IL256503B - Antibodies that bind sortilin and inhibit binding to progranulin - Google Patents

Antibodies that bind sortilin and inhibit binding to progranulin

Info

Publication number
IL256503B
IL256503B IL256503A IL25650317A IL256503B IL 256503 B IL256503 B IL 256503B IL 256503 A IL256503 A IL 256503A IL 25650317 A IL25650317 A IL 25650317A IL 256503 B IL256503 B IL 256503B
Authority
IL
Israel
Prior art keywords
progranulin
sortilin
antibodies
bind
inhibit
Prior art date
Application number
IL256503A
Other languages
English (en)
Hebrew (he)
Other versions
IL256503A (en
Inventor
Den Brink Edward Van
Paul Parren
Ibrahim John Malik
Ronn Lars Christian Biilmann
Jeffrey B Stavenhagen
Soren Christensen
Jan Egebjerg
Arnout Gerritsen
Jong Rob De
Original Assignee
H Lundbeck As
Den Brink Edward Van
Paul Parren
Ibrahim John Malik
Ronn Lars Christian Biilmann
Jeffrey B Stavenhagen
Soren Christensen
Jan Egebjerg
Arnout Gerritsen
Jong Rob De
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H Lundbeck As, Den Brink Edward Van, Paul Parren, Ibrahim John Malik, Ronn Lars Christian Biilmann, Jeffrey B Stavenhagen, Soren Christensen, Jan Egebjerg, Arnout Gerritsen, Jong Rob De filed Critical H Lundbeck As
Publication of IL256503A publication Critical patent/IL256503A/en
Publication of IL256503B publication Critical patent/IL256503B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/286—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against neuromediator receptors, e.g. serotonin receptor, dopamine receptor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IL256503A 2015-07-13 2017-12-22 Antibodies that bind sortilin and inhibit binding to progranulin IL256503B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1512215.3A GB201512215D0 (en) 2015-07-13 2015-07-13 Agents,uses and methods
PCT/EP2016/066516 WO2017009327A1 (en) 2015-07-13 2016-07-12 Antibodies that bind to sortilin and inhibit the binding of progranulin

Publications (2)

Publication Number Publication Date
IL256503A IL256503A (en) 2018-02-28
IL256503B true IL256503B (en) 2022-02-01

Family

ID=54013862

Family Applications (1)

Application Number Title Priority Date Filing Date
IL256503A IL256503B (en) 2015-07-13 2017-12-22 Antibodies that bind sortilin and inhibit binding to progranulin

Country Status (35)

Country Link
US (6) US10479835B2 (enExample)
EP (1) EP3322726B1 (enExample)
JP (2) JP6979397B2 (enExample)
KR (1) KR102778576B1 (enExample)
CN (3) CN114478775A (enExample)
AR (1) AR105335A1 (enExample)
AU (1) AU2016292980B2 (enExample)
BR (1) BR112018000771A2 (enExample)
CA (1) CA2989739A1 (enExample)
CL (2) CL2018000092A1 (enExample)
CO (1) CO2017012988A2 (enExample)
CR (1) CR20180002A (enExample)
DO (1) DOP2018000014A (enExample)
EA (1) EA201890038A1 (enExample)
EC (1) ECSP18002725A (enExample)
ES (1) ES3024469T3 (enExample)
GB (1) GB201512215D0 (enExample)
HR (1) HRP20250602T1 (enExample)
HU (1) HUE071424T2 (enExample)
IL (1) IL256503B (enExample)
JO (1) JO3710B1 (enExample)
MA (1) MA42440B1 (enExample)
MX (1) MX2018000506A (enExample)
NI (1) NI201800007A (enExample)
PE (1) PE20181014A1 (enExample)
PH (1) PH12018500100A1 (enExample)
PL (1) PL3322726T3 (enExample)
RS (1) RS66856B1 (enExample)
RU (1) RU2735639C2 (enExample)
SV (1) SV2018005613A (enExample)
TN (1) TN2017000534A1 (enExample)
TW (1) TWI760305B (enExample)
UA (1) UA125136C2 (enExample)
WO (1) WO2017009327A1 (enExample)
ZA (1) ZA201708613B (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10849992B1 (en) 2015-04-07 2020-12-01 Alector Llc Methods of screening for sortilin binding antagonists
LT3280441T (lt) 2015-04-07 2021-11-25 Alector Llc Anti-sortilino antikūnai ir jų naudojimo būdai
GB201512215D0 (en) 2015-07-13 2015-08-19 Lundbeck & Co As H Agents,uses and methods
US10894833B2 (en) * 2017-07-20 2021-01-19 H. Lundbeck A/S Agents, uses and methods for treatment
PE20210186A1 (es) 2018-07-13 2021-02-02 Alector Llc Anticuerpos anti-sortilina y metodos para su uso
EP3666281A1 (en) * 2018-12-14 2020-06-17 Insusense ApS Compositions comprising sortilin-1
IL293994A (en) * 2019-12-23 2022-08-01 Denali Therapeutics Inc Progranulin variants, compositions comprising same and uses thereof
CA3183994A1 (en) * 2020-06-24 2021-12-30 Philip James Dolan Iii Antibodies recognizing sortilin
CN119403786A (zh) 2022-06-23 2025-02-07 德罗普尼尔生物有限公司 选择性诱导细胞外靶标在溶酶体中降解的双功能分子
CN118496354A (zh) * 2023-02-15 2024-08-16 三优生物医药(上海)有限公司 包含共同轻链的抗体库、其制备方法及其用途
WO2025031098A1 (zh) * 2023-08-09 2025-02-13 瑞诺元(苏州)生物科技有限公司 一种分拣蛋白1特异性的纳米抗体、含有其的重组aav及应用
WO2025132764A1 (en) * 2023-12-21 2025-06-26 Amylonix Ab A sortilin-binding polypeptide

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Also Published As

Publication number Publication date
AR105335A1 (es) 2017-09-27
BR112018000771A2 (pt) 2018-09-25
TWI760305B (zh) 2022-04-11
US20200190188A1 (en) 2020-06-18
TW201702273A (zh) 2017-01-16
CL2018000092A1 (es) 2018-07-06
AU2016292980B2 (en) 2022-10-06
JP6979397B2 (ja) 2021-12-15
IL256503A (en) 2018-02-28
EA201890038A1 (ru) 2018-06-29
US10479835B2 (en) 2019-11-19
ES3024469T3 (en) 2025-06-04
CR20180002A (es) 2018-04-09
US10889650B2 (en) 2021-01-12
WO2017009327A1 (en) 2017-01-19
NI201800007A (es) 2018-10-18
US20250277040A1 (en) 2025-09-04
KR102778576B1 (ko) 2025-03-07
ECSP18002725A (es) 2018-03-31
CN107849135A (zh) 2018-03-27
CA2989739A1 (en) 2017-01-19
CN114478775A (zh) 2022-05-13
EP3322726B1 (en) 2025-03-12
ZA201708613B (en) 2021-03-31
RS66856B1 (sr) 2025-06-30
CL2020002468A1 (es) 2021-01-29
MA42440A (fr) 2018-05-23
US20210269524A1 (en) 2021-09-02
DOP2018000014A (es) 2018-04-15
EP3322726C0 (en) 2025-03-12
US20170267761A1 (en) 2017-09-21
PH12018500100A1 (en) 2018-07-30
KR20180030045A (ko) 2018-03-21
US11548950B2 (en) 2023-01-10
US10428147B2 (en) 2019-10-01
EP3322726A1 (en) 2018-05-23
TN2017000534A1 (en) 2019-04-12
AU2016292980A1 (en) 2018-01-18
US12331123B2 (en) 2025-06-17
RU2018100824A (ru) 2019-08-13
MA42440B1 (fr) 2025-05-30
RU2735639C2 (ru) 2020-11-05
HRP20250602T1 (hr) 2025-07-18
HUE071424T2 (hu) 2025-08-28
JO3710B1 (ar) 2021-01-31
JP2018529635A (ja) 2018-10-11
JP2022003058A (ja) 2022-01-11
US20180305455A1 (en) 2018-10-25
MX2018000506A (es) 2018-05-11
CN114478774A (zh) 2022-05-13
PL3322726T3 (pl) 2025-06-23
RU2018100824A3 (enExample) 2020-01-17
UA125136C2 (uk) 2022-01-19
GB201512215D0 (en) 2015-08-19
SV2018005613A (es) 2018-02-23
US20230159643A1 (en) 2023-05-25
PE20181014A1 (es) 2018-06-26
CO2017012988A2 (es) 2018-05-21
HK1254356A1 (en) 2019-07-19

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