JP5197606B2 - フューズ置換型アミノピロリジン誘導体 - Google Patents
フューズ置換型アミノピロリジン誘導体 Download PDFInfo
- Publication number
- JP5197606B2 JP5197606B2 JP2009527641A JP2009527641A JP5197606B2 JP 5197606 B2 JP5197606 B2 JP 5197606B2 JP 2009527641 A JP2009527641 A JP 2009527641A JP 2009527641 A JP2009527641 A JP 2009527641A JP 5197606 B2 JP5197606 B2 JP 5197606B2
- Authority
- JP
- Japan
- Prior art keywords
- group
- amino
- methyl
- carbon atoms
- reaction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 CC(N1C2=C3C(*C=C)=C(*)C(C)=I2)=CSC1=C(*)C3=O Chemical compound CC(N1C2=C3C(*C=C)=C(*)C(C)=I2)=CSC1=C(*)C3=O 0.000 description 23
- OOZGSCPDYHDFMX-UHFFFAOYSA-N CC(C)(C)OC(NC1(CN(C2)OC(c3ccccc3)=O)C2(C2)C2CC1)=O Chemical compound CC(C)(C)OC(NC1(CN(C2)OC(c3ccccc3)=O)C2(C2)C2CC1)=O OOZGSCPDYHDFMX-UHFFFAOYSA-N 0.000 description 2
- SWJOGONLMOMYAO-RHSMWYFYSA-N C[C@H](c1ccccc1)N(C[C@](CC=C)(COC)C1)C1=O Chemical compound C[C@H](c1ccccc1)N(C[C@](CC=C)(COC)C1)C1=O SWJOGONLMOMYAO-RHSMWYFYSA-N 0.000 description 2
- VMAWZWVZUYRLPW-UHFFFAOYSA-N C=CCCC(CN(C1)OC(c2ccccc2)=O)(C1CO1)C1=O Chemical compound C=CCCC(CN(C1)OC(c2ccccc2)=O)(C1CO1)C1=O VMAWZWVZUYRLPW-UHFFFAOYSA-N 0.000 description 1
- SDKJKWIPIMWOFN-YKXYSFTHSA-N CC(C)(C)OC(N[C@@]1(CC(C2)F)[C@H]2CNC1)=O Chemical compound CC(C)(C)OC(N[C@@]1(CC(C2)F)[C@H]2CNC1)=O SDKJKWIPIMWOFN-YKXYSFTHSA-N 0.000 description 1
- GZHJMBJEWHKLIA-CHWSQXEVSA-N CC(C)(C)OC(N[C@@]1(CCC2)[C@@]2(C)CNC1)=O Chemical compound CC(C)(C)OC(N[C@@]1(CCC2)[C@@]2(C)CNC1)=O GZHJMBJEWHKLIA-CHWSQXEVSA-N 0.000 description 1
- VXDHWDGFBJXECS-NWDGAFQWSA-N CC(C)(C)OC(N[C@](CCC1)(CNC2)[C@]12Cl)=O Chemical compound CC(C)(C)OC(N[C@](CCC1)(CNC2)[C@]12Cl)=O VXDHWDGFBJXECS-NWDGAFQWSA-N 0.000 description 1
- RZNHDYGCLDEGLK-FFFFSGIJSA-N CC(C)(C)OC(N[C@]1(CNC2)C2COCC1)=O Chemical compound CC(C)(C)OC(N[C@]1(CNC2)C2COCC1)=O RZNHDYGCLDEGLK-FFFFSGIJSA-N 0.000 description 1
- PGZYESLDSMCWSO-SKDRFNHKSA-N CC(C)(C)OC(N[C@]1(CNC2)[C@@H]2CCOC1)=O Chemical compound CC(C)(C)OC(N[C@]1(CNC2)[C@@H]2CCOC1)=O PGZYESLDSMCWSO-SKDRFNHKSA-N 0.000 description 1
- PGZYESLDSMCWSO-CABZTGNLSA-N CC(C)(C)OC(N[C@]1(CNC2)[C@H]2CCOC1)=O Chemical compound CC(C)(C)OC(N[C@]1(CNC2)[C@H]2CCOC1)=O PGZYESLDSMCWSO-CABZTGNLSA-N 0.000 description 1
- HSZVLFMFZYSSHR-MKJPBZQASA-N CC(c1ccccc1)N(CC1COCC2)C[C@@]12NC(OC(C)(C)C)=O Chemical compound CC(c1ccccc1)N(CC1COCC2)C[C@@]12NC(OC(C)(C)C)=O HSZVLFMFZYSSHR-MKJPBZQASA-N 0.000 description 1
- GEHCQAAVOCSKPU-GVJPCGBOSA-N CCOC(C([C@@H](CN1[C@@H](C)c2ccccc2)C2(CO)CC2)C1=O)=O Chemical compound CCOC(C([C@@H](CN1[C@@H](C)c2ccccc2)C2(CO)CC2)C1=O)=O GEHCQAAVOCSKPU-GVJPCGBOSA-N 0.000 description 1
- DFKYQTUJTMSPII-UHFFFAOYSA-N COC(C1(CCC2)C2CN(Cc2ccccc2)C1)=O Chemical compound COC(C1(CCC2)C2CN(Cc2ccccc2)C1)=O DFKYQTUJTMSPII-UHFFFAOYSA-N 0.000 description 1
- LWUCQGUVOGLSMM-UHFFFAOYSA-N COC(C1(CN(C2)OC(c3ccccc3)=O)C2=CCC1)=O Chemical compound COC(C1(CN(C2)OC(c3ccccc3)=O)C2=CCC1)=O LWUCQGUVOGLSMM-UHFFFAOYSA-N 0.000 description 1
- DOUPBUMELOYVOT-BVVSKGPKSA-N COc(c(N(C(C1)[C@H]1F)C=C1C(O)=O)c(cc2F)C1=O)c2N(CC1(CCC2)N)CC12Cl Chemical compound COc(c(N(C(C1)[C@H]1F)C=C1C(O)=O)c(cc2F)C1=O)c2N(CC1(CCC2)N)CC12Cl DOUPBUMELOYVOT-BVVSKGPKSA-N 0.000 description 1
- BHKIAANYWYSRKN-MKXJDEKUSA-N C[C@@H]1N(C=C(C(O)=O)C(c2cc(F)c3N(C[C@@H]4CCOC5)C[C@@]45N)=O)c2c3OC1 Chemical compound C[C@@H]1N(C=C(C(O)=O)C(c2cc(F)c3N(C[C@@H]4CCOC5)C[C@@]45N)=O)c2c3OC1 BHKIAANYWYSRKN-MKXJDEKUSA-N 0.000 description 1
- PWDXRSDQBUDFEZ-SNPRPXQTSA-O C[C@H](c1ccccc1)N(C[C@@H](C[OH2+])[C@@H]1CC=C)C1=O Chemical compound C[C@H](c1ccccc1)N(C[C@@H](C[OH2+])[C@@H]1CC=C)C1=O PWDXRSDQBUDFEZ-SNPRPXQTSA-O 0.000 description 1
- RSGZKCYVDLGNMN-UIAACRFSSA-N C[C@H](c1ccccc1)N(C[C@@]1(CCC2)NC(OC(C)(C)C)=O)C[C@]12Cl Chemical compound C[C@H](c1ccccc1)N(C[C@@]1(CCC2)NC(OC(C)(C)C)=O)C[C@]12Cl RSGZKCYVDLGNMN-UIAACRFSSA-N 0.000 description 1
- FZLAPXYUTZTYSV-PNMPEKGYSA-N C[C@H](c1ccccc1)N(C[C@](C1)([C@@H]2CC1F)C(O)=O)C2=O Chemical compound C[C@H](c1ccccc1)N(C[C@](C1)([C@@H]2CC1F)C(O)=O)C2=O FZLAPXYUTZTYSV-PNMPEKGYSA-N 0.000 description 1
- CTYPQNMFVCNODA-BJGZIPOHSA-N C[C@H](c1ccccc1)N(C[C@](C1)([C@@H]2CC1F)N)C2=O Chemical compound C[C@H](c1ccccc1)N(C[C@](C1)([C@@H]2CC1F)N)C2=O CTYPQNMFVCNODA-BJGZIPOHSA-N 0.000 description 1
- FOZQIHBDGZVZEE-CZUORRHYSA-N C[C@H](c1ccccc1)N(C[C@](CC=C)(CO)C1)C1=O Chemical compound C[C@H](c1ccccc1)N(C[C@](CC=C)(CO)C1)C1=O FOZQIHBDGZVZEE-CZUORRHYSA-N 0.000 description 1
- VPQYPCYSGMUFMX-RLCCDNCMSA-N C[C@H](c1ccccc1)N(C[C@](CCC1)([C@]11Cl)C(O)=O)C1=O Chemical compound C[C@H](c1ccccc1)N(C[C@](CCC1)([C@]11Cl)C(O)=O)C1=O VPQYPCYSGMUFMX-RLCCDNCMSA-N 0.000 description 1
- INNXNWLCRCSXEM-QRWLVFNGSA-N C[C@H](c1ccccc1)N(C[C@](CCCO)(C1)C(OC(C)(C)C)=O)C1=O Chemical compound C[C@H](c1ccccc1)N(C[C@](CCCO)(C1)C(OC(C)(C)C)=O)C1=O INNXNWLCRCSXEM-QRWLVFNGSA-N 0.000 description 1
- NIQOARFLOQPOLE-CZUORRHYSA-N C[C@H](c1ccccc1)N(C[C@](CCO)(COC)C1)C1=O Chemical compound C[C@H](c1ccccc1)N(C[C@](CCO)(COC)C1)C1=O NIQOARFLOQPOLE-CZUORRHYSA-N 0.000 description 1
- PAVMRYVMZLANOQ-MRVPVSSYSA-N C[C@H](c1ccccc1)NC(C)=O Chemical compound C[C@H](c1ccccc1)NC(C)=O PAVMRYVMZLANOQ-MRVPVSSYSA-N 0.000 description 1
- WOWVOTQIELNYOM-UHFFFAOYSA-N NC(CCC1)(C2)C1CN2c(c(F)cc1c2N(C3CC3)C=C(C(O)=O)C1=O)c2F Chemical compound NC(CCC1)(C2)C1CN2c(c(F)cc1c2N(C3CC3)C=C(C(O)=O)C1=O)c2F WOWVOTQIELNYOM-UHFFFAOYSA-N 0.000 description 1
- NMASXYCNDJMMFR-UHFFFAOYSA-N OC(C(C(c1cc(F)c2F)=O)=CN(C3CC3)c1c2F)=O Chemical compound OC(C(C(c1cc(F)c2F)=O)=CN(C3CC3)c1c2F)=O NMASXYCNDJMMFR-UHFFFAOYSA-N 0.000 description 1
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/06—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/08—Antibacterial agents for leprosy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Immunology (AREA)
- Ophthalmology & Optometry (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2009527641A JP5197606B2 (ja) | 2007-01-05 | 2007-12-28 | フューズ置換型アミノピロリジン誘導体 |
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2007000667 | 2007-01-05 | ||
| JP2007000667 | 2007-01-05 | ||
| JP2007074991 | 2007-03-22 | ||
| JP2007074991 | 2007-03-22 | ||
| PCT/JP2007/075434 WO2008082009A2 (en) | 2007-01-05 | 2007-12-28 | Fused substituted aminopyrrolidine derivative |
| JP2009527641A JP5197606B2 (ja) | 2007-01-05 | 2007-12-28 | フューズ置換型アミノピロリジン誘導体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010515663A JP2010515663A (ja) | 2010-05-13 |
| JP2010515663A5 JP2010515663A5 (OSRAM) | 2011-02-17 |
| JP5197606B2 true JP5197606B2 (ja) | 2013-05-15 |
Family
ID=39522355
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009527641A Expired - Fee Related JP5197606B2 (ja) | 2007-01-05 | 2007-12-28 | フューズ置換型アミノピロリジン誘導体 |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US8618094B2 (OSRAM) |
| EP (2) | EP2540715A1 (OSRAM) |
| JP (1) | JP5197606B2 (OSRAM) |
| KR (1) | KR101419085B1 (OSRAM) |
| AR (1) | AR064753A1 (OSRAM) |
| AU (1) | AU2007339692B2 (OSRAM) |
| BR (1) | BRPI0720771A2 (OSRAM) |
| CA (1) | CA2674369C (OSRAM) |
| CL (1) | CL2008000026A1 (OSRAM) |
| CY (1) | CY1114444T1 (OSRAM) |
| DK (1) | DK2097400T3 (OSRAM) |
| ES (1) | ES2428344T3 (OSRAM) |
| IL (1) | IL199694A (OSRAM) |
| MX (1) | MX2009007291A (OSRAM) |
| MY (1) | MY162052A (OSRAM) |
| NO (1) | NO20092804L (OSRAM) |
| NZ (1) | NZ577214A (OSRAM) |
| PE (1) | PE20081631A1 (OSRAM) |
| PL (1) | PL2097400T3 (OSRAM) |
| PT (1) | PT2097400E (OSRAM) |
| RU (1) | RU2443698C2 (OSRAM) |
| SI (1) | SI2097400T1 (OSRAM) |
| TW (1) | TWI409068B (OSRAM) |
| WO (1) | WO2008082009A2 (OSRAM) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2602253A4 (en) | 2010-08-06 | 2014-01-01 | Daiichi Sankyo Co Ltd | CRYSTAL OF AN ANTIBACTERIAL CONNECTION |
| TW201444558A (zh) * | 2013-03-15 | 2014-12-01 | Melinta Therapeutics Inc | 使用喹諾酮類抗生素治療淋病感染的方法 |
| LT3413892T (lt) | 2016-02-12 | 2022-06-10 | Cytokinetics, Incorporated | Tetrahidroizochinolino dariniai |
| MX2022004742A (es) * | 2019-10-23 | 2022-05-16 | Taigen Biotechnology Co Ltd | Derivados del acido carboxilico de quinolona. |
| KR20240141704A (ko) * | 2021-07-22 | 2024-09-27 | 더 텍사스 에이 & 엠 유니버시티 시스템 | 활성화된 페레이트 용액 및 이의 방법 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61282382A (ja) | 1985-06-06 | 1986-12-12 | Dainippon Pharmaceut Co Ltd | フエニル置換１，８−ナフチリジン誘導体、そのエステルおよびその塩 |
| EP0242789A3 (en) | 1986-04-25 | 1990-09-05 | Dainippon Pharmaceutical Co., Ltd. | Novel quinoline derivates and processes for preparation thereof |
| JPH0676400B2 (ja) * | 1987-08-25 | 1994-09-28 | 大日本製薬株式会社 | 新規ピリドンカルボン酸誘導体、そのエステルおよびその塩 |
| MY105136A (en) | 1988-04-27 | 1994-08-30 | Daiichi Seiyaku Co | Optically active pyridonecarboxylic acid derivatives. |
| JP2844079B2 (ja) * | 1988-05-23 | 1999-01-06 | 塩野義製薬株式会社 | ピリドンカルボン酸系抗菌剤 |
| JP2807277B2 (ja) | 1988-08-31 | 1998-10-08 | 第一製薬株式会社 | スピロ化合物 |
| JPH0278659A (ja) * | 1988-09-12 | 1990-03-19 | Shionogi & Co Ltd | アザビシクロアルカン類化合物 |
| WO1994014794A1 (fr) | 1992-12-28 | 1994-07-07 | Yoshitomi Pharmaceutical Industries, Ltd. | Derive d'acide 8-methoxyquinolonecarboxylique |
| JPH06345261A (ja) | 1993-04-16 | 1994-12-20 | Daihen Corp | 自動搬送装置の搬送用ハンド |
| PT812838E (pt) * | 1994-02-04 | 2002-10-31 | Dainippon Pharmaceutical Co | Derivado de acido piridonacarboxilico substituido com o grupo amino biciclico seu ester seu sal e amina biciclica como seu intermediario |
| DE4435479A1 (de) | 1994-10-04 | 1996-04-11 | Bayer Ag | Chinolon- und Naphthyridoncarbonsäure-Derivate |
| DK0807630T3 (da) * | 1995-02-02 | 2003-09-01 | Daiichi Seiyaku Co | Heterocykliske forbindelser |
| EP0871628A1 (en) * | 1995-06-06 | 1998-10-21 | Abbott Laboratories | Quinolizinone type compounds |
| JP4132155B2 (ja) * | 1996-10-25 | 2008-08-13 | 第一三共株式会社 | 三環性アミン誘導体 |
| BR9915599A (pt) * | 1998-11-24 | 2001-11-20 | Daiichi Seiyaku Co | Derivados de aminometilpirrolidina substituìdacom cicloalquila |
| CN1275970C (zh) * | 2000-11-24 | 2006-09-20 | 明治制果株式会社 | 新的碳青霉烯类衍生物 |
| WO2005049602A1 (en) * | 2003-11-18 | 2005-06-02 | Warner-Lambert Company Llc | Quinolone antibacterial agents |
| US7563805B2 (en) * | 2005-05-19 | 2009-07-21 | Daiichi Pharmaceutical Co., Ltd. | Tri-, tetra-substituted-3-aminopyrrolidine derivative |
-
2007
- 2007-12-28 MX MX2009007291A patent/MX2009007291A/es active IP Right Grant
- 2007-12-28 DK DK07860629.0T patent/DK2097400T3/da active
- 2007-12-28 JP JP2009527641A patent/JP5197606B2/ja not_active Expired - Fee Related
- 2007-12-28 MY MYPI20092809A patent/MY162052A/en unknown
- 2007-12-28 RU RU2009129975/04A patent/RU2443698C2/ru not_active IP Right Cessation
- 2007-12-28 PL PL07860629T patent/PL2097400T3/pl unknown
- 2007-12-28 SI SI200731318T patent/SI2097400T1/sl unknown
- 2007-12-28 WO PCT/JP2007/075434 patent/WO2008082009A2/en not_active Ceased
- 2007-12-28 ES ES07860629T patent/ES2428344T3/es active Active
- 2007-12-28 KR KR1020097013835A patent/KR101419085B1/ko not_active Expired - Fee Related
- 2007-12-28 PT PT78606290T patent/PT2097400E/pt unknown
- 2007-12-28 CA CA2674369A patent/CA2674369C/en not_active Expired - Fee Related
- 2007-12-28 AU AU2007339692A patent/AU2007339692B2/en not_active Ceased
- 2007-12-28 EP EP12186361A patent/EP2540715A1/en not_active Withdrawn
- 2007-12-28 NZ NZ577214A patent/NZ577214A/en not_active IP Right Cessation
- 2007-12-28 BR BRPI0720771-9A2A patent/BRPI0720771A2/pt not_active IP Right Cessation
- 2007-12-28 EP EP07860629.0A patent/EP2097400B1/en not_active Not-in-force
-
2008
- 2008-01-03 TW TW097100126A patent/TWI409068B/zh not_active IP Right Cessation
- 2008-01-04 AR ARP080100035A patent/AR064753A1/es not_active Application Discontinuation
- 2008-01-04 CL CL200800026A patent/CL2008000026A1/es unknown
- 2008-01-04 PE PE2008000090A patent/PE20081631A1/es not_active Application Discontinuation
-
2009
- 2009-07-02 US US12/459,612 patent/US8618094B2/en not_active Expired - Fee Related
- 2009-07-05 IL IL199694A patent/IL199694A/en not_active IP Right Cessation
- 2009-08-04 NO NO20092804A patent/NO20092804L/no not_active Application Discontinuation
-
2013
- 2013-09-30 CY CY20131100845T patent/CY1114444T1/el unknown
- 2013-11-19 US US14/084,485 patent/US20140142096A1/en not_active Abandoned
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP5475841B2 (ja) | トリ−、テトラ−置換−３−アミノピロリジン誘導体 | |
| US5849757A (en) | Pyridonecarboxylic acid derivatives substituted by a bicyclic amino group as antibacterials | |
| NO177638B (no) | Analogifremgangsmåte for fremstilling av en terapeutisk aktiv spiroforbindelse | |
| JP4040091B2 (ja) | 置換アミノシクロアルキルピロリジン誘導体 | |
| US20140142096A1 (en) | Fused Substituted Aminopyrrolidine Derivative | |
| CN101622240B (zh) | 稠合取代氨基吡咯烷衍生物 | |
| US6384050B1 (en) | Tricyclic amine derivatives | |
| MXPA04009026A (es) | Derivados de acido 10- (3- ciclopropilaminometil -1-pirrolidinil) piridobenzoxazin- carboxilico efectivos contra bacterias resistentes a farmacos. | |
| US20020183523A1 (en) | Cis-substituted aminocyclopropane derivative | |
| JPH10287669A (ja) | 置換アミノメチルピロリジン誘導体 | |
| JP2010031000A (ja) | フューズ置換型アミノピロリジン誘導体含有医薬組成物 | |
| EP2674430A1 (en) | Amino group-containing pyrrolidinone derivative | |
| HK1130056B (en) | Fused substituted aminopyrrolidine derivative | |
| JP5063032B2 (ja) | トリ−、テトラ−置換−３−アミノピロリジン誘導体 | |
| JPH1112278A (ja) | ピリドンカルボン酸誘導体、そのエステルまたはこれらの塩 | |
| JPWO1996024593A1 (ja) | ヘテロ環式スピロ誘導体 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A524 | Written submission of copy of amendment under article 19 pct |
Free format text: JAPANESE INTERMEDIATE CODE: A524 Effective date: 20101216 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20101222 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20101222 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20130107 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20130205 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20160215 Year of fee payment: 3 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 5197606 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| LAPS | Cancellation because of no payment of annual fees |