MX2017014278A - Sistema modular y proceso para la produccion continua reducida respecto del contenido de microbios y/o procesamiento de un producto. - Google Patents

Sistema modular y proceso para la produccion continua reducida respecto del contenido de microbios y/o procesamiento de un producto.

Info

Publication number
MX2017014278A
MX2017014278A MX2017014278A MX2017014278A MX2017014278A MX 2017014278 A MX2017014278 A MX 2017014278A MX 2017014278 A MX2017014278 A MX 2017014278A MX 2017014278 A MX2017014278 A MX 2017014278A MX 2017014278 A MX2017014278 A MX 2017014278A
Authority
MX
Mexico
Prior art keywords
product
carrying
manner
disinfected
preparing
Prior art date
Application number
MX2017014278A
Other languages
English (en)
Inventor
Schwan Peter
Möhrle Volker
Maiser Benjamin
Lobedan Martin
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of MX2017014278A publication Critical patent/MX2017014278A/es

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B01D15/1864—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns using two or more columns
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D19/00—Degasification of liquids
    • B01D19/0031—Degasification of liquids by filtration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • B01D61/145—Ultrafiltration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • B01D61/145—Ultrafiltration
    • B01D61/146—Ultrafiltration comprising multiple ultrafiltration steps
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/24—Dialysis ; Membrane extraction
    • B01D61/243—Dialysis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/58—Multistep processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/20—Partition-, reverse-phase or hydrophobic interaction chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M37/00—Means for sterilizing, maintaining sterile conditions or avoiding chemical or biological contamination
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/12—Purification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/16—Sterilization
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2311/00—Details relating to membrane separation process operations and control
    • B01D2311/12—Addition of chemical agents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2311/00—Details relating to membrane separation process operations and control
    • B01D2311/26—Further operations combined with membrane separation processes
    • B01D2311/2626—Absorption or adsorption
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2311/00—Details relating to membrane separation process operations and control
    • B01D2311/26—Further operations combined with membrane separation processes
    • B01D2311/2649—Filtration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2315/00—Details relating to the membrane module operation
    • B01D2315/16—Diafiltration

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Water Supply & Treatment (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Sustainable Development (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

La invención provee un método para el procesamiento y/o la producción continua reducida en cuanto al contenido de microbios de un producto macromolecular biológico biofarmacéutico de una mezcla heterogénea de fluido-cultivo celular, que comprende los siguientes pasos: (a) proveer un fluido libre de partículas de una mezcla heterogénea de fluidos-cultivo celular que contiene el producto, en forma de una corriente de producto, (b) al menos una filtración, que provee un filtrado, (c) al menos dos pasos de cromatografía para purificar el producto, (d) al menos un agotamiento de virus, (e) al menos una ultrafiltración y/o al menos una diafiltración de la corriente de producto de los pasos (b), (c) y/o (d), caracterizado porque los al menos dos pasos cromatografía de (c) comprenden una purificación mediante al menos dos columnas de cromatografía y/o adsorbentes de membrana en cada caso y que el proceso se realiza de manera cerrada y modular. La invención además provee un sistema modular correspondiente para realizar dicho método.
MX2017014278A 2015-05-07 2016-04-29 Sistema modular y proceso para la produccion continua reducida respecto del contenido de microbios y/o procesamiento de un producto. MX2017014278A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP15166686.4A EP3015542A1 (de) 2015-05-07 2015-05-07 Modulare anlage und verfahren zur kontinuierlichen, keimreduzierten produktion und/oder aufbereitung eines produktes
PCT/EP2016/059700 WO2016177650A1 (de) 2015-05-07 2016-04-29 Modulare anlage und verfahren zur kontinuierlichen, keimreduzierten produktion und/oder aufbereitung eines produktes

Publications (1)

Publication Number Publication Date
MX2017014278A true MX2017014278A (es) 2018-03-07

Family

ID=53177140

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2017014278A MX2017014278A (es) 2015-05-07 2016-04-29 Sistema modular y proceso para la produccion continua reducida respecto del contenido de microbios y/o procesamiento de un producto.

Country Status (18)

Country Link
US (1) US10696940B2 (es)
EP (2) EP3015542A1 (es)
JP (1) JP6794372B2 (es)
KR (1) KR20180002783A (es)
CN (1) CN107995924B (es)
AR (1) AR104523A1 (es)
AU (1) AU2016257253B2 (es)
BR (1) BR112017023912A2 (es)
CA (1) CA2984981A1 (es)
HK (1) HK1254902A1 (es)
IL (1) IL255383B (es)
MX (1) MX2017014278A (es)
RU (1) RU2721535C2 (es)
SA (1) SA517390299B1 (es)
SG (1) SG11201709094WA (es)
TW (1) TWI696696B (es)
WO (1) WO2016177650A1 (es)
ZA (1) ZA201708284B (es)

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Also Published As

Publication number Publication date
RU2017142617A (ru) 2019-06-10
JP6794372B2 (ja) 2020-12-02
WO2016177650A1 (de) 2016-11-10
RU2721535C2 (ru) 2020-05-19
CN107995924B (zh) 2021-09-07
AU2016257253A1 (en) 2017-11-30
CA2984981A1 (en) 2016-11-10
TW201706403A (zh) 2017-02-16
EP3292195A1 (de) 2018-03-14
IL255383A0 (en) 2017-12-31
EP3015542A1 (de) 2016-05-04
RU2017142617A3 (es) 2019-10-04
BR112017023912A2 (pt) 2018-07-17
SG11201709094WA (en) 2017-12-28
CN107995924A (zh) 2018-05-04
AU2016257253B2 (en) 2020-06-18
SA517390299B1 (ar) 2021-03-02
JP2018518161A (ja) 2018-07-12
ZA201708284B (en) 2021-05-26
US10696940B2 (en) 2020-06-30
KR20180002783A (ko) 2018-01-08
IL255383B (en) 2021-09-30
AR104523A1 (es) 2017-07-26
TWI696696B (zh) 2020-06-21
HK1254902A1 (zh) 2019-08-02
US20180135006A1 (en) 2018-05-17

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