EA032779B1 - Фармацевтические композиции и соли 1,2,4-оксадиазолбензойной кислоты - Google Patents

Info

Publication number

EA032779B1

EA032779B1 EA201691789A EA201691789A EA032779B1 EA 032779 B1 EA032779 B1 EA 032779B1 EA 201691789 A EA201691789 A EA 201691789A EA 201691789 A EA201691789 A EA 201691789A EA 032779 B1 EA032779 B1 EA 032779B1

Authority

EA

Eurasian Patent Office

Prior art keywords

compound

salt

present

syndrome

disease

Prior art date

2014-03-06

Links

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• 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 149
• 150000003839 salts Chemical class 0.000 title claims abstract description 114
• SNGNHEIIYFNIIL-UHFFFAOYSA-N benzoic acid;1,2,4-oxadiazole Chemical compound C=1N=CON=1.OC(=O)C1=CC=CC=C1 SNGNHEIIYFNIIL-UHFFFAOYSA-N 0.000 title description 8
• 238000000034 method Methods 0.000 claims abstract description 81
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• OOUGLTULBSNHNF-UHFFFAOYSA-N 3-[5-(2-fluorophenyl)-1,2,4-oxadiazol-3-yl]benzoic acid Chemical compound OC(=O)C1=CC=CC(C=2N=C(ON=2)C=2C(=CC=CC=2)F)=C1 OOUGLTULBSNHNF-UHFFFAOYSA-N 0.000 claims abstract description 58
• 230000037434 nonsense mutation Effects 0.000 claims abstract description 49
• 239000004472 Lysine Substances 0.000 claims abstract description 27
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• 208000008303 aniridia Diseases 0.000 claims description 37
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• KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims description 10
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• 201000003533 Leber congenital amaurosis Diseases 0.000 claims description 9
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• KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 abstract description 49
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• FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 29
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• FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 21
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• HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 20
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• VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 16
• 125000002059 L-arginyl group Chemical class O=C([*])[C@](N([H])[H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H] 0.000 description 16
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