TWI695717B - １,２,４-二唑苯甲酸之鹽及醫藥組合物 - Google Patents

１,２,４-二唑苯甲酸之鹽及醫藥組合物 Download PDF

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Publication number
TWI695717B
TWI695717B TW107124154A TW107124154A TWI695717B TW I695717 B TWI695717 B TW I695717B TW 107124154 A TW107124154 A TW 107124154A TW 107124154 A TW107124154 A TW 107124154A TW I695717 B TWI695717 B TW I695717B
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salt
weight
compound
formulation
benzoic acid
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TW107124154A
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English (en)
Chinese (zh)
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TW201836605A (zh
Inventor
V 達利曼達
高杉詹姆斯
L 威托爾瑪拉
威爾區伊簾
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美商 Ptc 治療公司
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/10—Ophthalmic agents for accommodation disorders, e.g. myopia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/12—Ophthalmic agents for cataracts
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Ophthalmology & Optometry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicinal Preparation (AREA)
TW107124154A 2014-03-06 2015-03-05 １,２,４-二唑苯甲酸之鹽及醫藥組合物 TWI695717B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201461949052P 2014-03-06 2014-03-06
US61/949,052 2014-03-06
US201462009111P 2014-06-06 2014-06-06
US62/009,111 2014-06-06

Publications (2)

Publication Number Publication Date
TW201836605A TW201836605A (zh) 2018-10-16
TWI695717B true TWI695717B (zh) 2020-06-11

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Family Applications (2)

Application Number Title Priority Date Filing Date
TW104107343A TWI636978B (zh) 2014-03-06 2015-03-05 １，２，４－二唑苯甲酸之鹽及醫藥組合物
TW107124154A TWI695717B (zh) 2014-03-06 2015-03-05 １,２,４-二唑苯甲酸之鹽及醫藥組合物

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TW104107343A TWI636978B (zh) 2014-03-06 2015-03-05 １，２，４－二唑苯甲酸之鹽及醫藥組合物

Country Status (10)

Country Link
US (3) US9873677B2 (enExample)
EP (1) EP3113619A4 (enExample)
JP (3) JP6946001B2 (enExample)
KR (2) KR102497273B1 (enExample)
CN (3) CN106455571A (enExample)
CA (2) CA3174516A1 (enExample)
EA (1) EA032779B1 (enExample)
IL (1) IL247653B (enExample)
TW (2) TWI636978B (enExample)
WO (1) WO2015134711A1 (enExample)

Families Citing this family (13)

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CA2603402C (en) 2005-04-08 2017-10-31 Ptc Therapeutics, Inc. Compositions of an orally active 1,2,4-oxadiazole for nonsense mutation suppression therapy
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CN106455571A (zh) * 2014-03-06 2017-02-22 Ptc医疗公司 1,2,4‑噁二唑苯甲酸的药物组合物和盐
TW201729807A (zh) 2015-10-30 2017-09-01 Ｐｔｃ治療公司 用於治療癲癇的方法
PT3377476T (pt) * 2015-11-16 2022-12-29 Ptc Therapeutics Inc Análogos enriquecidos com isótopo de hidrogénio de compostos de ácido 1,2,4-oxadiazole benzoico, composições e suas utilizações
JP2019505579A (ja) 2015-12-23 2019-02-28 ムーンショット ファーマ エルエルシー 免疫応答を誘導するための方法
EP3641752A4 (en) 2017-06-22 2021-03-17 Moonshot Pharma LLC CANCER TREATMENT METHODS USING COMPOSITIONS INCLUDING AMLEXANOX AND IMMUNOMODULATORS
US11203578B2 (en) 2017-11-23 2021-12-21 Universita'degli Studi Dipalermo Oxadiazole derivatives for the treatment of genetic diseases due to nonsense mutations
CN109678715B (zh) * 2018-11-28 2019-11-12 中国药科大学 2-(1-酰氧正戊基)苯甲酸与碱性氨基酸或氨基胍形成的盐、其制备方法及用途
US10637694B1 (en) 2018-12-21 2020-04-28 At&T Intellectual Property I, L.P. Reduction and/or mitigation of spatial emissions in multi-antenna wireless communication systems for advanced networks
EA202192767A1 (ru) 2019-04-10 2021-12-29 ПиТиСи ТЕРАПЬЮТИКС, ИНК. Способ лечения опосредуемой нонсенс-мутацией мышечной дистрофии дюшенна у педиатрических пациентов
EP4259097A1 (en) * 2020-12-14 2023-10-18 Institut National de la Santé et de la Recherche Médicale (INSERM) Ataluren eye drop formulation
WO2023205175A1 (en) * 2022-04-18 2023-10-26 Vanderbilt University Polysulfide microparticles and uses thereof

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US20120277234A1 (en) * 2003-04-11 2012-11-01 Gary Mitchell Karp 1,2,4-oxadiazole benzoic acids

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WO2015134711A1 (en) 2015-09-11
JP2020045354A (ja) 2020-03-26
JP2017507158A (ja) 2017-03-16
TWI636978B (zh) 2018-10-01
CA2942147C (en) 2022-12-13
EP3113619A1 (en) 2017-01-11
EA201691789A1 (ru) 2017-02-28
US20170066730A1 (en) 2017-03-09
US10618877B2 (en) 2020-04-14
EA032779B1 (ru) 2019-07-31
KR20230024431A (ko) 2023-02-20
KR20160122268A (ko) 2016-10-21
IL247653A0 (en) 2016-11-30
US20190152931A1 (en) 2019-05-23
CN112979574A (zh) 2021-06-18
JP6946001B2 (ja) 2021-10-06
TW201836605A (zh) 2018-10-16
KR102497273B1 (ko) 2023-02-07
EP3113619A4 (en) 2017-09-13
CA3174516A1 (en) 2015-09-11
US20180179170A1 (en) 2018-06-28
US10233161B2 (en) 2019-03-19
JP2021165299A (ja) 2021-10-14
TW201620883A (zh) 2016-06-16
JP7335795B2 (ja) 2023-08-30
IL247653B (en) 2022-04-01
CA2942147A1 (en) 2015-09-11
US9873677B2 (en) 2018-01-23
CN106455571A (zh) 2017-02-22
CN112979575A (zh) 2021-06-18

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