TWI572716B - Mononuclear Nucleic Acid Molecules with Nitrogen-Containing Liposomes - Google Patents

Mononuclear Nucleic Acid Molecules with Nitrogen-Containing Liposomes Download PDF

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Publication number
TWI572716B
TWI572716B TW104132132A TW104132132A TWI572716B TW I572716 B TWI572716 B TW I572716B TW 104132132 A TW104132132 A TW 104132132A TW 104132132 A TW104132132 A TW 104132132A TW I572716 B TWI572716 B TW I572716B
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Taiwan
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aforementioned
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rna
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TW104132132A
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English (en)
Chinese (zh)
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TW201615835A (zh
Inventor
Tadaaki Ohgi
Hirotake Hayashi
Hisao Shirohzu
Tomohiro Hamasaki
Akihiro Itoh
Hiroshi Suzuki
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Bonac Corp
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • C12N2310/3519—Fusion with another nucleic acid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed
    • C12N2310/531—Stem-loop; Hairpin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/50—Methods for regulating/modulating their activity
    • C12N2320/51—Methods for regulating/modulating their activity modulating the chemical stability, e.g. nuclease-resistance
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2330/00—Production
    • C12N2330/30—Production chemically synthesised

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrrole Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicinal Preparation (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
TW104132132A 2010-08-03 2011-08-02 Mononuclear Nucleic Acid Molecules with Nitrogen-Containing Liposomes TWI572716B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2010174915 2010-08-03
JP2010230806 2010-10-13
JP2010269823 2010-12-02
JP2011152381 2011-07-08

Publications (2)

Publication Number Publication Date
TW201615835A TW201615835A (zh) 2016-05-01
TWI572716B true TWI572716B (zh) 2017-03-01

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
TW104132132A TWI572716B (zh) 2010-08-03 2011-08-02 Mononuclear Nucleic Acid Molecules with Nitrogen-Containing Liposomes
TW100127384A TWI515294B (zh) 2010-08-03 2011-08-02 A single stranded nucleic acid molecule having a nitrogen-containing lipid ring skeleton

Family Applications After (1)

Application Number Title Priority Date Filing Date
TW100127384A TWI515294B (zh) 2010-08-03 2011-08-02 A single stranded nucleic acid molecule having a nitrogen-containing lipid ring skeleton

Country Status (9)

Country Link
EP (4) EP2436767B1 (enExample)
JP (3) JP4965745B2 (enExample)
KR (3) KR101849801B1 (enExample)
CN (3) CN104004018B (enExample)
DK (1) DK2674494T3 (enExample)
ES (4) ES2533129T3 (enExample)
PT (1) PT2674494E (enExample)
TW (2) TWI572716B (enExample)
WO (1) WO2012017919A1 (enExample)

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Also Published As

Publication number Publication date
TW201615835A (zh) 2016-05-01
DK2674494T3 (en) 2015-02-23
KR101894701B1 (ko) 2018-09-04
EP2639307A8 (en) 2014-04-30
JP2013138681A (ja) 2013-07-18
WO2012017919A1 (ja) 2012-02-09
JP4965745B2 (ja) 2012-07-04
ES2528285T3 (es) 2015-02-06
JP2013034470A (ja) 2013-02-21
EP2628801B1 (en) 2015-01-07
EP2639307A3 (en) 2014-02-05
EP2436767A4 (en) 2012-05-09
ES2533129T3 (es) 2015-04-07
EP2639307A2 (en) 2013-09-18
EP2674494B1 (en) 2014-12-17
JPWO2012017919A1 (ja) 2013-10-03
KR101894702B1 (ko) 2018-09-04
HK1200460A1 (en) 2015-08-07
ES2527660T3 (es) 2015-01-28
PT2674494E (pt) 2015-02-27
TWI515294B (zh) 2016-01-01
CN104059911A (zh) 2014-09-24
CN103052711A (zh) 2013-04-17
JP5261677B2 (ja) 2013-08-14
KR20180040728A (ko) 2018-04-20
KR101849801B1 (ko) 2018-04-17
CN103052711B (zh) 2016-08-03
TW201219570A (en) 2012-05-16
EP2639307B1 (en) 2015-03-04
JP5555346B2 (ja) 2014-07-23
HK1189910A1 (en) 2014-06-20
EP2436767A1 (en) 2012-04-04
CN104059911B (zh) 2017-01-04
CN104004018A (zh) 2014-08-27
EP2436767B1 (en) 2013-11-20
EP2628801A1 (en) 2013-08-21
KR20130095738A (ko) 2013-08-28
EP2674494A1 (en) 2013-12-18
KR20180040727A (ko) 2018-04-20
CN104004018B (zh) 2017-01-04
ES2443346T3 (es) 2014-02-19

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