CA2704258C - Novel thermosensitive liposomes containing therapeutic agents - Google Patents

Novel thermosensitive liposomes containing therapeutic agents Download PDF

Info

Publication number
CA2704258C
CA2704258C CA2704258A CA2704258A CA2704258C CA 2704258 C CA2704258 C CA 2704258C CA 2704258 A CA2704258 A CA 2704258A CA 2704258 A CA2704258 A CA 2704258A CA 2704258 C CA2704258 C CA 2704258C
Authority
CA
Canada
Prior art keywords
liposomes
thermosensitive
liposome
agent
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2704258A
Other languages
English (en)
French (fr)
Other versions
CA2704258A1 (en
Inventor
Xingguo Mei
Qingwei Jiang
Weiping Yu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Imunon Inc
Original Assignee
Celsion Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celsion Corp filed Critical Celsion Corp
Publication of CA2704258A1 publication Critical patent/CA2704258A1/en
Application granted granted Critical
Publication of CA2704258C publication Critical patent/CA2704258C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CA2704258A 2007-11-05 2008-11-05 Novel thermosensitive liposomes containing therapeutic agents Active CA2704258C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CNPCT/CN2007/003128 2007-11-05
PCT/CN2007/003128 WO2009059449A1 (en) 2007-11-05 2007-11-05 Novel thermosensitive liposomes containing therapeutic agents
PCT/CN2008/001846 WO2009062398A1 (en) 2007-11-05 2008-11-05 Novel thermosensitive liposomes containing therapeutic agents

Publications (2)

Publication Number Publication Date
CA2704258A1 CA2704258A1 (en) 2009-05-22
CA2704258C true CA2704258C (en) 2016-11-22

Family

ID=40625343

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2704258A Active CA2704258C (en) 2007-11-05 2008-11-05 Novel thermosensitive liposomes containing therapeutic agents

Country Status (14)

Country Link
US (1) US8642074B2 (https=)
EP (1) EP2217209B1 (https=)
JP (1) JP5570994B2 (https=)
KR (1) KR101652126B1 (https=)
CN (1) CN101883557B (https=)
AU (1) AU2008323514B2 (https=)
BR (1) BRPI0820505A2 (https=)
CA (1) CA2704258C (https=)
ES (1) ES2689259T3 (https=)
MX (1) MX2010004957A (https=)
MY (1) MY151268A (https=)
RU (1) RU2497499C2 (https=)
TW (1) TWI437995B (https=)
WO (2) WO2009059449A1 (https=)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2928387A1 (en) 2004-05-03 2005-11-17 Merrimack Pharmaceuticals, Inc. Drug delivery liposomes containing anionic polyols or anionic sugars
WO2012094020A1 (en) 2010-01-07 2012-07-12 Innopharma, Inc. Methods and compositions for delivery of taxanes in stable oil-in-water emulsions
JP2014503582A (ja) * 2011-01-28 2014-02-13 コーニンクレッカ フィリップス エヌ ヴェ 親水性プロドラッグの局所放出用担体
CN102579323B (zh) * 2011-02-21 2013-06-19 舒泰神（北京）生物制药股份有限公司 一种紫杉醇醇质体凝胶剂及其制备方法
CN102688193B (zh) * 2011-03-24 2016-05-11 中国人民解放军军事医学科学院毒物药物研究所 长春碱类药物的热敏脂质体制剂及其制备方法
US10449193B2 (en) * 2011-06-03 2019-10-22 Signpath Pharma Inc. Protective effect of DMPC, DMPG, DMPC/DMPG, lysoPG and lysoPC against drugs that cause channelopathies
WO2012167212A2 (en) 2011-06-03 2012-12-06 Signpath Pharma Inc. Liposomal mitigation of drug-induced long qt syndrome and potassium delayed-rectifier current
US10349884B2 (en) 2011-06-03 2019-07-16 Sighpath Pharma Inc. Liposomal mitigation of drug-induced inhibition of the cardiac ikr channel
US12004868B2 (en) 2011-06-03 2024-06-11 Signpath Pharma Inc. Liposomal mitigation of drug-induced inhibition of the cardiac IKr channel
US10117881B2 (en) 2011-06-03 2018-11-06 Signpath Pharma, Inc. Protective effect of DMPC, DMPG, DMPC/DMPG, LYSOPG and LYSOPC against drugs that cause channelopathies
US10238602B2 (en) 2011-06-03 2019-03-26 Signpath Pharma, Inc. Protective effect of DMPC, DMPG, DMPC/DMPG, LysoPG and LysoPC against drugs that cause channelopathies
KR20130042905A (ko) * 2011-10-19 2013-04-29 삼성전자주식회사 엘라스틴 유사 폴리펩티드를 포함하는 리포좀 및 그의 용도
CN102552144A (zh) * 2012-01-13 2012-07-11 北京大学 一种靶向热敏脂质体
JP2015507019A (ja) * 2012-02-17 2015-03-05 セルシオン コーポレイション 感熱性ナノ粒子製剤およびその製造方法
ITRM20120169A1 (it) 2012-04-19 2013-10-20 Consiglio Nazionale Ricerche Dispositivo di rilascio di specie chimiche a controllo ottico
WO2013172358A1 (ja) * 2012-05-14 2013-11-21 公立大学法人大阪府立大学 機能性化合物及びその化合物を含有する分子集合体、並びにそれらを含有する組成物及びキット並びにそれらの使用
US9801874B2 (en) * 2012-11-20 2017-10-31 Spectrum Pharmaceuticals Method for the preparation of liposome encapsulated vincristine for therapeutic use
KR102109188B1 (ko) 2013-04-01 2020-05-11 삼성전자주식회사 양이온성 지질을 포함하는 온도민감성 리포좀 및 그의 용도
TWI552761B (zh) 2013-05-03 2016-10-11 博信生物科技股份有限公司 一種脂質微／奈米氣泡、及其最佳化之製備方法及製備裝置
KR20150034517A (ko) 2013-09-26 2015-04-03 삼성전자주식회사 소수성 활성 성분 및 폴리펩티드의 복합체를 포함하는 리포좀, 및 그의 용도
KR20150047336A (ko) 2013-10-24 2015-05-04 삼성전자주식회사 나노입자, 이를 제조하는 방법, 및 이의 용도
KR20150062652A (ko) 2013-11-29 2015-06-08 삼성전자주식회사 초음파 감응성 리포좀, 그를 포함한 약제학적 조성물 및 그를 이용하여 개체의 체내에 활성제를 전달하는 방법
JP6895252B2 (ja) 2013-12-18 2021-06-30 サインパス ファルマ, インク.Signpath Pharma, Inc. 心筋ｉｋｒチャネルの薬剤誘発性阻害のリポソームによる軽減
JP2017516813A (ja) 2014-06-03 2017-06-22 サインパス ファルマ, インク.Signpath Pharma, Inc. チャネル病を引き起こす薬物に対するｄｍｐｃ、ｄｍｐｇ、ｄｍｐｃ／ｄｍｐｇ、ｅｇｐｇ、ｌｙｓｏｐｇ及びｌｙｓｏｐｃの防御効果
WO2016196648A1 (en) * 2015-06-01 2016-12-08 Autotelic Llc Phospholipid-coated therapeutic agent nanoparticles and related methods
US20160346221A1 (en) 2015-06-01 2016-12-01 Autotelic Llc Phospholipid-coated therapeutic agent nanoparticles and related methods
CN120392779A (zh) 2015-06-15 2025-08-01 华盛顿大学 用于延长血液和淋巴组织中的药物水平的多药脂质纳米颗粒组合物和相关方法
MX382522B (es) 2015-10-16 2025-03-13 Ipsen Biopharm Ltd Composiciones farmaceuticas estabilizantes de camptotecina.
EP3372223B1 (en) 2015-11-02 2024-04-17 FUJIFILM Corporation Liposome composition and method for producing same
KR102638618B1 (ko) 2016-04-27 2024-02-21 사인패스 파마 인코포레이티드 약물 유발된 방실 차단의 방지
MX2021005110A (es) * 2018-11-02 2021-08-24 Tesorx Pharma Llc Quimioterapia intraperitoneal mejorada con liposomas.
CN110292563B (zh) * 2019-06-12 2021-07-16 兰州大学 基于叶酸热敏脂质体的阴离子载体诱导癌细胞凋亡的方法
TWI810633B (zh) 2020-08-24 2023-08-01 國立清華大學 超音波搭配微氣泡輔助之氣球導管系統及其血管擴張方法
WO2023186923A1 (en) 2022-03-30 2023-10-05 Meta Materials Inc. Implanted agent delivery system
CN114832117A (zh) * 2022-05-20 2022-08-02 天津科技大学 一种细胞穿透肽修饰的核酸-阳离子热敏脂质体及其制备方法
WO2024174011A1 (pt) * 2023-02-24 2024-08-29 Rossi Bergmann Bartira Lipossoma, método de preparo de um lipossoma, composição intranasal compreendendo lipossoma, método de preparo de composição intranasal, kit e uso da composição

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3993754A (en) 1974-10-09 1976-11-23 The United States Of America As Represented By The United States Energy Research And Development Administration Liposome-encapsulated actinomycin for cancer chemotherapy
US4863739A (en) 1987-05-19 1989-09-05 Board Of Regents, The University Of Texas System Liposome compositions of anthracycline derivatives
US4952408A (en) 1988-05-23 1990-08-28 Georgetown University Liposome-encapsulated vinca alkaloids and their use in combatting tumors
JPH05194192A (ja) * 1991-08-21 1993-08-03 Shionogi & Co Ltd 分散性の改善された温度感受性ｍｌｖ型リポソ−ム
CN1148336A (zh) 1994-03-28 1997-04-23 第一制药株式会社 增大包封量的脂质体
US20050019266A1 (en) * 1997-05-06 2005-01-27 Unger Evan C. Novel targeted compositions for diagnostic and therapeutic use
CN1221250C (zh) * 1998-04-09 2005-10-05 阿莫萨姆保健公司 微粒造影剂在研究生理参数的诊断成像中的应用
US6726925B1 (en) * 1998-06-18 2004-04-27 Duke University Temperature-sensitive liposomal formulation
US6200598B1 (en) 1998-06-18 2001-03-13 Duke University Temperature-sensitive liposomal formulation
DE60222580T2 (de) 2001-11-13 2008-06-12 Celator Pharmaceuticals, Inc. Lipidträgerzusammensetzungen und verfahren zur verbesserten wirkstoffzurückhaltung
JP2007530639A (ja) * 2004-04-02 2007-11-01 イタルファルマコ，ソシエダ アノニマ リポソーム製剤
TWI388344B (zh) * 2005-08-23 2013-03-11 Celsion Corp 儲存奈米微粒調合物之方法

Also Published As

Publication number Publication date
AU2008323514B2 (en) 2014-06-12
WO2009059449A1 (en) 2009-05-14
EP2217209B1 (en) 2018-06-06
RU2497499C2 (ru) 2013-11-10
MX2010004957A (es) 2010-08-02
TW200930380A (en) 2009-07-16
CA2704258A1 (en) 2009-05-22
AU2008323514A1 (en) 2009-05-22
RU2010123009A (ru) 2011-12-20
AU2008323514A2 (en) 2012-05-17
CN101883557B (zh) 2013-05-29
EP2217209A4 (en) 2013-09-25
KR20100087030A (ko) 2010-08-02
JP5570994B2 (ja) 2014-08-13
BRPI0820505A2 (pt) 2015-06-16
TWI437995B (zh) 2014-05-21
EP2217209A1 (en) 2010-08-18
WO2009062398A1 (en) 2009-05-22
HK1146906A1 (en) 2011-07-22
US20110200665A1 (en) 2011-08-18
US8642074B2 (en) 2014-02-04
ES2689259T3 (es) 2018-11-12
MY151268A (en) 2014-04-30
KR101652126B1 (ko) 2016-08-29
CN101883557A (zh) 2010-11-10
JP2011502134A (ja) 2011-01-20

Similar Documents

Publication Publication Date Title
CA2704258C (en) Novel thermosensitive liposomes containing therapeutic agents
JP2011502134A5 (https=)
CN111228219B (zh) 以人参皂苷Rg3或其类似物为膜材的空白脂质体、其制备方法及应用
JP4555569B2 (ja) 増強された血中安定性を有する脂質キャリア組成物
KR100889139B1 (ko) 이리노테칸 제제
CN115243677A (zh) 用于递送治疗剂的生物可降解药物洗脱栓塞颗粒
TW201711677A (zh) 磷脂-膽固醇酯奈米調配物及其相關方法
Yang et al. Improved antitumor activity and tolerability of cabazitaxel derived remote-loading liposomes
US20070178147A1 (en) Liposomal compositions
CN107708670A (zh) 磷脂包衣的治疗剂纳米颗粒和有关的方法
KR20240037280A (ko) 리포솜 제형의 제조 방법
CN110200920B (zh) 一种还原敏感药物组合物及其制备和应用
HK1146906B (en) Novel thermosensitive liposomes containing therapeutic agents
Wedmann et al. Local drug delivery of irinotecan with phosphatidyldiglycerol-based thermosensitive liposomes reduces systemic exposure and increases therapeutic efficacy compared to systemic drug and Onivyde®
Rathi Development and Characterization of Functionalized Nanoconstructs for Effective Treatment of Lung Cancer
PL197939B1 (pl) Liposomowy preparat zawierający przeciwnowotworową substancję aktywną, sposób jego wytwarzania i zawierająca go kompozycja farmaceutyczna
PL197938B1 (pl) Liposomowy preparat zawierający przeciwnowotworową substancję aktywną, sposób jego wytwarzania i zawierająca go kompozycja farmaceutyczna

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20131104

H11 Ip right ceased following rejected request for revival

Free format text: ST27 STATUS EVENT CODE: T-6-6-H10-H11-H101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: TIME LIMIT FOR REVERSAL EXPIRED

Effective date: 20250506