KR101849801B1 - 함질소 지환식 골격을 갖는 일본쇄 핵산 분자 - Google Patents
함질소 지환식 골격을 갖는 일본쇄 핵산 분자 Download PDFInfo
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- KR101849801B1 KR101849801B1 KR1020137004646A KR20137004646A KR101849801B1 KR 101849801 B1 KR101849801 B1 KR 101849801B1 KR 1020137004646 A KR1020137004646 A KR 1020137004646A KR 20137004646 A KR20137004646 A KR 20137004646A KR 101849801 B1 KR101849801 B1 KR 101849801B1
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- 0 *C=C(*CC1)N1C1(O)OC1 Chemical compound *C=C(*CC1)N1C1(O)OC1 0.000 description 5
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
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- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/22—Amides of acids of phosphorus
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- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/111—General methods applicable to biologically active non-coding nucleic acids
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
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- C12N2310/00—Structure or type of the nucleic acid
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- C12N2310/11—Antisense
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/318—Chemical structure of the backbone where the PO2 is completely replaced, e.g. MMI or formacetal
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
- C12N2310/3519—Fusion with another nucleic acid
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/53—Physical structure partially self-complementary or closed
- C12N2310/531—Stem-loop; Hairpin
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- C12N2320/00—Applications; Uses
- C12N2320/50—Methods for regulating/modulating their activity
- C12N2320/51—Methods for regulating/modulating their activity modulating the chemical stability, e.g. nuclease-resistance
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- C12N2330/00—Production
- C12N2330/30—Production chemically synthesised
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyrrole Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Medicinal Preparation (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2010174915 | 2010-08-03 | ||
| JPJP-P-2010-174915 | 2010-08-03 | ||
| JP2010230806 | 2010-10-13 | ||
| JPJP-P-2010-230806 | 2010-10-13 | ||
| JPJP-P-2010-269823 | 2010-12-02 | ||
| JP2010269823 | 2010-12-02 | ||
| JP2011152381 | 2011-07-08 | ||
| JPJP-P-2011-152381 | 2011-07-08 | ||
| PCT/JP2011/067292 WO2012017919A1 (ja) | 2010-08-03 | 2011-07-28 | 含窒素脂環式骨格を有する一本鎖核酸分子 |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020187010011A Division KR101894702B1 (ko) | 2010-08-03 | 2011-07-28 | 함질소 지환식 골격을 갖는 일본쇄 핵산 분자 |
| KR1020187010010A Division KR101894701B1 (ko) | 2010-08-03 | 2011-07-28 | 함질소 지환식 골격을 갖는 일본쇄 핵산 분자 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20130095738A KR20130095738A (ko) | 2013-08-28 |
| KR101849801B1 true KR101849801B1 (ko) | 2018-04-17 |
Family
ID=45559420
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020137004646A Expired - Fee Related KR101849801B1 (ko) | 2010-08-03 | 2011-07-28 | 함질소 지환식 골격을 갖는 일본쇄 핵산 분자 |
| KR1020187010011A Expired - Fee Related KR101894702B1 (ko) | 2010-08-03 | 2011-07-28 | 함질소 지환식 골격을 갖는 일본쇄 핵산 분자 |
| KR1020187010010A Expired - Fee Related KR101894701B1 (ko) | 2010-08-03 | 2011-07-28 | 함질소 지환식 골격을 갖는 일본쇄 핵산 분자 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020187010011A Expired - Fee Related KR101894702B1 (ko) | 2010-08-03 | 2011-07-28 | 함질소 지환식 골격을 갖는 일본쇄 핵산 분자 |
| KR1020187010010A Expired - Fee Related KR101894701B1 (ko) | 2010-08-03 | 2011-07-28 | 함질소 지환식 골격을 갖는 일본쇄 핵산 분자 |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US8691782B2 (enExample) |
| EP (4) | EP2436767B1 (enExample) |
| JP (3) | JP4965745B2 (enExample) |
| KR (3) | KR101849801B1 (enExample) |
| CN (3) | CN104059911B (enExample) |
| DK (1) | DK2674494T3 (enExample) |
| ES (4) | ES2533129T3 (enExample) |
| PT (1) | PT2674494E (enExample) |
| TW (2) | TWI572716B (enExample) |
| WO (1) | WO2012017919A1 (enExample) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2533129T3 (es) | 2010-08-03 | 2015-04-07 | Bonac Corporation | Molécula de ARN monocatenario que tiene esqueleto alicíclico que contiene nitrógeno |
| WO2013077446A1 (ja) * | 2011-11-26 | 2013-05-30 | 株式会社ボナック | 遺伝子発現制御のための一本鎖核酸分子 |
| EP3254700B1 (en) | 2012-03-04 | 2019-10-23 | Bonac Corporation | Micro-rna inhibitor |
| WO2013133393A1 (ja) * | 2012-03-07 | 2013-09-12 | 学校法人東京医科大学 | Vegf遺伝子の発現抑制用一本鎖核酸分子 |
| JP6283859B2 (ja) * | 2012-03-29 | 2018-02-28 | 国立大学法人九州大学 | ペリオスチン遺伝子の発現抑制核酸分子、ペリオスチン遺伝子の発現抑制方法、およびその用途 |
| US9663784B2 (en) | 2012-05-26 | 2017-05-30 | Bonac Corporation | Single-stranded nucleic acid molecule for regulating expression of gene having delivering function |
| WO2015046451A1 (ja) * | 2013-09-27 | 2015-04-02 | 株式会社アクアセラピューティクス | 眼科疾患を除くペリオスチン発現に起因する疾患用医薬、およびその用途 |
| WO2015093495A1 (ja) * | 2013-12-16 | 2015-06-25 | 株式会社ボナック | TGF-β1遺伝子発現制御のための一本鎖核酸分子 |
| WO2015099122A1 (ja) | 2013-12-26 | 2015-07-02 | 学校法人東京医科大学 | 遺伝子発現制御のための人工ミミックmiRNAおよびその用途 |
| SG10201805087VA (en) * | 2013-12-27 | 2018-07-30 | Bonac Corp | Artificial match-type mirna for controlling gene expression and use therefor |
| WO2015099188A1 (ja) * | 2013-12-27 | 2015-07-02 | 株式会社ボナック | 遺伝子発現制御のための人工マッチ型miRNAおよびその用途 |
| HK1244035A1 (en) * | 2014-12-15 | 2018-07-27 | Bonac Corporation | Single-stranded nucleic acid molecule for inhibiting tgf- beta 1 expression |
| WO2016104775A1 (ja) | 2014-12-27 | 2016-06-30 | 株式会社ボナック | 遺伝子発現制御のための天然型miRNAおよびその用途 |
| HK1244030A1 (en) * | 2014-12-29 | 2018-07-27 | 东丽株式会社 | Composition containing nucleic acid molecule stably |
| JP6602847B2 (ja) | 2015-03-27 | 2019-11-06 | 株式会社ボナック | デリバリー機能と遺伝子発現制御能を有する一本鎖核酸分子 |
| JPWO2016167366A1 (ja) * | 2015-04-17 | 2018-04-05 | 国立大学法人 東京大学 | 眼疾患治療剤 |
| EP3369816B1 (en) | 2015-10-30 | 2024-03-13 | Toray Industries, Inc. | Composition stably containing single-stranded nucleic acid molecule that suppresses expression of tgf-beta1 gene |
| JP6634095B2 (ja) * | 2015-12-29 | 2020-01-22 | 国立大学法人北海道大学 | プロレニン遺伝子またはプロレニン受容体遺伝子の発現を抑制する一本鎖核酸分子およびその用途 |
| EP3409779A4 (en) * | 2016-01-26 | 2019-07-03 | Nissan Chemical Corporation | Single-stranded oligonucleotide |
| WO2017131237A1 (ja) * | 2016-01-30 | 2017-08-03 | 株式会社ボナック | 人工単一ガイドrna及びその用途 |
| ES2853732T3 (es) * | 2016-04-26 | 2021-09-17 | Sumitomo Chemical Co | Método de producción de un monómero para una molécula de ácido nucleico monocatenario |
| JP7188087B2 (ja) * | 2017-02-06 | 2022-12-13 | 日産化学株式会社 | 一本鎖オリゴヌクレオチド |
| US20200038427A1 (en) | 2017-03-31 | 2020-02-06 | Bonac Corporation | Cyclic nucleic acid molecule having gene expression control function |
| WO2018199338A1 (ja) * | 2017-04-27 | 2018-11-01 | 国立大学法人広島大学 | B型肝炎治療用核酸分子 |
| WO2019022257A1 (ja) * | 2017-07-28 | 2019-01-31 | 杏林製薬株式会社 | 線維症治療剤 |
| WO2019074110A1 (ja) | 2017-10-13 | 2019-04-18 | 株式会社ボナック | 一本鎖核酸分子およびその製造方法 |
| TWI830718B (zh) * | 2018-02-09 | 2024-02-01 | 日商住友化學股份有限公司 | 核酸分子之製造方法 |
| EP3770256A4 (en) | 2018-03-20 | 2021-12-22 | Tokyo Institute of Technology | ANTISENSE OLIGONUCLEOTIDE WITH REDUCED TOXICITY |
| US20210115485A1 (en) * | 2018-03-30 | 2021-04-22 | Sumitomo Chemical Company, Limited | Method for producing single-strand rna |
| EP3778886A4 (en) | 2018-03-30 | 2022-11-02 | Toray Industries, Inc. | Method for producing hairpin single-stranded rna molecule |
| US11401296B2 (en) | 2018-04-24 | 2022-08-02 | Sumitomo Chemical Company, Limited | Amidite compound and method for producing polynucleotide using said compound |
| CN112673102A (zh) * | 2018-10-02 | 2021-04-16 | 东丽株式会社 | 发夹型单链rna分子的制备方法 |
| WO2020152869A1 (ja) | 2019-01-25 | 2020-07-30 | 杏林製薬株式会社 | 線維症治療剤 |
| WO2020202952A1 (ja) | 2019-03-29 | 2020-10-08 | 住友化学株式会社 | 無機多孔質担体、及びこれを用いた核酸の製造方法 |
| JP7368456B2 (ja) | 2019-03-29 | 2023-10-24 | 住友化学株式会社 | 無機多孔質担体、及びこれを用いた核酸の製造方法 |
| US12371451B2 (en) | 2019-03-29 | 2025-07-29 | Sumitomo Chemical Company, Limited | Inorganic porous carrier and method for producing nucleic acids using same |
| US12378275B2 (en) | 2019-03-29 | 2025-08-05 | Sumitomo Chemical Company, Limited | Porous inorganic carrier and method for producing nucleic acid using same |
| EP3950695A4 (en) | 2019-03-29 | 2023-01-25 | Sumitomo Chemical Company, Limited | PROCEDURE FOR PRODUCTION OF RNA |
| CN114502566B (zh) | 2019-10-11 | 2025-02-11 | 住友化学株式会社 | 核酸寡聚物的制造方法 |
| CN115003680B (zh) | 2020-01-29 | 2025-01-28 | 住友化学株式会社 | 制备核酸寡聚物的方法 |
| KR20220133878A (ko) | 2020-01-29 | 2022-10-05 | 스미또모 가가꾸 가부시끼가이샤 | 핵산 올리고머의 제조 방법 |
| CN115335387A (zh) * | 2020-03-27 | 2022-11-11 | 住友化学株式会社 | 核酸寡聚物的制造方法 |
| EP4151597B1 (en) | 2020-05-13 | 2026-04-15 | Sumitomo Chemical Company, Limited | Inorganic porous substrate, inorganic porous support, and nucleic acid production method |
| KR20230034969A (ko) | 2020-07-09 | 2023-03-10 | 스미또모 가가꾸 가부시끼가이샤 | 핵산 올리고머의 제조 방법 |
| KR20230074205A (ko) * | 2020-09-24 | 2023-05-26 | 스미또모 가가꾸 가부시끼가이샤 | 핵산 올리고머의 제조 방법 |
| EP4410770A4 (en) | 2021-09-28 | 2026-03-25 | Sumitomo Chemical Co | PROCESS FOR THE PRODUCTION OF PURIFIED DICHLOROACETIC ACID |
| EP4488282A4 (en) | 2022-03-23 | 2025-11-19 | Sumitomo Chemical Co | PROCESS FOR THE PRODUCTION OF NUCLEIC ACID OLIGOMERS |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004090108A3 (en) * | 2003-04-03 | 2006-01-12 | Alnylam Pharmaceuticals | Irna conjugates |
| WO2009076321A2 (en) * | 2007-12-07 | 2009-06-18 | Halo-Bio Rnai Therapeutics Inc. | Compositions and methods for modulating gene expression using asymmetrically-active precursor polynucleotides |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3687808A (en) | 1969-08-14 | 1972-08-29 | Univ Leland Stanford Junior | Synthetic polynucleotides |
| US5631148A (en) | 1994-04-22 | 1997-05-20 | Chiron Corporation | Ribozymes with product ejection by strand displacement |
| GB9621367D0 (en) * | 1996-10-14 | 1996-12-04 | Isis Innovation | Chiral peptide nucleic acids |
| US6509323B1 (en) | 1998-07-01 | 2003-01-21 | California Institute Of Technology | Linear cyclodextrin copolymers |
| FR2790757B1 (fr) | 1999-03-09 | 2003-08-01 | Bioalliance Pharma | Oligonucleotides contenant une sequence antisens stabilises par une structure secondaire et compositions pharmaceutiques les contenant. |
| US6962906B2 (en) * | 2000-03-14 | 2005-11-08 | Active Motif | Oligonucleotide analogues, methods of synthesis and methods of use |
| TWI321054B (en) | 2000-12-19 | 2010-03-01 | California Inst Of Techn | Compositions containing inclusion complexes |
| EP1627061B1 (en) | 2001-05-18 | 2009-08-12 | Sirna Therapeutics, Inc. | RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING CHEMICALLY MODIFIED SHORT INTERFERING NUCLEIC ACID (siNA) |
| WO2003072745A2 (en) * | 2002-02-22 | 2003-09-04 | Eshleman James R | Antigene locks and therapeutic uses thereof |
| WO2003079757A2 (en) | 2002-03-20 | 2003-10-02 | Massachusetts Institute Of Technology | Hiv therapeutic |
| EP1857547B2 (en) | 2002-08-05 | 2020-12-02 | Silence Therapeutics GmbH | Further novel forms of interfering RNA molecules |
| AU2003256857A1 (en) * | 2002-08-08 | 2004-02-25 | Dharmacon, Inc. | Short interfering rnas having a hairpin structure containing a non-nucleotide loop |
| US6936651B2 (en) | 2002-12-17 | 2005-08-30 | E. I. Du Pont De Nemours And Company | Compatibility improvement in crystalline thermoplastics with mineral fillers |
| NL1022811C2 (nl) * | 2003-02-28 | 2004-08-31 | Fountain Patents B V | Systeem en werkwijze voor opslag en transport van zeecontainers. |
| US7595301B2 (en) | 2003-09-30 | 2009-09-29 | Anges Mg, Inc. | Staple type oligonucleotide and drug comprising the same |
| JP2008504840A (ja) * | 2004-06-30 | 2008-02-21 | アルニラム ファーマスーティカルズ インコーポレイテッド | 非リン酸骨格結合を含むオリゴヌクレオチド |
| JP2008526213A (ja) | 2004-12-30 | 2008-07-24 | トッド エム. ハウザー, | 自己保護オリゴヌクレオチドを使用する、遺伝子発現を調節するための組成物および方法 |
| US8846697B2 (en) * | 2006-05-31 | 2014-09-30 | The Regents Of The University Of California | Purine analogs |
| ES2538217T3 (es) * | 2007-03-21 | 2015-06-18 | Brookhaven Science Associates, Llc | Composiciones combinadas antisentido de horquilla y métodos para modular la expresión |
| JP5296328B2 (ja) | 2007-05-09 | 2013-09-25 | 独立行政法人理化学研究所 | 1本鎖環状rnaおよびその製造方法 |
| EP2171089B1 (en) * | 2007-06-25 | 2014-01-22 | Universität Duisburg-Essen | Screening-method for polymorphic markers in htra1 gene in neurodegenerative disorders |
| US20100317714A1 (en) * | 2007-11-29 | 2010-12-16 | Suzhou Ribo Life Science Co., Ltd | Complex molecule interfering the expression of target genes and its preparing methods |
| EP2229186A2 (en) | 2007-12-04 | 2010-09-22 | Alnylam Pharmaceuticals Inc. | Carbohydrate conjugates as delivery agents for oligonucleotides |
| EP2256191A4 (en) | 2008-02-15 | 2011-07-06 | Riken | CYCLIC SINGLE NUCLEIC ACID COMPLEX AND METHOD FOR THE PRODUCTION THEREOF |
| JP2010174915A (ja) | 2009-01-27 | 2010-08-12 | Toyota Motor Corp | 高圧ガスタンク |
| JP5449815B2 (ja) | 2009-03-26 | 2014-03-19 | 住友化学株式会社 | 偏光板の製造方法 |
| JP2010269823A (ja) | 2009-05-21 | 2010-12-02 | British American Tobacco Japan Kk | 喫煙品用容器 |
| US20110052666A1 (en) | 2009-09-03 | 2011-03-03 | Medtronic, Inc. | Compositions, Methods, and Systems for SIRNA Delivery |
| JP2011152381A (ja) | 2010-01-25 | 2011-08-11 | Ucom:Kk | 箸置き |
| JP5555940B2 (ja) | 2010-04-14 | 2014-07-23 | 国立大学法人佐賀大学 | 増殖糖尿病網膜症の検出方法および予防・治療剤のスクリーニング方法 |
| WO2011132672A1 (ja) | 2010-04-19 | 2011-10-27 | 独立行政法人理化学研究所 | 機能性核酸の安定化法 |
| SG186899A1 (en) | 2010-07-08 | 2013-02-28 | Bonac Corp | Single-strand nucleic acid molecule for controlling gene expression |
| ES2533129T3 (es) | 2010-08-03 | 2015-04-07 | Bonac Corporation | Molécula de ARN monocatenario que tiene esqueleto alicíclico que contiene nitrógeno |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004090108A3 (en) * | 2003-04-03 | 2006-01-12 | Alnylam Pharmaceuticals | Irna conjugates |
| WO2009076321A2 (en) * | 2007-12-07 | 2009-06-18 | Halo-Bio Rnai Therapeutics Inc. | Compositions and methods for modulating gene expression using asymmetrically-active precursor polynucleotides |
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