TWI696696B - 用於連續減少微生物產生及/或處理產物的模組化系統與方法 - Google Patents

用於連續減少微生物產生及/或處理產物的模組化系統與方法 Download PDF

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TWI696696B
TWI696696B TW105113911A TW105113911A TWI696696B TW I696696 B TWI696696 B TW I696696B TW 105113911 A TW105113911 A TW 105113911A TW 105113911 A TW105113911 A TW 105113911A TW I696696 B TWI696696 B TW I696696B
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filter
product
chromatography
steps
filtrate
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TW105113911A
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TW201706403A (zh
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班哲明 梅瑟
彼得 史旺
馬汀 羅伯丹
沃克 莫伊爾勒
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德商拜耳廠股份有限公司
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/12—Purification
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/24—Dialysis ; Membrane extraction
    • B01D61/243—Dialysis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B01D15/1864—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns using two or more columns
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D19/00—Degasification of liquids
    • B01D19/0031—Degasification of liquids by filtration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • B01D61/145—Ultrafiltration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/58—Multistep processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/20—Partition-, reverse-phase or hydrophobic interaction chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M37/00—Means for sterilizing, maintaining sterile conditions or avoiding chemical or biological contamination
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/16—Sterilization
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2311/00—Details relating to membrane separation process operations and control
    • B01D2311/12—Addition of chemical agents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2311/00—Details relating to membrane separation process operations and control
    • B01D2311/26—Further operations combined with membrane separation processes
    • B01D2311/2626—Absorption or adsorption
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2311/00—Details relating to membrane separation process operations and control
    • B01D2311/26—Further operations combined with membrane separation processes
    • B01D2311/2649—Filtration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2315/00—Details relating to the membrane module operation
    • B01D2315/16—Diafiltration

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Water Supply & Treatment (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Sustainable Development (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
TW105113911A 2015-05-07 2016-05-05 用於連續減少微生物產生及/或處理產物的模組化系統與方法 TWI696696B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP15166686.4 2015-05-07
EP15166686.4A EP3015542A1 (de) 2015-05-07 2015-05-07 Modulare anlage und verfahren zur kontinuierlichen, keimreduzierten produktion und/oder aufbereitung eines produktes

Publications (2)

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TW201706403A TW201706403A (zh) 2017-02-16
TWI696696B true TWI696696B (zh) 2020-06-21

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US (1) US10696940B2 (enExample)
EP (2) EP3015542A1 (enExample)
JP (1) JP6794372B2 (enExample)
KR (1) KR20180002783A (enExample)
CN (1) CN107995924B (enExample)
AR (1) AR104523A1 (enExample)
AU (1) AU2016257253B2 (enExample)
BR (1) BR112017023912A2 (enExample)
CA (1) CA2984981A1 (enExample)
HK (1) HK1254902A1 (enExample)
IL (1) IL255383B (enExample)
MX (1) MX383628B (enExample)
RU (1) RU2721535C2 (enExample)
SA (1) SA517390299B1 (enExample)
SG (1) SG11201709094WA (enExample)
TW (1) TWI696696B (enExample)
WO (1) WO2016177650A1 (enExample)
ZA (1) ZA201708284B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI788850B (zh) * 2021-05-17 2023-01-01 張勝致 生物力學測試系統及其反應器模組

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10967298B2 (en) 2012-03-15 2021-04-06 Flodesign Sonics, Inc. Driver and control for variable impedence load
US9458450B2 (en) 2012-03-15 2016-10-04 Flodesign Sonics, Inc. Acoustophoretic separation technology using multi-dimensional standing waves
US10704021B2 (en) 2012-03-15 2020-07-07 Flodesign Sonics, Inc. Acoustic perfusion devices
US9950282B2 (en) 2012-03-15 2018-04-24 Flodesign Sonics, Inc. Electronic configuration and control for acoustic standing wave generation
CN105939767B (zh) 2014-01-08 2018-04-06 弗洛设计声能学公司 具有双声电泳腔的声电泳装置
US11021699B2 (en) 2015-04-29 2021-06-01 FioDesign Sonics, Inc. Separation using angled acoustic waves
US11377651B2 (en) 2016-10-19 2022-07-05 Flodesign Sonics, Inc. Cell therapy processes utilizing acoustophoresis
US11708572B2 (en) 2015-04-29 2023-07-25 Flodesign Sonics, Inc. Acoustic cell separation techniques and processes
US11474085B2 (en) 2015-07-28 2022-10-18 Flodesign Sonics, Inc. Expanded bed affinity selection
US11459540B2 (en) 2015-07-28 2022-10-04 Flodesign Sonics, Inc. Expanded bed affinity selection
US11085035B2 (en) 2016-05-03 2021-08-10 Flodesign Sonics, Inc. Therapeutic cell washing, concentration, and separation utilizing acoustophoresis
US11214789B2 (en) 2016-05-03 2022-01-04 Flodesign Sonics, Inc. Concentration and washing of particles with acoustics
EP3529347A1 (en) 2016-10-19 2019-08-28 Flodesign Sonics, Inc. Affinity cell extraction by acoustics
EP3141594A3 (en) * 2016-11-11 2017-06-14 Bayer Pharma Aktiengesellschaft Method for sampling fluid streams for monitoring contaminants in a continuous flow
US20190359930A1 (en) * 2016-11-11 2019-11-28 Bayer Aktiengesellschaft Method for sampling fluid streams for monitoring contaminants in a continuous flow
CN106474466B (zh) 2016-12-07 2018-04-13 申联生物医药（上海）股份有限公司 一种口蹄疫疫苗的制备方法
BR112019017082A2 (pt) 2017-02-17 2020-04-07 Bayer Ag desgaseificação nos métodos para processamento contínuo de um produto para cuidado da saúde
EP3363517A1 (en) 2017-02-17 2018-08-22 Bayer Healthcare LLC Degassing in methods for continuous production of a healthcare product
CN107286226A (zh) * 2017-06-28 2017-10-24 浙江新银象生物工程有限公司 高清澈度和高效价乳酸链球菌素水溶液的制备方法
EP3431168A1 (en) * 2017-07-19 2019-01-23 Bayer Aktiengesellschaft Élimination de médicament non lié après couplage conjugué anticorps-médicament
DE102017127020A1 (de) * 2017-11-16 2019-05-16 Sartorius Stedim Biotech Gmbh Verfahren zum Filtrieren eines großen Volumens eines Mediums mit einer vorsterilisierbaren, wenigstens teilautomatisierten Einweg-Filtrationsvorrichtung
DE102017127017A1 (de) * 2017-11-16 2019-05-16 Sartorius Stedim Biotech Gmbh Automatisierte Einweg-Filtrationsvorrichtung und Verfahren zur Steuerung einer automatisierten Einweg-Filtrationsvorrichtung
CN114900773A (zh) 2017-12-14 2022-08-12 弗洛设计声能学公司 声泳系统及其操作方法、控制声换能器及声学系统的方法
US10792618B2 (en) * 2018-06-19 2020-10-06 Sartorius Stedim Biotech Gmbh Particle separation and/or purification of a fluid
US11028359B2 (en) * 2018-09-11 2021-06-08 Global Life Sciences Solutions Usa Llc Separation devices, associated methods, and systems
US20210355428A1 (en) * 2018-10-19 2021-11-18 Univercells Technologies S.A. Method for decontaminating a biomolecule production system and a system suitable for decontamination
US11433332B2 (en) 2018-11-05 2022-09-06 Hollingsworth & Vose Company Filter media with irregular structure
US11420143B2 (en) 2018-11-05 2022-08-23 Hollingsworth & Vose Company Filter media with irregular structure and/or reversibly stretchable layers
EP3663623A1 (en) * 2018-12-05 2020-06-10 Bayer AG Pressure stabilizer
CN109603201B (zh) * 2018-12-28 2021-07-16 晨光生物科技集团股份有限公司 辣椒提取物中苯甲酸的去除方法
JP7231419B2 (ja) * 2019-01-22 2023-03-01 日東電工株式会社 分離膜モジュール及びそれを用いた液体処理システム
CN110776138B (zh) * 2019-10-31 2021-12-24 南京工大膜应用技术研究所有限公司 一种钢铁酸洗废水膜法处理装置及方法
DE102020103925A1 (de) * 2020-02-14 2021-08-19 Sartorius Stedim Biotech Gmbh Einweg-Vorrichtung zur Separation oder Aufreinigung eines großen Volumens eines Stoffgemischs
JP7901062B2 (ja) 2021-03-15 2026-08-05 旭化成株式会社 原料液減容方法及びシステム
WO2022215495A1 (ja) * 2021-04-08 2022-10-13 株式会社カネカ 環状リポペプチド化合物のバイオバーデンの低減方法
EP4501334A4 (en) * 2022-03-30 2025-07-16 Fujifilm Corp METHOD FOR THE MANUFACTURE OF A BIOPHARMACEUTICAL DRUG SUBSTANCE, SYSTEM FOR THE MANUFACTURE OF A BIOPHARMACEUTICAL DRUG SUBSTANCE, AND BIOPHARMACEUTICAL DRUG SUBSTANCE
EP4501335A4 (en) 2022-03-30 2025-07-23 Fujifilm Corp METHOD FOR PRODUCING ACTIVE INGREDIENT OF BIOLOGICAL DRUG, SYSTEM FOR PRODUCING ACTIVE INGREDIENT OF BIOLOGICAL DRUG, AND ACTIVE INGREDIENT OF BIOLOGICAL DRUG
KR102853272B1 (ko) * 2022-12-27 2025-09-01 삼성바이오로직스 주식회사 분리된 정제구획을 포함하는 생물학적 물질의 정제 시스템
CN115645996B (zh) * 2022-12-28 2023-04-11 威县双赢化工有限公司 一种用于乳液输出的除气泡装置
CN116590137B (zh) * 2023-05-19 2026-04-07 四川大学华西医院 一次性高致病性微生物或灭活疫苗的生产系统以及方法
WO2025078462A1 (de) * 2023-10-12 2025-04-17 KyooBe Tech GmbH Modul für die förderung eines fluids
JP7751674B2 (ja) * 2024-02-06 2025-10-08 オルガノ株式会社 水処理装置およびその運転方法
WO2025217607A1 (en) * 2024-04-12 2025-10-16 Sartorius Bioanalytical Instruments, Inc. Cell culture systems and methods

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2682168A1 (en) * 2012-07-02 2014-01-08 Millipore Corporation Purification of biological molecules
WO2014180852A1 (en) * 2013-05-06 2014-11-13 Sanofi Continuous multistep process for purifying antibodies

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62298536A (ja) * 1986-06-17 1987-12-25 Green Cross Corp:The 生理活性物質の自動精製方法および自動精製装置
US6359114B1 (en) * 1995-06-07 2002-03-19 Aphton Corp. System for method for the modification and purification of proteins
US6773613B1 (en) * 1998-10-15 2004-08-10 Sangart, Inc. Method for production of stroma-free hemoglobin
JP2000202239A (ja) * 1999-01-13 2000-07-25 Canon Inc バイオリアクタ―及びそれを用いた微生物分解方法
US20060246537A1 (en) * 2005-04-29 2006-11-02 Jenkins Lauri L Multi-step process for the manufacture of therapeutic protein
GB2452301A (en) 2007-08-30 2009-03-04 Ge Healthcare Bio Sciences Ab Sterilization Method
US8109284B2 (en) * 2007-09-29 2012-02-07 Pendotech Bubble trap assembly for critical bioprocess applications
US8707760B2 (en) * 2009-07-31 2014-04-29 Tricorntech Corporation Gas collection and analysis system with front-end and back-end pre-concentrators and moisture removal
BR112012009377A2 (pt) * 2009-10-08 2016-06-07 Nestec Sa sistema segmentado para preparação de um produto nutricional
US10589239B2 (en) * 2010-07-07 2020-03-17 Ge Healthcare Bio-Sciences Ab Fluid mixing in a disposable fluid processing system
BR112013008738B1 (pt) * 2010-10-11 2017-12-19 Abbvie Bahamas Ltd. Method for purification of a protein
US20140284271A1 (en) * 2010-10-31 2014-09-25 Algaeon, Inc. Photobioreactor system and method of using the same
CN103562145B (zh) 2010-12-06 2016-09-21 颇尔公司 生物制品的连续加工方法
WO2013009491A2 (en) * 2011-07-08 2013-01-17 Nripen Singh Improved depth filters for disposable biotechnological processes
JP2015517306A (ja) * 2012-05-11 2015-06-22 ノバルティス アーゲー モノクローナル抗体の精製のための結晶化方法
WO2013192009A1 (en) * 2012-06-21 2013-12-27 Baxter International Inc. Virus filtration of cell culture media
RU2493872C1 (ru) * 2012-08-08 2013-09-27 Федеральное государственное унитарное предприятие "Научно-производственное объединение по медицинским иммунобиологическим препаратам "Микроген" Министерства здравоохранения Российской Федерации ( ФГУП "НПО "Микроген" Минздрава России) Способ очистки вируса гриппа
AU2014226126B2 (en) 2013-03-08 2019-02-14 Genzyme Corporation Continuous purification of therapeutic proteins

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2682168A1 (en) * 2012-07-02 2014-01-08 Millipore Corporation Purification of biological molecules
WO2014180852A1 (en) * 2013-05-06 2014-11-13 Sanofi Continuous multistep process for purifying antibodies

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI788850B (zh) * 2021-05-17 2023-01-01 張勝致 生物力學測試系統及其反應器模組

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MX383628B (es) 2025-03-14
JP2018518161A (ja) 2018-07-12
ZA201708284B (en) 2021-05-26
BR112017023912A2 (pt) 2018-07-17
IL255383A0 (en) 2017-12-31
EP3015542A1 (de) 2016-05-04
AR104523A1 (es) 2017-07-26
AU2016257253B2 (en) 2020-06-18
JP6794372B2 (ja) 2020-12-02
MX2017014278A (es) 2018-03-07
US20180135006A1 (en) 2018-05-17
WO2016177650A1 (de) 2016-11-10
IL255383B (en) 2021-09-30
RU2017142617A3 (enExample) 2019-10-04
RU2721535C2 (ru) 2020-05-19
SG11201709094WA (en) 2017-12-28
AU2016257253A1 (en) 2017-11-30
EP3292195A1 (de) 2018-03-14
KR20180002783A (ko) 2018-01-08
TW201706403A (zh) 2017-02-16
SA517390299B1 (ar) 2021-03-02
RU2017142617A (ru) 2019-06-10
US10696940B2 (en) 2020-06-30
CN107995924B (zh) 2021-09-07
CA2984981A1 (en) 2016-11-10
CN107995924A (zh) 2018-05-04
HK1254902A1 (zh) 2019-08-02

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