SA517381991B1 - أجسام مضادة لترانس ثيرتين - Google Patents

أجسام مضادة لترانس ثيرتين

Info

Publication number
SA517381991B1
SA517381991B1 SA517381991A SA517381991A SA517381991B1 SA 517381991 B1 SA517381991 B1 SA 517381991B1 SA 517381991 A SA517381991 A SA 517381991A SA 517381991 A SA517381991 A SA 517381991A SA 517381991 B1 SA517381991 B1 SA 517381991B1
Authority
SA
Saudi Arabia
Prior art keywords
ttr
antibodies
transthyretin
accumulation
amyloidosis
Prior art date
Application number
SA517381991A
Other languages
English (en)
Inventor
أس نيجار تارلوشان
أفيجيت تشاكرابارتي،
ان. هيجاكي جيفري
Original Assignee
بروثينا بايوسينسيس ليمتد
يونيفيرستي هيلث نتوورك
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by بروثينا بايوسينسيس ليمتد, يونيفيرستي هيلث نتوورك filed Critical بروثينا بايوسينسيس ليمتد
Publication of SA517381991B1 publication Critical patent/SA517381991B1/ar

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Psychiatry (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

أجسام مضادة لترانس ثيرتين Anti-Transthyretin Antibodies الملخـــص يتعلق الاختراع الحالي بتوفير أجسام مضادة antibodies ترتبط بشكل خاص بترانس ثيرتين transthyretin (TTR). يمكن استخدام الأجسام المضادة antibodies لعلاج أو تفعيل الوقاية effecting prophylaxis من الأمراض diseases أو الاضطرابات disorders المصحوبة بتراكم TTR TTR accumulation أو تراكم رواسب TTR accumulation of TTR deposits (على سبيل المثال، الداء النشواني amyloidosis الناتج عن TTR). يمكن أيضًا استخدام الأجسام المضادة antibodies لتشخيص الداء النشواني amyloidosis الناتج عن TTR وتثبيط أو خفض تَكَدُّس TTR reducing aggregation of TTR، من بين تطبيقات أخرى. شكل 1.
SA517381991A 2015-01-28 2017-07-26 أجسام مضادة لترانس ثيرتين SA517381991B1 (ar)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562109001P 2015-01-28 2015-01-28
US201562266557P 2015-12-11 2015-12-11

Publications (1)

Publication Number Publication Date
SA517381991B1 true SA517381991B1 (ar) 2021-12-13

Family

ID=55361912

Family Applications (1)

Application Number Title Priority Date Filing Date
SA517381991A SA517381991B1 (ar) 2015-01-28 2017-07-26 أجسام مضادة لترانس ثيرتين

Country Status (20)

Country Link
US (1) US20160257736A1 (ar)
EP (1) EP3250594B1 (ar)
JP (2) JP6875280B2 (ar)
KR (1) KR102619359B1 (ar)
CN (1) CN107428822B (ar)
AU (1) AU2016210887B2 (ar)
BR (1) BR112017016324A2 (ar)
CA (1) CA2974911A1 (ar)
CO (1) CO2017008469A2 (ar)
CU (1) CU24532B1 (ar)
EA (1) EA036048B1 (ar)
ES (1) ES2905311T3 (ar)
MX (1) MX2017009804A (ar)
MY (1) MY193674A (ar)
PE (1) PE20180200A1 (ar)
SA (1) SA517381991B1 (ar)
SG (1) SG11201706125QA (ar)
TW (2) TWI718121B (ar)
WO (1) WO2016120809A1 (ar)
ZA (1) ZA201705662B (ar)

Families Citing this family (12)

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US10464999B2 (en) 2015-01-28 2019-11-05 Prothena Biosciences Limited Anti-transthyretin antibodies
US9879080B2 (en) 2015-01-28 2018-01-30 Prothena Biosciences Limited Anti-transthyretin antibodies
US10633433B2 (en) 2015-01-28 2020-04-28 Prothena Biosciences Limited Anti-transthyretin antibodies
TWI718121B (zh) * 2015-01-28 2021-02-11 愛爾蘭商普羅佘納生物科技有限公司 抗甲狀腺素運送蛋白抗體
WO2018007922A2 (en) * 2016-07-02 2018-01-11 Prothena Biosciences Limited Anti-transthyretin antibodies
JP7016470B2 (ja) * 2016-07-02 2022-02-07 プロセナ バイオサイエンシーズ リミテッド 抗トランスサイレチン抗体
EP3478716A2 (en) * 2016-07-02 2019-05-08 Prothena Biosciences Limited Anti-transthyretin antibodies
JP7292569B2 (ja) * 2017-10-06 2023-06-19 ノボ ノルディスク エー／エス トランスサイレチンを検出する方法
MX2020003041A (es) * 2017-10-06 2020-10-05 Prothena Biosciences Ltd Anticuerpos anti-transtiretina.
MA51223A (fr) 2017-11-29 2020-10-07 Prothena Biosciences Ltd Formulation lyophilisée d'un anticorps monoclonal contre la transthyrétine
EP3801011A1 (en) 2019-06-04 2021-04-14 Regeneron Pharmaceuticals, Inc. Non-human animals comprising a humanized ttr locus with a beta-slip mutation and methods of use
CN112816453B (zh) * 2021-02-09 2022-07-08 黑龙江大学 蛋白在预测药物性能上的应用

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Also Published As

Publication number Publication date
JP7219928B2 (ja) 2023-02-09
AU2016210887B2 (en) 2021-11-04
KR102619359B1 (ko) 2024-01-02
WO2016120809A1 (en) 2016-08-04
BR112017016324A2 (pt) 2018-03-27
TW202118782A (zh) 2021-05-16
CO2017008469A2 (es) 2018-01-16
TWI718121B (zh) 2021-02-11
MY193674A (en) 2022-10-24
AU2016210887A1 (en) 2017-08-10
CU24532B1 (es) 2021-07-02
EA201791711A1 (ru) 2017-11-30
EP3250594B1 (en) 2021-11-17
PE20180200A1 (es) 2018-01-31
ZA201705662B (en) 2018-08-29
CN107428822A (zh) 2017-12-01
ES2905311T3 (es) 2022-04-07
US20160257736A1 (en) 2016-09-08
JP2021129562A (ja) 2021-09-09
MX2017009804A (es) 2018-08-15
EA036048B1 (ru) 2020-09-18
CN107428822B (zh) 2021-11-23
KR20170120607A (ko) 2017-10-31
JP6875280B2 (ja) 2021-05-26
TW201636372A (zh) 2016-10-16
CA2974911A1 (en) 2016-08-04
EP3250594A1 (en) 2017-12-06
CU20170096A7 (es) 2018-03-13
JP2018509889A (ja) 2018-04-12
SG11201706125QA (en) 2017-08-30
TWI781507B (zh) 2022-10-21

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