KR101849801B1 - 함질소 지환식 골격을 갖는 일본쇄 핵산 분자 - Google Patents

함질소 지환식 골격을 갖는 일본쇄 핵산 분자 Download PDF

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KR101849801B1
KR101849801B1 KR1020137004646A KR20137004646A KR101849801B1 KR 101849801 B1 KR101849801 B1 KR 101849801B1 KR 1020137004646 A KR1020137004646 A KR 1020137004646A KR 20137004646 A KR20137004646 A KR 20137004646A KR 101849801 B1 KR101849801 B1 KR 101849801B1
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nucleic acid
acid molecule
expression
formula
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KR20130095738A (ko
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다다아키 오기
히로타케 하야시
히사오 시로즈
도모히로 하마사키
아키히로 이토
히로시 스즈키
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가부시키가이샤 보낙
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KR1020137004646A 2010-08-03 2011-07-28 함질소 지환식 골격을 갖는 일본쇄 핵산 분자 Expired - Fee Related KR101849801B1 (ko)

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Application Number Priority Date Filing Date Title
JP2010174915 2010-08-03
JPJP-P-2010-174915 2010-08-03
JP2010230806 2010-10-13
JPJP-P-2010-230806 2010-10-13
JPJP-P-2010-269823 2010-12-02
JP2010269823 2010-12-02
JP2011152381 2011-07-08
JPJP-P-2011-152381 2011-07-08
PCT/JP2011/067292 WO2012017919A1 (ja) 2010-08-03 2011-07-28 含窒素脂環式骨格を有する一本鎖核酸分子

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KR1020187010011A Division KR101894702B1 (ko) 2010-08-03 2011-07-28 함질소 지환식 골격을 갖는 일본쇄 핵산 분자
KR1020187010010A Division KR101894701B1 (ko) 2010-08-03 2011-07-28 함질소 지환식 골격을 갖는 일본쇄 핵산 분자

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KR20130095738A KR20130095738A (ko) 2013-08-28
KR101849801B1 true KR101849801B1 (ko) 2018-04-17

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KR1020137004646A Expired - Fee Related KR101849801B1 (ko) 2010-08-03 2011-07-28 함질소 지환식 골격을 갖는 일본쇄 핵산 분자
KR1020187010011A Expired - Fee Related KR101894702B1 (ko) 2010-08-03 2011-07-28 함질소 지환식 골격을 갖는 일본쇄 핵산 분자
KR1020187010010A Expired - Fee Related KR101894701B1 (ko) 2010-08-03 2011-07-28 함질소 지환식 골격을 갖는 일본쇄 핵산 분자

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KR1020187010010A Expired - Fee Related KR101894701B1 (ko) 2010-08-03 2011-07-28 함질소 지환식 골격을 갖는 일본쇄 핵산 분자

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US (3) US8691782B2 (enExample)
EP (4) EP2436767B1 (enExample)
JP (3) JP4965745B2 (enExample)
KR (3) KR101849801B1 (enExample)
CN (3) CN104059911B (enExample)
DK (1) DK2674494T3 (enExample)
ES (4) ES2533129T3 (enExample)
PT (1) PT2674494E (enExample)
TW (2) TWI572716B (enExample)
WO (1) WO2012017919A1 (enExample)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2533129T3 (es) 2010-08-03 2015-04-07 Bonac Corporation Molécula de ARN monocatenario que tiene esqueleto alicíclico que contiene nitrógeno
WO2013077446A1 (ja) * 2011-11-26 2013-05-30 株式会社ボナック 遺伝子発現制御のための一本鎖核酸分子
EP3254700B1 (en) 2012-03-04 2019-10-23 Bonac Corporation Micro-rna inhibitor
WO2013133393A1 (ja) * 2012-03-07 2013-09-12 学校法人東京医科大学 Vegf遺伝子の発現抑制用一本鎖核酸分子
JP6283859B2 (ja) * 2012-03-29 2018-02-28 国立大学法人九州大学 ペリオスチン遺伝子の発現抑制核酸分子、ペリオスチン遺伝子の発現抑制方法、およびその用途
US9663784B2 (en) 2012-05-26 2017-05-30 Bonac Corporation Single-stranded nucleic acid molecule for regulating expression of gene having delivering function
WO2015046451A1 (ja) * 2013-09-27 2015-04-02 株式会社アクアセラピューティクス 眼科疾患を除くペリオスチン発現に起因する疾患用医薬、およびその用途
WO2015093495A1 (ja) * 2013-12-16 2015-06-25 株式会社ボナック TGF-β1遺伝子発現制御のための一本鎖核酸分子
WO2015099122A1 (ja) 2013-12-26 2015-07-02 学校法人東京医科大学 遺伝子発現制御のための人工ミミックmiRNAおよびその用途
SG10201805087VA (en) * 2013-12-27 2018-07-30 Bonac Corp Artificial match-type mirna for controlling gene expression and use therefor
WO2015099188A1 (ja) * 2013-12-27 2015-07-02 株式会社ボナック 遺伝子発現制御のための人工マッチ型miRNAおよびその用途
HK1244035A1 (en) * 2014-12-15 2018-07-27 Bonac Corporation Single-stranded nucleic acid molecule for inhibiting tgf- beta 1 expression
WO2016104775A1 (ja) 2014-12-27 2016-06-30 株式会社ボナック 遺伝子発現制御のための天然型miRNAおよびその用途
HK1244030A1 (en) * 2014-12-29 2018-07-27 东丽株式会社 Composition containing nucleic acid molecule stably
JP6602847B2 (ja) 2015-03-27 2019-11-06 株式会社ボナック デリバリー機能と遺伝子発現制御能を有する一本鎖核酸分子
JPWO2016167366A1 (ja) * 2015-04-17 2018-04-05 国立大学法人 東京大学 眼疾患治療剤
EP3369816B1 (en) 2015-10-30 2024-03-13 Toray Industries, Inc. Composition stably containing single-stranded nucleic acid molecule that suppresses expression of tgf-beta1 gene
JP6634095B2 (ja) * 2015-12-29 2020-01-22 国立大学法人北海道大学 プロレニン遺伝子またはプロレニン受容体遺伝子の発現を抑制する一本鎖核酸分子およびその用途
EP3409779A4 (en) * 2016-01-26 2019-07-03 Nissan Chemical Corporation Single-stranded oligonucleotide
WO2017131237A1 (ja) * 2016-01-30 2017-08-03 株式会社ボナック 人工単一ガイドrna及びその用途
ES2853732T3 (es) * 2016-04-26 2021-09-17 Sumitomo Chemical Co Método de producción de un monómero para una molécula de ácido nucleico monocatenario
JP7188087B2 (ja) * 2017-02-06 2022-12-13 日産化学株式会社 一本鎖オリゴヌクレオチド
US20200038427A1 (en) 2017-03-31 2020-02-06 Bonac Corporation Cyclic nucleic acid molecule having gene expression control function
WO2018199338A1 (ja) * 2017-04-27 2018-11-01 国立大学法人広島大学 B型肝炎治療用核酸分子
WO2019022257A1 (ja) * 2017-07-28 2019-01-31 杏林製薬株式会社 線維症治療剤
WO2019074110A1 (ja) 2017-10-13 2019-04-18 株式会社ボナック 一本鎖核酸分子およびその製造方法
TWI830718B (zh) * 2018-02-09 2024-02-01 日商住友化學股份有限公司 核酸分子之製造方法
EP3770256A4 (en) 2018-03-20 2021-12-22 Tokyo Institute of Technology ANTISENSE OLIGONUCLEOTIDE WITH REDUCED TOXICITY
US20210115485A1 (en) * 2018-03-30 2021-04-22 Sumitomo Chemical Company, Limited Method for producing single-strand rna
EP3778886A4 (en) 2018-03-30 2022-11-02 Toray Industries, Inc. Method for producing hairpin single-stranded rna molecule
US11401296B2 (en) 2018-04-24 2022-08-02 Sumitomo Chemical Company, Limited Amidite compound and method for producing polynucleotide using said compound
CN112673102A (zh) * 2018-10-02 2021-04-16 东丽株式会社 发夹型单链rna分子的制备方法
WO2020152869A1 (ja) 2019-01-25 2020-07-30 杏林製薬株式会社 線維症治療剤
WO2020202952A1 (ja) 2019-03-29 2020-10-08 住友化学株式会社 無機多孔質担体、及びこれを用いた核酸の製造方法
JP7368456B2 (ja) 2019-03-29 2023-10-24 住友化学株式会社 無機多孔質担体、及びこれを用いた核酸の製造方法
US12371451B2 (en) 2019-03-29 2025-07-29 Sumitomo Chemical Company, Limited Inorganic porous carrier and method for producing nucleic acids using same
US12378275B2 (en) 2019-03-29 2025-08-05 Sumitomo Chemical Company, Limited Porous inorganic carrier and method for producing nucleic acid using same
EP3950695A4 (en) 2019-03-29 2023-01-25 Sumitomo Chemical Company, Limited PROCEDURE FOR PRODUCTION OF RNA
CN114502566B (zh) 2019-10-11 2025-02-11 住友化学株式会社 核酸寡聚物的制造方法
CN115003680B (zh) 2020-01-29 2025-01-28 住友化学株式会社 制备核酸寡聚物的方法
KR20220133878A (ko) 2020-01-29 2022-10-05 스미또모 가가꾸 가부시끼가이샤 핵산 올리고머의 제조 방법
CN115335387A (zh) * 2020-03-27 2022-11-11 住友化学株式会社 核酸寡聚物的制造方法
EP4151597B1 (en) 2020-05-13 2026-04-15 Sumitomo Chemical Company, Limited Inorganic porous substrate, inorganic porous support, and nucleic acid production method
KR20230034969A (ko) 2020-07-09 2023-03-10 스미또모 가가꾸 가부시끼가이샤 핵산 올리고머의 제조 방법
KR20230074205A (ko) * 2020-09-24 2023-05-26 스미또모 가가꾸 가부시끼가이샤 핵산 올리고머의 제조 방법
EP4410770A4 (en) 2021-09-28 2026-03-25 Sumitomo Chemical Co PROCESS FOR THE PRODUCTION OF PURIFIED DICHLOROACETIC ACID
EP4488282A4 (en) 2022-03-23 2025-11-19 Sumitomo Chemical Co PROCESS FOR THE PRODUCTION OF NUCLEIC ACID OLIGOMERS

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004090108A3 (en) * 2003-04-03 2006-01-12 Alnylam Pharmaceuticals Irna conjugates
WO2009076321A2 (en) * 2007-12-07 2009-06-18 Halo-Bio Rnai Therapeutics Inc. Compositions and methods for modulating gene expression using asymmetrically-active precursor polynucleotides

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3687808A (en) 1969-08-14 1972-08-29 Univ Leland Stanford Junior Synthetic polynucleotides
US5631148A (en) 1994-04-22 1997-05-20 Chiron Corporation Ribozymes with product ejection by strand displacement
GB9621367D0 (en) * 1996-10-14 1996-12-04 Isis Innovation Chiral peptide nucleic acids
US6509323B1 (en) 1998-07-01 2003-01-21 California Institute Of Technology Linear cyclodextrin copolymers
FR2790757B1 (fr) 1999-03-09 2003-08-01 Bioalliance Pharma Oligonucleotides contenant une sequence antisens stabilises par une structure secondaire et compositions pharmaceutiques les contenant.
US6962906B2 (en) * 2000-03-14 2005-11-08 Active Motif Oligonucleotide analogues, methods of synthesis and methods of use
TWI321054B (en) 2000-12-19 2010-03-01 California Inst Of Techn Compositions containing inclusion complexes
EP1627061B1 (en) 2001-05-18 2009-08-12 Sirna Therapeutics, Inc. RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING CHEMICALLY MODIFIED SHORT INTERFERING NUCLEIC ACID (siNA)
WO2003072745A2 (en) * 2002-02-22 2003-09-04 Eshleman James R Antigene locks and therapeutic uses thereof
WO2003079757A2 (en) 2002-03-20 2003-10-02 Massachusetts Institute Of Technology Hiv therapeutic
EP1857547B2 (en) 2002-08-05 2020-12-02 Silence Therapeutics GmbH Further novel forms of interfering RNA molecules
AU2003256857A1 (en) * 2002-08-08 2004-02-25 Dharmacon, Inc. Short interfering rnas having a hairpin structure containing a non-nucleotide loop
US6936651B2 (en) 2002-12-17 2005-08-30 E. I. Du Pont De Nemours And Company Compatibility improvement in crystalline thermoplastics with mineral fillers
NL1022811C2 (nl) * 2003-02-28 2004-08-31 Fountain Patents B V Systeem en werkwijze voor opslag en transport van zeecontainers.
US7595301B2 (en) 2003-09-30 2009-09-29 Anges Mg, Inc. Staple type oligonucleotide and drug comprising the same
JP2008504840A (ja) * 2004-06-30 2008-02-21 アルニラム ファーマスーティカルズ インコーポレイテッド 非リン酸骨格結合を含むオリゴヌクレオチド
JP2008526213A (ja) 2004-12-30 2008-07-24 トッド エム. ハウザー, 自己保護オリゴヌクレオチドを使用する、遺伝子発現を調節するための組成物および方法
US8846697B2 (en) * 2006-05-31 2014-09-30 The Regents Of The University Of California Purine analogs
ES2538217T3 (es) * 2007-03-21 2015-06-18 Brookhaven Science Associates, Llc Composiciones combinadas antisentido de horquilla y métodos para modular la expresión
JP5296328B2 (ja) 2007-05-09 2013-09-25 独立行政法人理化学研究所 1本鎖環状rnaおよびその製造方法
EP2171089B1 (en) * 2007-06-25 2014-01-22 Universität Duisburg-Essen Screening-method for polymorphic markers in htra1 gene in neurodegenerative disorders
US20100317714A1 (en) * 2007-11-29 2010-12-16 Suzhou Ribo Life Science Co., Ltd Complex molecule interfering the expression of target genes and its preparing methods
EP2229186A2 (en) 2007-12-04 2010-09-22 Alnylam Pharmaceuticals Inc. Carbohydrate conjugates as delivery agents for oligonucleotides
EP2256191A4 (en) 2008-02-15 2011-07-06 Riken CYCLIC SINGLE NUCLEIC ACID COMPLEX AND METHOD FOR THE PRODUCTION THEREOF
JP2010174915A (ja) 2009-01-27 2010-08-12 Toyota Motor Corp 高圧ガスタンク
JP5449815B2 (ja) 2009-03-26 2014-03-19 住友化学株式会社 偏光板の製造方法
JP2010269823A (ja) 2009-05-21 2010-12-02 British American Tobacco Japan Kk 喫煙品用容器
US20110052666A1 (en) 2009-09-03 2011-03-03 Medtronic, Inc. Compositions, Methods, and Systems for SIRNA Delivery
JP2011152381A (ja) 2010-01-25 2011-08-11 Ucom:Kk 箸置き
JP5555940B2 (ja) 2010-04-14 2014-07-23 国立大学法人佐賀大学 増殖糖尿病網膜症の検出方法および予防・治療剤のスクリーニング方法
WO2011132672A1 (ja) 2010-04-19 2011-10-27 独立行政法人理化学研究所 機能性核酸の安定化法
SG186899A1 (en) 2010-07-08 2013-02-28 Bonac Corp Single-strand nucleic acid molecule for controlling gene expression
ES2533129T3 (es) 2010-08-03 2015-04-07 Bonac Corporation Molécula de ARN monocatenario que tiene esqueleto alicíclico que contiene nitrógeno

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004090108A3 (en) * 2003-04-03 2006-01-12 Alnylam Pharmaceuticals Irna conjugates
WO2009076321A2 (en) * 2007-12-07 2009-06-18 Halo-Bio Rnai Therapeutics Inc. Compositions and methods for modulating gene expression using asymmetrically-active precursor polynucleotides

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