening bandages
- A61L15/10—Stiffening bandages containing organic materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/27—Growth hormone [GH], i.e. somatotropin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Endocrinology (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Materials Engineering (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Prostheses (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US71989891A | 1991-06-24 | 1991-06-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA26137C2 true UA26137C2 (uk) | 1999-06-07 |
Family
ID=24891827
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UA93002879A UA26137C2 (uk) | 1991-06-24 | 1993-06-15 | Імплаhтат для пареhтеральhого введеhhя з коhтрольоваhою доставкою |
Country Status (24)
| Country | Link |
|---|---|
| EP (1) | EP0523330B1 (enExample) |
| JP (1) | JP3597205B2 (enExample) |
| KR (1) | KR100221031B1 (enExample) |
| CN (1) | CN1050301C (enExample) |
| AT (1) | ATE135565T1 (enExample) |
| AU (1) | AU656200B2 (enExample) |
| BR (1) | BR9202374A (enExample) |
| CA (1) | CA2071757C (enExample) |
| DE (1) | DE69209173T2 (enExample) |
| DK (1) | DK0523330T3 (enExample) |
| ES (1) | ES2087337T3 (enExample) |
| GE (1) | GEP19970992B (enExample) |
| GR (1) | GR3019457T3 (enExample) |
| HU (1) | HU217547B (enExample) |
| IE (1) | IE74398B1 (enExample) |
| IL (1) | IL102287A (enExample) |
| LV (1) | LV11816B (enExample) |
| MD (1) | MD1394G2 (enExample) |
| MX (1) | MX9203175A (enExample) |
| RU (1) | RU2080119C1 (enExample) |
| SG (1) | SG47955A1 (enExample) |
| TW (1) | TW215058B (enExample) |
| UA (1) | UA26137C2 (enExample) |
| ZA (1) | ZA924613B (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5736152A (en) * | 1995-10-27 | 1998-04-07 | Atrix Laboratories, Inc. | Non-polymeric sustained release delivery system |
| US8052982B2 (en) | 1998-07-20 | 2011-11-08 | Peptech Animal Health Pty Limited | Bioimplant formulation comprising lecithin and stearin |
| MXPA01000674A (es) * | 1998-07-20 | 2002-04-08 | Peptech Ltd | Formulacion de bioimplante. |
| JP2001058955A (ja) * | 1999-06-17 | 2001-03-06 | Inst Of Physical & Chemical Res | 生理活性ペプチド徐放性製剤 |
| AU2001238540A1 (en) | 2000-02-24 | 2001-09-03 | Monsanto Technology Llc | Non-aqueous injectable formulations for extended release of somatotropin |
| WO2002000261A2 (en) | 2000-06-26 | 2002-01-03 | Monsanto Technology Llc | Surfactant-containing formulations for extended release of somatotropin |
| US6664234B1 (en) | 2000-06-30 | 2003-12-16 | Monsanto Technology Llc | Non-aqueous injectable formulation preparation with pH adjusted for extended release of somatotropin |
| JP4931282B2 (ja) * | 2000-10-02 | 2012-05-16 | 日本ケミカルリサーチ株式会社 | 生理活性ペプチド含有粉末 |
| DE10161078A1 (de) * | 2001-12-12 | 2003-08-28 | Achim Goepferich | Matrizes zur Stabilisierung und kontrollierten Freisetzung von Problemarzneistoffen |
| SE526959C2 (sv) * | 2003-10-02 | 2005-11-29 | Tikomed Ab | Bioartificellt implantat innefattande en semipermeabel barriär samt förfarande för reducering av risken för bildning av bindrväv vid implantatet efter implantering genom att barriären förses med en permeabel beläggning av bioaktiv metall |
| JP2005145821A (ja) * | 2003-11-11 | 2005-06-09 | Kao Corp | 打錠製剤 |
| US20120283171A1 (en) | 2009-12-21 | 2012-11-08 | Ambrx, Inc. | Modified bovine somatotropin polypeptides and their uses |
| EA201290542A1 (ru) | 2009-12-21 | 2013-07-30 | Амбркс, Инк. | Модифицированные свиные соматотропиновые полипептиды и их применение |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4271113A (en) * | 1978-04-17 | 1981-06-02 | Alza Corporation | Process for forming a passageway in an osmotic device |
| CA1257199A (en) * | 1986-05-20 | 1989-07-11 | Paul Y. Wang | Preparation containing bioactive macromolecular substance for multi-months release in vivo |
| US4863736A (en) * | 1987-03-16 | 1989-09-05 | Monsanto Company | Somatotropin prolonged release |
| US4795644A (en) * | 1987-08-03 | 1989-01-03 | Merck & Co., Inc. | Device for pH independent release of drugs through the Donnan-like influence of charged insoluble resins |
| HUT69680A (en) * | 1990-08-09 | 1995-09-28 | Endocon Inc | Implant and apparatus for delivering multiple drug and process for production of theese |
-
1992
- 1992-04-29 EP EP92107278A patent/EP0523330B1/en not_active Expired - Lifetime
- 1992-04-29 ES ES92107278T patent/ES2087337T3/es not_active Expired - Lifetime
- 1992-04-29 SG SG1996005631A patent/SG47955A1/en unknown
- 1992-04-29 AT AT92107278T patent/ATE135565T1/de not_active IP Right Cessation
- 1992-04-29 DK DK92107278.1T patent/DK0523330T3/da active
- 1992-04-29 DE DE69209173T patent/DE69209173T2/de not_active Expired - Fee Related
- 1992-05-04 TW TW081103470A patent/TW215058B/zh active
- 1992-06-19 JP JP18465792A patent/JP3597205B2/ja not_active Expired - Fee Related
- 1992-06-22 CA CA002071757A patent/CA2071757C/en not_active Expired - Fee Related
- 1992-06-22 IL IL10228792A patent/IL102287A/xx not_active IP Right Cessation
- 1992-06-23 BR BR929202374A patent/BR9202374A/pt not_active Application Discontinuation
- 1992-06-23 MX MX9203175A patent/MX9203175A/es not_active IP Right Cessation
- 1992-06-23 HU HU9202092A patent/HU217547B/hu not_active IP Right Cessation
- 1992-06-23 KR KR1019920010911A patent/KR100221031B1/ko not_active Expired - Fee Related
- 1992-06-23 RU SU925052163A patent/RU2080119C1/ru not_active IP Right Cessation
- 1992-06-23 ZA ZA924613A patent/ZA924613B/xx unknown
- 1992-06-23 CN CN92105065A patent/CN1050301C/zh not_active Expired - Fee Related
- 1992-06-23 AU AU18470/92A patent/AU656200B2/en not_active Ceased
- 1992-07-01 IE IE922020A patent/IE74398B1/en not_active IP Right Cessation
-
1993
- 1993-06-15 UA UA93002879A patent/UA26137C2/uk unknown
- 1993-07-31 GE GEAP19931351A patent/GEP19970992B/en unknown
-
1994
- 1994-07-12 MD MD94-0370A patent/MD1394G2/ro unknown
-
1996
- 1996-03-29 GR GR950403216T patent/GR3019457T3/el unknown
-
1997
- 1997-03-05 LV LVP-97-37A patent/LV11816B/xx unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| UA26137C2 (uk) | Імплаhтат для пареhтеральhого введеhhя з коhтрольоваhою доставкою | |
| DE69531263T2 (de) | Membranen aus thermoplastischen Polymeren | |
| DE60226282T2 (de) | Injizierbare depotzusammensetzungen und deren verwendung | |
| DE69735384T2 (de) | Gelzusammensetzungen und verfahren | |
| EP1138321B1 (de) | Feste orale Darreichungsformen mit retardierter Wirkstoffreisetzung und hoher mechanischer Stabilität | |
| DE102004016947A1 (de) | Feste pharmazeutische Zusammensetzung | |
| DE3413608A1 (de) | Implantierbare zubereitungen von regulatorischen peptiden mit gesteuerter freisetzung und verfahren zu ihrer herstellung | |
| NZ238612A (en) | Coated veterinary implant comprising a solid core of biologically active material in a release inhibiting coating of polyvinyl alcohol | |
| CN1072861A (zh) | 一种用于缓释治疗剂的碳水化合物玻璃体基质 | |
| JPH05500668A (ja) | 制御放出組成物 | |
| KR920014466A (ko) | 반추동물의 치료법으로서 또는 성장 및 먹이 이용성을 개선시키는데 적합한 활성 물질의 조절된 방출제제 | |
| NZ243221A (en) | Implantable medicament composition for the sustained release of proteinaceous substance | |
| US20080226713A1 (en) | Controlled Release Pharmaceutical Compositions of Tolperisone for Oral Administration | |
| DE69002822T2 (de) | Pharmazeutische Zubereitung zur oralen Verabreichung in flüssiger Form. | |
| EP1337223A2 (de) | Dentalmassen mit verringerter temperatursensibilität | |
| JPH06256184A (ja) | 癌患者用アミノ酸製剤 | |
| US5688521A (en) | Lactulose pastilles | |
| Renzi et al. | Morphological, morphometric and stereological study of submandibular glands in rats with lesion of the anteroventrai region of the third ventricle (AV3V) | |
| CN110506802A (zh) | 恢复期配方奶粉及其制备方法 | |
| CN101204369A (zh) | 一种治疗实体肿瘤的索非拉尼缓释植入剂 | |
| RU2777558C2 (ru) | Усовершенствованные фармацевтические составы | |
| RU2044540C1 (ru) | Лекарственная форма пролонгированного действия для введения в преджелудки жвачных животных | |
| Ormrod et al. | Extended immunosuppression with cyclophosphamide using controlled-release polymeric implants | |
| KR20240164192A (ko) | 사이클로스포린의 속효성 3d 프린트 정제의 조성 및 제조 방법 | |
| Pluchino et al. | The mechanism of action of guanethidine on the isolated mammalian heart |