CN116056759A - 超声波搭配微气泡辅助的气球导管系统及其血管扩张方法 - Google Patents
超声波搭配微气泡辅助的气球导管系统及其血管扩张方法 Download PDFInfo
- Publication number
- CN116056759A CN116056759A CN202180052272.4A CN202180052272A CN116056759A CN 116056759 A CN116056759 A CN 116056759A CN 202180052272 A CN202180052272 A CN 202180052272A CN 116056759 A CN116056759 A CN 116056759A
- Authority
- CN
- China
- Prior art keywords
- balloon catheter
- ultrasonic
- probe
- microbubbles
- blood vessel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 title claims abstract description 30
- 230000024883 vasodilation Effects 0.000 title claims abstract description 13
- 239000000523 sample Substances 0.000 claims abstract description 95
- 208000004434 Calcinosis Diseases 0.000 claims abstract description 57
- 230000002308 calcification Effects 0.000 claims abstract description 57
- 210000004204 blood vessel Anatomy 0.000 claims abstract description 39
- 238000002604 ultrasonography Methods 0.000 claims abstract description 37
- 208000011775 arteriosclerosis disease Diseases 0.000 claims abstract description 9
- 238000002474 experimental method Methods 0.000 claims description 42
- 208000005475 Vascular calcification Diseases 0.000 claims description 35
- 229920001223 polyethylene glycol Polymers 0.000 claims description 18
- KILNVBDSWZSGLL-KXQOOQHDSA-N 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCC KILNVBDSWZSGLL-KXQOOQHDSA-N 0.000 claims description 16
- 239000000203 mixture Substances 0.000 claims description 11
- 239000002202 Polyethylene glycol Substances 0.000 claims description 10
- 230000001066 destructive effect Effects 0.000 claims description 7
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims description 6
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims description 6
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims description 6
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 6
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 6
- 101001000212 Rattus norvegicus Decorin Proteins 0.000 claims description 6
- FVJZSBGHRPJMMA-UHFFFAOYSA-N distearoyl phosphatidylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(COP(O)(=O)OCC(O)CO)OC(=O)CCCCCCCCCCCCCCCCC FVJZSBGHRPJMMA-UHFFFAOYSA-N 0.000 claims description 6
- 230000035939 shock Effects 0.000 claims description 6
- 230000002792 vascular Effects 0.000 claims description 6
- 239000007789 gas Substances 0.000 claims description 5
- 239000002904 solvent Substances 0.000 claims description 5
- 230000000304 vasodilatating effect Effects 0.000 claims description 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 4
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims description 4
- 238000010438 heat treatment Methods 0.000 claims description 3
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 3
- FVJZSBGHRPJMMA-DHPKCYQYSA-N [(2r)-3-[2,3-dihydroxypropoxy(hydroxy)phosphoryl]oxy-2-octadecanoyloxypropyl] octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OCC(O)CO)OC(=O)CCCCCCCCCCCCCCCCC FVJZSBGHRPJMMA-DHPKCYQYSA-N 0.000 claims description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 2
- 229910002092 carbon dioxide Inorganic materials 0.000 claims description 2
- 239000001569 carbon dioxide Substances 0.000 claims description 2
- NBVXSUQYWXRMNV-UHFFFAOYSA-N fluoromethane Chemical compound FC NBVXSUQYWXRMNV-UHFFFAOYSA-N 0.000 claims description 2
- 238000002156 mixing Methods 0.000 claims description 2
- 229910052757 nitrogen Inorganic materials 0.000 claims description 2
- 239000001301 oxygen Substances 0.000 claims description 2
- 229910052760 oxygen Inorganic materials 0.000 claims description 2
- FVJZSBGHRPJMMA-IOLBBIBUSA-N PG(18:0/18:0) Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@@H](O)CO)OC(=O)CCCCCCCCCCCCCCCCC FVJZSBGHRPJMMA-IOLBBIBUSA-N 0.000 claims 2
- 238000012360 testing method Methods 0.000 description 40
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 38
- 210000003278 egg shell Anatomy 0.000 description 16
- 230000005855 radiation Effects 0.000 description 15
- 102000002322 Egg Proteins Human genes 0.000 description 14
- 108010000912 Egg Proteins Proteins 0.000 description 14
- 230000000694 effects Effects 0.000 description 14
- 238000001727 in vivo Methods 0.000 description 12
- 238000010586 diagram Methods 0.000 description 11
- 239000010440 gypsum Substances 0.000 description 11
- 229910052602 gypsum Inorganic materials 0.000 description 11
- 230000006378 damage Effects 0.000 description 10
- 238000002360 preparation method Methods 0.000 description 10
- 230000004071 biological effect Effects 0.000 description 7
- 238000001514 detection method Methods 0.000 description 7
- 239000012895 dilution Substances 0.000 description 7
- 238000010790 dilution Methods 0.000 description 7
- 239000000243 solution Substances 0.000 description 6
- 201000001320 Atherosclerosis Diseases 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- 238000003776 cleavage reaction Methods 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- 239000002953 phosphate buffered saline Substances 0.000 description 3
- 150000003904 phospholipids Chemical class 0.000 description 3
- 230000007017 scission Effects 0.000 description 3
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical group [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
- 210000001367 artery Anatomy 0.000 description 2
- 229910052791 calcium Inorganic materials 0.000 description 2
- 239000011575 calcium Substances 0.000 description 2
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 2
- 238000009826 distribution Methods 0.000 description 2
- 238000003384 imaging method Methods 0.000 description 2
- 238000007711 solidification Methods 0.000 description 2
- 230000008023 solidification Effects 0.000 description 2
- 238000000527 sonication Methods 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- QQAHAGNPDBPSJP-UHFFFAOYSA-N 1,1,1,2,2,3,3,3-octachloropropane Chemical compound ClC(Cl)(Cl)C(Cl)(Cl)C(Cl)(Cl)Cl QQAHAGNPDBPSJP-UHFFFAOYSA-N 0.000 description 1
- 238000010146 3D printing Methods 0.000 description 1
- 208000017667 Chronic Disease Diseases 0.000 description 1
- 241000282887 Suidae Species 0.000 description 1
- 206010057469 Vascular stenosis Diseases 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 239000000919 ceramic Substances 0.000 description 1
- ARQRPTNYUOLOGH-UHFFFAOYSA-N chcl3 chloroform Chemical compound ClC(Cl)Cl.ClC(Cl)Cl ARQRPTNYUOLOGH-UHFFFAOYSA-N 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 238000007872 degassing Methods 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 239000013013 elastic material Substances 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 239000011259 mixed solution Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000011002 quantification Methods 0.000 description 1
- 238000004445 quantitative analysis Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
- A61B17/22004—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves
- A61B17/22012—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves in direct contact with, or very close to, the obstruction or concrement
- A61B17/2202—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves in direct contact with, or very close to, the obstruction or concrement the ultrasound transducer being inside patient's body at the distal end of the catheter
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
- A61B17/22004—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves
- A61B17/22012—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves in direct contact with, or very close to, the obstruction or concrement
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0028—Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
- A61B17/22004—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves
- A61B2017/22005—Effects, e.g. on tissue
- A61B2017/22007—Cavitation or pseudocavitation, i.e. creation of gas bubbles generating a secondary shock wave when collapsing
- A61B2017/22008—Cavitation or pseudocavitation, i.e. creation of gas bubbles generating a secondary shock wave when collapsing used or promoted
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
- A61B2017/22051—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for with an inflatable part, e.g. balloon, for positioning, blocking, or immobilisation
- A61B2017/22062—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for with an inflatable part, e.g. balloon, for positioning, blocking, or immobilisation to be filled with liquid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
- A61B2017/22051—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for with an inflatable part, e.g. balloon, for positioning, blocking, or immobilisation
- A61B2017/22065—Functions of balloons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
- A61B2017/22082—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for after introduction of a substance
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
- A61B2017/22082—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for after introduction of a substance
- A61B2017/22088—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for after introduction of a substance ultrasound absorbing, drug activated by ultrasound
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
- A61B2017/22082—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for after introduction of a substance
- A61B2017/22089—Gas-bubbles
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Vascular Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Mechanical Engineering (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Surgical Instruments (AREA)
Abstract
一种超声波搭配微气泡辅助的气球导管系统(1)及其血管扩张方法，该系统(1)包括：一控制器(10)；一传感器导管(20)；一高度聚焦式超声波探头(30)，该高度聚焦式超声波探头(30)及该传感器导管(20)连接于该控制器(10)；以及一气球导管(40)；该血管扩张方法，包括：提供一传感器导管(20)进入一血管，控制一高度聚焦式超声波探头(30)在血管硬化处进行对焦(S310)；将该传感器导管(20)从该血管移出，将一气球导管(40)进入该血管(S320)；将微气泡灌入该气球导管(40)，并控制该高度聚焦式超声波探头(30)开始工作破坏硬化血管的钙化点(S330)；顺利将该气球导管(40)在血管硬化的部分位置撑开(S340)。
Description
PCT国内申请，说明书已公开。
Claims (9)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063069190P | 2020-08-24 | 2020-08-24 | |
| US63/069,190 | 2020-08-24 | ||
| PCT/CN2021/114261 WO2022042531A1 (zh) | 2020-08-24 | 2021-08-24 | 超声波搭配微气泡辅助的气球导管系统及其血管扩张方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN116056759A true CN116056759A (zh) | 2023-05-02 |
Family
ID=80269103
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202180052272.4A Pending CN116056759A (zh) | 2020-08-24 | 2021-08-24 | 超声波搭配微气泡辅助的气球导管系统及其血管扩张方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20220054155A1 (zh) |
| EP (1) | EP4201481A1 (zh) |
| CN (1) | CN116056759A (zh) |
| TW (1) | TWI810633B (zh) |
| WO (1) | WO2022042531A1 (zh) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116942246A (zh) * | 2022-04-13 | 2023-10-27 | 深圳高性能医疗器械国家研究院有限公司 | 用于血管成形术的爆裂波发生方法及爆裂波发生系统 |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4841977A (en) * | 1987-05-26 | 1989-06-27 | Inter Therapy, Inc. | Ultra-thin acoustic transducer and balloon catheter using same in imaging array subassembly |
| JP3898754B2 (ja) * | 1993-07-01 | 2007-03-28 | ボストン サイエンティフィック リミテッド | 像形成、電位検出型及び切除カテーテル |
| BR9509217A (pt) * | 1994-10-03 | 1998-01-27 | Michel G Bergeron | Processo e formulações para tratamento de aids e várias outras doenças virais |
| US20040019318A1 (en) * | 2001-11-07 | 2004-01-29 | Wilson Richard R. | Ultrasound assembly for use with a catheter |
| US20070010702A1 (en) * | 2003-04-08 | 2007-01-11 | Xingwu Wang | Medical device with low magnetic susceptibility |
| CN1298400C (zh) * | 2003-09-01 | 2007-02-07 | 吴巍 | 超声微泡造影剂用于形成毛细血管栓塞的医疗装置 |
| US20060241524A1 (en) * | 2005-03-11 | 2006-10-26 | Qi Yu | Intravascular ultrasound catheter device and method for ablating atheroma |
| WO2009043031A2 (en) * | 2007-09-27 | 2009-04-02 | Children's Medical Center Corporation | Microbubbles and methods for oxygen delivery |
| JP2011500249A (ja) * | 2007-10-22 | 2011-01-06 | エンドクロス リミテッド | 血管閉塞を治療するためのバルーンおよびバルーン・カテーテル・システム |
| US20130023897A1 (en) * | 2009-10-06 | 2013-01-24 | Michael P Wallace | Devices and Methods for Endovascular Therapies |
| JP4734448B2 (ja) * | 2009-12-04 | 2011-07-27 | 株式会社日立製作所 | 超音波治療装置 |
| WO2011094379A1 (en) * | 2010-01-28 | 2011-08-04 | Cook Medical Technologies Llc | Apparatus and method for destruction of vascular thrombus |
| US8740835B2 (en) * | 2010-02-17 | 2014-06-03 | Ekos Corporation | Treatment of vascular occlusions using ultrasonic energy and microbubbles |
| WO2012162664A1 (en) * | 2011-05-26 | 2012-11-29 | The Trustees Of Columbia University In The City Of New York | Systems and methods for opening of a tissue barrier in primates |
| US20130331738A1 (en) * | 2012-06-11 | 2013-12-12 | Board Of Trustees University Of Arkansas | Compositions and methods for potentiating sonothrombolysis |
| EP2879595B1 (en) * | 2012-08-03 | 2019-04-10 | Muffin Incorporated | Weeping balloon catheter with ultrasound element |
| US9610380B2 (en) * | 2014-06-26 | 2017-04-04 | DePuy Synthes Products, Inc. | Vertebral body augmentation systems comprising microbubbles |
| CA3013341C (en) * | 2016-02-01 | 2024-01-02 | Trust Biosonics Inc. | Lipid microbubbles and process of making thereof |
| CN205548629U (zh) * | 2016-03-24 | 2016-09-07 | 广州军区广州总医院 | 一种超声微泡空化溶栓系统 |
| TW201740884A (zh) * | 2016-05-23 | 2017-12-01 | 佳世達科技股份有限公司 | 超音波導管及醫療系統 |
| CN105852911B (zh) * | 2016-05-26 | 2019-11-29 | 苏州佳世达电通有限公司 | 超音波导管及医疗系统 |
| US10232161B2 (en) * | 2016-09-13 | 2019-03-19 | National Tsing Hua University | Ultrasonic device for transversely manipulating drug delivery carriers and method using the same |
| US10945634B2 (en) * | 2016-09-22 | 2021-03-16 | Walter Kusumoto | Modular electrophysiology mapping system and method |
| WO2018194980A1 (en) * | 2017-04-21 | 2018-10-25 | Boston Scientific Scimed, Inc. | Lithotripsy angioplasty devices and methods |
| AU2018284963A1 (en) * | 2017-06-14 | 2020-02-06 | University Of Louisville Research Foundation | Systems and methods for preservation of cells |
| CN111886002A (zh) * | 2018-03-20 | 2020-11-03 | 百奥医福股份有限公司 | 一种包括用于递送药物的超声响应性微泡的脂质体的制备方法以及使用该方法的脂质体 |
| CN110548140B (zh) * | 2018-06-01 | 2022-03-15 | 叶秩光 | 带氧微气泡用于制备诱导病变组织血管正常化套组的用途 |
| TWI720319B (zh) * | 2018-06-12 | 2021-03-01 | 國立清華大學 | 超音波感應蛋白質以及利用超音波刺激細胞的方法 |
| US11793863B2 (en) * | 2019-04-26 | 2023-10-24 | University of Pittsburgh—of the Commonwealth System of Higher Education | Functionalized microbubble embodiments for ultrasound-mediated treatment and methods of making and using the same |
| CN110237256A (zh) * | 2019-07-22 | 2019-09-17 | 重庆医科大学 | 一种载n2o微泡及其制备方法与应用 |
| WO2021097224A1 (en) * | 2019-11-15 | 2021-05-20 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Cardioprotective microbubble-liposomal drug complexes |
| US11672599B2 (en) * | 2020-03-09 | 2023-06-13 | Bolt Medical, Inc. | Acoustic performance monitoring system and method within intravascular lithotripsy device |
-
2021
- 2021-08-24 US US17/410,232 patent/US20220054155A1/en active Pending
- 2021-08-24 TW TW110131308A patent/TWI810633B/zh active
- 2021-08-24 WO PCT/CN2021/114261 patent/WO2022042531A1/zh unknown
- 2021-08-24 CN CN202180052272.4A patent/CN116056759A/zh active Pending
- 2021-08-24 EP EP21860366.0A patent/EP4201481A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20220054155A1 (en) | 2022-02-24 |
| TW202207876A (zh) | 2022-03-01 |
| TWI810633B (zh) | 2023-08-01 |
| EP4201481A1 (en) | 2023-06-28 |
| WO2022042531A1 (zh) | 2022-03-03 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US11701134B2 (en) | Histotripsy for thrombolysis | |
| US5524620A (en) | Ablation of blood thrombi by means of acoustic energy | |
| US20190307472A1 (en) | Method for controlling histotripsy using confocal fundamental and harmonic superposition combined with hundred-microsecond ultrasound pulses | |
| Ohl et al. | Detachment and sonoporation of adherent HeLa-cells by shock wave-induced cavitation | |
| Schad et al. | In vitro characterization of perfluorocarbon droplets for focused ultrasound therapy | |
| CN105407968B (zh) | 用于对缺血性中风的超声处置的设备 | |
| US6113558A (en) | Pulsed mode lysis method | |
| US5219401A (en) | Apparatus for selective destruction of cells by implosion of gas bubbles | |
| Rosenschein et al. | Study of the mechanism of ultrasound angioplasty from human thrombi and bovine aorta | |
| JP2009508649A (ja) | パルス・キャビテーション超音波療法 | |
| WO2009094554A2 (en) | Histotripsy for thrombolysis | |
| AU2017290112A1 (en) | Method and apparatus for extracting and delivery of entities | |
| US20200107843A1 (en) | Systems and Methods for Treating Vascular Occlusions with Catheter Based Ultrasound | |
| CN116056759A (zh) | 超声波搭配微气泡辅助的气球导管系统及其血管扩张方法 | |
| WO2000053263A9 (en) | Dual transducer ultrasound lysis method and apparatus | |
| Pua et al. | Ultrasound-mediated drug delivery | |
| Shangguan et al. | Enhanced laser thrombolysis with photomechanical drug delivery: an in vitro study | |
| Goldenstedt et al. | Delivery by shock waves of active principle embedded in gelatin-based capsules | |
| Fan et al. | Feasibility of in vitro calcification plaque disruption using ultrasound-induced microbubble inertial cavitation | |
| Gong et al. | Histotripsy of blood clots within a hollow cylindrical transducer for aspiration thrombectomy applications | |
| Thomas et al. | Confocal lens focused piezoelectric lithotripter | |
| IL127967A (en) | Flushing solution for surgery using ultrasound energy | |
| Wu et al. | Rotational Intravascular Multidirectional Ultrasound Catheter for Sonothrombolysis of Retracted Clots: An in Vitro and in Vivo Study | |
| Gong et al. | Self-sensing with hollow cylindrical transducers for histotripsy enhanced aspiration mechanical thrombectomy applications | |
| Caskey et al. | Ultrasound mediated drug delivery: the effect of microbubbles on a gel boundary |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |