TWI409068B - 稠合經取代之胺基吡咯啶衍生物 - Google Patents

稠合經取代之胺基吡咯啶衍生物 Download PDF

Info

Publication number
TWI409068B
TWI409068B TW097100126A TW97100126A TWI409068B TW I409068 B TWI409068 B TW I409068B TW 097100126 A TW097100126 A TW 097100126A TW 97100126 A TW97100126 A TW 97100126A TW I409068 B TWI409068 B TW I409068B
Authority
TW
Taiwan
Prior art keywords
group
compound
formula
salt
methyl
Prior art date
Application number
TW097100126A
Other languages
English (en)
Chinese (zh)
Other versions
TW200836733A (en
Inventor
Hisashi Takahashi
Satoshi Komoriya
Takahiro Kitamura
Takashi Odagiri
Hiroaki Inagaki
Toshifumi Tsuda
Kiyoshi Nakayama
Makoto Takemura
Kenichi Yoshida
Rie Miyauchi
Masatoshi Nagamochi
Original Assignee
Daiichi Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Sankyo Co Ltd filed Critical Daiichi Sankyo Co Ltd
Publication of TW200836733A publication Critical patent/TW200836733A/zh
Application granted granted Critical
Publication of TWI409068B publication Critical patent/TWI409068B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/06—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/08—Antibacterial agents for leprosy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Immunology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
TW097100126A 2007-01-05 2008-01-03 稠合經取代之胺基吡咯啶衍生物 TWI409068B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007000667 2007-01-05
JP2007074991 2007-03-22

Publications (2)

Publication Number Publication Date
TW200836733A TW200836733A (en) 2008-09-16
TWI409068B true TWI409068B (zh) 2013-09-21

Family

ID=39522355

Family Applications (1)

Application Number Title Priority Date Filing Date
TW097100126A TWI409068B (zh) 2007-01-05 2008-01-03 稠合經取代之胺基吡咯啶衍生物

Country Status (24)

Country Link
US (2) US8618094B2 (OSRAM)
EP (2) EP2540715A1 (OSRAM)
JP (1) JP5197606B2 (OSRAM)
KR (1) KR101419085B1 (OSRAM)
AR (1) AR064753A1 (OSRAM)
AU (1) AU2007339692B2 (OSRAM)
BR (1) BRPI0720771A2 (OSRAM)
CA (1) CA2674369C (OSRAM)
CL (1) CL2008000026A1 (OSRAM)
CY (1) CY1114444T1 (OSRAM)
DK (1) DK2097400T3 (OSRAM)
ES (1) ES2428344T3 (OSRAM)
IL (1) IL199694A (OSRAM)
MX (1) MX2009007291A (OSRAM)
MY (1) MY162052A (OSRAM)
NO (1) NO20092804L (OSRAM)
NZ (1) NZ577214A (OSRAM)
PE (1) PE20081631A1 (OSRAM)
PL (1) PL2097400T3 (OSRAM)
PT (1) PT2097400E (OSRAM)
RU (1) RU2443698C2 (OSRAM)
SI (1) SI2097400T1 (OSRAM)
TW (1) TWI409068B (OSRAM)
WO (1) WO2008082009A2 (OSRAM)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2602253A4 (en) 2010-08-06 2014-01-01 Daiichi Sankyo Co Ltd CRYSTAL OF AN ANTIBACTERIAL CONNECTION
TW201444558A (zh) * 2013-03-15 2014-12-01 Melinta Therapeutics Inc 使用喹諾酮類抗生素治療淋病感染的方法
LT3413892T (lt) 2016-02-12 2022-06-10 Cytokinetics, Incorporated Tetrahidroizochinolino dariniai
MX2022004742A (es) * 2019-10-23 2022-05-16 Taigen Biotechnology Co Ltd Derivados del acido carboxilico de quinolona.
KR20240141704A (ko) * 2021-07-22 2024-09-27 더 텍사스 에이 & 엠 유니버시티 시스템 활성화된 페레이트 용액 및 이의 방법

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6456673A (en) * 1987-08-25 1989-03-03 Dainippon Pharmaceutical Co Novel pyridonecarboxylic acid derivative, its ester and salt
EP0343524A1 (en) * 1988-05-23 1989-11-29 Shionogi Seiyaku Kabushiki Kaisha Pyridonecarboxylic acids and antibacterial agents
WO1996023782A1 (en) * 1995-02-02 1996-08-08 Daiichi Pharmaceutical Co., Ltd. Heterocyclic compounds
WO1996039407A1 (en) * 1995-06-06 1996-12-12 Abbott Laboratories Quinolizinone type compounds
EP0812838A1 (en) * 1994-02-04 1997-12-17 Dainippon Pharmaceutical Co., Ltd. Pyridonecarboxylic acid derivative substituted by bicyclic amino group, ester thereof, salt thereof, and bicyclic amine as intermediate therefor
WO2005049602A1 (en) * 2003-11-18 2005-06-02 Warner-Lambert Company Llc Quinolone antibacterial agents

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61282382A (ja) 1985-06-06 1986-12-12 Dainippon Pharmaceut Co Ltd フエニル置換１，８−ナフチリジン誘導体、そのエステルおよびその塩
EP0242789A3 (en) 1986-04-25 1990-09-05 Dainippon Pharmaceutical Co., Ltd. Novel quinoline derivates and processes for preparation thereof
MY105136A (en) 1988-04-27 1994-08-30 Daiichi Seiyaku Co Optically active pyridonecarboxylic acid derivatives.
JP2807277B2 (ja) 1988-08-31 1998-10-08 第一製薬株式会社 スピロ化合物
JPH0278659A (ja) * 1988-09-12 1990-03-19 Shionogi & Co Ltd アザビシクロアルカン類化合物
WO1994014794A1 (fr) 1992-12-28 1994-07-07 Yoshitomi Pharmaceutical Industries, Ltd. Derive d'acide 8-methoxyquinolonecarboxylique
JPH06345261A (ja) 1993-04-16 1994-12-20 Daihen Corp 自動搬送装置の搬送用ハンド
DE4435479A1 (de) 1994-10-04 1996-04-11 Bayer Ag Chinolon- und Naphthyridoncarbonsäure-Derivate
JP4132155B2 (ja) * 1996-10-25 2008-08-13 第一三共株式会社 三環性アミン誘導体
BR9915599A (pt) * 1998-11-24 2001-11-20 Daiichi Seiyaku Co Derivados de aminometilpirrolidina substituìdacom cicloalquila
CN1275970C (zh) * 2000-11-24 2006-09-20 明治制果株式会社 新的碳青霉烯类衍生物
US7563805B2 (en) * 2005-05-19 2009-07-21 Daiichi Pharmaceutical Co., Ltd. Tri-, tetra-substituted-3-aminopyrrolidine derivative

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6456673A (en) * 1987-08-25 1989-03-03 Dainippon Pharmaceutical Co Novel pyridonecarboxylic acid derivative, its ester and salt
EP0343524A1 (en) * 1988-05-23 1989-11-29 Shionogi Seiyaku Kabushiki Kaisha Pyridonecarboxylic acids and antibacterial agents
EP0812838A1 (en) * 1994-02-04 1997-12-17 Dainippon Pharmaceutical Co., Ltd. Pyridonecarboxylic acid derivative substituted by bicyclic amino group, ester thereof, salt thereof, and bicyclic amine as intermediate therefor
WO1996023782A1 (en) * 1995-02-02 1996-08-08 Daiichi Pharmaceutical Co., Ltd. Heterocyclic compounds
WO1996039407A1 (en) * 1995-06-06 1996-12-12 Abbott Laboratories Quinolizinone type compounds
WO2005049602A1 (en) * 2003-11-18 2005-06-02 Warner-Lambert Company Llc Quinolone antibacterial agents

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Cianchetta Giovanni et al. "Chemometric Studies on the Bactericidal Activity of Quinolones via an Extended VolSurf Approach" Journal of Medicinal Chemistry,2004,vol.47,pages 3193-3201. *
Ogata M. et al.;"Synthesis and antibacterial activity of new 7-(aminoazabicycloalkanyl)quinolonecarboxylic acids";European Journal of Medicinal Chemistry,1991,vol.26,no.9,pages 889-906. *

Also Published As

Publication number Publication date
EP2097400B1 (en) 2013-07-03
IL199694A0 (en) 2010-04-15
NO20092804L (no) 2009-10-05
US20120108582A1 (en) 2012-05-03
US8618094B2 (en) 2013-12-31
HK1130056A1 (en) 2009-12-18
ES2428344T3 (es) 2013-11-07
US20140142096A1 (en) 2014-05-22
KR20090096618A (ko) 2009-09-11
TW200836733A (en) 2008-09-16
CA2674369C (en) 2012-04-03
SI2097400T1 (sl) 2013-10-30
JP2010515663A (ja) 2010-05-13
BRPI0720771A2 (pt) 2014-07-15
AU2007339692B2 (en) 2012-01-19
WO2008082009A2 (en) 2008-07-10
CA2674369A1 (en) 2008-07-10
EP2540715A1 (en) 2013-01-02
AR064753A1 (es) 2009-04-22
MX2009007291A (es) 2009-07-14
US20130029977A9 (en) 2013-01-31
CL2008000026A1 (es) 2008-05-16
RU2443698C2 (ru) 2012-02-27
AU2007339692A1 (en) 2008-07-10
WO2008082009A3 (en) 2008-12-11
PT2097400E (pt) 2013-10-10
JP5197606B2 (ja) 2013-05-15
PE20081631A1 (es) 2008-11-22
IL199694A (en) 2013-08-29
CY1114444T1 (el) 2016-08-31
DK2097400T3 (da) 2013-10-14
PL2097400T3 (pl) 2013-11-29
RU2009129975A (ru) 2011-02-10
EP2097400A2 (en) 2009-09-09
NZ577214A (en) 2011-11-25
MY162052A (en) 2017-05-31
KR101419085B1 (ko) 2014-07-15

Similar Documents

Publication Publication Date Title
JP5475841B2 (ja) トリ−、テトラ−置換−３−アミノピロリジン誘導体
TW200946528A (en) Piperidine derivatives
EP1304329A2 (en) Pyridonecarboxylic acid derivatives and their use as antibacterial agents
CN101622240B (zh) 稠合取代氨基吡咯烷衍生物
US20140142096A1 (en) Fused Substituted Aminopyrrolidine Derivative
WO1997019072A1 (en) Substituted aminocycloalkylpyrrolidine derivatives
WO1998018783A1 (en) Tricyclic amine derivatives
US6462040B1 (en) Cis-substituted aminocyclopropane derivative
IL143210A (en) Aminomethylpyrrolidine derivatives converted to cycloalkyl
JPH10287669A (ja) 置換アミノメチルピロリジン誘導体
JP4820290B2 (ja) 置換ピロリジン誘導体
TW201309689A (zh) 含胺基之吡咯啶酮衍生物
CN101189222B (zh) 三-、四-取代-3-氨基吡咯烷衍生物
HK1130056B (en) Fused substituted aminopyrrolidine derivative
JP2010031000A (ja) フューズ置換型アミノピロリジン誘導体含有医薬組成物
JP5063032B2 (ja) トリ−、テトラ−置換−３−アミノピロリジン誘導体
HK40105326A (zh) 取代的螺环衍生物
JPH11199561A (ja) シス置換アミノシクロプロパン化合物

Legal Events

Date Code Title Description
MM4A Annulment or lapse of patent due to non-payment of fees