GB201512215D0 - Agents,uses and methods - Google Patents

Agents,uses and methods

Info

Publication number
GB201512215D0
GB201512215D0 GBGB1512215.3A GB201512215A GB201512215D0 GB 201512215 D0 GB201512215 D0 GB 201512215D0 GB 201512215 A GB201512215 A GB 201512215A GB 201512215 D0 GB201512215 D0 GB 201512215D0
Authority
GB
United Kingdom
Prior art keywords
agents
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
GBGB1512215.3A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
H Lundbeck AS
Original Assignee
H Lundbeck AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H Lundbeck AS filed Critical H Lundbeck AS
Priority to GBGB1512215.3A priority Critical patent/GB201512215D0/en
Publication of GB201512215D0 publication Critical patent/GB201512215D0/en
Priority to JOP/2016/0141A priority patent/JO3710B1/ar
Priority to UAA201800574A priority patent/UA125136C2/uk
Priority to PL16739087.1T priority patent/PL3322726T3/pl
Priority to PCT/EP2016/066516 priority patent/WO2017009327A1/en
Priority to AU2016292980A priority patent/AU2016292980B2/en
Priority to RS20250507A priority patent/RS66856B1/sr
Priority to JP2018501182A priority patent/JP6979397B2/ja
Priority to US15/743,549 priority patent/US10479835B2/en
Priority to CA2989739A priority patent/CA2989739A1/en
Priority to ES16739087T priority patent/ES3024469T3/es
Priority to CN202210124752.3A priority patent/CN114478775A/zh
Priority to TNP/2017/000534A priority patent/TN2017000534A1/en
Priority to KR1020187001192A priority patent/KR102778576B1/ko
Priority to EA201890038A priority patent/EA201890038A1/ru
Priority to CN202210124751.9A priority patent/CN114478774A/zh
Priority to ARP160102109A priority patent/AR105335A1/es
Priority to RU2018100824A priority patent/RU2735639C2/ru
Priority to HRP20250602TT priority patent/HRP20250602T1/hr
Priority to US15/207,880 priority patent/US10428147B2/en
Priority to TW105121903A priority patent/TWI760305B/zh
Priority to HK18113432.9A priority patent/HK1254356B/en
Priority to CN201680040476.5A priority patent/CN107849135A/zh
Priority to MX2018000506A priority patent/MX2018000506A/es
Priority to MA42440A priority patent/MA42440B1/fr
Priority to PE2018000064A priority patent/PE20181014A1/es
Priority to BR112018000771-4A priority patent/BR112018000771A2/pt
Priority to EP16739087.1A priority patent/EP3322726B1/en
Priority to HUE16739087A priority patent/HUE071424T2/hu
Priority to CR20180002A priority patent/CR20180002A/es
Priority to ZA2017/08613A priority patent/ZA201708613B/en
Priority to CONC2017/0012988A priority patent/CO2017012988A2/es
Priority to IL256503A priority patent/IL256503B/en
Priority to DO2018000014A priority patent/DOP2018000014A/es
Priority to PH12018500100A priority patent/PH12018500100A1/en
Priority to CL2018000092A priority patent/CL2018000092A1/es
Priority to NI201800007A priority patent/NI201800007A/es
Priority to SV2018005613A priority patent/SV2018005613A/es
Priority to ECIEPI20182725A priority patent/ECSP18002725A/es
Priority to US16/521,279 priority patent/US10889650B2/en
Priority to CL2020002468A priority patent/CL2020002468A1/es
Priority to US17/097,457 priority patent/US11548950B2/en
Priority to JP2021151783A priority patent/JP2022003058A/ja
Priority to US18/057,104 priority patent/US12331123B2/en
Priority to US19/210,142 priority patent/US20250277040A1/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/286—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against neuromediator receptors, e.g. serotonin receptor, dopamine receptor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Neurosurgery (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
GBGB1512215.3A 2015-07-13 2015-07-13 Agents,uses and methods Ceased GB201512215D0 (en)

Priority Applications (45)

Application Number Priority Date Filing Date Title
GBGB1512215.3A GB201512215D0 (en) 2015-07-13 2015-07-13 Agents,uses and methods
JOP/2016/0141A JO3710B1 (ar) 2015-07-13 2016-07-11 أجسام مضادة ترتبط بسورتيلين وتثبط ارتباط البروجرانولين
CR20180002A CR20180002A (es) 2015-07-13 2016-07-12 Agentes, usos y métodos para el tratamiento
MX2018000506A MX2018000506A (es) 2015-07-13 2016-07-12 Agentes, usos y metodos para el tratamiento.
PL16739087.1T PL3322726T3 (pl) 2015-07-13 2016-07-12 Przeciwciała wiążące się z sortyliną i hamujące wiązanie progranuliny
PCT/EP2016/066516 WO2017009327A1 (en) 2015-07-13 2016-07-12 Antibodies that bind to sortilin and inhibit the binding of progranulin
AU2016292980A AU2016292980B2 (en) 2015-07-13 2016-07-12 Antibodies that bind to Sortilin and inhibit the binding of progranulin
RS20250507A RS66856B1 (sr) 2015-07-13 2016-07-12 Antitela koja se vezuju za sortilin i inhibiraju vezivanje progranulina
JP2018501182A JP6979397B2 (ja) 2015-07-13 2016-07-12 ソルチリンに結合し、プログラニュリンの結合を阻害する抗体
US15/743,549 US10479835B2 (en) 2015-07-13 2016-07-12 Agent, uses and methods for treatment
CA2989739A CA2989739A1 (en) 2015-07-13 2016-07-12 Antibodies that bind to sortilin and inhibit the binding of progranulin
ES16739087T ES3024469T3 (en) 2015-07-13 2016-07-12 Antibodies that bind to sortilin and inhibit the binding of progranulin
CN202210124752.3A CN114478775A (zh) 2015-07-13 2016-07-12 与分拣蛋白结合并抑制颗粒蛋白前体的结合的抗体
TNP/2017/000534A TN2017000534A1 (en) 2015-07-13 2016-07-12 Antibodies that bind to sortilin and inhibit the binding of progranulin
KR1020187001192A KR102778576B1 (ko) 2015-07-13 2016-07-12 소르틸린에 결합하고 프로그라눌린의 결합을 억제하는 항체
EA201890038A EA201890038A1 (ru) 2015-07-13 2016-07-12 Антитела, которые связываются с сортилином и подавляют связывание програнулина
CN202210124751.9A CN114478774A (zh) 2015-07-13 2016-07-12 与分拣蛋白结合并抑制颗粒蛋白前体的结合的抗体
ARP160102109A AR105335A1 (es) 2015-07-13 2016-07-12 Anticuerpos monoclonales anti-sortilina
RU2018100824A RU2735639C2 (ru) 2015-07-13 2016-07-12 Антитела, которые связываются с сортилином и подавляют связывание програнулина
HRP20250602TT HRP20250602T1 (hr) 2015-07-13 2016-07-12 Antitijela koja se vežu na sortilin i inhibiraju vezanje progranulina
US15/207,880 US10428147B2 (en) 2015-07-13 2016-07-12 Anti-sortilin antibodies, uses and methods for treatment
TW105121903A TWI760305B (zh) 2015-07-13 2016-07-12 抗分揀蛋白抗體、包含其之組成物與套組及其用途
HK18113432.9A HK1254356B (en) 2015-07-13 2016-07-12 Antibodies that bind to sortilin and inhibit the binding of progranulin
UAA201800574A UA125136C2 (uk) 2015-07-13 2016-07-12 Антитіла, які зв'язуються з сортиліном і пригнічують зв'язування програнуліну
MA42440A MA42440B1 (fr) 2015-07-13 2016-07-12 Anticorps contre la sortilin qui inhibent la liason à la progranulin
CN201680040476.5A CN107849135A (zh) 2015-07-13 2016-07-12 与分拣蛋白结合并抑制颗粒蛋白前体的结合的抗体
PE2018000064A PE20181014A1 (es) 2015-07-13 2016-07-12 Agentes, usos y metodos para el tratamiento
BR112018000771-4A BR112018000771A2 (pt) 2015-07-13 2016-07-12 anticorpos que se ligam à sortilina e inibem a ligação de progranulina, composições farmacêuticas, preparações dos mesmos, uso de anticorpos, kit e método de prevenção ou tratamento de uma doença associada a níveis diminuídos de pgrn
EP16739087.1A EP3322726B1 (en) 2015-07-13 2016-07-12 Antibodies that bind to sortilin and inhibit the binding of progranulin
HUE16739087A HUE071424T2 (hu) 2015-07-13 2016-07-12 Szortilinhez kötõdõ és a progranulin kötõdését gátló antitestek
CONC2017/0012988A CO2017012988A2 (es) 2015-07-13 2017-12-18 Agentes, usos y métodos para el tratamiento
ZA2017/08613A ZA201708613B (en) 2015-07-13 2017-12-18 Antibodies that bind to sortilin and inhibit the binding of progranulin
IL256503A IL256503B (en) 2015-07-13 2017-12-22 Antibodies that bind sortilin and inhibit binding to progranulin
DO2018000014A DOP2018000014A (es) 2015-07-13 2018-01-11 Anticuerpos que se unen a la sortilina e inhiben la vinculación de progranulina
PH12018500100A PH12018500100A1 (en) 2015-07-13 2018-01-11 Antibodies that bind to sortilin and inhibit the binding of progranulin
CL2018000092A CL2018000092A1 (es) 2015-07-13 2018-01-11 Anticuerpos que se unen a la sortilina e inhiben la union de progranulina.
NI201800007A NI201800007A (es) 2015-07-13 2018-01-11 Agentes, usos y métodos para el tratamiento
SV2018005613A SV2018005613A (es) 2015-07-13 2018-01-11 Agentes, usos y metodos para el tratamiento
ECIEPI20182725A ECSP18002725A (es) 2015-07-13 2018-01-12 Agentes, usos y métodos para el tratamiento
US16/521,279 US10889650B2 (en) 2015-07-13 2019-07-24 Agent, uses and methods for treatment
CL2020002468A CL2020002468A1 (es) 2015-07-13 2020-09-24 Anticuerpos que se unen a la sortilina e inhiben la union de progranulina.(divisional de solicitud 92-2018)
US17/097,457 US11548950B2 (en) 2015-07-13 2020-11-13 Agent, uses and methods for treatment
JP2021151783A JP2022003058A (ja) 2015-07-13 2021-09-17 ソルチリンに結合し、プログラニュリンの結合を阻害する抗体
US18/057,104 US12331123B2 (en) 2015-07-13 2022-11-18 Agent, uses and methods for treatment
US19/210,142 US20250277040A1 (en) 2015-07-13 2025-05-16 Agent, uses and methods for treatment

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB1512215.3A GB201512215D0 (en) 2015-07-13 2015-07-13 Agents,uses and methods

Publications (1)

Publication Number Publication Date
GB201512215D0 true GB201512215D0 (en) 2015-08-19

Family

ID=54013862

Family Applications (1)

Application Number Title Priority Date Filing Date
GBGB1512215.3A Ceased GB201512215D0 (en) 2015-07-13 2015-07-13 Agents,uses and methods

Country Status (35)

Country Link
US (6) US10428147B2 (enExample)
EP (1) EP3322726B1 (enExample)
JP (2) JP6979397B2 (enExample)
KR (1) KR102778576B1 (enExample)
CN (3) CN114478774A (enExample)
AR (1) AR105335A1 (enExample)
AU (1) AU2016292980B2 (enExample)
BR (1) BR112018000771A2 (enExample)
CA (1) CA2989739A1 (enExample)
CL (2) CL2018000092A1 (enExample)
CO (1) CO2017012988A2 (enExample)
CR (1) CR20180002A (enExample)
DO (1) DOP2018000014A (enExample)
EA (1) EA201890038A1 (enExample)
EC (1) ECSP18002725A (enExample)
ES (1) ES3024469T3 (enExample)
GB (1) GB201512215D0 (enExample)
HR (1) HRP20250602T1 (enExample)
HU (1) HUE071424T2 (enExample)
IL (1) IL256503B (enExample)
JO (1) JO3710B1 (enExample)
MA (1) MA42440B1 (enExample)
MX (1) MX2018000506A (enExample)
NI (1) NI201800007A (enExample)
PE (1) PE20181014A1 (enExample)
PH (1) PH12018500100A1 (enExample)
PL (1) PL3322726T3 (enExample)
RS (1) RS66856B1 (enExample)
RU (1) RU2735639C2 (enExample)
SV (1) SV2018005613A (enExample)
TN (1) TN2017000534A1 (enExample)
TW (1) TWI760305B (enExample)
UA (1) UA125136C2 (enExample)
WO (1) WO2017009327A1 (enExample)
ZA (1) ZA201708613B (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10849992B1 (en) 2015-04-07 2020-12-01 Alector Llc Methods of screening for sortilin binding antagonists
HUE057432T2 (hu) 2015-04-07 2022-05-28 Alector Llc Anti-sortilin antitestek és ezek alkalmazási módjai
GB201512215D0 (en) 2015-07-13 2015-08-19 Lundbeck & Co As H Agents,uses and methods
US10894833B2 (en) * 2017-07-20 2021-01-19 H. Lundbeck A/S Agents, uses and methods for treatment
RS64034B1 (sr) * 2018-07-13 2023-04-28 Alector Llc Anti-sortilin antitela i načini njihove upotrebe
EP3666281A1 (en) * 2018-12-14 2020-06-17 Insusense ApS Compositions comprising sortilin-1
AU2020411480B2 (en) * 2019-12-23 2023-12-21 Denali Therapeutics Inc. Progranulin variants
JP7753264B2 (ja) * 2020-06-24 2025-10-14 プロシーナ バイオサイエンシーズ リミテッド ソルチリンを認識する抗体
EP4543858A1 (en) 2022-06-23 2025-04-30 Draupnir Bio ApS Bifunctional molecules that selectively induce degradation of extracellular targets in lysosomes
CN118496354A (zh) * 2023-02-15 2024-08-16 三优生物医药(上海)有限公司 包含共同轻链的抗体库、其制备方法及其用途
WO2025031098A1 (zh) * 2023-08-09 2025-02-13 瑞诺元(苏州)生物科技有限公司 一种分拣蛋白1特异性的纳米抗体、含有其的重组aav及应用
WO2025132764A1 (en) * 2023-12-21 2025-06-26 Amylonix Ab A sortilin-binding polypeptide

Family Cites Families (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4179337A (en) 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
JPS5896026A (ja) 1981-10-30 1983-06-07 Nippon Chemiphar Co Ltd 新規ウロキナ−ゼ誘導体およびその製造法ならびにそれを含有する血栓溶解剤
US4609546A (en) 1982-06-24 1986-09-02 Japan Chemical Research Co., Ltd. Long-acting composition
US4681581A (en) 1983-12-05 1987-07-21 Coates Fredrica V Adjustable size diaper and folding method therefor
US4766106A (en) 1985-06-26 1988-08-23 Cetus Corporation Solubilization of proteins for pharmaceutical compositions using polymer conjugation
US4735210A (en) 1985-07-05 1988-04-05 Immunomedics, Inc. Lymphographic and organ imaging method and kit
US5776093A (en) 1985-07-05 1998-07-07 Immunomedics, Inc. Method for imaging and treating organs and tissues
US5101827A (en) 1985-07-05 1992-04-07 Immunomedics, Inc. Lymphographic and organ imaging method and kit
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US5750172A (en) 1987-06-23 1998-05-12 Pharming B.V. Transgenic non human mammal milk
US5648471A (en) 1987-12-03 1997-07-15 Centocor, Inc. One vial method for labeling antibodies with Technetium-99m
GB8823869D0 (en) 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US5703055A (en) 1989-03-21 1997-12-30 Wisconsin Alumni Research Foundation Generation of antibodies through lipid mediated DNA delivery
ATE172879T1 (de) 1989-08-09 1998-11-15 Rhomed Inc Direkte radioetikettierung von antikörpern und sonstigen proteinen mittels technetium oder rhenium
US5633076A (en) 1989-12-01 1997-05-27 Pharming Bv Method of producing a transgenic bovine or transgenic bovine embryo
US5859205A (en) 1989-12-21 1999-01-12 Celltech Limited Humanised antibodies
US5101990A (en) 1990-03-23 1992-04-07 Continental Pet Technologies, Inc. Stretch blow molded oblong or oval container
US5814318A (en) 1990-08-29 1998-09-29 Genpharm International Inc. Transgenic non-human animals for producing heterologous antibodies
US5633425A (en) 1990-08-29 1997-05-27 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
US6300129B1 (en) 1990-08-29 2001-10-09 Genpharm International Transgenic non-human animals for producing heterologous antibodies
US5661016A (en) 1990-08-29 1997-08-26 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
ES2108048T3 (es) 1990-08-29 1997-12-16 Genpharm Int Produccion y utilizacion de animales inferiores transgenicos capaces de producir anticuerpos heterologos.
US5877397A (en) 1990-08-29 1999-03-02 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
US5770429A (en) 1990-08-29 1998-06-23 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5874299A (en) 1990-08-29 1999-02-23 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5625126A (en) 1990-08-29 1997-04-29 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
US5789650A (en) 1990-08-29 1998-08-04 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
AU2235992A (en) 1991-06-14 1993-01-12 Genpharm International, Inc. Transgenic immunodeficient non-human animals
EP0940468A1 (en) 1991-06-14 1999-09-08 Genentech, Inc. Humanized antibody variable domain
JPH06508880A (ja) 1991-07-08 1994-10-06 ユニバーシティ　オブ　マサチューセッツ　アット　アムハースト サーモトロピック液晶セグメント化ブロックコポリマー
DK0804070T3 (da) 1993-03-09 2000-08-07 Genzyme Corp Fremgangsmåde til isolering af proteiner fra mælk
JPH08509612A (ja) 1993-04-26 1996-10-15 ジェンファーム インターナショナル インコーポレイテッド 異種抗体を産生することができるトランスジェニック非ヒト動物
US5827690A (en) 1993-12-20 1998-10-27 Genzyme Transgenics Corporatiion Transgenic production of antibodies in milk
US6077835A (en) 1994-03-23 2000-06-20 Case Western Reserve University Delivery of compacted nucleic acid to cells
KR970029803A (ko) 1995-11-03 1997-06-26 김광호 반도체 메모리장치의 프리차지 회로
DE60013773T2 (de) 1999-02-03 2005-11-10 Biosante Pharmaceuticals, Inc. Methoden zur Herstellung von therapeutischen Kalziumphosphat Partikeln
US6281005B1 (en) 1999-05-14 2001-08-28 Copernicus Therapeutics, Inc. Automated nucleic acid compaction device
IL147765A0 (en) 1999-07-29 2002-08-14 Medarex Inc HUMAN MONOCLONAL ANTIBODIES TO HER2/neu
NZ517202A (en) 1999-08-24 2004-05-28 Medarex Inc Human CTLA-4 antibodies and their uses
JP3523245B1 (ja) 2000-11-30 2004-04-26 メダレックス，インコーポレーテッド ヒト抗体作製用トランスジェニック染色体導入齧歯動物
IL166244A0 (en) 2001-07-12 2006-01-15 Jefferson Foote Super humanized antibodies
DK1891966T3 (da) 2002-12-20 2012-04-02 Lundbeck & Co As H Modulation af neurotrophinaktivitet; fremgangsmåde til screening
AU2006317242A1 (en) 2005-11-28 2007-05-31 Genmab A/S Recombinant monovalent antibodies and methods for production thereof
US20100028333A1 (en) 2006-12-15 2010-02-04 Getty Krista L Receptor for amyloid beta and uses thereof
RS60019B1 (sr) 2006-12-21 2020-04-30 H Lundbeck As Modulacija aktivnosti proneurotrofina
JP5588866B2 (ja) 2007-08-10 2014-09-10 メダレックス エル．エル．シー． Ｈｃｏ３２およびｈｃｏ２７、ならびに関連実施例
JP5715045B2 (ja) 2008-04-27 2015-05-07 ハー・ルンドベック・アクチエゼルスカベット ソルチリンに対する特異的リガンドの設計
JP2011524741A (ja) 2008-05-27 2011-09-08 協和発酵キリン株式会社 インターロイキン１０受容体（ｉｌ−１０ｒ）抗体及び使用方法
US20120039865A1 (en) 2008-08-19 2012-02-16 Yale University Identification of sortilin as a neuronal receptor for the frontotemporal dementia protein, progranulin
WO2010069331A2 (en) 2008-12-19 2010-06-24 H. Lundbeck A/S Modulation of the vps 10-domain receptor family for the treatment of mental and behavioural disorders
RU2536232C2 (ru) * 2011-07-01 2014-12-20 Олег Ильич Эпштейн Лекарственное средство для лечения болезни альцгеймера и способ лечения болезни альцгеймера
WO2014071131A1 (en) 2012-11-02 2014-05-08 The Brigham And Women's Hospital, Inc. Sortilin 1 is a novel inducer of vascular calcification
HUE057432T2 (hu) 2015-04-07 2022-05-28 Alector Llc Anti-sortilin antitestek és ezek alkalmazási módjai
GB201512215D0 (en) 2015-07-13 2015-08-19 Lundbeck & Co As H Agents,uses and methods
US10894833B2 (en) 2017-07-20 2021-01-19 H. Lundbeck A/S Agents, uses and methods for treatment
RS64034B1 (sr) 2018-07-13 2023-04-28 Alector Llc Anti-sortilin antitela i načini njihove upotrebe

Also Published As

Publication number Publication date
TW201702273A (zh) 2017-01-16
CR20180002A (es) 2018-04-09
EP3322726A1 (en) 2018-05-23
US20200190188A1 (en) 2020-06-18
ES3024469T3 (en) 2025-06-04
SV2018005613A (es) 2018-02-23
US10889650B2 (en) 2021-01-12
ECSP18002725A (es) 2018-03-31
MA42440A (fr) 2018-05-23
CL2020002468A1 (es) 2021-01-29
US10428147B2 (en) 2019-10-01
EP3322726B1 (en) 2025-03-12
EP3322726C0 (en) 2025-03-12
UA125136C2 (uk) 2022-01-19
US12331123B2 (en) 2025-06-17
KR20180030045A (ko) 2018-03-21
CL2018000092A1 (es) 2018-07-06
RS66856B1 (sr) 2025-06-30
US20210269524A1 (en) 2021-09-02
HUE071424T2 (hu) 2025-08-28
US20250277040A1 (en) 2025-09-04
CN114478775A (zh) 2022-05-13
MA42440B1 (fr) 2025-05-30
US11548950B2 (en) 2023-01-10
JP2022003058A (ja) 2022-01-11
JO3710B1 (ar) 2021-01-31
PE20181014A1 (es) 2018-06-26
BR112018000771A2 (pt) 2018-09-25
AU2016292980A1 (en) 2018-01-18
AU2016292980B2 (en) 2022-10-06
ZA201708613B (en) 2021-03-31
TWI760305B (zh) 2022-04-11
CO2017012988A2 (es) 2018-05-21
JP2018529635A (ja) 2018-10-11
RU2735639C2 (ru) 2020-11-05
PH12018500100A1 (en) 2018-07-30
CA2989739A1 (en) 2017-01-19
RU2018100824A (ru) 2019-08-13
WO2017009327A1 (en) 2017-01-19
HRP20250602T1 (hr) 2025-07-18
HK1254356A1 (en) 2019-07-19
US20180305455A1 (en) 2018-10-25
US20170267761A1 (en) 2017-09-21
TN2017000534A1 (en) 2019-04-12
IL256503B (en) 2022-02-01
US20230159643A1 (en) 2023-05-25
MX2018000506A (es) 2018-05-11
AR105335A1 (es) 2017-09-27
US10479835B2 (en) 2019-11-19
PL3322726T3 (pl) 2025-06-23
KR102778576B1 (ko) 2025-03-07
CN107849135A (zh) 2018-03-27
IL256503A (en) 2018-02-28
NI201800007A (es) 2018-10-18
DOP2018000014A (es) 2018-04-15
JP6979397B2 (ja) 2021-12-15
CN114478774A (zh) 2022-05-13
RU2018100824A3 (enExample) 2020-01-17
EA201890038A1 (ru) 2018-06-29

Similar Documents

Publication Publication Date Title
IL325256A (en) FAP-activated medical materials and related uses
GB201512203D0 (en) Agents,uses and methods
IL255577B (en) Binding materials - tigit and their uses
IL253433A0 (en) Binders - tnfrsf and their uses
SG11201608943VA (en) Substituted 4-phenylpiperidines, their preparaiton and use
GB201512215D0 (en) Agents,uses and methods
IL252430A0 (en) Antibodies, uses and methods
GB201603311D0 (en) New uses and methods
GB201408673D0 (en) Medicaments,uses and methods
ZA201801052B (en) Combinations and uses thereof
GB201612858D0 (en) New uses and methods
GB201616657D0 (en) Methods, compositions and uses relating thereto
GB201715768D0 (en) Methods, compositions and uses relating thereto
GB201706349D0 (en) Methods, compositions and uses relating thereto
GB201616670D0 (en) Methods, compositions and uses relating thereto
GB2548839B (en) New uses and methods
IL254241A0 (en) Etv2 and its uses
HUE047919T2 (hu) Biológiai asszimilációra alkalmas proteo-melanisztikus komplex, készítmény és felhasználásai
GB201616660D0 (en) Methods, compositions and uses relating thereto
GB201616666D0 (en) Methods, compositions and uses relating thereto
GB201616674D0 (en) Methods, compositions and uses relating thereto
GB201518375D0 (en) Agents,uses and methods
GB201512211D0 (en) Agents, uses and methods
GB201512216D0 (en) Agents uses and methods
GB201616648D0 (en) Methods, compositions and uses relating thereto

Legal Events

Date Code Title Description
AT Applications terminated before publication under section 16(1)