MD1394G2 - Compoziţie implantabilă pentru administrare parenterală care conţine proteină, peptidă sau polipeptidă biologic active şi procedeu de preparare a ei - Google Patents
Compoziţie implantabilă pentru administrare parenterală care conţine proteină, peptidă sau polipeptidă biologic active şi procedeu de preparare a eiInfo
- Publication number
- MD1394G2 MD1394G2 MD94-0370A MD940370A MD1394G2 MD 1394 G2 MD1394 G2 MD 1394G2 MD 940370 A MD940370 A MD 940370A MD 1394 G2 MD1394 G2 MD 1394G2
- Authority
- MD
- Moldova
- Prior art keywords
- polypeptide
- peptide
- active protein
- preparation
- biologic active
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 6
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 6
- 229920001184 polypeptide Polymers 0.000 title abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 3
- 102000004169 proteins and genes Human genes 0.000 title abstract 3
- 108090000623 proteins and genes Proteins 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- 238000007911 parenteral administration Methods 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 abstract 2
- 239000011248 coating agent Substances 0.000 abstract 2
- 238000000576 coating method Methods 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000000843 powder Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/07—Stiffening bandages
- A61L15/10—Stiffening bandages containing organic materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/27—Growth hormone [GH], i.e. somatotropin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Endocrinology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Materials Engineering (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Prostheses (AREA)
Abstract
Compoziţia solicitată conform invenţiei este compactă, cu o cavitate şi parţial învelită, conţinând de la unu până la trei straturi, fiecare din ele conţine de la 20% până la 80% de proteină, peptidă sau polipeptidă biologic active, de la 10% până la 75% de grăsime sau ceară, sau amestec al acestora, de la 0 până la 20% de tampon sau sare, sau un amestec al acestora, şi de la 0 până la 25% de zahăr.Procedeul de preparare a compoziţiei implantabile include amestecarea proteinei, peptidei sau polipeptidei biologic active cu grăsime sau ceară topită, sau cu un amestec al acestora şi neobligatoriu cu un tampon, sare sau zahăr pentru a forma un praf grosier, compactarea lui de la unu până la trei straturi şi obţinerea unei mase compacte, perforarea ei până la formarea cavităţii conice şi acoperirea ei în aşa mod încât să se formeze o trecere prin cavitate din masa compactă prin înveliş.Rezultatul tehnic al invenţiei constă în menţinerea la nivel înalt a conţinutului de proteine, peptide sau polipeptide biologic active în organismul animalelor pentru o perioadă îndelungată de timp.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US71989891A | 1991-06-24 | 1991-06-24 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| MD940370A MD940370A (ro) | 1996-06-28 |
| MD1394F2 MD1394F2 (ro) | 2000-01-31 |
| MD1394G2 true MD1394G2 (ro) | 2000-11-30 |
Family
ID=24891827
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MD94-0370A MD1394G2 (ro) | 1991-06-24 | 1994-07-12 | Compoziţie implantabilă pentru administrare parenterală care conţine proteină, peptidă sau polipeptidă biologic active şi procedeu de preparare a ei |
Country Status (24)
| Country | Link |
|---|---|
| EP (1) | EP0523330B1 (ro) |
| JP (1) | JP3597205B2 (ro) |
| KR (1) | KR100221031B1 (ro) |
| CN (1) | CN1050301C (ro) |
| AT (1) | ATE135565T1 (ro) |
| AU (1) | AU656200B2 (ro) |
| BR (1) | BR9202374A (ro) |
| CA (1) | CA2071757C (ro) |
| DE (1) | DE69209173T2 (ro) |
| DK (1) | DK0523330T3 (ro) |
| ES (1) | ES2087337T3 (ro) |
| GE (1) | GEP19970992B (ro) |
| GR (1) | GR3019457T3 (ro) |
| HU (1) | HU217547B (ro) |
| IE (1) | IE74398B1 (ro) |
| IL (1) | IL102287A (ro) |
| LV (1) | LV11816B (ro) |
| MD (1) | MD1394G2 (ro) |
| MX (1) | MX9203175A (ro) |
| RU (1) | RU2080119C1 (ro) |
| SG (1) | SG47955A1 (ro) |
| TW (1) | TW215058B (ro) |
| UA (1) | UA26137C2 (ro) |
| ZA (1) | ZA924613B (ro) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5736152A (en) * | 1995-10-27 | 1998-04-07 | Atrix Laboratories, Inc. | Non-polymeric sustained release delivery system |
| US8052982B2 (en) | 1998-07-20 | 2011-11-08 | Peptech Animal Health Pty Limited | Bioimplant formulation comprising lecithin and stearin |
| BR9912275A (pt) | 1998-07-20 | 2001-04-17 | Peptech Ltd | Formulação de bioimplante |
| JP2001058955A (ja) * | 1999-06-17 | 2001-03-06 | Inst Of Physical & Chemical Res | 生理活性ペプチド徐放性製剤 |
| AU2001238540A1 (en) | 2000-02-24 | 2001-09-03 | Monsanto Technology Llc | Non-aqueous injectable formulations for extended release of somatotropin |
| KR20030023878A (ko) | 2000-06-26 | 2003-03-20 | 몬산토 테크놀로지 엘엘씨 | 소마토트로핀의 지속적인 방출을 위한 계면활성제 함유비수성 제제들 |
| US6664234B1 (en) | 2000-06-30 | 2003-12-16 | Monsanto Technology Llc | Non-aqueous injectable formulation preparation with pH adjusted for extended release of somatotropin |
| JP4931282B2 (ja) * | 2000-10-02 | 2012-05-16 | 日本ケミカルリサーチ株式会社 | 生理活性ペプチド含有粉末 |
| DE10161078A1 (de) * | 2001-12-12 | 2003-08-28 | Achim Goepferich | Matrizes zur Stabilisierung und kontrollierten Freisetzung von Problemarzneistoffen |
| JP2005145821A (ja) * | 2003-11-11 | 2005-06-09 | Kao Corp | 打錠製剤 |
| CN102753573A (zh) | 2009-12-21 | 2012-10-24 | Ambrx公司 | 经过修饰的牛促生长素多肽和其用途 |
| SG181769A1 (en) | 2009-12-21 | 2012-07-30 | Ambrx Inc | Modified porcine somatotropin polypeptides and their uses |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4271113A (en) * | 1978-04-17 | 1981-06-02 | Alza Corporation | Process for forming a passageway in an osmotic device |
| US4795644A (en) * | 1987-08-03 | 1989-01-03 | Merck & Co., Inc. | Device for pH independent release of drugs through the Donnan-like influence of charged insoluble resins |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1257199A (en) * | 1986-05-20 | 1989-07-11 | Paul Y. Wang | Preparation containing bioactive macromolecular substance for multi-months release in vivo |
| US4863736A (en) * | 1987-03-16 | 1989-09-05 | Monsanto Company | Somatotropin prolonged release |
| JPH11508224A (ja) * | 1990-08-09 | 1999-07-21 | エンドコン・インコーポレーテッド | 多重ドラッグデリバリーシステム |
-
1992
- 1992-04-29 AT AT92107278T patent/ATE135565T1/de not_active IP Right Cessation
- 1992-04-29 ES ES92107278T patent/ES2087337T3/es not_active Expired - Lifetime
- 1992-04-29 DK DK92107278.1T patent/DK0523330T3/da active
- 1992-04-29 DE DE69209173T patent/DE69209173T2/de not_active Expired - Fee Related
- 1992-04-29 EP EP92107278A patent/EP0523330B1/en not_active Expired - Lifetime
- 1992-04-29 SG SG1996005631A patent/SG47955A1/en unknown
- 1992-05-04 TW TW081103470A patent/TW215058B/zh active
- 1992-06-19 JP JP18465792A patent/JP3597205B2/ja not_active Expired - Fee Related
- 1992-06-22 CA CA002071757A patent/CA2071757C/en not_active Expired - Fee Related
- 1992-06-22 IL IL10228792A patent/IL102287A/xx not_active IP Right Cessation
- 1992-06-23 AU AU18470/92A patent/AU656200B2/en not_active Ceased
- 1992-06-23 MX MX9203175A patent/MX9203175A/es not_active IP Right Cessation
- 1992-06-23 ZA ZA924613A patent/ZA924613B/xx unknown
- 1992-06-23 HU HU9202092A patent/HU217547B/hu not_active IP Right Cessation
- 1992-06-23 BR BR929202374A patent/BR9202374A/pt not_active Application Discontinuation
- 1992-06-23 KR KR1019920010911A patent/KR100221031B1/ko not_active IP Right Cessation
- 1992-06-23 CN CN92105065A patent/CN1050301C/zh not_active Expired - Fee Related
- 1992-06-23 RU SU925052163A patent/RU2080119C1/ru not_active IP Right Cessation
- 1992-07-01 IE IE922020A patent/IE74398B1/en not_active IP Right Cessation
-
1993
- 1993-06-15 UA UA93002879A patent/UA26137C2/uk unknown
- 1993-07-31 GE GEAP19931351A patent/GEP19970992B/en unknown
-
1994
- 1994-07-12 MD MD94-0370A patent/MD1394G2/ro unknown
-
1996
- 1996-03-29 GR GR950403216T patent/GR3019457T3/el unknown
-
1997
- 1997-03-05 LV LVP-97-37A patent/LV11816B/xx unknown
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4271113A (en) * | 1978-04-17 | 1981-06-02 | Alza Corporation | Process for forming a passageway in an osmotic device |
| US4795644A (en) * | 1987-08-03 | 1989-01-03 | Merck & Co., Inc. | Device for pH independent release of drugs through the Donnan-like influence of charged insoluble resins |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PD99 | Pending application |