TWI384998B - 抗-TGF-β受體II抗體 - Google Patents

抗-TGF-β受體II抗體 Download PDF

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Publication number
TWI384998B
TWI384998B TW098135300A TW98135300A TWI384998B TW I384998 B TWI384998 B TW I384998B TW 098135300 A TW098135300 A TW 098135300A TW 98135300 A TW98135300 A TW 98135300A TW I384998 B TWI384998 B TW I384998B
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TW
Taiwan
Prior art keywords
antibody
tgfβrii
seq
human
sequence
Prior art date
Application number
TW098135300A
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English (en)
Chinese (zh)
Other versions
TW201026326A (en
Inventor
Yan Wu
Original Assignee
Imclone Llc
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Publication date
Application filed by Imclone Llc filed Critical Imclone Llc
Publication of TW201026326A publication Critical patent/TW201026326A/zh
Application granted granted Critical
Publication of TWI384998B publication Critical patent/TWI384998B/zh

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
TW098135300A 2008-11-07 2009-10-19 抗-TGF-β受體II抗體 TWI384998B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19869708P 2008-11-07 2008-11-07
US17036909P 2009-04-17 2009-04-17

Publications (2)

Publication Number Publication Date
TW201026326A TW201026326A (en) 2010-07-16
TWI384998B true TWI384998B (zh) 2013-02-11

Family

ID=41508691

Family Applications (1)

Application Number Title Priority Date Filing Date
TW098135300A TWI384998B (zh) 2008-11-07 2009-10-19 抗-TGF-β受體II抗體

Country Status (19)

Country Link
US (2) US8147834B2 (cg-RX-API-DMAC7.html)
EP (1) EP2356152A1 (cg-RX-API-DMAC7.html)
JP (1) JP5667067B2 (cg-RX-API-DMAC7.html)
KR (1) KR101283856B1 (cg-RX-API-DMAC7.html)
CN (1) CN102209727B (cg-RX-API-DMAC7.html)
AR (1) AR073909A1 (cg-RX-API-DMAC7.html)
AU (1) AU2009311375B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0921263A2 (cg-RX-API-DMAC7.html)
CA (1) CA2742961C (cg-RX-API-DMAC7.html)
EA (1) EA025169B1 (cg-RX-API-DMAC7.html)
IL (1) IL211842A (cg-RX-API-DMAC7.html)
JO (1) JO3096B1 (cg-RX-API-DMAC7.html)
MX (1) MX2011004871A (cg-RX-API-DMAC7.html)
NZ (1) NZ591943A (cg-RX-API-DMAC7.html)
PA (1) PA8846101A1 (cg-RX-API-DMAC7.html)
SG (1) SG10201401280TA (cg-RX-API-DMAC7.html)
TW (1) TWI384998B (cg-RX-API-DMAC7.html)
WO (1) WO2010053814A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA201103178B (cg-RX-API-DMAC7.html)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012093125A1 (en) * 2011-01-06 2012-07-12 Glaxo Group Limited Ligands that bind tgf-beta receptor ii
AR086044A1 (es) 2011-05-12 2013-11-13 Imclone Llc Anticuerpos que se unen especificamente a un dominio extracelular de c-kit y usos de los mismos
EP4653013A2 (en) 2014-10-31 2025-11-26 The Trustees of the University of Pennsylvania Methods and compositions for modified t cells
ES2947589T3 (es) 2015-01-31 2023-08-11 Univ Pennsylvania Composiciones y métodos para el suministro de moléculas terapéuticas a linfocitos T
PT3370768T (pt) * 2015-11-03 2022-04-21 Janssen Biotech Inc Anticorpos que se ligam especificamente ao pd-1 e seus usos
DK3365368T3 (da) 2016-03-11 2023-06-26 Scholar Rock Inc Tgfbeta1-bindende immunoglobuliner og anvendelse deraf
WO2017201527A2 (en) * 2016-05-20 2017-11-23 President And Fellows Of Harvard College Gene therapy methods for age-related diseases and conditions
AR109770A1 (es) 2016-10-18 2019-01-23 Lilly Co Eli ANTICUERPOS DEL RECEPTOR II DE TGF-b
CN117398457A (zh) * 2017-01-06 2024-01-16 供石公司 亚型特异性、背景许可性TGFβ1抑制剂及其用途
CN106884005A (zh) * 2017-01-19 2017-06-23 樊克兴 一种结直肠癌抗原特异性t细胞的制备方法
US10899843B2 (en) 2017-10-24 2021-01-26 Magenta Therapeutics, Inc. Compositions and methods for the depletion of CD117+ cells
WO2019084053A1 (en) * 2017-10-24 2019-05-02 Magenta Therapeutics, Inc. COMPOSITIONS AND METHODS FOR DEPLOYING CD117 + CELLS
AU2018354189A1 (en) 2017-10-24 2020-04-23 Crispr Therapeutics Ag Compositions and methods for the depletion of CD117+ cells
CN107973853B (zh) * 2017-12-12 2021-04-30 山西农业大学 一种利用特征多肽制备Smad2蛋白特异性抗体的方法及其应用
US12398209B2 (en) 2018-01-22 2025-08-26 Janssen Biotech, Inc. Methods of treating cancers with antagonistic anti-PD-1 antibodies
AU2020412201A1 (en) * 2019-12-24 2022-07-14 Merus N.V. TGF-beta-RII binding proteins
KR102314157B1 (ko) * 2020-01-10 2021-10-19 주식회사 뉴클릭스바이오 TGF-β 수용체에 특이적으로 결합하는 항체 및 이의 이용방법
KR20250005109A (ko) * 2022-04-15 2025-01-09 바이오사이토젠 파마슈티컬스 (베이징) 컴퍼니 리미티드 항-cd40 항체 및 이의 용도
CN116178567B (zh) * 2022-10-28 2025-01-28 四川大学华西医院 一种靶向TGFβRII的嵌合抗原受体及其用途

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1245676A1 (en) * 1999-11-18 2002-10-02 Japan Tobacco Inc. Human monoclonal antibodies against tgf-beta ii receptor and medicinal use thereof
JP2004121001A (ja) * 2002-08-07 2004-04-22 Japan Tobacco Inc TGF−βII型受容体に対する高親和性モノクローナル抗体

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5565332A (en) 1991-09-23 1996-10-15 Medical Research Council Production of chimeric antibodies - a combinatorial approach
CA2122491A1 (en) 1991-10-31 1993-05-13 Herbert Y. Lin Tgf-.beta. type receptor cdnas and uses therefor
JPWO2007088651A1 (ja) 2006-02-01 2009-06-25 国立大学法人 東京大学 TGF−βシグナル阻害剤と抗腫瘍剤の組み合せ使用

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1245676A1 (en) * 1999-11-18 2002-10-02 Japan Tobacco Inc. Human monoclonal antibodies against tgf-beta ii receptor and medicinal use thereof
JP2004121001A (ja) * 2002-08-07 2004-04-22 Japan Tobacco Inc TGF−βII型受容体に対する高親和性モノクローナル抗体

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Hemmie R Hoogenboom, Selecting and screening recombinant antibody libraries, Nature Biotechnology, 2005, Vol. 23, pages 1105-1116 *
Teicher BA, Transforming growth factor-beta in in vivo resistance, Cancer Chemother Pharmacol, 1996, Vol.37, pages 601-9 *

Also Published As

Publication number Publication date
SG10201401280TA (en) 2014-05-29
BRPI0921263A2 (pt) 2015-08-04
CA2742961C (en) 2016-08-30
KR101283856B1 (ko) 2013-07-15
AU2009311375A1 (en) 2010-05-14
KR20110067155A (ko) 2011-06-21
EP2356152A1 (en) 2011-08-17
JO3096B1 (ar) 2017-03-15
JP2012508170A (ja) 2012-04-05
EA025169B1 (ru) 2016-11-30
NZ591943A (en) 2012-11-30
ZA201103178B (en) 2012-10-31
CA2742961A1 (en) 2010-05-14
MX2011004871A (es) 2011-07-13
AR073909A1 (es) 2010-12-09
US8147834B2 (en) 2012-04-03
US20120177666A1 (en) 2012-07-12
US20100119516A1 (en) 2010-05-13
WO2010053814A1 (en) 2010-05-14
CN102209727B (zh) 2014-07-30
AU2009311375B2 (en) 2014-07-31
CN102209727A (zh) 2011-10-05
IL211842A (en) 2016-09-29
JP5667067B2 (ja) 2015-02-12
PA8846101A1 (es) 2010-06-28
IL211842A0 (en) 2011-06-30
EA201170659A1 (ru) 2011-10-31
TW201026326A (en) 2010-07-16

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