RU2497499C2 - Новые термочувствительные липосомы, содержащие терапевтические агенты - Google Patents

Новые термочувствительные липосомы, содержащие терапевтические агенты Download PDF

Info

Publication number
RU2497499C2
RU2497499C2 RU2010123009/15A RU2010123009A RU2497499C2 RU 2497499 C2 RU2497499 C2 RU 2497499C2 RU 2010123009/15 A RU2010123009/15 A RU 2010123009/15A RU 2010123009 A RU2010123009 A RU 2010123009A RU 2497499 C2 RU2497499 C2 RU 2497499C2
Authority
RU
Russia
Prior art keywords
liposomes
liposome
carboplatin
thermosensitive
active agent
Prior art date
Application number
RU2010123009/15A
Other languages
English (en)
Russian (ru)
Other versions
RU2010123009A (ru
Inventor
Синго МЭЙ
Цинвэй ЦЗЯН
Вэйпин ЮЙ
Original Assignee
Селшн Корпорейшн
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Селшн Корпорейшн filed Critical Селшн Корпорейшн
Publication of RU2010123009A publication Critical patent/RU2010123009A/ru
Application granted granted Critical
Publication of RU2497499C2 publication Critical patent/RU2497499C2/ru

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
RU2010123009/15A 2007-11-05 2008-11-05 Новые термочувствительные липосомы, содержащие терапевтические агенты RU2497499C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CNPCT/CN2007/003128 2007-11-05
PCT/CN2007/003128 WO2009059449A1 (en) 2007-11-05 2007-11-05 Novel thermosensitive liposomes containing therapeutic agents
PCT/CN2008/001846 WO2009062398A1 (en) 2007-11-05 2008-11-05 Novel thermosensitive liposomes containing therapeutic agents

Publications (2)

Publication Number Publication Date
RU2010123009A RU2010123009A (ru) 2011-12-20
RU2497499C2 true RU2497499C2 (ru) 2013-11-10

Family

ID=40625343

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2010123009/15A RU2497499C2 (ru) 2007-11-05 2008-11-05 Новые термочувствительные липосомы, содержащие терапевтические агенты

Country Status (14)

Country Link
US (1) US8642074B2 (https=)
EP (1) EP2217209B1 (https=)
JP (1) JP5570994B2 (https=)
KR (1) KR101652126B1 (https=)
CN (1) CN101883557B (https=)
AU (1) AU2008323514B2 (https=)
BR (1) BRPI0820505A2 (https=)
CA (1) CA2704258C (https=)
ES (1) ES2689259T3 (https=)
MX (1) MX2010004957A (https=)
MY (1) MY151268A (https=)
RU (1) RU2497499C2 (https=)
TW (1) TWI437995B (https=)
WO (2) WO2009059449A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2833053C2 (ru) * 2015-10-16 2025-01-14 Ипсен Биофарм Лтд. Стабилизирующие фармацевтические композиции камптотецина

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2928387A1 (en) 2004-05-03 2005-11-17 Merrimack Pharmaceuticals, Inc. Drug delivery liposomes containing anionic polyols or anionic sugars
WO2012094020A1 (en) 2010-01-07 2012-07-12 Innopharma, Inc. Methods and compositions for delivery of taxanes in stable oil-in-water emulsions
JP2014503582A (ja) * 2011-01-28 2014-02-13 コーニンクレッカ フィリップス エヌ ヴェ 親水性プロドラッグの局所放出用担体
CN102579323B (zh) * 2011-02-21 2013-06-19 舒泰神（北京）生物制药股份有限公司 一种紫杉醇醇质体凝胶剂及其制备方法
CN102688193B (zh) * 2011-03-24 2016-05-11 中国人民解放军军事医学科学院毒物药物研究所 长春碱类药物的热敏脂质体制剂及其制备方法
US10449193B2 (en) * 2011-06-03 2019-10-22 Signpath Pharma Inc. Protective effect of DMPC, DMPG, DMPC/DMPG, lysoPG and lysoPC against drugs that cause channelopathies
WO2012167212A2 (en) 2011-06-03 2012-12-06 Signpath Pharma Inc. Liposomal mitigation of drug-induced long qt syndrome and potassium delayed-rectifier current
US10349884B2 (en) 2011-06-03 2019-07-16 Sighpath Pharma Inc. Liposomal mitigation of drug-induced inhibition of the cardiac ikr channel
US12004868B2 (en) 2011-06-03 2024-06-11 Signpath Pharma Inc. Liposomal mitigation of drug-induced inhibition of the cardiac IKr channel
US10117881B2 (en) 2011-06-03 2018-11-06 Signpath Pharma, Inc. Protective effect of DMPC, DMPG, DMPC/DMPG, LYSOPG and LYSOPC against drugs that cause channelopathies
US10238602B2 (en) 2011-06-03 2019-03-26 Signpath Pharma, Inc. Protective effect of DMPC, DMPG, DMPC/DMPG, LysoPG and LysoPC against drugs that cause channelopathies
KR20130042905A (ko) * 2011-10-19 2013-04-29 삼성전자주식회사 엘라스틴 유사 폴리펩티드를 포함하는 리포좀 및 그의 용도
CN102552144A (zh) * 2012-01-13 2012-07-11 北京大学 一种靶向热敏脂质体
JP2015507019A (ja) * 2012-02-17 2015-03-05 セルシオン コーポレイション 感熱性ナノ粒子製剤およびその製造方法
ITRM20120169A1 (it) 2012-04-19 2013-10-20 Consiglio Nazionale Ricerche Dispositivo di rilascio di specie chimiche a controllo ottico
WO2013172358A1 (ja) * 2012-05-14 2013-11-21 公立大学法人大阪府立大学 機能性化合物及びその化合物を含有する分子集合体、並びにそれらを含有する組成物及びキット並びにそれらの使用
US9801874B2 (en) * 2012-11-20 2017-10-31 Spectrum Pharmaceuticals Method for the preparation of liposome encapsulated vincristine for therapeutic use
KR102109188B1 (ko) 2013-04-01 2020-05-11 삼성전자주식회사 양이온성 지질을 포함하는 온도민감성 리포좀 및 그의 용도
TWI552761B (zh) 2013-05-03 2016-10-11 博信生物科技股份有限公司 一種脂質微／奈米氣泡、及其最佳化之製備方法及製備裝置
KR20150034517A (ko) 2013-09-26 2015-04-03 삼성전자주식회사 소수성 활성 성분 및 폴리펩티드의 복합체를 포함하는 리포좀, 및 그의 용도
KR20150047336A (ko) 2013-10-24 2015-05-04 삼성전자주식회사 나노입자, 이를 제조하는 방법, 및 이의 용도
KR20150062652A (ko) 2013-11-29 2015-06-08 삼성전자주식회사 초음파 감응성 리포좀, 그를 포함한 약제학적 조성물 및 그를 이용하여 개체의 체내에 활성제를 전달하는 방법
JP6895252B2 (ja) 2013-12-18 2021-06-30 サインパス ファルマ, インク.Signpath Pharma, Inc. 心筋ｉｋｒチャネルの薬剤誘発性阻害のリポソームによる軽減
JP2017516813A (ja) 2014-06-03 2017-06-22 サインパス ファルマ, インク.Signpath Pharma, Inc. チャネル病を引き起こす薬物に対するｄｍｐｃ、ｄｍｐｇ、ｄｍｐｃ／ｄｍｐｇ、ｅｇｐｇ、ｌｙｓｏｐｇ及びｌｙｓｏｐｃの防御効果
WO2016196648A1 (en) * 2015-06-01 2016-12-08 Autotelic Llc Phospholipid-coated therapeutic agent nanoparticles and related methods
US20160346221A1 (en) 2015-06-01 2016-12-01 Autotelic Llc Phospholipid-coated therapeutic agent nanoparticles and related methods
CN120392779A (zh) 2015-06-15 2025-08-01 华盛顿大学 用于延长血液和淋巴组织中的药物水平的多药脂质纳米颗粒组合物和相关方法
MX382522B (es) 2015-10-16 2025-03-13 Ipsen Biopharm Ltd Composiciones farmaceuticas estabilizantes de camptotecina.
EP3372223B1 (en) 2015-11-02 2024-04-17 FUJIFILM Corporation Liposome composition and method for producing same
KR102638618B1 (ko) 2016-04-27 2024-02-21 사인패스 파마 인코포레이티드 약물 유발된 방실 차단의 방지
MX2021005110A (es) * 2018-11-02 2021-08-24 Tesorx Pharma Llc Quimioterapia intraperitoneal mejorada con liposomas.
CN110292563B (zh) * 2019-06-12 2021-07-16 兰州大学 基于叶酸热敏脂质体的阴离子载体诱导癌细胞凋亡的方法
TWI810633B (zh) 2020-08-24 2023-08-01 國立清華大學 超音波搭配微氣泡輔助之氣球導管系統及其血管擴張方法
WO2023186923A1 (en) 2022-03-30 2023-10-05 Meta Materials Inc. Implanted agent delivery system
CN114832117A (zh) * 2022-05-20 2022-08-02 天津科技大学 一种细胞穿透肽修饰的核酸-阳离子热敏脂质体及其制备方法
WO2024174011A1 (pt) * 2023-02-24 2024-08-29 Rossi Bergmann Bartira Lipossoma, método de preparo de um lipossoma, composição intranasal compreendendo lipossoma, método de preparo de composição intranasal, kit e uso da composição

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4952408A (en) * 1988-05-23 1990-08-28 Georgetown University Liposome-encapsulated vinca alkaloids and their use in combatting tumors
RU96119991A (ru) * 1994-03-28 1998-12-27 Дайити Фармасьютикал Ко., Лтд. Липосомы с повышенной инкапсулирующей способностью
US6726925B1 (en) * 1998-06-18 2004-04-27 Duke University Temperature-sensitive liposomal formulation

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3993754A (en) 1974-10-09 1976-11-23 The United States Of America As Represented By The United States Energy Research And Development Administration Liposome-encapsulated actinomycin for cancer chemotherapy
US4863739A (en) 1987-05-19 1989-09-05 Board Of Regents, The University Of Texas System Liposome compositions of anthracycline derivatives
JPH05194192A (ja) * 1991-08-21 1993-08-03 Shionogi & Co Ltd 分散性の改善された温度感受性ｍｌｖ型リポソ−ム
CN1148336A (zh) 1994-03-28 1997-04-23 第一制药株式会社 增大包封量的脂质体
US20050019266A1 (en) * 1997-05-06 2005-01-27 Unger Evan C. Novel targeted compositions for diagnostic and therapeutic use
CN1221250C (zh) * 1998-04-09 2005-10-05 阿莫萨姆保健公司 微粒造影剂在研究生理参数的诊断成像中的应用
US6200598B1 (en) 1998-06-18 2001-03-13 Duke University Temperature-sensitive liposomal formulation
DE60222580T2 (de) 2001-11-13 2008-06-12 Celator Pharmaceuticals, Inc. Lipidträgerzusammensetzungen und verfahren zur verbesserten wirkstoffzurückhaltung
JP2007530639A (ja) * 2004-04-02 2007-11-01 イタルファルマコ，ソシエダ アノニマ リポソーム製剤
TWI388344B (zh) * 2005-08-23 2013-03-11 Celsion Corp 儲存奈米微粒調合物之方法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4952408A (en) * 1988-05-23 1990-08-28 Georgetown University Liposome-encapsulated vinca alkaloids and their use in combatting tumors
RU96119991A (ru) * 1994-03-28 1998-12-27 Дайити Фармасьютикал Ко., Лтд. Липосомы с повышенной инкапсулирующей способностью
US6726925B1 (en) * 1998-06-18 2004-04-27 Duke University Temperature-sensitive liposomal formulation

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
David Needham et al. "A New Temperature-sensitive Liposome for Use with Mild Hyperthermia: Characterization and Testing in a Human Tumor Xenograft Model", Cancer Res 2000; 60: 1197-1201. *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2833053C2 (ru) * 2015-10-16 2025-01-14 Ипсен Биофарм Лтд. Стабилизирующие фармацевтические композиции камптотецина

Also Published As

Publication number Publication date
AU2008323514B2 (en) 2014-06-12
WO2009059449A1 (en) 2009-05-14
EP2217209B1 (en) 2018-06-06
MX2010004957A (es) 2010-08-02
TW200930380A (en) 2009-07-16
CA2704258A1 (en) 2009-05-22
AU2008323514A1 (en) 2009-05-22
RU2010123009A (ru) 2011-12-20
CA2704258C (en) 2016-11-22
AU2008323514A2 (en) 2012-05-17
CN101883557B (zh) 2013-05-29
EP2217209A4 (en) 2013-09-25
KR20100087030A (ko) 2010-08-02
JP5570994B2 (ja) 2014-08-13
BRPI0820505A2 (pt) 2015-06-16
TWI437995B (zh) 2014-05-21
EP2217209A1 (en) 2010-08-18
WO2009062398A1 (en) 2009-05-22
HK1146906A1 (en) 2011-07-22
US20110200665A1 (en) 2011-08-18
US8642074B2 (en) 2014-02-04
ES2689259T3 (es) 2018-11-12
MY151268A (en) 2014-04-30
KR101652126B1 (ko) 2016-08-29
CN101883557A (zh) 2010-11-10
JP2011502134A (ja) 2011-01-20

Similar Documents

Publication Publication Date Title
RU2497499C2 (ru) Новые термочувствительные липосомы, содержащие терапевтические агенты
JP2011502134A5 (https=)
JP4555569B2 (ja) 増強された血中安定性を有する脂質キャリア組成物
ES2967961T3 (es) Liposomas útiles en la administración de fármacos
WO2019105408A1 (en) Novel liposomes with ginsenoside derivative as membrane material and preparations thereof
US9844656B2 (en) Localization of agents at a target site with a composition and an energy source
JP2018528269A (ja) ギンセノシドを膜材料として有するリポソームならびにその調製および使用
JP2011506432A (ja) 非ラメラ形成脂質を含む音響感受性薬物送達粒子
EP2007355A2 (en) Liposomal compositions
US20240350411A1 (en) Methods for preparing liposomal formulations
CN105431139A (zh) 用于以长期循环的刺激-敏感性纳米载体系统进行局部治疗的立体特异性脂质
CN121003588A (zh) 一种复方脂质体、冻干粉针剂及其制备方法、应用
US8940334B2 (en) Pharmaceutical composition of an anthracycline
CN110200920B (zh) 一种还原敏感药物组合物及其制备和应用
HK1146906B (en) Novel thermosensitive liposomes containing therapeutic agents
PL197938B1 (pl) Liposomowy preparat zawierający przeciwnowotworową substancję aktywną, sposób jego wytwarzania i zawierająca go kompozycja farmaceutyczna