UA125284C2 - Рекомбінантне антитіло, яке специфічно зв'язується з tl1a - Google Patents
Рекомбінантне антитіло, яке специфічно зв'язується з tl1a Download PDFInfo
- Publication number
- UA125284C2 UA125284C2 UAA201804192A UAA201804192A UA125284C2 UA 125284 C2 UA125284 C2 UA 125284C2 UA A201804192 A UAA201804192 A UA A201804192A UA A201804192 A UAA201804192 A UA A201804192A UA 125284 C2 UA125284 C2 UA 125284C2
- Authority
- UA
- Ukraine
- Prior art keywords
- rgo
- acid sequence
- antibody
- amino acid
- variable region
- Prior art date
Links
- 108091033319 polynucleotide Proteins 0.000 claims abstract description 73
- 102000040430 polynucleotide Human genes 0.000 claims abstract description 73
- 239000002157 polynucleotide Substances 0.000 claims abstract description 73
- 238000000034 method Methods 0.000 claims abstract description 51
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 199
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 93
- 150000007523 nucleic acids Chemical group 0.000 claims description 92
- 230000027455 binding Effects 0.000 claims description 79
- 210000004027 cell Anatomy 0.000 claims description 75
- 241000282414 Homo sapiens Species 0.000 claims description 72
- 230000000694 effects Effects 0.000 claims description 64
- 238000011282 treatment Methods 0.000 claims description 48
- 238000004458 analytical method Methods 0.000 claims description 31
- 239000000203 mixture Substances 0.000 claims description 28
- 208000006673 asthma Diseases 0.000 claims description 27
- 206010009887 colitis Diseases 0.000 claims description 20
- 229940092253 ovalbumin Drugs 0.000 claims description 15
- 210000002966 serum Anatomy 0.000 claims description 15
- 108010058846 Ovalbumin Proteins 0.000 claims description 14
- 101000777271 Mus musculus Calcineurin B homologous protein 3 Proteins 0.000 claims description 13
- 241000700199 Cavia porcellus Species 0.000 claims description 11
- 102000011727 Caspases Human genes 0.000 claims description 10
- 108010076667 Caspases Proteins 0.000 claims description 10
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 10
- 210000003979 eosinophil Anatomy 0.000 claims description 10
- 241000282326 Felis catus Species 0.000 claims description 9
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims description 8
- 241000283973 Oryctolagus cuniculus Species 0.000 claims description 8
- 210000001072 colon Anatomy 0.000 claims description 8
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 claims description 8
- 241000282553 Macaca Species 0.000 claims description 6
- 241000699670 Mus sp. Species 0.000 claims description 6
- 210000002345 respiratory system Anatomy 0.000 claims description 5
- 208000031481 Pathologic Constriction Diseases 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 240000001829 Catharanthus roseus Species 0.000 claims 4
- 235000002568 Capsicum frutescens Nutrition 0.000 claims 2
- 244000005894 Albizia lebbeck Species 0.000 claims 1
- 241000272525 Anas platyrhynchos Species 0.000 claims 1
- 206010003445 Ascites Diseases 0.000 claims 1
- 241000282472 Canis lupus familiaris Species 0.000 claims 1
- 241001327708 Coriaria sarmentosa Species 0.000 claims 1
- 235000005459 Digitaria exilis Nutrition 0.000 claims 1
- 235000002917 Fraxinus ornus Nutrition 0.000 claims 1
- 244000182067 Fraxinus ornus Species 0.000 claims 1
- 240000005546 Piper methysticum Species 0.000 claims 1
- 235000016787 Piper methysticum Nutrition 0.000 claims 1
- 244000046146 Pueraria lobata Species 0.000 claims 1
- 235000010575 Pueraria lobata Nutrition 0.000 claims 1
- 235000011449 Rosa Nutrition 0.000 claims 1
- 241001415849 Strigiformes Species 0.000 claims 1
- 241001424341 Tara spinosa Species 0.000 claims 1
- 241001622399 Thala Species 0.000 claims 1
- CCAZWUJBLXKBAY-ULZPOIKGSA-N Tutin Chemical compound C([C@]12[C@@H]3O[C@@H]3[C@@]3(O)[C@H]4C(=O)O[C@@H]([C@H]([C@]32C)O)[C@H]4C(=C)C)O1 CCAZWUJBLXKBAY-ULZPOIKGSA-N 0.000 claims 1
- 101100020289 Xenopus laevis koza gene Proteins 0.000 claims 1
- 239000004110 Zinc silicate Substances 0.000 claims 1
- 239000004071 soot Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract description 2
- 102100024587 Tumor necrosis factor ligand superfamily member 15 Human genes 0.000 abstract 2
- 108090000138 Tumor necrosis factor ligand superfamily member 15 Proteins 0.000 abstract 2
- 238000000338 in vitro Methods 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 description 73
- 102000004169 proteins and genes Human genes 0.000 description 67
- 101100460719 Mus musculus Noto gene Proteins 0.000 description 54
- 101100187345 Xenopus laevis noto gene Proteins 0.000 description 54
- 241000700159 Rattus Species 0.000 description 34
- 241001130469 Tila Species 0.000 description 30
- 238000006467 substitution reaction Methods 0.000 description 30
- 238000002474 experimental method Methods 0.000 description 28
- 230000007717 exclusion Effects 0.000 description 24
- 201000010099 disease Diseases 0.000 description 23
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 23
- 230000001965 increasing effect Effects 0.000 description 22
- 230000003993 interaction Effects 0.000 description 21
- 238000012933 kinetic analysis Methods 0.000 description 20
- 241001465754 Metazoa Species 0.000 description 17
- 201000003883 Cystic fibrosis Diseases 0.000 description 16
- 210000001519 tissue Anatomy 0.000 description 16
- 206010003246 arthritis Diseases 0.000 description 14
- 108020004414 DNA Proteins 0.000 description 12
- 241000699666 Mus <mouse, genus> Species 0.000 description 11
- 238000006243 chemical reaction Methods 0.000 description 11
- 208000005069 pulmonary fibrosis Diseases 0.000 description 11
- 102000005962 receptors Human genes 0.000 description 11
- 108020003175 receptors Proteins 0.000 description 11
- 230000004044 response Effects 0.000 description 11
- 208000017520 skin disease Diseases 0.000 description 11
- 208000018522 Gastrointestinal disease Diseases 0.000 description 10
- 239000000872 buffer Substances 0.000 description 10
- 238000010494 dissociation reaction Methods 0.000 description 10
- 230000005593 dissociations Effects 0.000 description 10
- 230000001976 improved effect Effects 0.000 description 10
- 239000006228 supernatant Substances 0.000 description 10
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 description 9
- 206010012438 Dermatitis atopic Diseases 0.000 description 9
- 206010064212 Eosinophilic oesophagitis Diseases 0.000 description 9
- 206010016654 Fibrosis Diseases 0.000 description 9
- 241000283984 Rodentia Species 0.000 description 9
- 241000282898 Sus scrofa Species 0.000 description 9
- 239000000427 antigen Substances 0.000 description 9
- 108091007433 antigens Proteins 0.000 description 9
- 102000036639 antigens Human genes 0.000 description 9
- 201000008937 atopic dermatitis Diseases 0.000 description 9
- 208000010643 digestive system disease Diseases 0.000 description 9
- 201000000708 eosinophilic esophagitis Diseases 0.000 description 9
- 230000004761 fibrosis Effects 0.000 description 9
- 239000012634 fragment Substances 0.000 description 9
- 208000018685 gastrointestinal system disease Diseases 0.000 description 9
- 210000001035 gastrointestinal tract Anatomy 0.000 description 9
- 230000006872 improvement Effects 0.000 description 9
- 230000004048 modification Effects 0.000 description 9
- 238000012986 modification Methods 0.000 description 9
- 230000000638 stimulation Effects 0.000 description 9
- 241000700198 Cavia Species 0.000 description 8
- 102000004127 Cytokines Human genes 0.000 description 8
- 108090000695 Cytokines Proteins 0.000 description 8
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 description 8
- 230000002829 reductive effect Effects 0.000 description 8
- 241000894007 species Species 0.000 description 8
- 239000013598 vector Substances 0.000 description 8
- 206010009900 Colitis ulcerative Diseases 0.000 description 7
- 208000011231 Crohn disease Diseases 0.000 description 7
- 241000009328 Perro Species 0.000 description 7
- 201000006704 Ulcerative Colitis Diseases 0.000 description 7
- 239000013604 expression vector Substances 0.000 description 7
- 230000002757 inflammatory effect Effects 0.000 description 7
- 208000023504 respiratory system disease Diseases 0.000 description 7
- 206010039073 rheumatoid arthritis Diseases 0.000 description 7
- 239000000523 sample Substances 0.000 description 7
- 239000000243 solution Substances 0.000 description 7
- 239000010936 titanium Substances 0.000 description 7
- 238000001890 transfection Methods 0.000 description 7
- 206010039085 Rhinitis allergic Diseases 0.000 description 6
- 230000001154 acute effect Effects 0.000 description 6
- 201000010105 allergic rhinitis Diseases 0.000 description 6
- 230000001684 chronic effect Effects 0.000 description 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
- 238000002347 injection Methods 0.000 description 6
- 239000007924 injection Substances 0.000 description 6
- 208000002551 irritable bowel syndrome Diseases 0.000 description 6
- 201000003651 pulmonary sarcoidosis Diseases 0.000 description 6
- 108700015048 receptor decoy activity proteins Proteins 0.000 description 6
- 239000003981 vehicle Substances 0.000 description 6
- 229910019567 Re Re Inorganic materials 0.000 description 5
- 239000000443 aerosol Substances 0.000 description 5
- 150000001412 amines Chemical class 0.000 description 5
- 230000006907 apoptotic process Effects 0.000 description 5
- 239000011324 bead Substances 0.000 description 5
- 230000000112 colonic effect Effects 0.000 description 5
- 230000006378 damage Effects 0.000 description 5
- 239000012530 fluid Substances 0.000 description 5
- 210000004072 lung Anatomy 0.000 description 5
- 210000002540 macrophage Anatomy 0.000 description 5
- 229940126601 medicinal product Drugs 0.000 description 5
- 238000002360 preparation method Methods 0.000 description 5
- 210000003491 skin Anatomy 0.000 description 5
- 230000001225 therapeutic effect Effects 0.000 description 5
- 108010047041 Complementarity Determining Regions Proteins 0.000 description 4
- 238000002965 ELISA Methods 0.000 description 4
- WZUVPPKBWHMQCE-UHFFFAOYSA-N Haematoxylin Chemical compound C12=CC(O)=C(O)C=C2CC2(O)C1C1=CC=C(O)C(O)=C1OC2 WZUVPPKBWHMQCE-UHFFFAOYSA-N 0.000 description 4
- 108060003951 Immunoglobulin Proteins 0.000 description 4
- 241000124008 Mammalia Species 0.000 description 4
- 208000018569 Respiratory Tract disease Diseases 0.000 description 4
- 206010039710 Scleroderma Diseases 0.000 description 4
- 208000025865 Ulcer Diseases 0.000 description 4
- 208000026935 allergic disease Diseases 0.000 description 4
- 125000003277 amino group Chemical group 0.000 description 4
- 208000010668 atopic eczema Diseases 0.000 description 4
- 230000015572 biosynthetic process Effects 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 4
- 239000008280 blood Substances 0.000 description 4
- 238000011067 equilibration Methods 0.000 description 4
- 229960001340 histamine Drugs 0.000 description 4
- 206010020718 hyperplasia Diseases 0.000 description 4
- 102000018358 immunoglobulin Human genes 0.000 description 4
- 238000010253 intravenous injection Methods 0.000 description 4
- 239000005022 packaging material Substances 0.000 description 4
- 230000001575 pathological effect Effects 0.000 description 4
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 4
- 239000004926 polymethyl methacrylate Substances 0.000 description 4
- 238000011002 quantification Methods 0.000 description 4
- 208000024891 symptom Diseases 0.000 description 4
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 3
- WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 description 3
- 208000000884 Airway Obstruction Diseases 0.000 description 3
- 102000019034 Chemokines Human genes 0.000 description 3
- 108010012236 Chemokines Proteins 0.000 description 3
- 101150060303 SOK2 gene Proteins 0.000 description 3
- 229920002684 Sepharose Polymers 0.000 description 3
- 210000001744 T-lymphocyte Anatomy 0.000 description 3
- 102100040247 Tumor necrosis factor Human genes 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 230000002860 competitive effect Effects 0.000 description 3
- 238000013211 curve analysis Methods 0.000 description 3
- YPHMISFOHDHNIV-FSZOTQKASA-N cycloheximide Chemical compound C1[C@@H](C)C[C@H](C)C(=O)[C@@H]1[C@H](O)CC1CC(=O)NC(=O)C1 YPHMISFOHDHNIV-FSZOTQKASA-N 0.000 description 3
- 238000001514 detection method Methods 0.000 description 3
- 239000000539 dimer Substances 0.000 description 3
- 210000002175 goblet cell Anatomy 0.000 description 3
- 230000006698 induction Effects 0.000 description 3
- 230000005764 inhibitory process Effects 0.000 description 3
- 238000003367 kinetic assay Methods 0.000 description 3
- 230000001404 mediated effect Effects 0.000 description 3
- 230000035772 mutation Effects 0.000 description 3
- 239000012071 phase Substances 0.000 description 3
- 230000009257 reactivity Effects 0.000 description 3
- 230000009467 reduction Effects 0.000 description 3
- 238000006722 reduction reaction Methods 0.000 description 3
- 230000010076 replication Effects 0.000 description 3
- 239000000779 smoke Substances 0.000 description 3
- -1 sulfenyl halides Chemical class 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 231100000397 ulcer Toxicity 0.000 description 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 2
- NHJVRSWLHSJWIN-UHFFFAOYSA-N 2,4,6-trinitrobenzenesulfonic acid Chemical compound OS(=O)(=O)C1=C([N+]([O-])=O)C=C([N+]([O-])=O)C=C1[N+]([O-])=O NHJVRSWLHSJWIN-UHFFFAOYSA-N 0.000 description 2
- 241001103870 Adia Species 0.000 description 2
- 208000036065 Airway Remodeling Diseases 0.000 description 2
- 241000486679 Antitype Species 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 2
- 108010006654 Bleomycin Proteins 0.000 description 2
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 2
- 101710155857 C-C motif chemokine 2 Proteins 0.000 description 2
- 101100492787 Caenorhabditis elegans mai-1 gene Proteins 0.000 description 2
- 102000000018 Chemokine CCL2 Human genes 0.000 description 2
- 102000009058 Death Domain Receptors Human genes 0.000 description 2
- 108010049207 Death Domain Receptors Proteins 0.000 description 2
- QSJXEFYPDANLFS-UHFFFAOYSA-N Diacetyl Chemical compound CC(=O)C(C)=O QSJXEFYPDANLFS-UHFFFAOYSA-N 0.000 description 2
- 206010012735 Diarrhoea Diseases 0.000 description 2
- 206010014950 Eosinophilia Diseases 0.000 description 2
- 208000009386 Experimental Arthritis Diseases 0.000 description 2
- 206010017943 Gastrointestinal conditions Diseases 0.000 description 2
- 102000004269 Granulocyte Colony-Stimulating Factor Human genes 0.000 description 2
- 108010017080 Granulocyte Colony-Stimulating Factor Proteins 0.000 description 2
- 241000282412 Homo Species 0.000 description 2
- 101000939500 Homo sapiens UBX domain-containing protein 11 Proteins 0.000 description 2
- 206010020751 Hypersensitivity Diseases 0.000 description 2
- 108010002616 Interleukin-5 Proteins 0.000 description 2
- 102000000743 Interleukin-5 Human genes 0.000 description 2
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 2
- 239000004472 Lysine Substances 0.000 description 2
- 108091034117 Oligonucleotide Proteins 0.000 description 2
- 241000288906 Primates Species 0.000 description 2
- 241001115903 Raphus cucullatus Species 0.000 description 2
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 2
- 241000555745 Sciuridae Species 0.000 description 2
- 108060008682 Tumor Necrosis Factor Proteins 0.000 description 2
- 102100029645 UBX domain-containing protein 11 Human genes 0.000 description 2
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 2
- 230000004913 activation Effects 0.000 description 2
- 230000010933 acylation Effects 0.000 description 2
- 238000005917 acylation reaction Methods 0.000 description 2
- 230000036428 airway hyperreactivity Effects 0.000 description 2
- 230000029936 alkylation Effects 0.000 description 2
- 238000005804 alkylation reaction Methods 0.000 description 2
- 239000013566 allergen Substances 0.000 description 2
- 229940037003 alum Drugs 0.000 description 2
- 125000000539 amino acid group Chemical group 0.000 description 2
- 230000009830 antibody antigen interaction Effects 0.000 description 2
- 239000002246 antineoplastic agent Substances 0.000 description 2
- 210000004436 artificial bacterial chromosome Anatomy 0.000 description 2
- 239000012298 atmosphere Substances 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- 230000004071 biological effect Effects 0.000 description 2
- 229960001561 bleomycin Drugs 0.000 description 2
- OYVAGSVQBOHSSS-UAPAGMARSA-O bleomycin A2 Chemical compound N([C@H](C(=O)N[C@H](C)[C@@H](O)[C@H](C)C(=O)N[C@@H]([C@H](O)C)C(=O)NCCC=1SC=C(N=1)C=1SC=C(N=1)C(=O)NCCC[S+](C)C)[C@@H](O[C@H]1[C@H]([C@@H](O)[C@H](O)[C@H](CO)O1)O[C@@H]1[C@H]([C@@H](OC(N)=O)[C@H](O)[C@@H](CO)O1)O)C=1N=CNC=1)C(=O)C1=NC([C@H](CC(N)=O)NC[C@H](N)C(N)=O)=NC(N)=C1C OYVAGSVQBOHSSS-UAPAGMARSA-O 0.000 description 2
- 230000000903 blocking effect Effects 0.000 description 2
- 210000004271 bone marrow stromal cell Anatomy 0.000 description 2
- 229940098773 bovine serum albumin Drugs 0.000 description 2
- 230000021235 carbamoylation Effects 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 210000004978 chinese hamster ovary cell Anatomy 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- XLJMAIOERFSOGZ-UHFFFAOYSA-M cyanate Chemical compound [O-]C#N XLJMAIOERFSOGZ-UHFFFAOYSA-M 0.000 description 2
- 230000016396 cytokine production Effects 0.000 description 2
- 229940127089 cytotoxic agent Drugs 0.000 description 2
- 239000003651 drinking water Substances 0.000 description 2
- 235000020188 drinking water Nutrition 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000003623 enhancer Substances 0.000 description 2
- YQGOJNYOYNNSMM-UHFFFAOYSA-N eosin Chemical compound [Na+].OC(=O)C1=CC=CC=C1C1=C2C=C(Br)C(=O)C(Br)=C2OC2=C(Br)C(O)=C(Br)C=C21 YQGOJNYOYNNSMM-UHFFFAOYSA-N 0.000 description 2
- 210000005081 epithelial layer Anatomy 0.000 description 2
- 210000003238 esophagus Anatomy 0.000 description 2
- 238000000684 flow cytometry Methods 0.000 description 2
- 230000002496 gastric effect Effects 0.000 description 2
- LEQAOMBKQFMDFZ-UHFFFAOYSA-N glyoxal Chemical compound O=CC=O LEQAOMBKQFMDFZ-UHFFFAOYSA-N 0.000 description 2
- 239000008187 granular material Substances 0.000 description 2
- 210000004408 hybridoma Anatomy 0.000 description 2
- 230000009610 hypersensitivity Effects 0.000 description 2
- 238000011534 incubation Methods 0.000 description 2
- 230000001939 inductive effect Effects 0.000 description 2
- 230000004941 influx Effects 0.000 description 2
- 239000003112 inhibitor Substances 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 230000000968 intestinal effect Effects 0.000 description 2
- 238000007912 intraperitoneal administration Methods 0.000 description 2
- 238000001990 intravenous administration Methods 0.000 description 2
- JDNTWHVOXJZDSN-UHFFFAOYSA-N iodoacetic acid Chemical compound OC(=O)CI JDNTWHVOXJZDSN-UHFFFAOYSA-N 0.000 description 2
- 239000003446 ligand Substances 0.000 description 2
- 230000004199 lung function Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 210000004379 membrane Anatomy 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 239000000178 monomer Substances 0.000 description 2
- 238000002414 normal-phase solid-phase extraction Methods 0.000 description 2
- 230000003647 oxidation Effects 0.000 description 2
- 238000007254 oxidation reaction Methods 0.000 description 2
- OJUGVDODNPJEEC-UHFFFAOYSA-N phenylglyoxal Chemical compound O=CC(=O)C1=CC=CC=C1 OJUGVDODNPJEEC-UHFFFAOYSA-N 0.000 description 2
- 230000008488 polyadenylation Effects 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- 238000003259 recombinant expression Methods 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 230000019491 signal transduction Effects 0.000 description 2
- 102000035025 signaling receptors Human genes 0.000 description 2
- 108091005475 signaling receptors Proteins 0.000 description 2
- 238000007920 subcutaneous administration Methods 0.000 description 2
- 238000002198 surface plasmon resonance spectroscopy Methods 0.000 description 2
- 235000013616 tea Nutrition 0.000 description 2
- 125000003396 thiol group Chemical group [H]S* 0.000 description 2
- 230000009278 visceral effect Effects 0.000 description 2
- 230000003442 weekly effect Effects 0.000 description 2
- KMOUUZVZFBCRAM-OLQVQODUSA-N (3as,7ar)-3a,4,7,7a-tetrahydro-2-benzofuran-1,3-dione Chemical compound C1C=CC[C@@H]2C(=O)OC(=O)[C@@H]21 KMOUUZVZFBCRAM-OLQVQODUSA-N 0.000 description 1
- OVOJUAKDTOOXRF-UHFFFAOYSA-N 2,4-dinitrobenzenesulfonic acid Chemical compound OS(=O)(=O)C1=CC=C([N+]([O-])=O)C=C1[N+]([O-])=O OVOJUAKDTOOXRF-UHFFFAOYSA-N 0.000 description 1
- 150000003923 2,5-pyrrolediones Chemical class 0.000 description 1
- KFDPCYZHENQOBV-UHFFFAOYSA-N 2-(bromomethyl)-4-nitrophenol Chemical compound OC1=CC=C([N+]([O-])=O)C=C1CBr KFDPCYZHENQOBV-UHFFFAOYSA-N 0.000 description 1
- FALRKNHUBBKYCC-UHFFFAOYSA-N 2-(chloromethyl)pyridine-3-carbonitrile Chemical compound ClCC1=NC=CC=C1C#N FALRKNHUBBKYCC-UHFFFAOYSA-N 0.000 description 1
- BSCMKVMJAHJNJW-UHFFFAOYSA-L 3-[2-carboxyethyl(dichloro)stannyl]propanoic acid Chemical compound OC(=O)CC[Sn](Cl)(Cl)CCC(O)=O BSCMKVMJAHJNJW-UHFFFAOYSA-L 0.000 description 1
- FBTSQILOGYXGMD-LURJTMIESA-N 3-nitro-L-tyrosine Chemical class OC(=O)[C@@H](N)CC1=CC=C(O)C([N+]([O-])=O)=C1 FBTSQILOGYXGMD-LURJTMIESA-N 0.000 description 1
- 206010003598 Atelectasis Diseases 0.000 description 1
- 208000032116 Autoimmune Experimental Encephalomyelitis Diseases 0.000 description 1
- 208000034309 Bacterial disease carrier Diseases 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 101100148933 Caenorhabditis elegans sdhb-1 gene Proteins 0.000 description 1
- 101100256965 Caenorhabditis elegans sip-1 gene Proteins 0.000 description 1
- 101100500421 Chlamydomonas reinhardtii DHC1 gene Proteins 0.000 description 1
- 208000017667 Chronic Disease Diseases 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 102000018832 Cytochromes Human genes 0.000 description 1
- 108010052832 Cytochromes Proteins 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 101100291267 Drosophila melanogaster Miga gene Proteins 0.000 description 1
- 101100536354 Drosophila melanogaster tant gene Proteins 0.000 description 1
- 239000012591 Dulbecco’s Phosphate Buffered Saline Substances 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 208000027004 Eosinophilic disease Diseases 0.000 description 1
- 241000283086 Equidae Species 0.000 description 1
- 206010015150 Erythema Diseases 0.000 description 1
- 241000206602 Eukaryota Species 0.000 description 1
- 241000287828 Gallus gallus Species 0.000 description 1
- 101710171457 Glycoprotein O Proteins 0.000 description 1
- 241000238631 Hexapoda Species 0.000 description 1
- 101000984746 Homo sapiens BRCA1-associated protein Proteins 0.000 description 1
- 101000942008 Homo sapiens Colorectal mutant cancer protein Proteins 0.000 description 1
- 101001033249 Homo sapiens Interleukin-1 beta Proteins 0.000 description 1
- 101000600766 Homo sapiens Podoplanin Proteins 0.000 description 1
- 101000800488 Homo sapiens T-cell leukemia homeobox protein 1 Proteins 0.000 description 1
- 102100039065 Interleukin-1 beta Human genes 0.000 description 1
- 102000013691 Interleukin-17 Human genes 0.000 description 1
- 108050003558 Interleukin-17 Proteins 0.000 description 1
- 108090000978 Interleukin-4 Proteins 0.000 description 1
- 108090001005 Interleukin-6 Proteins 0.000 description 1
- 102000004889 Interleukin-6 Human genes 0.000 description 1
- 208000029523 Interstitial Lung disease Diseases 0.000 description 1
- 206010023799 Large intestinal ulcer Diseases 0.000 description 1
- 108010047357 Luminescent Proteins Proteins 0.000 description 1
- 102000006830 Luminescent Proteins Human genes 0.000 description 1
- 208000019693 Lung disease Diseases 0.000 description 1
- 208000032376 Lung infection Diseases 0.000 description 1
- 241000282567 Macaca fascicularis Species 0.000 description 1
- 102000009571 Macrophage Inflammatory Proteins Human genes 0.000 description 1
- 108010009474 Macrophage Inflammatory Proteins Proteins 0.000 description 1
- PEEHTFAAVSWFBL-UHFFFAOYSA-N Maleimide Chemical compound O=C1NC(=O)C=C1 PEEHTFAAVSWFBL-UHFFFAOYSA-N 0.000 description 1
- 241001529936 Murinae Species 0.000 description 1
- 101100009348 Mus musculus Depp1 gene Proteins 0.000 description 1
- 101100286247 Mus musculus Id1 gene Proteins 0.000 description 1
- 241000282339 Mustela Species 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 150000007930 O-acyl isoureas Chemical class 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- 101100491259 Oryza sativa subsp. japonica AP2-2 gene Proteins 0.000 description 1
- 101000825640 Oryza sativa subsp. japonica Shikimate kinase 3, chloroplastic Proteins 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 101710132772 Peroxidase 1 Proteins 0.000 description 1
- 206010036790 Productive cough Diseases 0.000 description 1
- 208000007123 Pulmonary Atelectasis Diseases 0.000 description 1
- 101100009350 Rattus norvegicus Depp gene Proteins 0.000 description 1
- 208000002200 Respiratory Hypersensitivity Diseases 0.000 description 1
- 101100385396 Schizosaccharomyces pombe (strain 972 / ATCC 24843) cka1 gene Proteins 0.000 description 1
- 101710193490 Serine/threonine protein kinase OSK3 Proteins 0.000 description 1
- 241000282887 Suidae Species 0.000 description 1
- 108700023707 TUG1 Proteins 0.000 description 1
- NYTOUQBROMCLBJ-UHFFFAOYSA-N Tetranitromethane Chemical compound [O-][N+](=O)C([N+]([O-])=O)([N+]([O-])=O)[N+]([O-])=O NYTOUQBROMCLBJ-UHFFFAOYSA-N 0.000 description 1
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 1
- 208000036142 Viral infection Diseases 0.000 description 1
- 102220589714 YjeF N-terminal domain-containing protein 3_T24Y_mutation Human genes 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 208000024716 acute asthma Diseases 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 230000008371 airway function Effects 0.000 description 1
- 230000010085 airway hyperresponsiveness Effects 0.000 description 1
- 208000037883 airway inflammation Diseases 0.000 description 1
- 150000001299 aldehydes Chemical class 0.000 description 1
- 230000009435 amidation Effects 0.000 description 1
- 238000007112 amidation reaction Methods 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000033115 angiogenesis Effects 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 210000000612 antigen-presenting cell Anatomy 0.000 description 1
- 230000005775 apoptotic pathway Effects 0.000 description 1
- 125000000637 arginyl group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 description 1
- 210000001106 artificial yeast chromosome Anatomy 0.000 description 1
- 210000003567 ascitic fluid Anatomy 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 239000012131 assay buffer Substances 0.000 description 1
- 208000027697 autoimmune lymphoproliferative syndrome due to CTLA4 haploinsuffiency Diseases 0.000 description 1
- 210000003719 b-lymphocyte Anatomy 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- SRSXLGNVWSONIS-UHFFFAOYSA-N benzenesulfonic acid Chemical compound OS(=O)(=O)C1=CC=CC=C1 SRSXLGNVWSONIS-UHFFFAOYSA-N 0.000 description 1
- 230000002146 bilateral effect Effects 0.000 description 1
- 239000013060 biological fluid Substances 0.000 description 1
- 229960002685 biotin Drugs 0.000 description 1
- 235000020958 biotin Nutrition 0.000 description 1
- 239000011616 biotin Substances 0.000 description 1
- 210000004899 c-terminal region Anatomy 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 150000001718 carbodiimides Chemical class 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 238000000423 cell based assay Methods 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 125000003636 chemical group Chemical group 0.000 description 1
- AWGTVRDHKJQFAX-UHFFFAOYSA-M chloro(phenyl)mercury Chemical compound Cl[Hg]C1=CC=CC=C1 AWGTVRDHKJQFAX-UHFFFAOYSA-M 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 208000023819 chronic asthma Diseases 0.000 description 1
- 235000019504 cigarettes Nutrition 0.000 description 1
- 238000012761 co-transfection Methods 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 230000008951 colonic inflammation Effects 0.000 description 1
- 230000004600 colonic motility Effects 0.000 description 1
- 230000009137 competitive binding Effects 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 239000007859 condensation product Substances 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 230000009260 cross reactivity Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 210000004443 dendritic cell Anatomy 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 229920003045 dextran sodium sulfate Polymers 0.000 description 1
- FFYPMLJYZAEMQB-UHFFFAOYSA-N diethyl pyrocarbonate Chemical compound CCOC(=O)OC(=O)OCC FFYPMLJYZAEMQB-UHFFFAOYSA-N 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 150000002019 disulfides Chemical class 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 235000013601 eggs Nutrition 0.000 description 1
- 210000002889 endothelial cell Anatomy 0.000 description 1
- 230000002327 eosinophilic effect Effects 0.000 description 1
- 210000000981 epithelium Anatomy 0.000 description 1
- 231100000321 erythema Toxicity 0.000 description 1
- 210000003527 eukaryotic cell Anatomy 0.000 description 1
- 208000012997 experimental autoimmune encephalomyelitis Diseases 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 238000011832 ferret model Methods 0.000 description 1
- 102000034287 fluorescent proteins Human genes 0.000 description 1
- 108091006047 fluorescent proteins Proteins 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 238000002523 gelfiltration Methods 0.000 description 1
- 238000010353 genetic engineering Methods 0.000 description 1
- 229940015043 glyoxal Drugs 0.000 description 1
- ZRALSGWEFCBTJO-UHFFFAOYSA-N guanidine group Chemical group NC(=N)N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 description 1
- 238000011554 guinea pig model Methods 0.000 description 1
- 230000012447 hatching Effects 0.000 description 1
- XLYOFNOQVPJJNP-ZSJDYOACSA-N heavy water Substances [2H]O[2H] XLYOFNOQVPJJNP-ZSJDYOACSA-N 0.000 description 1
- 125000000623 heterocyclic group Chemical group 0.000 description 1
- 210000003630 histaminocyte Anatomy 0.000 description 1
- 125000000487 histidyl group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C([H])=N1 0.000 description 1
- 102000050209 human BRAP Human genes 0.000 description 1
- 102000050077 human MCC Human genes 0.000 description 1
- 102000044958 human TLX1 Human genes 0.000 description 1
- 125000002883 imidazolyl group Chemical group 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 238000002649 immunization Methods 0.000 description 1
- 238000003018 immunoassay Methods 0.000 description 1
- 230000005847 immunogenicity Effects 0.000 description 1
- 125000001041 indolyl group Chemical group 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 210000004964 innate lymphoid cell Anatomy 0.000 description 1
- 208000020082 intraepithelial neoplasia Diseases 0.000 description 1
- 239000007928 intraperitoneal injection Substances 0.000 description 1
- PGLTVOMIXTUURA-UHFFFAOYSA-N iodoacetamide Chemical compound NC(=O)CI PGLTVOMIXTUURA-UHFFFAOYSA-N 0.000 description 1
- 210000001503 joint Anatomy 0.000 description 1
- 210000002510 keratinocyte Anatomy 0.000 description 1
- 230000002147 killing effect Effects 0.000 description 1
- 210000002429 large intestine Anatomy 0.000 description 1
- 208000010729 leg swelling Diseases 0.000 description 1
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 1
- FPYJFEHAWHCUMM-UHFFFAOYSA-N maleic anhydride Chemical compound O=C1OC(=O)C=C1 FPYJFEHAWHCUMM-UHFFFAOYSA-N 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000001693 membrane extraction with a sorbent interface Methods 0.000 description 1
- 150000002730 mercury Chemical class 0.000 description 1
- 150000002731 mercury compounds Chemical class 0.000 description 1
- 108020004999 messenger RNA Proteins 0.000 description 1
- SJFKGZZCMREBQH-UHFFFAOYSA-N methyl ethanimidate Chemical compound COC(C)=N SJFKGZZCMREBQH-UHFFFAOYSA-N 0.000 description 1
- 108091028838 miR-2 stem-loop Proteins 0.000 description 1
- 230000007659 motor function Effects 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 201000006417 multiple sclerosis Diseases 0.000 description 1
- 238000007837 multiplex assay Methods 0.000 description 1
- 238000002663 nebulization Methods 0.000 description 1
- 239000013642 negative control Substances 0.000 description 1
- 230000010807 negative regulation of binding Effects 0.000 description 1
- 210000000440 neutrophil Anatomy 0.000 description 1
- 238000006396 nitration reaction Methods 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 239000013612 plasmid Substances 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 230000004481 post-translational protein modification Effects 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 239000012562 protein A resin Substances 0.000 description 1
- 230000006337 proteolytic cleavage Effects 0.000 description 1
- 208000002815 pulmonary hypertension Diseases 0.000 description 1
- 239000002096 quantum dot Substances 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 238000001525 receptor binding assay Methods 0.000 description 1
- 238000005932 reductive alkylation reaction Methods 0.000 description 1
- 210000003289 regulatory T cell Anatomy 0.000 description 1
- 238000007634 remodeling Methods 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 238000010839 reverse transcription Methods 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 102220075283 rs200435907 Human genes 0.000 description 1
- 102200114051 rs372699811 Human genes 0.000 description 1
- 102200094314 rs74315399 Human genes 0.000 description 1
- 235000002020 sage Nutrition 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 230000011664 signaling Effects 0.000 description 1
- 210000003802 sputum Anatomy 0.000 description 1
- 208000024794 sputum Diseases 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 229940014800 succinic anhydride Drugs 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 230000030968 tissue homeostasis Effects 0.000 description 1
- 229910052719 titanium Inorganic materials 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 108700012359 toxins Proteins 0.000 description 1
- 238000013518 transcription Methods 0.000 description 1
- 230000035897 transcription Effects 0.000 description 1
- 230000005030 transcription termination Effects 0.000 description 1
- 230000002103 transcriptional effect Effects 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 238000013519 translation Methods 0.000 description 1
- 125000000430 tryptophan group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12 0.000 description 1
- 125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 1
- 230000036269 ulceration Effects 0.000 description 1
- 241000701447 unidentified baculovirus Species 0.000 description 1
- 241001529453 unidentified herpesvirus Species 0.000 description 1
- 230000035899 viability Effects 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- 239000013603 viral vector Substances 0.000 description 1
- 230000004584 weight gain Effects 0.000 description 1
- 235000019786 weight gain Nutrition 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Transplantation (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Sorting Of Articles (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562220442P | 2015-09-18 | 2015-09-18 | |
| PCT/US2016/052040 WO2017049024A1 (en) | 2015-09-18 | 2016-09-16 | Antibodies that specifically bind to tl1a |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA125284C2 true UA125284C2 (uk) | 2022-02-16 |
Family
ID=57043002
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UAA201804192A UA125284C2 (uk) | 2015-09-18 | 2016-09-16 | Рекомбінантне антитіло, яке специфічно зв'язується з tl1a |
Country Status (33)
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110229471A1 (en) | 2008-11-26 | 2011-09-22 | Cedars-Sinai Medical Center | Methods of determining responsiveness to anti-tnf alpha therapy in inflammatory bowel disease |
| KR101982899B1 (ko) | 2011-09-30 | 2019-05-27 | 테바 파마슈티컬즈 오스트레일리아 피티와이 엘티디 | ＴＬ1ａ에 대한 항체 및 그의 용도 |
| CA2908553A1 (en) | 2013-03-27 | 2014-10-02 | Cedars-Sinai Medical Center | Mitigation and reversal of fibrosis and inflammation by inhibition of tl1a function and related signaling pathways |
| EP4105236A1 (en) | 2013-07-19 | 2022-12-21 | Cedars-Sinai Medical Center | Anti-tl1a (tnfsf15) antibody for treatment of inflammatory bowel disease |
| TWI703158B (zh) | 2015-09-18 | 2020-09-01 | 美商希佛隆公司 | 特異性結合tl1a之抗體 |
| EP4338672A3 (en) * | 2015-12-04 | 2024-07-17 | University Of Iowa Research Foundation | System for screening delirium patients for the presence of encephalopathy |
| JP7082945B2 (ja) | 2016-03-17 | 2022-06-09 | シーダーズ―シナイ メディカル センター | Ｒｎａｓｅｔ２により炎症性腸疾患を診断する方法 |
| MY191324A (en) | 2016-10-26 | 2022-06-15 | Cedars Sinai Medical Center | Neutralizing anti-tl1a monoclonal antibodies |
| WO2018199337A1 (ja) * | 2017-04-28 | 2018-11-01 | 味の素株式会社 | 可溶性タンパク質に対する親和性物質、切断性部分および反応性基を有する化合物またはその塩 |
| CA3098374A1 (en) | 2018-04-25 | 2019-10-31 | Prometheus Biosciences, Inc. | Optimized anti-tl1a antibodies |
| AU2020275413A1 (en) | 2019-05-14 | 2021-12-23 | Cedars-Sinai Medical Center | TL1A patient selection methods, systems, and devices |
| CA3158638A1 (en) | 2019-10-24 | 2021-04-29 | Prometheus Biosciences, Inc. | Humanized antibodies to tnf-like ligand 1a (tl1a) and uses thereof |
| WO2022040302A1 (en) * | 2020-08-19 | 2022-02-24 | Janssen Biotech, Inc. | Materials and methods of using engineered ligands |
| WO2024026395A1 (en) | 2022-07-27 | 2024-02-01 | Cephalon Llc | Anti-tl1a antibodies for the treatment of ulcerative colitis and crohn's disease |
| WO2024026386A1 (en) | 2022-07-27 | 2024-02-01 | Cephalon Llc | Anti-tl1a antibody formulations |
| WO2024239006A1 (en) | 2023-05-17 | 2024-11-21 | Genentech, Inc. | Anti-tl1a antibody therapeutic methods |
| WO2024263900A2 (en) * | 2023-06-22 | 2024-12-26 | Paragon Therapeutics, Inc. | Il-23 antibody compositions and methods of use |
| TW202515910A (zh) * | 2023-06-22 | 2025-04-16 | 美商派拉岡醫療公司 | Il-17抗體組合物及使用方法 |
| WO2025038473A1 (en) * | 2023-08-11 | 2025-02-20 | Paragon Therapeutics, Inc. | Tl1a binding antibodies and methods of use |
| US12473370B2 (en) | 2023-10-03 | 2025-11-18 | Absci Corporation | TL1A associated antibody compositions and methods of use |
| CN120058933A (zh) * | 2023-11-30 | 2025-05-30 | 北京智仁美博生物科技有限公司 | 抗肿瘤坏死因子样配体1a的抗体及其用途 |
| US20250230251A1 (en) | 2023-12-20 | 2025-07-17 | Bristol-Myers Squibb Company | Antibodies targeting il-18 receptor beta (il-18rb) and related methods |
| CN120424214A (zh) * | 2024-02-05 | 2025-08-05 | 三生国健药业（上海）股份有限公司 | 一种抗tl1a抗体及其制备方法和用途 |
| WO2025240922A1 (en) | 2024-05-17 | 2025-11-20 | Genentech, Inc. | Methods for treatment of inflammatory bowel disease with an anti-tl1a antibody |
| CN119552252B (zh) * | 2025-01-16 | 2025-11-25 | 华润生物医药有限公司 | 抗tl1a抗体及其制备方法和应用 |
Family Cites Families (65)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7597886B2 (en) | 1994-11-07 | 2009-10-06 | Human Genome Sciences, Inc. | Tumor necrosis factor-gamma |
| US7820798B2 (en) | 1994-11-07 | 2010-10-26 | Human Genome Sciences, Inc. | Tumor necrosis factor-gamma |
| PL220113B1 (pl) | 1999-01-15 | 2015-08-31 | Genentech Inc | Wariant macierzystego polipeptydu zawierającego region Fc, polipeptyd zawierający wariant regionu Fc o zmienionym powinowactwie wiązania receptora Fc gamma (FcγR), polipeptyd zawierający wariant regionu Fc o zmienionym powinowactwie wiązania noworodkowego receptora Fc (FcRn), kompozycja, wyizolowany kwas nukleinowy, wektor, komórka gospodarza, sposób otrzymywania wariantu polipeptydu, zastosowanie wariantu polipeptydu i sposób otrzymywania wariantu regionu Fc |
| US6548062B2 (en) * | 2000-02-29 | 2003-04-15 | Cephalon, Inc. | Method of treating cancer with anti-neurotrophin agents |
| PT1355919E (pt) | 2000-12-12 | 2011-03-02 | Medimmune Llc | Moléculas com semivida longa, composições que as contêm e suas utilizações |
| US20040132101A1 (en) | 2002-09-27 | 2004-07-08 | Xencor | Optimized Fc variants and methods for their generation |
| US7317091B2 (en) | 2002-03-01 | 2008-01-08 | Xencor, Inc. | Optimized Fc variants |
| US7217797B2 (en) | 2002-10-15 | 2007-05-15 | Pdl Biopharma, Inc. | Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis |
| AU2003293543A1 (en) | 2002-12-13 | 2004-07-09 | Abgenix, Inc. | System and method for stabilizing antibodies with histidine |
| WO2005018571A2 (en) | 2003-08-20 | 2005-03-03 | University Of Miami | Compositions and methods for treating inflammatory lung disease |
| CA2560742A1 (en) | 2004-03-23 | 2005-10-06 | Biogen Idec Ma Inc. | Receptor coupling agents and therapeutic uses thereof |
| GB0521621D0 (en) * | 2005-10-24 | 2005-11-30 | Domantis Ltd | Tumor necrosis factor receptor 1 antagonists for treating respiratory diseases |
| WO2006127900A2 (en) | 2005-05-25 | 2006-11-30 | Biogen Idec Ma Inc. | Tl1a in the treatment of disease |
| US20070128184A1 (en) | 2005-08-30 | 2007-06-07 | Eckhard Podack | Immunomodulating tumor necrosis factor receptor 25 (TNFR25) agonists, antagonists and immunotoxins |
| US20090269345A1 (en) | 2005-12-23 | 2009-10-29 | Rong Fan | CLN248 Antibody Compositions and Methods of Use |
| US20110217310A1 (en) | 2007-01-10 | 2011-09-08 | Siegel Richard M | Blockade of tl1a-dr3 interactions to ameliorate t cell mediated disease pathology |
| WO2008106451A2 (en) | 2007-02-26 | 2008-09-04 | Cedars-Sinai Medical Center | Methods of using single nucleotide polymorphisms in the tl1a gene to predict or diagnose inflammatory bowel disease |
| US20100240043A1 (en) | 2007-10-19 | 2010-09-23 | Cedars-Sinai Medical Center | Methods of using genetic variants to diagnose and predict inflammatory bowel disease |
| MX2010005282A (es) | 2007-11-13 | 2010-08-31 | Teva Pharma | Anticuerpos humanizados contra tl1a. |
| US20120073585A1 (en) | 2009-04-08 | 2012-03-29 | Cedars-Sinai Medical Center | Methods of predicting complication and surgery in crohn's disease |
| WO2011080314A2 (en) | 2009-12-31 | 2011-07-07 | Deutsches Krebsforschungszentrum | Novel modulators of trail signalling |
| JO3375B1 (ar) | 2010-11-08 | 2019-03-13 | Regeneron Pharma | أجسام مضادة بشرية للجين a1 الشبيه بعامل النخر الورمي (tl1a) |
| CA2836898A1 (en) | 2011-05-20 | 2012-11-29 | Government Of The United States, As Represented By The Secretary, Department Of Health And Human Services | Blockade of tl1a-dr3 interactions to ameliorate t cell mediated disease pathology and antibodies thereof |
| EP2720719A4 (en) | 2011-06-15 | 2015-12-09 | Glaxosmithkline Ip No 2 Ltd | METHOD FOR SELECTION OF THERAPEUTIC INDICATIONS |
| KR101982899B1 (ko) | 2011-09-30 | 2019-05-27 | 테바 파마슈티컬즈 오스트레일리아 피티와이 엘티디 | ＴＬ1ａ에 대한 항체 및 그의 용도 |
| US9592297B2 (en) | 2012-08-31 | 2017-03-14 | Bayer Healthcare Llc | Antibody and protein formulations |
| EA201591153A1 (ru) | 2013-01-02 | 2016-01-29 | Гленмарк Фармасьютикалс С.А. | Антитела, связывающиеся с tl1a, и их применение |
| CA2908553A1 (en) | 2013-03-27 | 2014-10-02 | Cedars-Sinai Medical Center | Mitigation and reversal of fibrosis and inflammation by inhibition of tl1a function and related signaling pathways |
| JP2016522168A (ja) * | 2013-04-05 | 2016-07-28 | ジェネンテック， インコーポレイテッド | 抗ｉｌ−４抗体及び二重特異性抗体及びその使用 |
| KR20210107176A (ko) | 2013-05-17 | 2021-08-31 | 세다르스-신나이 메디칼 센터 | 크론병과 연관된 tnfsf15와 dcr3의 변이체 |
| EP2996717A4 (en) | 2013-05-17 | 2016-11-23 | Cedars Sinai Medical Center | DIFFERENT EFFECTS OF IFN-GAMMA AND IL-17 ON TL1A-MODULATED INFLAMMATION AND FIBROSIS |
| EP4105236A1 (en) | 2013-07-19 | 2022-12-21 | Cedars-Sinai Medical Center | Anti-tl1a (tnfsf15) antibody for treatment of inflammatory bowel disease |
| MX2016002879A (es) | 2013-09-06 | 2016-08-17 | Cedars Sinai Medical Center | Sistemas, dispositivos y metodos para la terapia anti-tl1a. |
| BR112016009797A2 (pt) | 2013-11-13 | 2017-12-05 | Bristol Myers Squibb Co | anticorpos específicos de ligante 1a do tipo fator de necrose tumoral e composições e usos dos mesmos |
| PT3283499T (pt) | 2015-04-15 | 2022-08-23 | Biosearch Tech Inc | Sondas de extintor dual |
| KR20180004818A (ko) | 2015-05-15 | 2018-01-12 | 세다르스-신나이 메디칼 센터 | 염증성 장 질환의 치료를 위한 모델, 방법 및 조성물 |
| HK1257443A1 (zh) | 2015-08-21 | 2019-10-18 | The Children's Hospital Of Philadelphia | 治疗具有dcr3或dcr3网络基因中的遗传变异的患者的自身免疫病症的方法 |
| TWI703158B (zh) | 2015-09-18 | 2020-09-01 | 美商希佛隆公司 | 特異性結合tl1a之抗體 |
| US20180319889A1 (en) | 2015-11-02 | 2018-11-08 | La Jolla Institute For Allergy & Immunology | Method and medicament for treating airway and/or lung diseases |
| CR20180365A (es) | 2015-12-16 | 2018-09-28 | Amgen Inc | PROTEÍNAS DE UNIÓN AL ANTÍGENO BISPECÍFICO DE ANTI-TL1A/ANTI-TNF-a Y SUS USOS |
| JP7082945B2 (ja) | 2016-03-17 | 2022-06-09 | シーダーズ―シナイ メディカル センター | Ｒｎａｓｅｔ２により炎症性腸疾患を診断する方法 |
| EP3455256A1 (en) | 2016-05-09 | 2019-03-20 | Bristol-Myers Squibb Company | Tl1a antibodies and uses thereof |
| GB201608323D0 (en) | 2016-05-12 | 2016-06-29 | Ucb Biopharma Sprl | Pharmaceutical compositions |
| CN109219620B (zh) | 2016-06-09 | 2023-01-31 | 派立卡恩治疗公司 | 抗-tnfrsf25抗体 |
| MY191324A (en) | 2016-10-26 | 2022-06-15 | Cedars Sinai Medical Center | Neutralizing anti-tl1a monoclonal antibodies |
| WO2018195328A1 (en) | 2017-04-20 | 2018-10-25 | Cedars-Sinai Medical Center | Methods of predicting non-response to anti-tnf treatment in subjects with inflammatory bowel disease |
| CA3098374A1 (en) | 2018-04-25 | 2019-10-31 | Prometheus Biosciences, Inc. | Optimized anti-tl1a antibodies |
| AU2019261933B2 (en) | 2018-04-30 | 2025-12-18 | Cedars-Sinai Medical Center | Methods and systems for selection and treatment of patients with inflammatory diseases |
| CA3121167A1 (en) | 2018-11-29 | 2020-06-04 | Cedars-Sinai Medical Center | Methods of stratifying and treating a sub-population of inflammatory bowel disease patients |
| AU2020275413A1 (en) | 2019-05-14 | 2021-12-23 | Cedars-Sinai Medical Center | TL1A patient selection methods, systems, and devices |
| TWI871367B (zh) | 2019-10-24 | 2025-02-01 | 美商普羅米修斯生物科學股份有限公司 | 針對類-tnf配體1a(tl1a)之人類化抗體及其用途 |
| EP4065727A4 (en) | 2019-11-27 | 2024-03-27 | Cedars-Sinai Medical Center | PREDICTING EXTRAINTESTINAL MANIFESTATIONS OF INFLAMMATORY BOWEL DISEASE |
| EP4162067A4 (en) | 2020-06-03 | 2024-07-10 | Cedars-Sinai Medical Center | METHODS AND SYSTEMS FOR MEASURING THE RECURRENCE OF POSTOPERATIVE DISEASES |
| EP4162076A4 (en) | 2020-06-03 | 2024-10-02 | Cedars-Sinai Medical Center | TREATMENTS FOR A SUBPOPULATION OF PATIENTS WITH INFLAMMATORY BOWEL DISEASE |
| US20230235070A1 (en) | 2020-06-26 | 2023-07-27 | Pfizer Inc. | Method of treatment of inflammatory bowel disease using anti-tl1a antibodies |
| PH12023500011A1 (en) | 2020-11-13 | 2024-03-11 | Cedars Sinai Medical Center | Methods, systems, and kits for treatment of inflammatory diseases targeting tl1a |
| WO2022119842A1 (en) | 2020-12-01 | 2022-06-09 | Cedars-Sinai Medical Center | Methods and systems of stratifying inflammatory disease patients |
| EP4263585A4 (en) | 2020-12-21 | 2024-11-27 | Cedars-Sinai Medical Center | THERAPEUTIC COMPOSITIONS OF TL1A AND METHODS OF TREATMENT USING THEM |
| KR20230158494A (ko) | 2021-02-18 | 2023-11-20 | 프로메테우스 바이오사이언시즈, 인크. | 항-tl1a 항체 조성물 및 폐에서의 치료 방법 |
| JP2024506940A (ja) | 2021-02-18 | 2024-02-15 | プロメテウス バイオサイエンシーズ，インク． | Ｔｎｆ様リガンド１ａ（ｔｌ１ａ）に対するヒト化抗体を含む組成物及びその使用 |
| WO2022232253A1 (en) | 2021-04-28 | 2022-11-03 | Cedars-Sinai Medical Center | Patient selection methods and kits for therapies targeting tl1a |
| WO2023102051A1 (en) | 2021-12-01 | 2023-06-08 | Cedars-Sinai Medical Center | Intestinal mononuclear phagocytes as prognostic biomarker for crohn's disease |
| WO2023102071A1 (en) | 2021-12-01 | 2023-06-08 | Cedars-Sinai Medical Center | Microbial metabolites on intestinal inflammation |
| TW202346344A (zh) | 2022-01-07 | 2023-12-01 | 美商普羅米修斯生物科學股份有限公司 | 以tl1a抑制劑及il23抑制劑的組合治療發炎疾病之方法 |
| US20240059799A1 (en) | 2022-05-11 | 2024-02-22 | Pfizer Inc. | Anti-tl1a antibodies and methods of use thereof |
-
2016
- 2016-09-14 TW TW105130075A patent/TWI703158B/zh active
- 2016-09-16 ES ES16774750T patent/ES2810751T3/es active Active
- 2016-09-16 US US15/267,213 patent/US10138296B2/en active Active
- 2016-09-16 KR KR1020187007337A patent/KR101998535B1/ko active Active
- 2016-09-16 HR HRP20201323TT patent/HRP20201323T1/hr unknown
- 2016-09-16 PL PL16774750T patent/PL3350223T3/pl unknown
- 2016-09-16 IL IL257761A patent/IL257761B2/en unknown
- 2016-09-16 AR ARP160102834A patent/AR106055A1/es unknown
- 2016-09-16 EP EP16774750.0A patent/EP3350223B1/en active Active
- 2016-09-16 PT PT167747500T patent/PT3350223T/pt unknown
- 2016-09-16 EA EA201890756A patent/EA201890756A1/ru unknown
- 2016-09-16 MD MDE20180714T patent/MD3350223T2/ro unknown
- 2016-09-16 JP JP2018512167A patent/JP7013366B2/ja active Active
- 2016-09-16 RS RS20200983A patent/RS60703B1/sr unknown
- 2016-09-16 CN CN201680053598.8A patent/CN108137693B/zh active Active
- 2016-09-16 SM SM20200500T patent/SMT202000500T1/it unknown
- 2016-09-16 PH PH1/2018/500580A patent/PH12018500580B1/en unknown
- 2016-09-16 MA MA42825A patent/MA42825B1/fr unknown
- 2016-09-16 DK DK16774750.0T patent/DK3350223T3/da active
- 2016-09-16 BR BR122021002400A patent/BR122021002400A8/pt active Search and Examination
- 2016-09-16 MA MA052643A patent/MA52643A/fr unknown
- 2016-09-16 AU AU2016323460A patent/AU2016323460B2/en active Active
- 2016-09-16 PE PE2018000398A patent/PE20181080A1/es unknown
- 2016-09-16 EP EP20151834.7A patent/EP3693393A1/en active Pending
- 2016-09-16 CA CA2997015A patent/CA2997015A1/en active Pending
- 2016-09-16 MX MX2018003185A patent/MX2018003185A/es unknown
- 2016-09-16 UA UAA201804192A patent/UA125284C2/uk unknown
- 2016-09-16 WO PCT/US2016/052040 patent/WO2017049024A1/en not_active Ceased
- 2016-09-16 HU HUE16774750A patent/HUE051496T2/hu unknown
- 2016-09-16 BR BR112018005407A patent/BR112018005407A8/pt active IP Right Grant
- 2016-09-16 LT LTEP16774750.0T patent/LT3350223T/lt unknown
- 2016-09-16 SI SI201630885T patent/SI3350223T1/sl unknown
-
2018
- 2018-02-28 ZA ZA2018/01427A patent/ZA201801427B/en unknown
- 2018-03-16 CL CL2018000711A patent/CL2018000711A1/es unknown
- 2018-04-09 CO CONC2018/0003736A patent/CO2018003736A2/es unknown
- 2018-10-18 US US16/164,509 patent/US11220549B2/en active Active
-
2020
- 2020-08-17 CY CY20201100767T patent/CY1123499T1/el unknown
-
2021
- 2021-11-30 US US17/538,530 patent/US12162946B2/en active Active
-
2022
- 2022-01-17 JP JP2022005039A patent/JP7341259B2/ja active Active
-
2023
- 2023-06-01 AU AU2023203440A patent/AU2023203440A1/en active Pending
-
2024
- 2024-11-06 US US18/939,176 patent/US20250179202A1/en active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| UA125284C2 (uk) | Рекомбінантне антитіло, яке специфічно зв'язується з tl1a | |
| ES2791333T3 (es) | Anticuerpos anti-MIF para su uso en el tratamiento de enfermedades inflamatorias | |
| RU2760334C2 (ru) | Моноклональные антитела к альфа-синуклеину для предотвращения агрегации тау-белка | |
| US10604562B2 (en) | Anti-transthyretin humanized antibody | |
| US11186630B2 (en) | Anti-transthyretin human antibody | |
| CN106794129B (zh) | 对il-21具有特异性的结合分子及其用途 | |
| CN104262483A (zh) | 用于生成抗体混合物的方法 | |
| RS66178B1 (sr) | Interleukin-31 monoklonalno antitelo | |
| KR20190002644A (ko) | FcγRIIA에 특이적인 결합 분자 및 이의 용도 | |
| JP6286757B2 (ja) | 抗ヒトｃｄ６９抗体、及びその医薬用途 | |
| US10981977B2 (en) | Anti-HERV-K envelope protein antibodies and methods for detecting HERV-K envelope protein in patients with sporadic amyotrophic lateral sclerosis | |
| CN109311992A (zh) | 用于治疗t细胞介导疾病的新型抗cd6抗体 | |
| TW201321408A (zh) | 作為診斷標記之oxMIF | |
| US20190262425A1 (en) | Uses of il-41 | |
| EP3992205A1 (en) | Sars coronavirus-2 spike protein binding compounds | |
| JP6872756B2 (ja) | 抗Ｍｙｌ９抗体 | |
| WO2022060900A1 (en) | Shark-derived binding molecules for sars-cov-2 coronavirus and uses thereof | |
| CN101415438A (zh) | Toll样受体3拮抗剂、方法和用途 | |
| CN120137017A (zh) | 抗p24抗体及其用途 | |
| CN118922439A (zh) | 抗糖蛋白ｄ抗体及其制备方法和用途 | |
| Hoban | Chimeric IgM immunoglobulin specific to the measles nucleoprotein: a positive control in measles diagnostic tests and proficiency panels | |
| EA042971B1 (ru) | Антитела, которые специфически связываются с tl1a | |
| BR122024020794A2 (pt) | Anticorpos que se ligam especificamente à il-15 humana e seus usos, composição, método in vitro para detecção de il-15 ou um complexo de il-15 e receptor de il-15-alfa, polinucleotídeo, vetor e método de produção do dito anticorpo |