CA3174516A1 - Pharmaceutical compositions and salts of a 1,2,4-oxadiazole benzoic acid - Google Patents

Info

Publication number

CA3174516A1

CA3174516A1 CA3174516A CA3174516A CA3174516A1 CA 3174516 A1 CA3174516 A1 CA 3174516A1 CA 3174516 A CA3174516 A CA 3174516A CA 3174516 A CA3174516 A CA 3174516A CA 3174516 A1 CA3174516 A1 CA 3174516A1

Authority

CA

Canada

Prior art keywords

salt

compound

syndrome

ocular disease

salt form

Prior art date

2014-03-06

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

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• Global Dossier
• CIPO
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• 150000003839 salts Chemical class 0.000 title claims abstract description 168
• 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 162
• SNGNHEIIYFNIIL-UHFFFAOYSA-N benzoic acid;1,2,4-oxadiazole Chemical compound C=1N=CON=1.OC(=O)C1=CC=CC=C1 SNGNHEIIYFNIIL-UHFFFAOYSA-N 0.000 title description 9
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• 208000022873 Ocular disease Diseases 0.000 claims abstract description 54
• 238000000634 powder X-ray diffraction Methods 0.000 claims abstract description 50
• LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 claims description 78
• 239000002253 acid Substances 0.000 claims description 77
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• 201000001321 Bardet-Biedl syndrome Diseases 0.000 claims description 23
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• FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims description 16
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• DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 14
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