TWI437995B - 新穎的熱敏性內含治療劑之脂質體 - Google Patents
新穎的熱敏性內含治療劑之脂質體 Download PDFInfo
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- TWI437995B TWI437995B TW097142732A TW97142732A TWI437995B TW I437995 B TWI437995 B TW I437995B TW 097142732 A TW097142732 A TW 097142732A TW 97142732 A TW97142732 A TW 97142732A TW I437995 B TWI437995 B TW I437995B
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- Prior art keywords
- liposome
- anticancer agent
- thermosensitive
- phospholipid
- liposomes
- Prior art date
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Dispersion Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CN2007/003128 WO2009059449A1 (en) | 2007-11-05 | 2007-11-05 | Novel thermosensitive liposomes containing therapeutic agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW200930380A TW200930380A (en) | 2009-07-16 |
| TWI437995B true TWI437995B (zh) | 2014-05-21 |
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| TW097142732A TWI437995B (zh) | 2007-11-05 | 2008-11-05 | 新穎的熱敏性內含治療劑之脂質體 |
Country Status (14)
| Country | Link |
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| US (1) | US8642074B2 (https=) |
| EP (1) | EP2217209B1 (https=) |
| JP (1) | JP5570994B2 (https=) |
| KR (1) | KR101652126B1 (https=) |
| CN (1) | CN101883557B (https=) |
| AU (1) | AU2008323514B2 (https=) |
| BR (1) | BRPI0820505A2 (https=) |
| CA (1) | CA2704258C (https=) |
| ES (1) | ES2689259T3 (https=) |
| MX (1) | MX2010004957A (https=) |
| MY (1) | MY151268A (https=) |
| RU (1) | RU2497499C2 (https=) |
| TW (1) | TWI437995B (https=) |
| WO (2) | WO2009059449A1 (https=) |
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| CA2928387A1 (en) | 2004-05-03 | 2005-11-17 | Merrimack Pharmaceuticals, Inc. | Drug delivery liposomes containing anionic polyols or anionic sugars |
| WO2012094020A1 (en) | 2010-01-07 | 2012-07-12 | Innopharma, Inc. | Methods and compositions for delivery of taxanes in stable oil-in-water emulsions |
| JP2014503582A (ja) * | 2011-01-28 | 2014-02-13 | コーニンクレッカ フィリップス エヌ ヴェ | 親水性プロドラッグの局所放出用担体 |
| CN102579323B (zh) * | 2011-02-21 | 2013-06-19 | 舒泰神（北京）生物制药股份有限公司 | 一种紫杉醇醇质体凝胶剂及其制备方法 |
| CN102688193B (zh) * | 2011-03-24 | 2016-05-11 | 中国人民解放军军事医学科学院毒物药物研究所 | 长春碱类药物的热敏脂质体制剂及其制备方法 |
| US10449193B2 (en) * | 2011-06-03 | 2019-10-22 | Signpath Pharma Inc. | Protective effect of DMPC, DMPG, DMPC/DMPG, lysoPG and lysoPC against drugs that cause channelopathies |
| WO2012167212A2 (en) | 2011-06-03 | 2012-12-06 | Signpath Pharma Inc. | Liposomal mitigation of drug-induced long qt syndrome and potassium delayed-rectifier current |
| US10349884B2 (en) | 2011-06-03 | 2019-07-16 | Sighpath Pharma Inc. | Liposomal mitigation of drug-induced inhibition of the cardiac ikr channel |
| US12004868B2 (en) | 2011-06-03 | 2024-06-11 | Signpath Pharma Inc. | Liposomal mitigation of drug-induced inhibition of the cardiac IKr channel |
| US10117881B2 (en) | 2011-06-03 | 2018-11-06 | Signpath Pharma, Inc. | Protective effect of DMPC, DMPG, DMPC/DMPG, LYSOPG and LYSOPC against drugs that cause channelopathies |
| US10238602B2 (en) | 2011-06-03 | 2019-03-26 | Signpath Pharma, Inc. | Protective effect of DMPC, DMPG, DMPC/DMPG, LysoPG and LysoPC against drugs that cause channelopathies |
| KR20130042905A (ko) * | 2011-10-19 | 2013-04-29 | 삼성전자주식회사 | 엘라스틴 유사 폴리펩티드를 포함하는 리포좀 및 그의 용도 |
| CN102552144A (zh) * | 2012-01-13 | 2012-07-11 | 北京大学 | 一种靶向热敏脂质体 |
| JP2015507019A (ja) * | 2012-02-17 | 2015-03-05 | セルシオン コーポレイション | 感熱性ナノ粒子製剤およびその製造方法 |
| ITRM20120169A1 (it) | 2012-04-19 | 2013-10-20 | Consiglio Nazionale Ricerche | Dispositivo di rilascio di specie chimiche a controllo ottico |
| WO2013172358A1 (ja) * | 2012-05-14 | 2013-11-21 | 公立大学法人大阪府立大学 | 機能性化合物及びその化合物を含有する分子集合体、並びにそれらを含有する組成物及びキット並びにそれらの使用 |
| US9801874B2 (en) * | 2012-11-20 | 2017-10-31 | Spectrum Pharmaceuticals | Method for the preparation of liposome encapsulated vincristine for therapeutic use |
| KR102109188B1 (ko) | 2013-04-01 | 2020-05-11 | 삼성전자주식회사 | 양이온성 지질을 포함하는 온도민감성 리포좀 및 그의 용도 |
| TWI552761B (zh) | 2013-05-03 | 2016-10-11 | 博信生物科技股份有限公司 | 一種脂質微／奈米氣泡、及其最佳化之製備方法及製備裝置 |
| KR20150034517A (ko) | 2013-09-26 | 2015-04-03 | 삼성전자주식회사 | 소수성 활성 성분 및 폴리펩티드의 복합체를 포함하는 리포좀, 및 그의 용도 |
| KR20150047336A (ko) | 2013-10-24 | 2015-05-04 | 삼성전자주식회사 | 나노입자, 이를 제조하는 방법, 및 이의 용도 |
| KR20150062652A (ko) | 2013-11-29 | 2015-06-08 | 삼성전자주식회사 | 초음파 감응성 리포좀, 그를 포함한 약제학적 조성물 및 그를 이용하여 개체의 체내에 활성제를 전달하는 방법 |
| JP6895252B2 (ja) | 2013-12-18 | 2021-06-30 | サインパス ファルマ, インク.Signpath Pharma, Inc. | 心筋ｉｋｒチャネルの薬剤誘発性阻害のリポソームによる軽減 |
| JP2017516813A (ja) | 2014-06-03 | 2017-06-22 | サインパス ファルマ, インク.Signpath Pharma, Inc. | チャネル病を引き起こす薬物に対するｄｍｐｃ、ｄｍｐｇ、ｄｍｐｃ／ｄｍｐｇ、ｅｇｐｇ、ｌｙｓｏｐｇ及びｌｙｓｏｐｃの防御効果 |
| WO2016196648A1 (en) * | 2015-06-01 | 2016-12-08 | Autotelic Llc | Phospholipid-coated therapeutic agent nanoparticles and related methods |
| US20160346221A1 (en) | 2015-06-01 | 2016-12-01 | Autotelic Llc | Phospholipid-coated therapeutic agent nanoparticles and related methods |
| CN120392779A (zh) | 2015-06-15 | 2025-08-01 | 华盛顿大学 | 用于延长血液和淋巴组织中的药物水平的多药脂质纳米颗粒组合物和相关方法 |
| MX382522B (es) | 2015-10-16 | 2025-03-13 | Ipsen Biopharm Ltd | Composiciones farmaceuticas estabilizantes de camptotecina. |
| EP3372223B1 (en) | 2015-11-02 | 2024-04-17 | FUJIFILM Corporation | Liposome composition and method for producing same |
| KR102638618B1 (ko) | 2016-04-27 | 2024-02-21 | 사인패스 파마 인코포레이티드 | 약물 유발된 방실 차단의 방지 |
| MX2021005110A (es) * | 2018-11-02 | 2021-08-24 | Tesorx Pharma Llc | Quimioterapia intraperitoneal mejorada con liposomas. |
| CN110292563B (zh) * | 2019-06-12 | 2021-07-16 | 兰州大学 | 基于叶酸热敏脂质体的阴离子载体诱导癌细胞凋亡的方法 |
| TWI810633B (zh) | 2020-08-24 | 2023-08-01 | 國立清華大學 | 超音波搭配微氣泡輔助之氣球導管系統及其血管擴張方法 |
| WO2023186923A1 (en) | 2022-03-30 | 2023-10-05 | Meta Materials Inc. | Implanted agent delivery system |
| CN114832117A (zh) * | 2022-05-20 | 2022-08-02 | 天津科技大学 | 一种细胞穿透肽修饰的核酸-阳离子热敏脂质体及其制备方法 |
| WO2024174011A1 (pt) * | 2023-02-24 | 2024-08-29 | Rossi Bergmann Bartira | Lipossoma, método de preparo de um lipossoma, composição intranasal compreendendo lipossoma, método de preparo de composição intranasal, kit e uso da composição |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3993754A (en) | 1974-10-09 | 1976-11-23 | The United States Of America As Represented By The United States Energy Research And Development Administration | Liposome-encapsulated actinomycin for cancer chemotherapy |
| US4863739A (en) | 1987-05-19 | 1989-09-05 | Board Of Regents, The University Of Texas System | Liposome compositions of anthracycline derivatives |
| US4952408A (en) | 1988-05-23 | 1990-08-28 | Georgetown University | Liposome-encapsulated vinca alkaloids and their use in combatting tumors |
| JPH05194192A (ja) * | 1991-08-21 | 1993-08-03 | Shionogi & Co Ltd | 分散性の改善された温度感受性ｍｌｖ型リポソ−ム |
| CN1148336A (zh) | 1994-03-28 | 1997-04-23 | 第一制药株式会社 | 增大包封量的脂质体 |
| US20050019266A1 (en) * | 1997-05-06 | 2005-01-27 | Unger Evan C. | Novel targeted compositions for diagnostic and therapeutic use |
| CN1221250C (zh) * | 1998-04-09 | 2005-10-05 | 阿莫萨姆保健公司 | 微粒造影剂在研究生理参数的诊断成像中的应用 |
| US6726925B1 (en) * | 1998-06-18 | 2004-04-27 | Duke University | Temperature-sensitive liposomal formulation |
| US6200598B1 (en) | 1998-06-18 | 2001-03-13 | Duke University | Temperature-sensitive liposomal formulation |
| DE60222580T2 (de) | 2001-11-13 | 2008-06-12 | Celator Pharmaceuticals, Inc. | Lipidträgerzusammensetzungen und verfahren zur verbesserten wirkstoffzurückhaltung |
| JP2007530639A (ja) * | 2004-04-02 | 2007-11-01 | イタルファルマコ，ソシエダ アノニマ | リポソーム製剤 |
| TWI388344B (zh) * | 2005-08-23 | 2013-03-11 | Celsion Corp | 儲存奈米微粒調合物之方法 |
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2007
- 2007-11-05 WO PCT/CN2007/003128 patent/WO2009059449A1/en not_active Ceased
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- 2008-11-05 MY MYPI20102010 patent/MY151268A/en unknown
- 2008-11-05 JP JP2010531403A patent/JP5570994B2/ja not_active Expired - Fee Related
- 2008-11-05 KR KR1020107012248A patent/KR101652126B1/ko not_active Expired - Fee Related
- 2008-11-05 BR BRPI0820505-1A patent/BRPI0820505A2/pt not_active Application Discontinuation
- 2008-11-05 RU RU2010123009/15A patent/RU2497499C2/ru active
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- 2008-11-05 CN CN2008801147881A patent/CN101883557B/zh not_active Expired - Fee Related
- 2008-11-05 EP EP08850143.2A patent/EP2217209B1/en active Active
- 2008-11-05 CA CA2704258A patent/CA2704258C/en active Active
- 2008-11-05 ES ES08850143.2T patent/ES2689259T3/es active Active
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|---|---|
| AU2008323514B2 (en) | 2014-06-12 |
| WO2009059449A1 (en) | 2009-05-14 |
| EP2217209B1 (en) | 2018-06-06 |
| RU2497499C2 (ru) | 2013-11-10 |
| MX2010004957A (es) | 2010-08-02 |
| TW200930380A (en) | 2009-07-16 |
| CA2704258A1 (en) | 2009-05-22 |
| AU2008323514A1 (en) | 2009-05-22 |
| RU2010123009A (ru) | 2011-12-20 |
| CA2704258C (en) | 2016-11-22 |
| AU2008323514A2 (en) | 2012-05-17 |
| CN101883557B (zh) | 2013-05-29 |
| EP2217209A4 (en) | 2013-09-25 |
| KR20100087030A (ko) | 2010-08-02 |
| JP5570994B2 (ja) | 2014-08-13 |
| BRPI0820505A2 (pt) | 2015-06-16 |
| EP2217209A1 (en) | 2010-08-18 |
| WO2009062398A1 (en) | 2009-05-22 |
| HK1146906A1 (en) | 2011-07-22 |
| US20110200665A1 (en) | 2011-08-18 |
| US8642074B2 (en) | 2014-02-04 |
| ES2689259T3 (es) | 2018-11-12 |
| MY151268A (en) | 2014-04-30 |
| KR101652126B1 (ko) | 2016-08-29 |
| CN101883557A (zh) | 2010-11-10 |
| JP2011502134A (ja) | 2011-01-20 |
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