TWI535723B - 螺－吲哚酮ｍｄｍ２拮抗劑 - Google Patents

螺－吲哚酮ｍｄｍ２拮抗劑 Download PDF

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Publication number
TWI535723B
TWI535723B TW100141225A TW100141225A TWI535723B TW I535723 B TWI535723 B TW I535723B TW 100141225 A TW100141225 A TW 100141225A TW 100141225 A TW100141225 A TW 100141225A TW I535723 B TWI535723 B TW I535723B
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Taiwan
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group
compound
optionally substituted
hydrogen
formula
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TW100141225A
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English (en)
Chinese (zh)
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TW201305177A (zh
Inventor
王少萌
趙玉軍
孫威
桑傑夫 庫馬
蘭斯 利奧波德
羅倫特 德布斯切
德里克 博勒爾
珍克里斯多福 凱瑞
奎米 阿曼尼
郭民
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密西根大學董事會
亞森塔授權公司
賽諾菲公司
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Publication of TW201305177A publication Critical patent/TW201305177A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
TW100141225A 2010-11-12 2011-11-11 螺－吲哚酮ｍｄｍ２拮抗劑 TWI535723B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US41309410P 2010-11-12 2010-11-12
US201161451968P 2011-03-11 2011-03-11
US201161451958P 2011-03-11 2011-03-11
US201161470992P 2011-04-01 2011-04-01

Publications (2)

Publication Number Publication Date
TW201305177A TW201305177A (zh) 2013-02-01
TWI535723B true TWI535723B (zh) 2016-06-01

Family

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Family Applications (1)

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TW100141225A TWI535723B (zh) 2010-11-12 2011-11-11 螺－吲哚酮ｍｄｍ２拮抗劑

Country Status (27)

Country Link
US (2) US8680132B2 (https=)
EP (1) EP2638046A4 (https=)
JP (1) JP2014500870A (https=)
KR (1) KR101929188B1 (https=)
CN (1) CN103298818B (https=)
AR (1) AR083849A1 (https=)
AU (1) AU2011326395B2 (https=)
CA (1) CA2817585A1 (https=)
CO (1) CO6721010A2 (https=)
CR (1) CR20130271A (https=)
DO (1) DOP2013000104A (https=)
EA (1) EA201390682A1 (https=)
EC (1) ECSP13012678A (https=)
GT (1) GT201300118A (https=)
IL (1) IL226275A0 (https=)
MA (1) MA34732B1 (https=)
MX (1) MX2013005238A (https=)
NI (1) NI201300041A (https=)
NZ (1) NZ611866A (https=)
PE (1) PE20140408A1 (https=)
PH (1) PH12013500955A1 (https=)
SG (1) SG190230A1 (https=)
TW (1) TWI535723B (https=)
UA (1) UA109464C2 (https=)
UY (1) UY33725A (https=)
WO (1) WO2012065022A2 (https=)
ZA (1) ZA201304042B (https=)

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US9302120B2 (en) 2016-04-05
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