UA123786C2 - Деструктори білка mdm2 - Google Patents
Деструктори білка mdm2 Download PDFInfo
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- UA123786C2 UA123786C2 UAA201810884A UAA201810884A UA123786C2 UA 123786 C2 UA123786 C2 UA 123786C2 UA A201810884 A UAA201810884 A UA A201810884A UA A201810884 A UAA201810884 A UA A201810884A UA 123786 C2 UA123786 C2 UA 123786C2
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Classifications
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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Landscapes
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| PCT/US2017/026274 WO2017176957A1 (en) | 2016-04-06 | 2017-04-06 | Mdm2 protein degraders |
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| AU2017246452C1 (en) | 2021-06-03 |
| RU2018138735A (ru) | 2020-05-12 |
| RU2021102253A (ru) | 2021-03-03 |
| KR20180132125A (ko) | 2018-12-11 |
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| US20220411432A1 (en) | 2022-12-29 |
| IL262103B (en) | 2021-05-31 |
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| RU2743432C2 (ru) | 2021-02-18 |
| EP3440066B1 (en) | 2022-11-30 |
| WO2017176957A1 (en) | 2017-10-12 |
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| CN109415336B (zh) | 2023-08-29 |
| IL262103A (en) | 2018-11-29 |
| ZA201806968B (en) | 2020-02-26 |
| KR102387316B1 (ko) | 2022-04-15 |
| RU2018138735A3 (enExample) | 2020-05-12 |
| CN109415336A (zh) | 2019-03-01 |
| WO2017176957A8 (en) | 2018-11-08 |
| CN113788818A (zh) | 2021-12-14 |
| US20190127387A1 (en) | 2019-05-02 |
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| SG11201808728QA (en) | 2018-11-29 |
| EP3440066A1 (en) | 2019-02-13 |
| JP2022078201A (ja) | 2022-05-24 |
| JP2019510798A (ja) | 2019-04-18 |
| CA3020275A1 (en) | 2017-10-12 |
| AU2017246452B2 (en) | 2021-02-25 |
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