MX383628B - Sistema modular y proceso para la producción continua reducida respecto del contenido de microbios y/o procesamiento de un producto. - Google Patents

Sistema modular y proceso para la producción continua reducida respecto del contenido de microbios y/o procesamiento de un producto.

Info

Publication number
MX383628B
MX383628B MX2017014278A MX2017014278A MX383628B MX 383628 B MX383628 B MX 383628B MX 2017014278 A MX2017014278 A MX 2017014278A MX 2017014278 A MX2017014278 A MX 2017014278A MX 383628 B MX383628 B MX 383628B
Authority
MX
Mexico
Prior art keywords
product
carrying
modular system
respect
processing
Prior art date
Application number
MX2017014278A
Other languages
English (en)
Other versions
MX2017014278A (es
Inventor
Benjamin Maiser
Martin LOBEDAN
Peter Schwan
Volker Möhrle
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of MX2017014278A publication Critical patent/MX2017014278A/es
Publication of MX383628B publication Critical patent/MX383628B/es

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B01D15/1864—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns using two or more columns
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D19/00—Degasification of liquids
    • B01D19/0031—Degasification of liquids by filtration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • B01D61/145—Ultrafiltration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/24—Dialysis ; Membrane extraction
    • B01D61/243—Dialysis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/58—Multistep processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/20—Partition-, reverse-phase or hydrophobic interaction chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M37/00—Means for sterilizing, maintaining sterile conditions or avoiding chemical or biological contamination
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/12—Purification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/16—Sterilization
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2311/00—Details relating to membrane separation process operations and control
    • B01D2311/12—Addition of chemical agents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2311/00—Details relating to membrane separation process operations and control
    • B01D2311/26—Further operations combined with membrane separation processes
    • B01D2311/2626—Absorption or adsorption
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2311/00—Details relating to membrane separation process operations and control
    • B01D2311/26—Further operations combined with membrane separation processes
    • B01D2311/2649—Filtration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2315/00—Details relating to the membrane module operation
    • B01D2315/16—Diafiltration

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Water Supply & Treatment (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Sustainable Development (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

La invención provee un método para el procesamiento y/o la producción continua reducida en cuanto al contenido de microbios de un producto macromolecular biológico biofarmacéutico de una mezcla heterogénea de fluido-cultivo celular, que comprende los siguientes pasos: (a) proveer un fluido libre de partículas de una mezcla heterogénea de fluidos-cultivo celular que contiene el producto, en forma de una corriente de producto, (b) al menos una filtración, que provee un filtrado, (c) al menos dos pasos de cromatografía para purificar el producto, (d) al menos un agotamiento de virus, (e) al menos una ultrafiltración y/o al menos una diafiltración de la corriente de producto de los pasos (b), (c) y/o (d), caracterizado porque los al menos dos pasos cromatografía de (c) comprenden una purificación mediante al menos dos columnas de cromatografía y/o adsorbentes de membrana en cada caso y que el proceso se realiza de manera cerrada y modular. La invención además provee un sistema modular correspondiente para realizar dicho método.
MX2017014278A 2015-05-07 2016-04-29 Sistema modular y proceso para la producción continua reducida respecto del contenido de microbios y/o procesamiento de un producto. MX383628B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP15166686.4A EP3015542A1 (de) 2015-05-07 2015-05-07 Modulare anlage und verfahren zur kontinuierlichen, keimreduzierten produktion und/oder aufbereitung eines produktes
PCT/EP2016/059700 WO2016177650A1 (de) 2015-05-07 2016-04-29 Modulare anlage und verfahren zur kontinuierlichen, keimreduzierten produktion und/oder aufbereitung eines produktes

Publications (2)

Publication Number Publication Date
MX2017014278A MX2017014278A (es) 2018-03-07
MX383628B true MX383628B (es) 2025-03-14

Family

ID=53177140

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2017014278A MX383628B (es) 2015-05-07 2016-04-29 Sistema modular y proceso para la producción continua reducida respecto del contenido de microbios y/o procesamiento de un producto.

Country Status (18)

Country Link
US (1) US10696940B2 (es)
EP (2) EP3015542A1 (es)
JP (1) JP6794372B2 (es)
KR (1) KR20180002783A (es)
CN (1) CN107995924B (es)
AR (1) AR104523A1 (es)
AU (1) AU2016257253B2 (es)
BR (1) BR112017023912A2 (es)
CA (1) CA2984981A1 (es)
HK (1) HK1254902A1 (es)
IL (1) IL255383B (es)
MX (1) MX383628B (es)
RU (1) RU2721535C2 (es)
SA (1) SA517390299B1 (es)
SG (1) SG11201709094WA (es)
TW (1) TWI696696B (es)
WO (1) WO2016177650A1 (es)
ZA (1) ZA201708284B (es)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10967298B2 (en) 2012-03-15 2021-04-06 Flodesign Sonics, Inc. Driver and control for variable impedence load
US9950282B2 (en) 2012-03-15 2018-04-24 Flodesign Sonics, Inc. Electronic configuration and control for acoustic standing wave generation
US9458450B2 (en) 2012-03-15 2016-10-04 Flodesign Sonics, Inc. Acoustophoretic separation technology using multi-dimensional standing waves
US10704021B2 (en) 2012-03-15 2020-07-07 Flodesign Sonics, Inc. Acoustic perfusion devices
US9725710B2 (en) 2014-01-08 2017-08-08 Flodesign Sonics, Inc. Acoustophoresis device with dual acoustophoretic chamber
US11708572B2 (en) 2015-04-29 2023-07-25 Flodesign Sonics, Inc. Acoustic cell separation techniques and processes
US11377651B2 (en) 2016-10-19 2022-07-05 Flodesign Sonics, Inc. Cell therapy processes utilizing acoustophoresis
US11021699B2 (en) 2015-04-29 2021-06-01 FioDesign Sonics, Inc. Separation using angled acoustic waves
US11474085B2 (en) 2015-07-28 2022-10-18 Flodesign Sonics, Inc. Expanded bed affinity selection
US11459540B2 (en) 2015-07-28 2022-10-04 Flodesign Sonics, Inc. Expanded bed affinity selection
US11214789B2 (en) 2016-05-03 2022-01-04 Flodesign Sonics, Inc. Concentration and washing of particles with acoustics
US11085035B2 (en) 2016-05-03 2021-08-10 Flodesign Sonics, Inc. Therapeutic cell washing, concentration, and separation utilizing acoustophoresis
KR20190127655A (ko) 2016-10-19 2019-11-13 프로디자인 소닉스, 인크. 음향학에 의한 친화성 세포 추출
EP3141594A3 (en) * 2016-11-11 2017-06-14 Bayer Pharma Aktiengesellschaft Method for sampling fluid streams for monitoring contaminants in a continuous flow
AU2017358509A1 (en) * 2016-11-11 2019-05-09 Bayer Aktiengesellschaft Method for sampling fluid streams for monitoring contaminants in a continuous flow
CN106474466B (zh) * 2016-12-07 2018-04-13 申联生物医药（上海）股份有限公司 一种口蹄疫疫苗的制备方法
CN110267724A (zh) 2017-02-17 2019-09-20 拜耳股份公司 连续加工保健产品的方法中的脱气
EP3363517A1 (en) 2017-02-17 2018-08-22 Bayer Healthcare LLC Degassing in methods for continuous production of a healthcare product
CN107286226A (zh) * 2017-06-28 2017-10-24 浙江新银象生物工程有限公司 高清澈度和高效价乳酸链球菌素水溶液的制备方法
EP3431168A1 (en) * 2017-07-19 2019-01-23 Bayer Aktiengesellschaft Élimination de médicament non lié après couplage conjugué anticorps-médicament
DE102017127020A1 (de) * 2017-11-16 2019-05-16 Sartorius Stedim Biotech Gmbh Verfahren zum Filtrieren eines großen Volumens eines Mediums mit einer vorsterilisierbaren, wenigstens teilautomatisierten Einweg-Filtrationsvorrichtung
DE102017127017A1 (de) * 2017-11-16 2019-05-16 Sartorius Stedim Biotech Gmbh Automatisierte Einweg-Filtrationsvorrichtung und Verfahren zur Steuerung einer automatisierten Einweg-Filtrationsvorrichtung
JP2021507561A (ja) 2017-12-14 2021-02-22 フロデザイン ソニックス， インク．Ｆｌｏｄｅｓｉｇｎ Ｓｏｎｉｃｓ， Ｉｎｃ． 音響トランスデューサドライバ及びコントローラ
US10792618B2 (en) * 2018-06-19 2020-10-06 Sartorius Stedim Biotech Gmbh Particle separation and/or purification of a fluid
US11028359B2 (en) * 2018-09-11 2021-06-08 Global Life Sciences Solutions Usa Llc Separation devices, associated methods, and systems
CN113227349A (zh) * 2018-10-19 2021-08-06 尤尼沃尔塞尔斯技术股份公司 净化生物分子生产系统的方法及适用于净化的系统
US11420143B2 (en) * 2018-11-05 2022-08-23 Hollingsworth & Vose Company Filter media with irregular structure and/or reversibly stretchable layers
US11433332B2 (en) * 2018-11-05 2022-09-06 Hollingsworth & Vose Company Filter media with irregular structure
EP3663623A1 (en) * 2018-12-05 2020-06-10 Bayer AG Pressure stabilizer
CN109603201B (zh) * 2018-12-28 2021-07-16 晨光生物科技集团股份有限公司 辣椒提取物中苯甲酸的去除方法
JP7231419B2 (ja) * 2019-01-22 2023-03-01 日東電工株式会社 分離膜モジュール及びそれを用いた液体処理システム
CN110776138B (zh) * 2019-10-31 2021-12-24 南京工大膜应用技术研究所有限公司 一种钢铁酸洗废水膜法处理装置及方法
DE102020103925A1 (de) * 2020-02-14 2021-08-19 Sartorius Stedim Biotech Gmbh Einweg-Vorrichtung zur Separation oder Aufreinigung eines großen Volumens eines Stoffgemischs
EP4309769A4 (en) * 2021-03-15 2025-06-11 Asahi Kasei Kabushiki Kaisha Method and system for reducing volume of raw material liquid
WO2022215495A1 (ja) * 2021-04-08 2022-10-13 株式会社カネカ 環状リポペプチド化合物のバイオバーデンの低減方法
TWI788850B (zh) * 2021-05-17 2023-01-01 張勝致 生物力學測試系統及其反應器模組
WO2023191009A1 (ja) 2022-03-30 2023-10-05 富士フイルム株式会社 バイオ医薬品の原薬の製造方法、バイオ医薬品の原薬の製造システム、およびバイオ医薬品の原薬
WO2023191008A1 (ja) * 2022-03-30 2023-10-05 富士フイルム株式会社 バイオ医薬品の原薬の製造方法、バイオ医薬品の原薬の製造システム、およびバイオ医薬品の原薬
KR102853272B1 (ko) * 2022-12-27 2025-09-01 삼성바이오로직스 주식회사 분리된 정제구획을 포함하는 생물학적 물질의 정제 시스템
CN115645996B (zh) * 2022-12-28 2023-04-11 威县双赢化工有限公司 一种用于乳液输出的除气泡装置
CN116590137A (zh) * 2023-05-19 2023-08-15 四川大学华西医院 一次性高致病性微生物或灭活疫苗的生产系统以及方法
WO2025078462A1 (de) * 2023-10-12 2025-04-17 KyooBe Tech GmbH Modul für die förderung eines fluids
JP7751674B2 (ja) * 2024-02-06 2025-10-08 オルガノ株式会社 水処理装置およびその運転方法
WO2025217607A1 (en) * 2024-04-12 2025-10-16 Sartorius Bioanalytical Instruments, Inc. Cell culture systems and methods

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62298536A (ja) * 1986-06-17 1987-12-25 Green Cross Corp:The 生理活性物質の自動精製方法および自動精製装置
US6359114B1 (en) * 1995-06-07 2002-03-19 Aphton Corp. System for method for the modification and purification of proteins
US6773613B1 (en) * 1998-10-15 2004-08-10 Sangart, Inc. Method for production of stroma-free hemoglobin
JP2000202239A (ja) * 1999-01-13 2000-07-25 Canon Inc バイオリアクタ―及びそれを用いた微生物分解方法
US20060246537A1 (en) * 2005-04-29 2006-11-02 Jenkins Lauri L Multi-step process for the manufacture of therapeutic protein
GB2452301A (en) 2007-08-30 2009-03-04 Ge Healthcare Bio Sciences Ab Sterilization Method
US8109284B2 (en) * 2007-09-29 2012-02-07 Pendotech Bubble trap assembly for critical bioprocess applications
US8707760B2 (en) * 2009-07-31 2014-04-29 Tricorntech Corporation Gas collection and analysis system with front-end and back-end pre-concentrators and moisture removal
RU2542224C2 (ru) * 2009-10-08 2015-02-20 Нестек С.А. Система порционного приготовления продукта питания
EP2591349B1 (en) * 2010-07-07 2016-06-08 GE Healthcare Bio-Sciences AB Fluid mixing in a disposable fluid processing system
JP6023715B2 (ja) * 2010-10-11 2016-11-09 アッヴィ・バハマズ・リミテッド タンパク質の精製方法
US20140284271A1 (en) * 2010-10-31 2014-09-25 Algaeon, Inc. Photobioreactor system and method of using the same
EP2649016B1 (en) 2010-12-06 2020-06-10 Pall Corporation Continuous processing methods for biological products
SG194763A1 (en) * 2011-07-08 2013-12-30 Emd Millipore Corp Improved depth filters for disposable biotechnological processes
EP2846830A1 (en) * 2012-05-11 2015-03-18 Novartis AG Crystallization methods for purification of monoclonal antibodies
MX386767B (es) * 2012-06-21 2025-03-19 Takeda Pharmaceuticals Co Filtración de virus de medio de cultivo celular.
EP2682168A1 (en) * 2012-07-02 2014-01-08 Millipore Corporation Purification of biological molecules
RU2493872C1 (ru) * 2012-08-08 2013-09-27 Федеральное государственное унитарное предприятие "Научно-производственное объединение по медицинским иммунобиологическим препаратам "Микроген" Министерства здравоохранения Российской Федерации ( ФГУП "НПО "Микроген" Минздрава России) Способ очистки вируса гриппа
US9650412B2 (en) 2013-03-08 2017-05-16 Genzyme Corporation Integrated continuous manufacturing of therapeutic protein drug substances
ES2665645T3 (es) * 2013-05-06 2018-04-26 Sanofi Proceso multietapa continuo para purificar anticuerpos

Also Published As

Publication number Publication date
JP2018518161A (ja) 2018-07-12
MX2017014278A (es) 2018-03-07
KR20180002783A (ko) 2018-01-08
CN107995924B (zh) 2021-09-07
SA517390299B1 (ar) 2021-03-02
HK1254902A1 (zh) 2019-08-02
TWI696696B (zh) 2020-06-21
WO2016177650A1 (de) 2016-11-10
BR112017023912A2 (pt) 2018-07-17
RU2017142617A (ru) 2019-06-10
ZA201708284B (en) 2021-05-26
US10696940B2 (en) 2020-06-30
US20180135006A1 (en) 2018-05-17
TW201706403A (zh) 2017-02-16
AU2016257253A1 (en) 2017-11-30
CA2984981A1 (en) 2016-11-10
AR104523A1 (es) 2017-07-26
EP3292195A1 (de) 2018-03-14
IL255383B (en) 2021-09-30
AU2016257253B2 (en) 2020-06-18
CN107995924A (zh) 2018-05-04
SG11201709094WA (en) 2017-12-28
RU2017142617A3 (es) 2019-10-04
JP6794372B2 (ja) 2020-12-02
EP3015542A1 (de) 2016-05-04
IL255383A0 (en) 2017-12-31
RU2721535C2 (ru) 2020-05-19

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