UA125136C2 - Антитіла, які зв'язуються з сортиліном і пригнічують зв'язування програнуліну - Google Patents

Антитіла, які зв'язуються з сортиліном і пригнічують зв'язування програнуліну Download PDF

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Publication number
UA125136C2
UA125136C2 UAA201800574A UAA201800574A UA125136C2 UA 125136 C2 UA125136 C2 UA 125136C2 UA A201800574 A UAA201800574 A UA A201800574A UA A201800574 A UAA201800574 A UA A201800574A UA 125136 C2 UA125136 C2 UA 125136C2
Authority
UA
Ukraine
Prior art keywords
variable domain
antibody
heavy chain
light chain
zeo
Prior art date
Application number
UAA201800574A
Other languages
English (en)
Ukrainian (uk)
Inventor
Рьонн Ларс Крістіан Білманн
Рённ Ларс Криситан Билманн
Ібрагім Джон Малік
Ибрагим Джон МАЛИК
Джеффрі Бі. Ставенхаґен
Джеффри Б. СТАВЕНХАГЕН
Сьорен Крістенсен
Сёрен Кристенсен
Ян Еґебьєрґ
Ян Эгебьерг
Арно Ґеррітсен
Арно Герритсен
ден Брінк Едвард ван
Ден Бринк Эдвард Ван
Пол ПАРРЕН
Йонґ Роб де
Йонг Роб Де
Original Assignee
Х. Луннбек А/С
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Х. Луннбек А/С filed Critical Х. Луннбек А/С
Publication of UA125136C2 publication Critical patent/UA125136C2/uk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/286—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against neuromediator receptors, e.g. serotonin receptor, dopamine receptor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Neurosurgery (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
UAA201800574A 2015-07-13 2016-07-12 Антитіла, які зв'язуються з сортиліном і пригнічують зв'язування програнуліну UA125136C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1512215.3A GB201512215D0 (en) 2015-07-13 2015-07-13 Agents,uses and methods
PCT/EP2016/066516 WO2017009327A1 (en) 2015-07-13 2016-07-12 Antibodies that bind to sortilin and inhibit the binding of progranulin

Publications (1)

Publication Number Publication Date
UA125136C2 true UA125136C2 (uk) 2022-01-19

Family

ID=54013862

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201800574A UA125136C2 (uk) 2015-07-13 2016-07-12 Антитіла, які зв'язуються з сортиліном і пригнічують зв'язування програнуліну

Country Status (35)

Country Link
US (6) US10479835B2 (enExample)
EP (1) EP3322726B1 (enExample)
JP (2) JP6979397B2 (enExample)
KR (1) KR102778576B1 (enExample)
CN (3) CN107849135A (enExample)
AR (1) AR105335A1 (enExample)
AU (1) AU2016292980B2 (enExample)
BR (1) BR112018000771A2 (enExample)
CA (1) CA2989739A1 (enExample)
CL (2) CL2018000092A1 (enExample)
CO (1) CO2017012988A2 (enExample)
CR (1) CR20180002A (enExample)
DO (1) DOP2018000014A (enExample)
EA (1) EA201890038A1 (enExample)
EC (1) ECSP18002725A (enExample)
ES (1) ES3024469T3 (enExample)
GB (1) GB201512215D0 (enExample)
HR (1) HRP20250602T1 (enExample)
HU (1) HUE071424T2 (enExample)
IL (1) IL256503B (enExample)
JO (1) JO3710B1 (enExample)
MA (1) MA42440B1 (enExample)
MX (1) MX2018000506A (enExample)
NI (1) NI201800007A (enExample)
PE (1) PE20181014A1 (enExample)
PH (1) PH12018500100A1 (enExample)
PL (1) PL3322726T3 (enExample)
RS (1) RS66856B1 (enExample)
RU (1) RU2735639C2 (enExample)
SV (1) SV2018005613A (enExample)
TN (1) TN2017000534A1 (enExample)
TW (1) TWI760305B (enExample)
UA (1) UA125136C2 (enExample)
WO (1) WO2017009327A1 (enExample)
ZA (1) ZA201708613B (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3991748A3 (en) 2015-04-07 2022-08-24 Alector LLC Anti-sortilin antibodies and methods of use thereof
US10849992B1 (en) 2015-04-07 2020-12-01 Alector Llc Methods of screening for sortilin binding antagonists
GB201512215D0 (en) 2015-07-13 2015-08-19 Lundbeck & Co As H Agents,uses and methods
US10894833B2 (en) * 2017-07-20 2021-01-19 H. Lundbeck A/S Agents, uses and methods for treatment
PT3618928T (pt) 2018-07-13 2023-03-29 Alector Llc Anticorpos anti-sortilina e métodos de utilização dos mesmos
EP3666281A1 (en) * 2018-12-14 2020-06-17 Insusense ApS Compositions comprising sortilin-1
AU2020270966B2 (en) * 2019-04-10 2025-05-15 Regeneron Pharmaceuticals, Inc. Human antibodies that bind ret and methods of use thereof
MX2022007486A (es) * 2019-12-23 2022-06-29 Denali Therapeutics Inc Variantes de progranulina.
AU2021297540A1 (en) * 2020-06-24 2023-02-02 Prothena Biosciences Limited Antibodies recognizing sortilin
WO2023247754A1 (en) 2022-06-23 2023-12-28 Draupnir Bio Aps Bifunctional molecules that selectively induce degradation of extracellular targets in lysosomes
CN118496354A (zh) * 2023-02-15 2024-08-16 三优生物医药(上海)有限公司 包含共同轻链的抗体库、其制备方法及其用途
WO2025031098A1 (zh) * 2023-08-09 2025-02-13 瑞诺元(苏州)生物科技有限公司 一种分拣蛋白1特异性的纳米抗体、含有其的重组aav及应用
WO2025132764A1 (en) * 2023-12-21 2025-06-26 Amylonix Ab A sortilin-binding polypeptide

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Also Published As

Publication number Publication date
US12331123B2 (en) 2025-06-17
PE20181014A1 (es) 2018-06-26
CN114478774A (zh) 2022-05-13
TWI760305B (zh) 2022-04-11
JO3710B1 (ar) 2021-01-31
DOP2018000014A (es) 2018-04-15
US10428147B2 (en) 2019-10-01
EP3322726B1 (en) 2025-03-12
CN107849135A (zh) 2018-03-27
WO2017009327A1 (en) 2017-01-19
US20250277040A1 (en) 2025-09-04
HK1254356A1 (en) 2019-07-19
CR20180002A (es) 2018-04-09
CO2017012988A2 (es) 2018-05-21
CA2989739A1 (en) 2017-01-19
ECSP18002725A (es) 2018-03-31
JP6979397B2 (ja) 2021-12-15
US20180305455A1 (en) 2018-10-25
RS66856B1 (sr) 2025-06-30
EP3322726A1 (en) 2018-05-23
SV2018005613A (es) 2018-02-23
GB201512215D0 (en) 2015-08-19
KR20180030045A (ko) 2018-03-21
IL256503B (en) 2022-02-01
US10479835B2 (en) 2019-11-19
MA42440A (fr) 2018-05-23
US20200190188A1 (en) 2020-06-18
US20170267761A1 (en) 2017-09-21
IL256503A (en) 2018-02-28
JP2018529635A (ja) 2018-10-11
AR105335A1 (es) 2017-09-27
US10889650B2 (en) 2021-01-12
BR112018000771A2 (pt) 2018-09-25
MA42440B1 (fr) 2025-05-30
AU2016292980A1 (en) 2018-01-18
NI201800007A (es) 2018-10-18
TW201702273A (zh) 2017-01-16
CN114478775A (zh) 2022-05-13
TN2017000534A1 (en) 2019-04-12
US11548950B2 (en) 2023-01-10
ZA201708613B (en) 2021-03-31
PH12018500100A1 (en) 2018-07-30
CL2018000092A1 (es) 2018-07-06
JP2022003058A (ja) 2022-01-11
CL2020002468A1 (es) 2021-01-29
HUE071424T2 (hu) 2025-08-28
RU2018100824A (ru) 2019-08-13
MX2018000506A (es) 2018-05-11
ES3024469T3 (en) 2025-06-04
AU2016292980B2 (en) 2022-10-06
HRP20250602T1 (hr) 2025-07-18
RU2018100824A3 (enExample) 2020-01-17
EP3322726C0 (en) 2025-03-12
KR102778576B1 (ko) 2025-03-07
EA201890038A1 (ru) 2018-06-29
PL3322726T3 (pl) 2025-06-23
RU2735639C2 (ru) 2020-11-05
US20210269524A1 (en) 2021-09-02
US20230159643A1 (en) 2023-05-25

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