KR102497273B1 - 1,2,4-옥사디아졸 벤조산의 약학 조성물 및 염 - Google Patents

1,2,4-옥사디아졸 벤조산의 약학 조성물 및 염 Download PDF

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KR102497273B1
KR102497273B1 KR1020167027606A KR20167027606A KR102497273B1 KR 102497273 B1 KR102497273 B1 KR 102497273B1 KR 1020167027606 A KR1020167027606 A KR 1020167027606A KR 20167027606 A KR20167027606 A KR 20167027606A KR 102497273 B1 KR102497273 B1 KR 102497273B1
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salt
compound
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ophthalmic
pharmaceutical composition
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KR20160122268A (ko
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만다르 브이 달리
제임스 타카스기
마를라 엘 위톨
엘렌 웰치
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피티씨 테라퓨틱스, 인크.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/10—Ophthalmic agents for accommodation disorders, e.g. myopia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/12—Ophthalmic agents for cataracts
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • Y10S514/912—
    • Y10S514/913—

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicinal Preparation (AREA)
KR1020167027606A 2014-03-06 2015-03-05 1,2,4-옥사디아졸 벤조산의 약학 조성물 및 염 Active KR102497273B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020237003980A KR20230024431A (ko) 2014-03-06 2015-03-05 1,2,4-옥사디아졸 벤조산의 약학 조성물 및 염

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201461949052P 2014-03-06 2014-03-06
US61/949,052 2014-03-06
US201462009111P 2014-06-06 2014-06-06
US62/009,111 2014-06-06
PCT/US2015/018889 WO2015134711A1 (en) 2014-03-06 2015-03-05 Pharmaceutical compositions and salts of a 1,2,4-oxadiazole benzoic acid

Related Child Applications (1)

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KR1020237003980A Division KR20230024431A (ko) 2014-03-06 2015-03-05 1,2,4-옥사디아졸 벤조산의 약학 조성물 및 염

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KR20160122268A KR20160122268A (ko) 2016-10-21
KR102497273B1 true KR102497273B1 (ko) 2023-02-07

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KR1020167027606A Active KR102497273B1 (ko) 2014-03-06 2015-03-05 1,2,4-옥사디아졸 벤조산의 약학 조성물 및 염
KR1020237003980A Ceased KR20230024431A (ko) 2014-03-06 2015-03-05 1,2,4-옥사디아졸 벤조산의 약학 조성물 및 염

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US (3) US9873677B2 (enExample)
EP (1) EP3113619A4 (enExample)
JP (3) JP6946001B2 (enExample)
KR (2) KR102497273B1 (enExample)
CN (3) CN112979574A (enExample)
CA (2) CA3174516A1 (enExample)
EA (1) EA032779B1 (enExample)
IL (1) IL247653B (enExample)
TW (2) TWI636978B (enExample)
WO (1) WO2015134711A1 (enExample)

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WO2006110483A1 (en) 2005-04-08 2006-10-19 Ptc Therapeutics, Inc. Compositions of an orally active 1,2,4-oxadiazole for nonsense mutation suppression therapy
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KR102497273B1 (ko) * 2014-03-06 2023-02-07 피티씨 테라퓨틱스, 인크. 1,2,4-옥사디아졸 벤조산의 약학 조성물 및 염
TW201729807A (zh) 2015-10-30 2017-09-01 Ｐｔｃ治療公司 用於治療癲癇的方法
WO2017087364A1 (en) * 2015-11-16 2017-05-26 Ptc Therapeutics, Inc. Hydrogen isotope-enriched analogues of 1,2,4-oxandiazole benzoic acid compounds, compositions and uses thereof
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WO2018237326A1 (en) 2017-06-22 2018-12-27 1AlMOONSHOT PHARMA LLC Methods for treating cancer with compositions comprising amlexanox and immune modulators
US11203578B2 (en) 2017-11-23 2021-12-21 Universita'degli Studi Dipalermo Oxadiazole derivatives for the treatment of genetic diseases due to nonsense mutations
CN109678715B (zh) * 2018-11-28 2019-11-12 中国药科大学 2-(1-酰氧正戊基)苯甲酸与碱性氨基酸或氨基胍形成的盐、其制备方法及用途
US10637694B1 (en) 2018-12-21 2020-04-28 At&T Intellectual Property I, L.P. Reduction and/or mitigation of spatial emissions in multi-antenna wireless communication systems for advanced networks
EP3952867A4 (en) 2019-04-10 2023-01-11 PTC Therapeutics, Inc. METHODS OF TREATMENT OF NONSENSE MUTATION MEDIATED DUCHENNE MUSCULAR DYSTROPHY IN PEDIATRIC PATIENTS
EP4259097A1 (en) * 2020-12-14 2023-10-18 Institut National de la Santé et de la Recherche Médicale (INSERM) Ataluren eye drop formulation
WO2023205175A1 (en) * 2022-04-18 2023-10-26 Vanderbilt University Polysulfide microparticles and uses thereof

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US20080114039A1 (en) 2006-10-12 2008-05-15 Samit Hirawat Methods for dosing an orally active 1,2,4-oxadiazole for nonsense mutation suppression therapy

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Also Published As

Publication number Publication date
CN106455571A (zh) 2017-02-22
WO2015134711A1 (en) 2015-09-11
US20170066730A1 (en) 2017-03-09
KR20160122268A (ko) 2016-10-21
JP7335795B2 (ja) 2023-08-30
EP3113619A4 (en) 2017-09-13
JP2021165299A (ja) 2021-10-14
CA2942147A1 (en) 2015-09-11
TWI695717B (zh) 2020-06-11
TW201620883A (zh) 2016-06-16
KR20230024431A (ko) 2023-02-20
IL247653B (en) 2022-04-01
EP3113619A1 (en) 2017-01-11
JP6946001B2 (ja) 2021-10-06
CN112979575A (zh) 2021-06-18
US20180179170A1 (en) 2018-06-28
US10618877B2 (en) 2020-04-14
CA2942147C (en) 2022-12-13
CA3174516A1 (en) 2015-09-11
EA201691789A1 (ru) 2017-02-28
US9873677B2 (en) 2018-01-23
JP2020045354A (ja) 2020-03-26
TW201836605A (zh) 2018-10-16
JP2017507158A (ja) 2017-03-16
EA032779B1 (ru) 2019-07-31
US10233161B2 (en) 2019-03-19
IL247653A0 (en) 2016-11-30
CN112979574A (zh) 2021-06-18
US20190152931A1 (en) 2019-05-23
TWI636978B (zh) 2018-10-01

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