DOP2018000014A - Anticuerpos que se unen a la sortilina e inhiben la vinculación de progranulina - Google Patents

Anticuerpos que se unen a la sortilina e inhiben la vinculación de progranulina

Info

Publication number
DOP2018000014A
DOP2018000014A DO2018000014A DO2018000014A DOP2018000014A DO P2018000014 A DOP2018000014 A DO P2018000014A DO 2018000014 A DO2018000014 A DO 2018000014A DO 2018000014 A DO2018000014 A DO 2018000014A DO P2018000014 A DOP2018000014 A DO P2018000014A
Authority
DO
Dominican Republic
Prior art keywords
antibodies
sortiline
progranulin
bind
inhibit
Prior art date
Application number
DO2018000014A
Other languages
English (en)
Spanish (es)
Inventor
John Malik Ibrahim
B Stavenhagen Jeffrey
Egebjerg Jan
Van Den Brink Edward
Parren Paul
Christian Biilmann Rønn Lars
Christensen Søren
Gerritsen Arnout
De Jong Rob
Original Assignee
H Lundbeck As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H Lundbeck As filed Critical H Lundbeck As
Publication of DOP2018000014A publication Critical patent/DOP2018000014A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/286—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against neuromediator receptors, e.g. serotonin receptor, dopamine receptor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DO2018000014A 2015-07-13 2018-01-11 Anticuerpos que se unen a la sortilina e inhiben la vinculación de progranulina DOP2018000014A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB1512215.3A GB201512215D0 (en) 2015-07-13 2015-07-13 Agents,uses and methods

Publications (1)

Publication Number Publication Date
DOP2018000014A true DOP2018000014A (es) 2018-04-15

Family

ID=54013862

Family Applications (1)

Application Number Title Priority Date Filing Date
DO2018000014A DOP2018000014A (es) 2015-07-13 2018-01-11 Anticuerpos que se unen a la sortilina e inhiben la vinculación de progranulina

Country Status (35)

Country Link
US (6) US10428147B2 (enExample)
EP (1) EP3322726B1 (enExample)
JP (2) JP6979397B2 (enExample)
KR (1) KR102778576B1 (enExample)
CN (3) CN114478774A (enExample)
AR (1) AR105335A1 (enExample)
AU (1) AU2016292980B2 (enExample)
BR (1) BR112018000771A2 (enExample)
CA (1) CA2989739A1 (enExample)
CL (2) CL2018000092A1 (enExample)
CO (1) CO2017012988A2 (enExample)
CR (1) CR20180002A (enExample)
DO (1) DOP2018000014A (enExample)
EA (1) EA201890038A1 (enExample)
EC (1) ECSP18002725A (enExample)
ES (1) ES3024469T3 (enExample)
GB (1) GB201512215D0 (enExample)
HR (1) HRP20250602T1 (enExample)
HU (1) HUE071424T2 (enExample)
IL (1) IL256503B (enExample)
JO (1) JO3710B1 (enExample)
MA (1) MA42440B1 (enExample)
MX (1) MX2018000506A (enExample)
NI (1) NI201800007A (enExample)
PE (1) PE20181014A1 (enExample)
PH (1) PH12018500100A1 (enExample)
PL (1) PL3322726T3 (enExample)
RS (1) RS66856B1 (enExample)
RU (1) RU2735639C2 (enExample)
SV (1) SV2018005613A (enExample)
TN (1) TN2017000534A1 (enExample)
TW (1) TWI760305B (enExample)
UA (1) UA125136C2 (enExample)
WO (1) WO2017009327A1 (enExample)
ZA (1) ZA201708613B (enExample)

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MX2019012869A (es) * 2018-07-13 2020-01-23 Alector Llc Anticuerpos anti-sortilina y metodos para su uso.
EP3666281A1 (en) * 2018-12-14 2020-06-17 Insusense ApS Compositions comprising sortilin-1
CA3165846A1 (en) * 2019-12-23 2021-07-01 Denali Therapeutics Inc. Progranulin variants
IL299329A (en) * 2020-06-24 2023-02-01 Prothena Biosciences Ltd Antibodies recognizing sortilin
KR20250028349A (ko) 2022-06-23 2025-02-28 드라우프니르 바이오 에이피에스 리소좀 내 세포외 표적의 분해를 선택적으로 유도하는 이작용성 분자
CN118496354A (zh) * 2023-02-15 2024-08-16 三优生物医药(上海)有限公司 包含共同轻链的抗体库、其制备方法及其用途
WO2025031098A1 (zh) * 2023-08-09 2025-02-13 瑞诺元(苏州)生物科技有限公司 一种分拣蛋白1特异性的纳米抗体、含有其的重组aav及应用
WO2025132764A1 (en) * 2023-12-21 2025-06-26 Amylonix Ab A sortilin-binding polypeptide

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Also Published As

Publication number Publication date
IL256503A (en) 2018-02-28
CN107849135A (zh) 2018-03-27
KR20180030045A (ko) 2018-03-21
RU2018100824A3 (enExample) 2020-01-17
TWI760305B (zh) 2022-04-11
CL2020002468A1 (es) 2021-01-29
EP3322726A1 (en) 2018-05-23
CN114478775A (zh) 2022-05-13
TW201702273A (zh) 2017-01-16
US20180305455A1 (en) 2018-10-25
JP2022003058A (ja) 2022-01-11
PE20181014A1 (es) 2018-06-26
GB201512215D0 (en) 2015-08-19
JP2018529635A (ja) 2018-10-11
IL256503B (en) 2022-02-01
SV2018005613A (es) 2018-02-23
CN114478774A (zh) 2022-05-13
UA125136C2 (uk) 2022-01-19
AU2016292980B2 (en) 2022-10-06
US12331123B2 (en) 2025-06-17
MX2018000506A (es) 2018-05-11
US20170267761A1 (en) 2017-09-21
AR105335A1 (es) 2017-09-27
US11548950B2 (en) 2023-01-10
KR102778576B1 (ko) 2025-03-07
AU2016292980A1 (en) 2018-01-18
TN2017000534A1 (en) 2019-04-12
US20200190188A1 (en) 2020-06-18
HK1254356A1 (en) 2019-07-19
JO3710B1 (ar) 2021-01-31
PH12018500100A1 (en) 2018-07-30
EP3322726B1 (en) 2025-03-12
RU2018100824A (ru) 2019-08-13
CL2018000092A1 (es) 2018-07-06
MA42440A (fr) 2018-05-23
NI201800007A (es) 2018-10-18
RS66856B1 (sr) 2025-06-30
CR20180002A (es) 2018-04-09
HRP20250602T1 (hr) 2025-07-18
RU2735639C2 (ru) 2020-11-05
JP6979397B2 (ja) 2021-12-15
EA201890038A1 (ru) 2018-06-29
EP3322726C0 (en) 2025-03-12
MA42440B1 (fr) 2025-05-30
HUE071424T2 (hu) 2025-08-28
CO2017012988A2 (es) 2018-05-21
BR112018000771A2 (pt) 2018-09-25
WO2017009327A1 (en) 2017-01-19
CA2989739A1 (en) 2017-01-19
US20230159643A1 (en) 2023-05-25
US10889650B2 (en) 2021-01-12
US20210269524A1 (en) 2021-09-02
US10428147B2 (en) 2019-10-01
US10479835B2 (en) 2019-11-19
ECSP18002725A (es) 2018-03-31
US20250277040A1 (en) 2025-09-04
PL3322726T3 (pl) 2025-06-23
ES3024469T3 (en) 2025-06-04
ZA201708613B (en) 2021-03-31

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