ES3024469T3 - Antibodies that bind to sortilin and inhibit the binding of progranulin - Google Patents

Antibodies that bind to sortilin and inhibit the binding of progranulin Download PDF

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Publication number
ES3024469T3
ES3024469T3 ES16739087T ES16739087T ES3024469T3 ES 3024469 T3 ES3024469 T3 ES 3024469T3 ES 16739087 T ES16739087 T ES 16739087T ES 16739087 T ES16739087 T ES 16739087T ES 3024469 T3 ES3024469 T3 ES 3024469T3
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ES
Spain
Prior art keywords
seq
variable domain
chain variable
antibody
heavy chain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES16739087T
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English (en)
Spanish (es)
Inventor
Rønn Lars Biilmann
Ibrahim Malik
Jeffrey Stavenhagen
Søren Christensen
Jan Egebjerg
Arnout Gerritsen
Den Brink Edward Van
Paul Parren
Jong Rob De
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H Lundbeck AS
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H Lundbeck AS
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/286—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against neuromediator receptors, e.g. serotonin receptor, dopamine receptor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Psychiatry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • General Chemical & Material Sciences (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ES16739087T 2015-07-13 2016-07-12 Antibodies that bind to sortilin and inhibit the binding of progranulin Active ES3024469T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1512215.3A GB201512215D0 (en) 2015-07-13 2015-07-13 Agents,uses and methods
PCT/EP2016/066516 WO2017009327A1 (en) 2015-07-13 2016-07-12 Antibodies that bind to sortilin and inhibit the binding of progranulin

Publications (1)

Publication Number Publication Date
ES3024469T3 true ES3024469T3 (en) 2025-06-04

Family

ID=54013862

Family Applications (1)

Application Number Title Priority Date Filing Date
ES16739087T Active ES3024469T3 (en) 2015-07-13 2016-07-12 Antibodies that bind to sortilin and inhibit the binding of progranulin

Country Status (35)

Country Link
US (6) US10428147B2 (enExample)
EP (1) EP3322726B1 (enExample)
JP (2) JP6979397B2 (enExample)
KR (1) KR102778576B1 (enExample)
CN (3) CN107849135A (enExample)
AR (1) AR105335A1 (enExample)
AU (1) AU2016292980B2 (enExample)
BR (1) BR112018000771A2 (enExample)
CA (1) CA2989739A1 (enExample)
CL (2) CL2018000092A1 (enExample)
CO (1) CO2017012988A2 (enExample)
CR (1) CR20180002A (enExample)
DO (1) DOP2018000014A (enExample)
EA (1) EA201890038A1 (enExample)
EC (1) ECSP18002725A (enExample)
ES (1) ES3024469T3 (enExample)
GB (1) GB201512215D0 (enExample)
HR (1) HRP20250602T1 (enExample)
HU (1) HUE071424T2 (enExample)
IL (1) IL256503B (enExample)
JO (1) JO3710B1 (enExample)
MA (1) MA42440B1 (enExample)
MX (1) MX2018000506A (enExample)
NI (1) NI201800007A (enExample)
PE (1) PE20181014A1 (enExample)
PH (1) PH12018500100A1 (enExample)
PL (1) PL3322726T3 (enExample)
RS (1) RS66856B1 (enExample)
RU (1) RU2735639C2 (enExample)
SV (1) SV2018005613A (enExample)
TN (1) TN2017000534A1 (enExample)
TW (1) TWI760305B (enExample)
UA (1) UA125136C2 (enExample)
WO (1) WO2017009327A1 (enExample)
ZA (1) ZA201708613B (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
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CA2981851A1 (en) 2015-04-07 2016-10-13 Alector Llc Anti-sortilin antibodies and methods of use thereof
GB201512215D0 (en) 2015-07-13 2015-08-19 Lundbeck & Co As H Agents,uses and methods
US10894833B2 (en) * 2017-07-20 2021-01-19 H. Lundbeck A/S Agents, uses and methods for treatment
ES2940311T3 (es) 2018-07-13 2023-05-05 Alector Llc Anticuerpos anti-sortilina y métodos de uso de los mismos
EP3666281A1 (en) * 2018-12-14 2020-06-17 Insusense ApS Compositions comprising sortilin-1
JP2023507846A (ja) * 2019-12-23 2023-02-27 デナリ セラピューティクス インコーポレイテッド プログラニュリン変異体
EP4171743A4 (en) 2020-06-24 2024-07-24 Prothena Biosciences Limited Antibodies recognizing sortilin
KR20250028349A (ko) 2022-06-23 2025-02-28 드라우프니르 바이오 에이피에스 리소좀 내 세포외 표적의 분해를 선택적으로 유도하는 이작용성 분자
CN118496354A (zh) * 2023-02-15 2024-08-16 三优生物医药(上海)有限公司 包含共同轻链的抗体库、其制备方法及其用途
WO2025031098A1 (zh) * 2023-08-09 2025-02-13 瑞诺元(苏州)生物科技有限公司 一种分拣蛋白1特异性的纳米抗体、含有其的重组aav及应用
WO2025132764A1 (en) * 2023-12-21 2025-06-26 Amylonix Ab A sortilin-binding polypeptide

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GB201512215D0 (en) 2015-07-13 2015-08-19 Lundbeck & Co As H Agents,uses and methods
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Also Published As

Publication number Publication date
CN114478774A (zh) 2022-05-13
KR20180030045A (ko) 2018-03-21
CO2017012988A2 (es) 2018-05-21
WO2017009327A1 (en) 2017-01-19
JP6979397B2 (ja) 2021-12-15
JP2022003058A (ja) 2022-01-11
CN114478775A (zh) 2022-05-13
PH12018500100A1 (en) 2018-07-30
PE20181014A1 (es) 2018-06-26
AR105335A1 (es) 2017-09-27
US11548950B2 (en) 2023-01-10
US10889650B2 (en) 2021-01-12
CL2020002468A1 (es) 2021-01-29
MA42440B1 (fr) 2025-05-30
BR112018000771A2 (pt) 2018-09-25
ZA201708613B (en) 2021-03-31
IL256503B (en) 2022-02-01
KR102778576B1 (ko) 2025-03-07
TW201702273A (zh) 2017-01-16
US20210269524A1 (en) 2021-09-02
AU2016292980A1 (en) 2018-01-18
US20230159643A1 (en) 2023-05-25
ECSP18002725A (es) 2018-03-31
UA125136C2 (uk) 2022-01-19
CR20180002A (es) 2018-04-09
CL2018000092A1 (es) 2018-07-06
CN107849135A (zh) 2018-03-27
HUE071424T2 (hu) 2025-08-28
RU2018100824A3 (enExample) 2020-01-17
EA201890038A1 (ru) 2018-06-29
HK1254356A1 (en) 2019-07-19
IL256503A (en) 2018-02-28
PL3322726T3 (pl) 2025-06-23
DOP2018000014A (es) 2018-04-15
GB201512215D0 (en) 2015-08-19
US20170267761A1 (en) 2017-09-21
RU2735639C2 (ru) 2020-11-05
AU2016292980B2 (en) 2022-10-06
US20250277040A1 (en) 2025-09-04
US10479835B2 (en) 2019-11-19
JO3710B1 (ar) 2021-01-31
EP3322726C0 (en) 2025-03-12
RU2018100824A (ru) 2019-08-13
JP2018529635A (ja) 2018-10-11
TWI760305B (zh) 2022-04-11
US20180305455A1 (en) 2018-10-25
TN2017000534A1 (en) 2019-04-12
SV2018005613A (es) 2018-02-23
HRP20250602T1 (hr) 2025-07-18
US10428147B2 (en) 2019-10-01
MA42440A (fr) 2018-05-23
EP3322726B1 (en) 2025-03-12
US12331123B2 (en) 2025-06-17
EP3322726A1 (en) 2018-05-23
NI201800007A (es) 2018-10-18
US20200190188A1 (en) 2020-06-18
MX2018000506A (es) 2018-05-11
CA2989739A1 (en) 2017-01-19
RS66856B1 (sr) 2025-06-30

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