CL2020002468A1 - Anticuerpos que se unen a la sortilina e inhiben la union de progranulina.(divisional de solicitud 92-2018) - Google Patents
Anticuerpos que se unen a la sortilina e inhiben la union de progranulina.(divisional de solicitud 92-2018)Info
- Publication number
- CL2020002468A1 CL2020002468A1 CL2020002468A CL2020002468A CL2020002468A1 CL 2020002468 A1 CL2020002468 A1 CL 2020002468A1 CL 2020002468 A CL2020002468 A CL 2020002468A CL 2020002468 A CL2020002468 A CL 2020002468A CL 2020002468 A1 CL2020002468 A1 CL 2020002468A1
- Authority
- CL
- Chile
- Prior art keywords
- antibodies
- progranulin
- sortilin
- bind
- inhibit
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/286—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against neuromediator receptors, e.g. serotonin receptor, dopamine receptor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Neurosurgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
La presente invención se refiere a anticuerpos monoclonales anti-sortilina que se ha encontrado que son útiles en la corrección de un nivel deficiente de progranulina (PGRN). En particular, pueden usarse estos anticuerpos en el tratamiento de demencia frontotemporal (DFT) y esclerosis lateral amiotrófica (ELA).
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB1512215.3A GB201512215D0 (en) | 2015-07-13 | 2015-07-13 | Agents,uses and methods |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2020002468A1 true CL2020002468A1 (es) | 2021-01-29 |
Family
ID=54013862
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2018000092A CL2018000092A1 (es) | 2015-07-13 | 2018-01-11 | Anticuerpos que se unen a la sortilina e inhiben la union de progranulina. |
CL2020002468A CL2020002468A1 (es) | 2015-07-13 | 2020-09-24 | Anticuerpos que se unen a la sortilina e inhiben la union de progranulina.(divisional de solicitud 92-2018) |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2018000092A CL2018000092A1 (es) | 2015-07-13 | 2018-01-11 | Anticuerpos que se unen a la sortilina e inhiben la union de progranulina. |
Country Status (31)
Country | Link |
---|---|
US (5) | US10479835B2 (es) |
EP (1) | EP3322726A1 (es) |
JP (2) | JP6979397B2 (es) |
KR (1) | KR20180030045A (es) |
CN (3) | CN114478775A (es) |
AR (1) | AR105335A1 (es) |
AU (1) | AU2016292980B2 (es) |
BR (1) | BR112018000771A2 (es) |
CA (1) | CA2989739A1 (es) |
CL (2) | CL2018000092A1 (es) |
CO (1) | CO2017012988A2 (es) |
CR (1) | CR20180002A (es) |
DO (1) | DOP2018000014A (es) |
EA (1) | EA201890038A1 (es) |
EC (1) | ECSP18002725A (es) |
GB (1) | GB201512215D0 (es) |
HK (1) | HK1254356A1 (es) |
IL (1) | IL256503B (es) |
JO (1) | JO3710B1 (es) |
MA (1) | MA42440A (es) |
MX (1) | MX2018000506A (es) |
NI (1) | NI201800007A (es) |
PE (1) | PE20181014A1 (es) |
PH (1) | PH12018500100A1 (es) |
RU (1) | RU2735639C2 (es) |
SV (1) | SV2018005613A (es) |
TN (1) | TN2017000534A1 (es) |
TW (1) | TWI760305B (es) |
UA (1) | UA125136C2 (es) |
WO (1) | WO2017009327A1 (es) |
ZA (1) | ZA201708613B (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HRP20211980T1 (hr) * | 2015-04-07 | 2022-04-01 | Alector Llc | Protutijela protiv sortilina i postupci njihove upotrebe |
WO2016164608A1 (en) | 2015-04-07 | 2016-10-13 | Alector Llc | Methods of screening for sortilin binding antagonists |
GB201512215D0 (en) | 2015-07-13 | 2015-08-19 | Lundbeck & Co As H | Agents,uses and methods |
US10894833B2 (en) * | 2017-07-20 | 2021-01-19 | H. Lundbeck A/S | Agents, uses and methods for treatment |
HUE061841T2 (hu) * | 2018-07-13 | 2023-08-28 | Alector Llc | Anti-sortilin antitestek és felhasználásuk módszerei |
WO2023247754A1 (en) | 2022-06-23 | 2023-12-28 | Draupnir Bio Aps | Bifunctional molecules that selectively induce degradation of extracellular targets in lysosomes |
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US4609546A (en) | 1982-06-24 | 1986-09-02 | Japan Chemical Research Co., Ltd. | Long-acting composition |
US4681581A (en) | 1983-12-05 | 1987-07-21 | Coates Fredrica V | Adjustable size diaper and folding method therefor |
US4766106A (en) | 1985-06-26 | 1988-08-23 | Cetus Corporation | Solubilization of proteins for pharmaceutical compositions using polymer conjugation |
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JP3070763B2 (ja) | 1989-08-09 | 2000-07-31 | ロメッド インコーポレイティド | テクネチウムまたはレニウムでの抗体または他のタンパク質の直接放射能標識 |
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US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
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HRP20211980T1 (hr) | 2015-04-07 | 2022-04-01 | Alector Llc | Protutijela protiv sortilina i postupci njihove upotrebe |
GB201512215D0 (en) | 2015-07-13 | 2015-08-19 | Lundbeck & Co As H | Agents,uses and methods |
US10894833B2 (en) | 2017-07-20 | 2021-01-19 | H. Lundbeck A/S | Agents, uses and methods for treatment |
HUE061841T2 (hu) | 2018-07-13 | 2023-08-28 | Alector Llc | Anti-sortilin antitestek és felhasználásuk módszerei |
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2015
- 2015-07-13 GB GBGB1512215.3A patent/GB201512215D0/en not_active Ceased
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2016
- 2016-07-11 JO JOP/2016/0141A patent/JO3710B1/ar active
- 2016-07-12 CN CN202210124752.3A patent/CN114478775A/zh active Pending
- 2016-07-12 CR CR20180002A patent/CR20180002A/es unknown
- 2016-07-12 US US15/743,549 patent/US10479835B2/en active Active
- 2016-07-12 TW TW105121903A patent/TWI760305B/zh not_active IP Right Cessation
- 2016-07-12 PE PE2018000064A patent/PE20181014A1/es unknown
- 2016-07-12 CA CA2989739A patent/CA2989739A1/en active Pending
- 2016-07-12 MA MA042440A patent/MA42440A/fr unknown
- 2016-07-12 RU RU2018100824A patent/RU2735639C2/ru active
- 2016-07-12 KR KR1020187001192A patent/KR20180030045A/ko not_active Application Discontinuation
- 2016-07-12 CN CN201680040476.5A patent/CN107849135A/zh active Pending
- 2016-07-12 US US15/207,880 patent/US10428147B2/en active Active
- 2016-07-12 BR BR112018000771-4A patent/BR112018000771A2/pt not_active IP Right Cessation
- 2016-07-12 EA EA201890038A patent/EA201890038A1/ru unknown
- 2016-07-12 JP JP2018501182A patent/JP6979397B2/ja active Active
- 2016-07-12 TN TNP/2017/000534A patent/TN2017000534A1/en unknown
- 2016-07-12 EP EP16739087.1A patent/EP3322726A1/en active Pending
- 2016-07-12 CN CN202210124751.9A patent/CN114478774A/zh active Pending
- 2016-07-12 AR ARP160102109A patent/AR105335A1/es unknown
- 2016-07-12 MX MX2018000506A patent/MX2018000506A/es unknown
- 2016-07-12 UA UAA201800574A patent/UA125136C2/uk unknown
- 2016-07-12 AU AU2016292980A patent/AU2016292980B2/en active Active
- 2016-07-12 WO PCT/EP2016/066516 patent/WO2017009327A1/en active Application Filing
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2017
- 2017-12-18 ZA ZA2017/08613A patent/ZA201708613B/en unknown
- 2017-12-18 CO CONC2017/0012988A patent/CO2017012988A2/es unknown
- 2017-12-22 IL IL256503A patent/IL256503B/en unknown
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2018
- 2018-01-11 CL CL2018000092A patent/CL2018000092A1/es unknown
- 2018-01-11 DO DO2018000014A patent/DOP2018000014A/es unknown
- 2018-01-11 NI NI201800007A patent/NI201800007A/es unknown
- 2018-01-11 SV SV2018005613A patent/SV2018005613A/es unknown
- 2018-01-11 PH PH12018500100A patent/PH12018500100A1/en unknown
- 2018-01-12 EC ECIEPI20182725A patent/ECSP18002725A/es unknown
- 2018-10-19 HK HK18113432.9A patent/HK1254356A1/zh unknown
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2019
- 2019-07-24 US US16/521,279 patent/US10889650B2/en active Active
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2020
- 2020-09-24 CL CL2020002468A patent/CL2020002468A1/es unknown
- 2020-11-13 US US17/097,457 patent/US11548950B2/en active Active
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2021
- 2021-09-17 JP JP2021151783A patent/JP2022003058A/ja active Pending
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2022
- 2022-11-18 US US18/057,104 patent/US20230159643A1/en active Pending
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