CN104059911B - 具有含氮脂环式骨架的单链核酸分子 - Google Patents
具有含氮脂环式骨架的单链核酸分子 Download PDFInfo
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- CN104059911B CN104059911B CN201410217512.3A CN201410217512A CN104059911B CN 104059911 B CN104059911 B CN 104059911B CN 201410217512 A CN201410217512 A CN 201410217512A CN 104059911 B CN104059911 B CN 104059911B
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- QHCCDDQKNUYGNC-UHFFFAOYSA-N CCCCNCC Chemical compound CCCCNCC QHCCDDQKNUYGNC-UHFFFAOYSA-N 0.000 description 1
- DLXZNAXHANQTGT-UHFFFAOYSA-N C[N](C)(C)ON(OC1CCCCCCCCCCC1)O[N](C)(C)C Chemical compound C[N](C)(C)ON(OC1CCCCCCCCCCC1)O[N](C)(C)C DLXZNAXHANQTGT-UHFFFAOYSA-N 0.000 description 1
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- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
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- C12N2310/30—Chemical structure
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- C12N2310/318—Chemical structure of the backbone where the PO2 is completely replaced, e.g. MMI or formacetal
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- C12N2310/00—Structure or type of the nucleic acid
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- C12N2310/00—Structure or type of the nucleic acid
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- C12N2310/53—Physical structure partially self-complementary or closed
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2010174915 | 2010-08-03 | ||
| JP2010-174915 | 2010-08-03 | ||
| JP2010230806 | 2010-10-13 | ||
| JP2010-230806 | 2010-10-13 | ||
| JP2010-269823 | 2010-12-02 | ||
| JP2010269823 | 2010-12-02 | ||
| JP2011-152381 | 2011-07-08 | ||
| JP2011152381 | 2011-07-08 | ||
| CN201180037592.9A CN103052711B (zh) | 2010-08-03 | 2011-07-28 | 具有含氮脂环式骨架的单链核酸分子 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201180037592.9A Division CN103052711B (zh) | 2010-08-03 | 2011-07-28 | 具有含氮脂环式骨架的单链核酸分子 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104059911A CN104059911A (zh) | 2014-09-24 |
| CN104059911B true CN104059911B (zh) | 2017-01-04 |
Family
ID=45559420
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410217512.3A Expired - Fee Related CN104059911B (zh) | 2010-08-03 | 2011-07-28 | 具有含氮脂环式骨架的单链核酸分子 |
| CN201410217071.7A Expired - Fee Related CN104004018B (zh) | 2010-08-03 | 2011-07-28 | 具有含氮脂环式骨架的单链核酸分子 |
| CN201180037592.9A Expired - Fee Related CN103052711B (zh) | 2010-08-03 | 2011-07-28 | 具有含氮脂环式骨架的单链核酸分子 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410217071.7A Expired - Fee Related CN104004018B (zh) | 2010-08-03 | 2011-07-28 | 具有含氮脂环式骨架的单链核酸分子 |
| CN201180037592.9A Expired - Fee Related CN103052711B (zh) | 2010-08-03 | 2011-07-28 | 具有含氮脂环式骨架的单链核酸分子 |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US8691782B2 (enExample) |
| EP (4) | EP2436767B1 (enExample) |
| JP (3) | JP4965745B2 (enExample) |
| KR (3) | KR101849801B1 (enExample) |
| CN (3) | CN104059911B (enExample) |
| DK (1) | DK2674494T3 (enExample) |
| ES (4) | ES2533129T3 (enExample) |
| PT (1) | PT2674494E (enExample) |
| TW (2) | TWI572716B (enExample) |
| WO (1) | WO2012017919A1 (enExample) |
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|---|---|---|---|---|
| ES2533129T3 (es) | 2010-08-03 | 2015-04-07 | Bonac Corporation | Molécula de ARN monocatenario que tiene esqueleto alicíclico que contiene nitrógeno |
| WO2013077446A1 (ja) * | 2011-11-26 | 2013-05-30 | 株式会社ボナック | 遺伝子発現制御のための一本鎖核酸分子 |
| EP3254700B1 (en) | 2012-03-04 | 2019-10-23 | Bonac Corporation | Micro-rna inhibitor |
| WO2013133393A1 (ja) * | 2012-03-07 | 2013-09-12 | 学校法人東京医科大学 | Vegf遺伝子の発現抑制用一本鎖核酸分子 |
| JP6283859B2 (ja) * | 2012-03-29 | 2018-02-28 | 国立大学法人九州大学 | ペリオスチン遺伝子の発現抑制核酸分子、ペリオスチン遺伝子の発現抑制方法、およびその用途 |
| US9663784B2 (en) | 2012-05-26 | 2017-05-30 | Bonac Corporation | Single-stranded nucleic acid molecule for regulating expression of gene having delivering function |
| WO2015046451A1 (ja) * | 2013-09-27 | 2015-04-02 | 株式会社アクアセラピューティクス | 眼科疾患を除くペリオスチン発現に起因する疾患用医薬、およびその用途 |
| WO2015093495A1 (ja) * | 2013-12-16 | 2015-06-25 | 株式会社ボナック | TGF-β1遺伝子発現制御のための一本鎖核酸分子 |
| WO2015099122A1 (ja) | 2013-12-26 | 2015-07-02 | 学校法人東京医科大学 | 遺伝子発現制御のための人工ミミックmiRNAおよびその用途 |
| SG10201805087VA (en) * | 2013-12-27 | 2018-07-30 | Bonac Corp | Artificial match-type mirna for controlling gene expression and use therefor |
| WO2015099188A1 (ja) * | 2013-12-27 | 2015-07-02 | 株式会社ボナック | 遺伝子発現制御のための人工マッチ型miRNAおよびその用途 |
| HK1244035A1 (en) * | 2014-12-15 | 2018-07-27 | Bonac Corporation | Single-stranded nucleic acid molecule for inhibiting tgf- beta 1 expression |
| WO2016104775A1 (ja) | 2014-12-27 | 2016-06-30 | 株式会社ボナック | 遺伝子発現制御のための天然型miRNAおよびその用途 |
| HK1244030A1 (en) * | 2014-12-29 | 2018-07-27 | 东丽株式会社 | Composition containing nucleic acid molecule stably |
| JP6602847B2 (ja) | 2015-03-27 | 2019-11-06 | 株式会社ボナック | デリバリー機能と遺伝子発現制御能を有する一本鎖核酸分子 |
| JPWO2016167366A1 (ja) * | 2015-04-17 | 2018-04-05 | 国立大学法人 東京大学 | 眼疾患治療剤 |
| EP3369816B1 (en) | 2015-10-30 | 2024-03-13 | Toray Industries, Inc. | Composition stably containing single-stranded nucleic acid molecule that suppresses expression of tgf-beta1 gene |
| JP6634095B2 (ja) * | 2015-12-29 | 2020-01-22 | 国立大学法人北海道大学 | プロレニン遺伝子またはプロレニン受容体遺伝子の発現を抑制する一本鎖核酸分子およびその用途 |
| EP3409779A4 (en) * | 2016-01-26 | 2019-07-03 | Nissan Chemical Corporation | Single-stranded oligonucleotide |
| WO2017131237A1 (ja) * | 2016-01-30 | 2017-08-03 | 株式会社ボナック | 人工単一ガイドrna及びその用途 |
| ES2853732T3 (es) * | 2016-04-26 | 2021-09-17 | Sumitomo Chemical Co | Método de producción de un monómero para una molécula de ácido nucleico monocatenario |
| JP7188087B2 (ja) * | 2017-02-06 | 2022-12-13 | 日産化学株式会社 | 一本鎖オリゴヌクレオチド |
| US20200038427A1 (en) | 2017-03-31 | 2020-02-06 | Bonac Corporation | Cyclic nucleic acid molecule having gene expression control function |
| WO2018199338A1 (ja) * | 2017-04-27 | 2018-11-01 | 国立大学法人広島大学 | B型肝炎治療用核酸分子 |
| WO2019022257A1 (ja) * | 2017-07-28 | 2019-01-31 | 杏林製薬株式会社 | 線維症治療剤 |
| WO2019074110A1 (ja) | 2017-10-13 | 2019-04-18 | 株式会社ボナック | 一本鎖核酸分子およびその製造方法 |
| TWI830718B (zh) * | 2018-02-09 | 2024-02-01 | 日商住友化學股份有限公司 | 核酸分子之製造方法 |
| EP3770256A4 (en) | 2018-03-20 | 2021-12-22 | Tokyo Institute of Technology | ANTISENSE OLIGONUCLEOTIDE WITH REDUCED TOXICITY |
| US20210115485A1 (en) * | 2018-03-30 | 2021-04-22 | Sumitomo Chemical Company, Limited | Method for producing single-strand rna |
| EP3778886A4 (en) | 2018-03-30 | 2022-11-02 | Toray Industries, Inc. | Method for producing hairpin single-stranded rna molecule |
| US11401296B2 (en) | 2018-04-24 | 2022-08-02 | Sumitomo Chemical Company, Limited | Amidite compound and method for producing polynucleotide using said compound |
| CN112673102A (zh) * | 2018-10-02 | 2021-04-16 | 东丽株式会社 | 发夹型单链rna分子的制备方法 |
| WO2020152869A1 (ja) | 2019-01-25 | 2020-07-30 | 杏林製薬株式会社 | 線維症治療剤 |
| WO2020202952A1 (ja) | 2019-03-29 | 2020-10-08 | 住友化学株式会社 | 無機多孔質担体、及びこれを用いた核酸の製造方法 |
| JP7368456B2 (ja) | 2019-03-29 | 2023-10-24 | 住友化学株式会社 | 無機多孔質担体、及びこれを用いた核酸の製造方法 |
| US12371451B2 (en) | 2019-03-29 | 2025-07-29 | Sumitomo Chemical Company, Limited | Inorganic porous carrier and method for producing nucleic acids using same |
| US12378275B2 (en) | 2019-03-29 | 2025-08-05 | Sumitomo Chemical Company, Limited | Porous inorganic carrier and method for producing nucleic acid using same |
| EP3950695A4 (en) | 2019-03-29 | 2023-01-25 | Sumitomo Chemical Company, Limited | PROCEDURE FOR PRODUCTION OF RNA |
| CN114502566B (zh) | 2019-10-11 | 2025-02-11 | 住友化学株式会社 | 核酸寡聚物的制造方法 |
| CN115003680B (zh) | 2020-01-29 | 2025-01-28 | 住友化学株式会社 | 制备核酸寡聚物的方法 |
| KR20220133878A (ko) | 2020-01-29 | 2022-10-05 | 스미또모 가가꾸 가부시끼가이샤 | 핵산 올리고머의 제조 방법 |
| CN115335387A (zh) * | 2020-03-27 | 2022-11-11 | 住友化学株式会社 | 核酸寡聚物的制造方法 |
| EP4151597B1 (en) | 2020-05-13 | 2026-04-15 | Sumitomo Chemical Company, Limited | Inorganic porous substrate, inorganic porous support, and nucleic acid production method |
| KR20230034969A (ko) | 2020-07-09 | 2023-03-10 | 스미또모 가가꾸 가부시끼가이샤 | 핵산 올리고머의 제조 방법 |
| KR20230074205A (ko) * | 2020-09-24 | 2023-05-26 | 스미또모 가가꾸 가부시끼가이샤 | 핵산 올리고머의 제조 방법 |
| EP4410770A4 (en) | 2021-09-28 | 2026-03-25 | Sumitomo Chemical Co | PROCESS FOR THE PRODUCTION OF PURIFIED DICHLOROACETIC ACID |
| EP4488282A4 (en) | 2022-03-23 | 2025-11-19 | Sumitomo Chemical Co | PROCESS FOR THE PRODUCTION OF NUCLEIC ACID OLIGOMERS |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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