TWI712603B - 作為ｂｅｔ蛋白抑制劑之三環雜環 - Google Patents
作為ｂｅｔ蛋白抑制劑之三環雜環 Download PDFInfo
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- TWI712603B TWI712603B TW104130337A TW104130337A TWI712603B TW I712603 B TWI712603 B TW I712603B TW 104130337 A TW104130337 A TW 104130337A TW 104130337 A TW104130337 A TW 104130337A TW I712603 B TWI712603 B TW I712603B
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- compound
- cancer
- pharmaceutically acceptable
- acceptable salt
- methyl
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Classifications
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Landscapes
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| US62/050,500 | 2014-09-15 |
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| EP3019502B1 (en) | 2013-07-08 | 2017-05-17 | Incyte Holdings Corporation | Tricyclic heterocycles as bet protein inhibitors |
| US9399640B2 (en) | 2013-11-26 | 2016-07-26 | Incyte Corporation | Substituted pyrrolo[2,3-c]pyridines and pyrazolo[3,4-c]pyridines as BET protein inhibitors |
| US9315501B2 (en) | 2013-11-26 | 2016-04-19 | Incyte Corporation | Bicyclic heterocycles as BET protein inhibitors |
| US9309246B2 (en) | 2013-12-19 | 2016-04-12 | Incyte Corporation | Tricyclic heterocycles as BET protein inhibitors |
| SMT202000133T1 (it) | 2014-04-23 | 2020-05-08 | Incyte Corp | 1h-pirrolo[2,3-c]piridin-7(6h)-oni e pirazolo[3,4-c]piridin-7(6h)-oni come inibitori di proteine bet |
| JP6599979B2 (ja) | 2014-09-15 | 2019-10-30 | インサイト・コーポレイション | Ｂｅｔタンパク質阻害剤として用いるための三環式複素環化合物 |
| WO2017075377A1 (en) * | 2015-10-29 | 2017-05-04 | Incyte Corporation | Amorphous solid form of a bet protein inhibitor |
| CN109715625B (zh) | 2016-06-20 | 2022-04-19 | 因赛特公司 | Bet抑制剂的结晶固体形式 |
| CN112351778B (zh) * | 2018-06-28 | 2023-04-04 | 江苏恒瑞医药股份有限公司 | 稠合三环杂环类化合物及其治疗用途 |
| AU2019326633B2 (en) * | 2018-08-24 | 2022-09-08 | Adlai Nortye Biopharma Co., Ltd. | High activity sting protein agonist |
| US11833155B2 (en) | 2020-06-03 | 2023-12-05 | Incyte Corporation | Combination therapy for treatment of myeloproliferative neoplasms |
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| EP0732334A1 (fr) * | 1995-03-13 | 1996-09-18 | Synthelabo | Dérivés de pipéridine, leur procédé de préparation et leur application en thérapeutique |
| WO2007018998A2 (en) * | 2005-08-05 | 2007-02-15 | Astrazeneca Ab | Tricyclic benzimidazoles and their use as metabotropic glutamate receptor modulators |
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| JPS59170313A (ja) | 1983-03-14 | 1984-09-26 | Kurimoto Iron Works Ltd | スクリ−ンゲ−ト |
| JPS6085739U (ja) | 1983-11-18 | 1985-06-13 | クラリオン株式会社 | テ−プレコ−ダにおけるピンチロ−ラ装置 |
| JPH0314566A (ja) | 1989-06-09 | 1991-01-23 | Sankyo Co Ltd | ベンズイミダゾール誘導体 |
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| FR2710915B1 (fr) | 1993-10-04 | 1995-11-24 | Synthelabo | Dérivés de pipéridine, leur préparation et leur utilisation en thérapeutique. |
| FR2747678B1 (fr) * | 1996-04-22 | 1998-05-22 | Synthelabo | Composes derives d'imidazobenzoxazine, leurs procedes de preparation et leurs utilisations en therapeutique |
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| WO2011054851A1 (en) | 2009-11-05 | 2011-05-12 | Glaxosmithkline Llc | Novel process |
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- 2015-09-14 TW TW104130337A patent/TWI712603B/zh active
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| US10227359B2 (en) | 2019-03-12 |
| TW201613935A (en) | 2016-04-16 |
| US9834565B2 (en) | 2017-12-05 |
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| US20180222920A1 (en) | 2018-08-09 |
| EP3194406B8 (en) | 2021-03-31 |
| US20170158710A1 (en) | 2017-06-08 |
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| US10618910B2 (en) | 2020-04-14 |
| ES2855225T3 (es) | 2021-09-23 |
| JP2017526731A (ja) | 2017-09-14 |
| WO2016044130A1 (en) | 2016-03-24 |
| JP6599979B2 (ja) | 2019-10-30 |
| EP3194406B1 (en) | 2020-12-16 |
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